Review
Engineering, Biomedical
Lana Papafilippou, Andrew Claxton, Paul Dark, Kostas Kostarelos, Marilena Hadjidemetriou
Summary: Sepsis is a major cause of death worldwide, but current laboratory culture tests and blood markers like CRP and PCT have limitations in accurate diagnosis. Nanomaterials show promise for improving both diagnostic and therapeutic approaches in sepsis, with potential for clinical translation.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Physics, Applied
Kai Wang, Bo Liu, Zhanqi Liu, Xiao Jiang, Zemin Zhang, Weihua Han
Summary: Metal oxides are commonly used as photoanode materials for photoelectrochemical reactions due to their stability and low cost. However, the high recombination rate of photocarriers limits their commercial applications. This study demonstrates that building an inner electric field through band engineering techniques can effectively improve the photocarrier separation and photocatalytic performance of metal oxide photocatalysts.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Xinrui Yang, Junmeng Hang, Weiyu Qu, Yulan Wang, Lei Wang, Ping Zhou, Hao Ding, Bin Su, Jianping Lei, Weiliang Guo, Zhihui Dai
Summary: Developing highly sensitive multipleximmunoassays is urgently needed to guide medical research and improve clinical diagnosis. In this study, proximity electrochemiluminescence (ECL) generation enabled by gold microbeads (GMBs) was used to enhance the sensitivity and multiplexing capacity of ECL immunoassays. By employing GMBs as solid carriers, the ECL generation through proximity low oxidation potential (LOP) route significantly increased the turnover frequency compared to conventional non-conductive microbeads. Moreover, the proximity ECL generation allowed for the simultaneous detection of multiple acute myocardial infarction biomarkers using size-encoded GMB-based multiplex ECLIAs. This work provides new insights into ECL mechanisms and advances the practical use of multiplex ECLIAs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Mengnan Zhao, Rujing Wang, Kunmeng Yang, Yuhong Jiang, Yachen Peng, Yuke Li, Zhen Zhang, Jianxun Ding, Sanjun Shi
Summary: RNAs play crucial roles in disease progression and have become powerful targets for therapy and biomarkers for diagnosis. However, delivering therapeutic RNA efficiently to targeted locations and accurately detecting RNA markers remains challenging. Recent attention has focused on using nucleic acid nanoassemblies for diagnosis and treatment. Due to the flexibility and deformability of nucleic acids, these nanoassemblies can be fabricated into different shapes and structures. By hybridizing with other nucleic acids, such as DNA and RNA nanostructures, they can enhance RNA therapy and diagnostics. This review provides a brief overview of the construction and properties of nucleic acid nanoassemblies, their applications, and prospects for further development.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Pharmacology & Pharmacy
Demi Zapata, Jordan Higgs, Hunter Wittholt, Kishore Chittimalli, Amanda E. Brooks, Pranothi Mulinti
Summary: Infection remains a major threat to global health, and osteomyelitis, a difficult condition to diagnose and treat, is particularly troublesome. The challenges in diagnosing and treating osteomyelitis stem from the complexities of opportunistic infections, changes in host vasculature, and the heterogeneity of infectious presentations. Despite advancements in preclinical treatment, clinical strategies remain stagnant.
Review
Pharmacology & Pharmacy
Olga Kammona, Evgenia Tsanaktsidou
Summary: Leishmaniasis, a prevalent parasitic infection in neglected tropical diseases, lacks efficient diagnostic tools and treatments, posing a serious threat to public health in low- and middle-income countries. Nanotechnology may offer novel approaches to enhance disease detection, therapy, and prevention.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Xiping He, Yifan Ma, Haotian Xie, Gaofeng Rao, Zhaogang Yang, Jingjing Zhang, Zhong Feng
Summary: The discovery and clinical application of biomarkers are crucial for early cancer diagnosis and reducing mortality rates. Although nanotechnology-based bioinspired detection systems show promise, challenges like contamination and unstable signal-to-noise ratios persist. Natural materials in biological frames are inspiring researchers to develop new bioinspired and biomimetic nanostructures that can enhance detection sensitivity and specificity for effective cancer diagnosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Oncology
Qi Zhang, Kai Hou, Hongbo Chen, Ning Zeng, Yiping Wu
Summary: Recent advances in nanotechnologies for cancer diagnosis and treatment have shown promising applications in improving the effectiveness of probes and drugs, as well as playing a crucial role in early clinical diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Mesfin Dessale, Getachew Mengistu, Hylemariam Mihiretie Mengist
Summary: Cancer is the most devastating disease worldwide, and current conventional diagnostic and therapeutic methods are not efficient. Nanotechnology holds promise for quick, safe, cost-effective, and efficient cancer diagnosis and treatment, providing simultaneous diagnosis and therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Joao Paulo Assolini, Amanda Cristina Machado Carloto, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Fernanda Tomiotto Pellissier, Paulo Emilio Feuser, Arthur Poester Cordeiro, Pedro Henrique Hermes de Araujo, Claudia Sayer, Milena Menegazzo Miranda Sapla, Wander Rogerio Pavanelli
Summary: This review highlights the recent advances in nanomedicine for improving the diagnosis, treatment, and vaccine development of leishmaniasis. Nanotechnology can enhance the sensitivity and specificity of diagnostic tests as biosensors, and can also act as drug carriers to reduce toxic effects. In addition, nanomaterials can carry Leishmania antigens to produce effective vaccines.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yadong Xu, Cheng Luo, Jieqiong Wang, Lingwu Chen, Junxing Chen, Tianfeng Chen, Qinsong Zeng
Summary: Bladder cancer remains a common malignancy with unsatisfactory theranostic approaches. Nanotechnology has shown promising potential in improving efficiency of diagnosis and treatment through targeted delivery of agents and distinguishing normal and abnormal bladder tissues. Future research on novel nanoparticles for bladder cancer management is encouraged.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Medical Laboratory Technology
Kaj Blennow, Erik Stomrud, Henrik Zetterberg, Niels Borlinghaus, Veronika Corradini, Ekaterina Manuilova, Laura Muller-Hubner, Frances-Catherine Quevenco, Sandra Rutz, Oskar Hansson
Summary: This study evaluated the analytical performance of second-generation Elecsys CSF Gen II immunoassays and adjusted existing cut-offs to evaluate their potential utility in clinical routine. The findings suggest that the Gen II immunoassays have potential utility in aiding the diagnosis of Alzheimer's disease.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Li Li, Rendong He, Haili Yan, Zhengwei Leng, Shuang Zhu, Zhanjun Gu
Summary: This review provides a brief overview and analysis of the development of nanotechnology in Alzheimer's disease (AD). Through bibliometric analysis, the publishing trend, countries/institutions, reference sources, and research hotspots of AD-related nanotechnology are analyzed and visualized. The key roles of nanotechnology in both diagnostic and therapeutic aspects of AD are summarized, along with the potential nanotoxicity of nanomaterials. The review also highlights the prospects for the development of nanotechnology in AD applications.
Article
Hematology
Luana Rittener-Ruff, Matteo Marchetti, Elena Matthey-Guirao, Francesco Grandoni, Francisco J. Gomez, Lorenzo Alberio
Summary: This study evaluated the diagnostic performance of two rapid immunoassays in detecting heparin-induced thrombocytopenia and compared different diagnostic algorithms. The results showed that the Bayesian approach of sequentially using two rapid immunoassays was most effective in accurately diagnosing heparin-induced thrombocytopenia.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Chemistry, Multidisciplinary
Liu Li, Shiyong Sun, Rui Lv, Yevgeny Aleksandrovich Golubev, Ke Wang, Faqin Dong, Tao Duan, Olga Borisovna Kotova, Elena Leonidovna Kotova
Summary: Glucose oxidase and Fe-aminoclay were combined to construct a mimic multi-enzyme system for cascade reaction. The obtained system showed excellent catalytic activity and reusability, laying the foundation for the development of a new glucose biosensor.
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
(2021)
Article
Biophysics
Yong Ju, Jaemin Kim, Yeonkyung Park, Chang Yeol Lee, Kyungnam Kim, Ki Ho Hong, Hyukmin Lee, Dongeun Yong, Hyun Gyu Park
Summary: The rapid and accurate clinical testing for COVID-19 using NESBA showed ultrasensitive detection of SARS-CoV-2 genomic RNA. Through the addition of nicking recognition sequences in NASBA primers, the technique was able to exponentially amplify genetic material in a short amount of time. The results were in full agreement with qRT-PCR, demonstrating 100% clinical sensitivity and specificity.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Jayeon Song, Chang Yeol Lee, Hyun Gyu Park
Summary: A ultrasensitive isothermal strategy for detecting miRNAs in a multiplexed manner by utilizing a self-priming hairpin-triggered cascade reaction and the adsorption properties of graphene oxide (GO) is described. This approach allows for the simultaneous identification of multiple target miRNAs down to attomolar levels within 30 minutes.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Hansol Kim, Seoyoung Lee, Jinhwan Lee, Hyun Gyu Park
Summary: An ultrasensitive RNase H assay utilizing CRISPR/Cas12a collateral cleavage activity has been successfully developed, achieving a detection limit of 0.00024 U mL(-1), which is significantly superior to alternative approaches.
CHEMICAL COMMUNICATIONS
(2022)
Article
Environmental Sciences
Ho Kyeong Kim, Phuong Thy Nguyen, Moon Il Kim, Byoung Chan Kim
Summary: Mercury emissions are increasing globally due to industrialization, and its persistence and bioaccumulation can severely affect human health. Hybrid nanoflowers were synthesized for Hg adsorption and elimination from solutions, with the functionalized Apt-Ag-MNP-PDA-Cu NFs showing significantly improved performance in Hg removal. The results suggest that the Apt-Ag-MNP-PDA-Cu NFs could be an efficient Hg-removing adsorbent by providing binding sites for the formation of T-Hg2+-T complexes.
Article
Biochemistry & Molecular Biology
Xuan Ai Le, Thao Nguyen Le, Moon Il Kim
Summary: In this study, a hybrid nanoflower-based strategy was developed for the sensitive fluorescent detection of biothiols. The nanoflowers exhibited dual catalytic activities and were successfully used to selectively detect and quantify biothiols in human serum, showing great potential for clinical diagnostics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Weldejewergis Gebrewahid Kidanu, Jaehyun Hur, Hyung Wook Choi, Moon Il Kim, Il Tae Kim
Summary: In this study, VO2 nanorods were successfully synthesized using a hydrothermal method and transformed into V2O5.nH(2)O through an electrochemical oxidation technique. The aqueous zinc-ion full cell based on VO2@C/Zn showed remarkable reversible capacity, cycling stability, and rate capabilities.
JOURNAL OF POWER SOURCES
(2022)
Article
Chemistry, Multidisciplinary
Tae Won Nam, Yeonkyung Park, Yeon Sik Jung, Hyun Gyu Park
Summary: In this study, a polychromatic quantum dot array (PQDA) was developed for accurate quantification of multiple miRNAs. The PQDA, manufactured using advanced patterning techniques, showed a wide dynamic range and high specificity, enabling the identification of target miRNAs with high sensitivity.
Article
Chemistry, Multidisciplinary
Jayeon Song, Baekdong Cha, Jeong Moon, Hyowon Jang, Sunjoo Kim, Jieun Jang, Dongeun Yong, Hyung-Jun Kwon, In-Chul Lee, Eun-Kyung Lim, Juyeon Jung, Hyun Gyu Park, Taejoon Kang
Summary: A DAMPR assay for the detection of SARS-CoV-2 and its variants genes with high accuracy and sensitivity is reported. A portable detection system and a smartphone application were developed to examine the diagnostic results. This method is of great significance for the rapid and accurate detection of SARS-CoV-2 and its variants genes, as well as the diagnosis of various infectious diseases.
Article
Biophysics
Jeong Moon, Jayeon Song, Hyowon Jang, Hyunju Kang, Yong-Min Huh, Hye Young Son, Hyun Wook Rho, Mirae Park, Chandana S. Talwar, Kwang-Hyun Park, Euijeon Woo, Jaewoo Lim, Eun-Kyung Lim, Juyeon Jung, Yongwon Jung, Hyun Gyu Park, Taejoon Kang
Summary: In this study, a ligation-free DNA extension method for nucleic acid amplification was developed. This method allows for high sensitivity detection of target RNA and shows potential applications in cancer companion diagnostics and other gene detection platforms.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Yan Li, Hansol Kim, Yong Ju, Yeonkyung Park, Taejoon Kang, Dongeun Yong, Hyun Gyu Park
Summary: This study establishes a new method for detecting SARS-CoV-2 using self-priming hairpin-utilized isothermal amplification of the G-rich sequence. The method successfully detects the virus at low concentrations and demonstrates excellent clinical sensitivity and specificity in clinical samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Phan Ba Khanh Chau, Trung Hieu Vu, Moon Il Kim
Summary: This article reports a fluorescent assay for the determination of VB12 based on the inner filter effect of PDT-AgNPs. The fluorescence of PDT-AgNPs is significantly quenched in the presence of VB12 via IFE, allowing for quantitative detection of VB12 in drug tablets.
Article
Chemistry, Analytical
Phan Ba Khanh Chau, Thinh Viet Dang, Moon Il Kim
Summary: We synthesized crystalline MnOOH nanowires (MNWs) via a simple solvothermal treatment of KMnO4, which exhibited excellent oxidase-like activity due to the presence of pure Mn3+ sites. MNWs catalyzed the rapid oxidation of dopamine into aminochromes, resulting in a vivid brown color. Based on the catalytic features of MNWs, we developed a paper dipstick for the one-step colorimetric detection of dopamine.
Article
Chemistry, Analytical
Jeong Ah Park, Yein Kwon, Xuan Ai Le, Trung Hieu Vu, Hanbin Park, Hoseok Lee, Hye Kyu Choi, Chulhwan Park, Moon Il Kim, Taek Lee
Summary: This study developed a rapid electrochemical biosensor using nanozymes and aptamers for the detection of microcystin-LR (MC-LR). The detection time was reduced to 10 minutes using alternating current electrothermal flow (ACEF). The sensitivity of MC-LR detection was improved by using MnO2/MC-LR aptamer conjugates. The study achieved an LOD of 3.36 pg mL(-1) in the linear concentration range of 10 pg mL(-1) to 1 mu g mL(-1).
Article
Chemistry, Multidisciplinary
Jayeon Song, Yong Ju, Soohyun Kim, Hansol Kim, Hyun Gyu Park
Summary: In this study, we developed a palindromic hyperbranched rolling circle amplification (PH-RCA) reaction for ultrasensitive detection of microRNAs. The PH-RCA reaction significantly enhances the sensitivity and reduces the reaction time within 30 minutes, making it a promising technique for miRNA detection.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Seoyoung Lee, Hansol Kim, Yeonkyung Park, Hyun Gyu Park
Summary: We have described a novel method for detecting miRNA by using a target-triggered transcription of a light-up RNA aptamer. This method generates a highly enhanced fluorescence signal through specific binding of the light-up RNA aptamer to a corresponding dye. With this strategy, we were able to identify target miRNA down to 59.4 aM with excellent specificity.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
