Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model

(2010) K. Yizhak et al.   BIOINFORMATICS

Combined data preprocessing and multivariate statistical analysis characterizes fed-batch culture of mouse hybridoma cells for rational medium design

(2010) Suresh Selvarasu et al.   JOURNAL OF BIOTECHNOLOGY

Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: Overexpression of malate dehydrogenase II

(2010) William P.K. Chong et al.   JOURNAL OF BIOTECHNOLOGY

Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media

(2010) William P.K. Chong et al.   JOURNAL OF BIOTECHNOLOGY

Developing genomic platforms for Chinese hamster ovary cells

(2009) Anne Kantardjieff et al.   BIOTECHNOLOGY ADVANCES

CHO gene expression profiling in biopharmaceutical process analysis and design

(2009) Jochen Schaub et al.   BIOTECHNOLOGY AND BIOENGINEERING

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Connecting extracellular metabolomic measurements to intracellular flux states in yeast

(2009) Monica L Mo et al.   BMC Systems Biology

Macromolecular and elemental composition analysis and extracellular metabolite balances of Pichia pastoris growing at different oxygen levels

(2009) Marc Carnicer et al.   Microbial Cell Factories

Genome-scale modeling and in silico analysis of mouse cell metabolic network

(2009) Suresh Selvarasu et al.   Molecular BioSystems

Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture

(2009) William P. K. Chong et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Metabolic flux model for an anchorage-dependent MDCK cell line: Characteristic growth phases and minimum substrate consumption flux distribution

(2008) Aljoscha Wahl et al.   BIOTECHNOLOGY AND BIOENGINEERING

Elucidation of metabolism in hybridoma cells grown in fed-batch culture by genome-scale modeling

(2008) Suresh Selvarasu et al.   BIOTECHNOLOGY AND BIOENGINEERING

A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?

(2008) Janet Chusainow et al.   BIOTECHNOLOGY AND BIOENGINEERING

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress

(2007) Navasona Krishnan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Substitution of Glutamine by Pyruvate To Reduce Ammonia Formation and Growth Inhibition of Mammalian Cells

(2005) Yvonne Genzel et al.   BIOTECHNOLOGY PROGRESS