Review
Chemistry, Analytical
Jingjing Jiang, Jili Xia, Yang Zang, Guowang Diao
Summary: Electrochemistry- and photoelectrochemistry-based biosensors have been recognized as powerful tools for trace monitoring of carcinoembryonic antigen (CEA) due to their high sensitivity, excellent selectivity, and low cost. They are classified into two main categories: immunosensors and aptasensors. This review presents recent examples and discusses signaling strategies, advanced materials, and detection modes.
Article
Chemistry, Analytical
Yibin Lu, Yaqun Xu, Tongtong Ding, Caifeng Ding, Gao-Chao Fan, Xiliang Luo
Summary: Photocathodic immunosensors, based on a featured photocathode-photoanode system, demonstrate stronger anti-interference abilities compared to photoanodic immunosensors. By integrating a photocathode with a photoanode, this efficient and feasible photoelectrochemical immunosensor allows for sensitive and specific detection of target antigens. This strategy provides a promising approach for developing high-performance PEC immunosensors for biological matrix detection.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Linzheng Ma, Dequan Zhang, Peiwen Zhao, Bo Wang, Xiliang Luo
Summary: This study presents a novel and efficient cathodic aptasensor for high sensitivity and accurate detection of targets in real samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Xiaoqian Tang, Jiasi Zuo, Cheng Yang, Jun Jiang, Qi Zhang, Jianfeng Ping, Peiwu Li
Summary: Biotoxins, including mycotoxins, marine toxins, and bacterial food toxins, pose significant threats in various fields such as food, feed, seafood, and medicine due to their potential harmful effects on humans. The increased consumption of fast food and prepared food without considering associated toxins is a critical issue. Therefore, the development of effective methods for monitoring biotoxins is crucial. In recent years, biosensors have been widely used for biotoxin detection due to their simplicity, quick detection procedure, low cost, and other advantages. This study provides a comprehensive overview of the application of biosensors in biotoxin detection, focusing on optical, electrochemical, piezoelectric, and photothermal applications. Additionally, the integration of different detection platforms as multimodal combination biosensors is discussed to meet the demand for highly accurate technologies. Major challenges faced by biosensors are examined, and novel insights for improving food safety technology are provided.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yimeng Sun, Cong Ma, Man Wu, Chunping Jia, Shilun Feng, Jianlong Zhao, Lijuan Liang
Summary: This study utilized a photoelectrochemical aptasensor to successfully detect chloramphenicol, demonstrating its potential in antibiotic monitoring. The nanoarrays based on TiO2@MoS2 showed excellent biochemical stability, allowing for accurate detection of chloramphenicol content within the range of 0.1 pM to 1 mu M.
Article
Chemistry, Analytical
Jintao Dong, Feng Chen, Li Xu, Pengcheng Yan, Junchao Qian, Yun Chen, Mengying Yang, Henan Li
Summary: A highly sensitive and selective photoelectrochemical aptasensor was developed for detecting trace chloramphenicol. The aptasensor, based on Ag nanoparticles sensitized bismuth oxyiodide composites, showed enhanced CAP detection performance with wide linear range, low detection limit, and superior selectivity. Moreover, the aptasensor exhibited favorable stability and reproducibility.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Liang Fan, Gang Xiao, Mingliang Wang, Shuang Zhao, Qiaochun Yang, Linyang Cheng, Jinhui Jeanne Huang, Zhao Yue
Summary: By optimizing experimental conditions and introducing different nanomaterials, the sensing properties of PEC immunosensors based on MUA-AuNCs were successfully enhanced. Among them, MUA-AuNCs/cGO showed the best sensing performance.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Yibin Lu, Hao Wang, Xiao-Mei Shi, Caifeng Ding, Gao-Chao Fan
Summary: In this study, a novel cathodic immunosensor supported by a photoanode was designed for the sensitive and specific detection of HCG. Through a photoelectrochemical system, the signal conversion and immune recognition events were achieved, demonstrating excellent performance and anti-interference ability. This study provides a potential path for the development of enhanced immunosensors in the application of biological samples.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Analytical
Longsheng Jin, Weishuai Liu, Ziying Xiao, Haijian Yang, Huihui Yu, Changxun Dong, Meisheng Wu
Summary: Rapid and efficient detection of mycotoxins is crucial in ensuring food safety. This review discusses various traditional and commercial methods of detection, including HPLC, LC/MS, ELISA, and test strips. ECL biosensors, known for their high sensitivity and specificity, have gained significant attention in mycotoxins detection. This article focuses on the recent advancements in the design of ECL biosensors for mycotoxins assay, particularly with regards to amplification strategies and working mechanisms.
Article
Chemistry, Analytical
Yi-Ge Feng, Jian-Hong Zhu, Xiao-Yu Wang, Ai-Jun Wang, Li-Ping Mei, Pei-Xin Yuan, Jiu-Ju Feng
Summary: Early screening and detection of breast cancer is crucial, with traditional approaches having limited applications. Biomarkers serve as good indicators for developing highly sensitive and specific immunoassays to detect breast cancer.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Dong Liu, Shuyun Meng, Xiuli Shen, Yuye Li, Xiaohong Yan, Tianyan You
Summary: This work presents a dual-ratiometric aptasensor for streptomycin detection, utilizing the in-situ coupling of photoelectrochemical and electrochemical assays. The use of methylene blue as a bifunctional probe enables the simultaneous generation of photocurrent and redox current, resulting in enhanced analytical performances compared to single-signal or single-ratiometric assays. The MB-based dual-mode sensing offers a promising tool for studying interactions between PEC and EC behaviors.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Applied
Qi Chen, Meng Meng, Wang Li, Ying Xiong, Yong Fang, Qinlu Lin
Summary: This review highlights the recent advances in immunosensors, aptasensors, and other emerging receptor-based sensors for the detection of AFM(1) in milk and dairy products. It discusses their unique advantages, drawbacks, and future opportunities and challenges.
Article
Food Science & Technology
Simone Balbinot, Anand Mohan Srivastav, Jasmina Vidic, Ibrahim Abdulhalim, Marisa Manzano
Summary: This article highlights the importance and advantages of optical biosensors in food safety, comparing them with traditional methods and showcasing the applications of different technologies and future trends.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Sadman Sakib, Amin Hosseini, Igor Zhitomirsky, Leyla Soleymani
Summary: The study presents a photoelectrochemical immunosensor for detecting IL-6 by utilizing catecholate-modified TiO2 photoelectrodes, achieving high sensitivity and signal-to-noise ratio enhancement.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Jiafeng Pan, Fang Deng, Zhi Liu, Gu Shi, Junhua Chen
Summary: In this work, an enzyme-free biosensor based on toehold-mediated catalytic hairpin assembly and DNAzyme-cascaded hydrolysis reaction is reported for mycotoxin detection. The sensor showed high sensitivity and selectivity, and was successfully applied for the quantification of mycotoxins in wine samples. Additionally, the platform was used to fabricate concatenated logic gates, providing a universal sensing strategy for the intelligent detection of multiplex mycotoxins.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ilaria Sorrentino, Marie Carriere, Helene Jamet, Ilaria Stanzione, Alessandra Piscitelli, Paola Giardina, Alan Le Goff
Summary: We investigated the use of POXA1b laccase from Pleurotus ostreatus for the oxidation of anthracene into anthraquinone. Different pathways can occur depending on the redox mediator combined to laccase, leading to different isomers. Carbon nanotubes were shown to act as redox mediators for anthracene oxidation into 9,10-anthraquinone, which was corroborated by theoretical calculations. The efficient adsorption of anthraquinones at CNT electrodes allows for low limit-of-detection of anthracene using laccase in solution, CNT-supported laccase, or laccase immobilized at magnetic beads.
Article
Chemistry, Analytical
Li-Ping Zong, Junji Li, Guofang Shu, Xinye Liu, Robert S. Marks, Xue-Ji Zhang, Serge Cosnier, Dan Shan
Summary: A novel ECL amplification strategy was established by designing Fe-N-C nanosheets with exceptional catalytic activity for O-2 activation. The material was successfully applied for antibiotic detection, indicating promising prospects for biological analysis and environmental monitoring.
ANALYTICAL CHEMISTRY
(2022)
Article
Polymer Science
Monica Brachi, Paulo Henrique M. Buzzetti, Karine Gorgy, Dan Shan, Pierre Audebert, Alan le Goff, Hong Li, Redouane Borsali, Serge Cosnier
Summary: In this study, fluorescent organic 2,5,8-tris((adamantan-1-yl)-methoxy)-heptazine (HTZ-Ad) was solubilized in water by inclusion of adamantane groups into free beta-cyclodextrins or a cyclodextrin shell of glyconanoparticles. The modified nanoparticles showed fluorescence emission both in aqueous media and in their adsorbed state, providing the first spectroscopic characterization of a trialkoxyheptazine in aqueous medium. The binding of the glyconanoparticles to a surface was achieved through host-guest interactions with an electrochemically generated poly(pyrrole-adamantane) film, resulting in spatially controlled fluorescence.
Article
Chemistry, Multidisciplinary
Umberto Contaldo, Mathieu Curtil, Julien Perard, Christine Cavazza, Alan Le Goff
Summary: An AcPyTACN compound was synthesized for immobilizing recombinant CODH on carbon-nanotube electrodes, resulting in high current density and stability for electroenzymatic CO2 reduction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemical Research Methods
Martin Gillard, Hugues Bonnet, Remy Lartia, Hiba Yacoub, Jerome Dejeu, Eric Defrancq, Benjamin Elias
Summary: The recent development of genomic screening has led to the search for new tools for cancer risk screening. This study reports on the capacity of Ru(II) polyazaaromatic complexes to photoprobe 8-oxoguanine in the human telomeric sequence in order to develop these new tools.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Michael Holzinger, Serge Cosnier, Paulo Henrique M. Buzzetti
Summary: This article introduces the applications of pyrene and its derivatives as immobilization tools in bioelectrochemical applications. The stable pi-stacking interaction between pyrene and nanostructured sp2 carbon materials can be formed under mild conditions without affecting the functionality of pyrene or the carbon material. Pyrene has various beneficial properties for bioelectrochemical studies. Furthermore, pyrene can form supramolecular inclusion complexes and interact with enzymes, and can also serve as a cross-linker and a redox mediator.
Article
Chemistry, Multidisciplinary
Michael G. Allan, Thomas Pichon, Jade A. McCune, Christine Cavazza, Alan Le Goff, Moritz F. Kuhnel
Summary: This work demonstrates the performance of [NiFeSe] hydrogenase from Desulfomicrobium baculatum for solar-driven hydrogen generation in a variety of organic-based deep eutectic solvents. It shows that the hydrogenase exhibits remarkable performance under aerobic conditions in these solvents when paired with a TiO2 photocatalyst. The tuning of water content further enhances hydrogen evolution activity and quantum yield. Contrary to common belief, these findings suggest that placing natural hydrogenases in non-natural environments can enhance their intrinsic activity, opening possibilities for full water splitting using hydrogenases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Umberto Contaldo, David Roura Padrosa, Helene Jamet, Martin Albrecht, Francesca Paradisi, Alan Le Goff
Summary: The study demonstrates the immobilization of copper-containing nitrite reductase (NiR) from Alcaligenes faecalis on functionalised multi-walled carbon nanotube (MWCNT) electrodes. The immobilization is mainly driven by hydrophobic interactions, promoted by the modification of MWCNTs with adamantyl groups. The direct electrochemistry shows high bioelectrochemical reduction of nitrite at the redox potential of NiR with a high current density of 1.41 mA cm(-2). Furthermore, the immobilization-induced desymmetrization of the trimer causes an independent electrocatalytic behavior for each subunit, which is supported by an electron-tunneling distance dependence.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Jeireimy Domergue, Pawel Guinard, Magali Douillard, Jacques Pecaut, Sarah Hostachy, Olivier Proux, Colette Lebrun, Alan Le Goff, Pascale Maldivi, Carole Duboc, Pascale Delangle
Summary: To control the cellular level of reactive oxygen species (ROS) and prevent pathologies related to oxidative stress, designing antioxidants based on natural enzymes involved in ROS degradation is a promising strategy. In this study, Ni complexes with tripeptides derived from the ATCUN motif were synthesized to mimic the active site of nickel superoxide dismutase (NiSOD). Six different Ni(II) complexes with various coordination modes were characterized and found to exhibit SOD-like activity. The complexes with equilibrium between N-coordination and S-coordination showed the highest efficiency, indicating the beneficial effect of a nearby proton relay. This study also demonstrated that two bound thiolates and two amidates are not prerequisites for the catalytic activity of NiSOD mimics.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Yoann Colas, Stephane Menage, Caroline Marchi-Delapierre, Nicolas Spinelli
Summary: This study reveals the chiral control mechanism of G-quadruplexes in asymmetric sulfoxidation of thioanisole derivatives by constraining their structure. The results show that catalysis at different regions leads to the generation of different enantiomers.
Article
Chemistry, Physical
Umberto Contaldo, Solene Gentil, Elise Courvoisier-Dezord, Pierre Rousselot-Pailley, Fabrice Thomas, Thierry Tron, Alan Le Goff
Summary: We report the unprecedented use of laccase to functionalize phenol-modified carbon nanotubes (CNTs). Enzymatically-generated metallopolyphenols or the laccase itself can be mildly and efficiently immobilized using the ability of laccase to generate phenoxyl radicals. Electrochemistry, XPS and EPR spectroscopy were used to assess the enzyme-catalyzed CNT functionalization. The efficient immobilization of laccase is confirmed by the high direct bioelectrocatalytic reduction of oxygen with a maximum current density of 1.95 mA cm(-2).
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Analytical
Monica Vallejo-Perez, Essohanam Beke, Chantal Gondran, Karine Gorgy, Isabelle Gelard, Celine Ternon, Nicolas Spinelli, Valerie Stambouli
Summary: This study describes the design and testing of aptamer sensors based on Si nanonets for electrochemical detection of thrombin. Si nanonets were placed on a glassy carbon electrode and functionalized for specific binding to thrombin. The results showed linear detection of thrombin concentration using cyclic voltammetry and impedance measurements, demonstrating the potential of Si nanonets for detecting biomolecules.
SENSING AND BIO-SENSING RESEARCH
(2023)
Article
Chemistry, Physical
Monica Brachi, Fabien Giroud, Serge Cosnier, Alan Le Goff
Summary: In this study, we report a method to modify carbon nanotubes using alkyne-modified diazonium salts and alkyne-modified pyrene, followed by photo-irradiated thiol-yne click reaction. The results demonstrate that the photo-irradiation provides the highest reaction yields. The functionalized carbon nanotubes enable mediated bioelectrocatalytic glucose oxidation under low overpotential and high current density conditions.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Analytical
Marina Pons, Marine Perenon, Hugues Bonnet, Emilie Gillon, Celio Vallee, Liliane Coche-Guerente, Eric Defrancq, Nicolas Spinelli, Angeline Van der Heyden, Jerome Dejeu
Summary: In this study, negative or null SPR signals were observed for the recognition of a low molecular weight target by an aptamer. The introduction of a spacer group for aptamer immobilization led to a null SPR signal due to significant conformational transitions affecting the refractive index increment deviation. The unconventional signal was attributed to the positive contribution of aptamer recognition and folding, as well as the negative contribution from the refractive index increment deviation upon complex formation.
Article
Chemistry, Multidisciplinary
Hugues Bonnet, Maeva Morel, Alexandre Devaux, Joseph Boissieras, Anton Granzhan, Benjamin Elias, Thomas Lavergne, Jerome Dejeu, Eric Defrancq
Summary: In this study, BLI and CD spectroscopy were used to investigate the interaction between i-motif DNA (i-DNA) ligands and folded or unfolded i-DNA under different acidic and near-neutral conditions. The results showed that although some ligands exhibited good affinity for the i-DNA structure, none of them displayed selective interactions or promoted its formation.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
