Review
Chemistry, Analytical
Onyinyechi Vivian Uhuo, Tesfaye Taddese Waryo, Kaylin Cleo Januarie, Kelechi Chiemezie Nwambaekwe, Miranda Mengwi Ndipingwi, Precious Ekwere, Emmanuel Iheanyichukwu Iwuoha
Summary: The high incidence of tuberculosis is a global concern. Traditional diagnostic techniques are not suitable for resource-poor countries due to their complexity and high cost. Biosensors offer advantages such as independence from Mycobacterium tuberculosis, simplicity, low-cost, and high sensitivity. Aptamers, as biorecognition elements, are also gaining interest in tuberculosis diagnosis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biophysics
Jose M. R. Flauzino, Emily P. Nguyen, Qiuyue Yang, Giulio Rosati, David Panacek, Ana G. Brito-Madurro, Joao M. Madurro, Aristides Bakandritsos, Michal Otyepka, Arben Merkoci
Summary: This study presents a label-free impedimetric genosensor for the sensitive detection of pork residues in meat, utilizing the biosensing capabilities of graphene acid. The sensor can detect pork residues in beef in less than 45 minutes, with a detection limit of 9%.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Medicinal
Xinggui Yang, Xu Chen, Junfei Huang, Yijiang Chen, Wenlin Zheng, Wei Chen, Huijuan Chen, Shiguang Lei, Shijun Li
Summary: A simple, specific, low-cost, and highly sensitive detection method for Mycobacterium tuberculosis (MTB) was developed using multiplex loop-mediated isothermal amplification combined with a label-based lateral flow immuno-assay biosensor (mLAMP-LFIA). The mLAMP-LFIA method, targeting the IS6110 and mpb64 genes, showed a detection limit of 100 fg per reaction for MTB DNA, and a sensitivity of 100% and specificity of 98.04% in preliminary clinical evaluations. This method has the potential to be used as a screening and/or diagnostic tool for MTB in various settings.
ACS INFECTIOUS DISEASES
(2023)
Article
Chemistry, Analytical
Chenhui Wu, Yunkang Ma, Yingxia Zhou, Wenjie Yang, Lihua Chen
Summary: This study presents a superior antifouling coating based on chondroitin sulfate, prepared with a novel design strategy to enhance the material's antifouling properties, showing excellent performance in various biological samples, even in high concentration goat serum. The antifouling interface material is also successfully applied for the specific detection of the tuberculosis gene in undiluted biofluids.
Article
Chemistry, Analytical
Chih-Hung Wang, Jia-Ru Chang, Shang-Cheng Hung, Horng-Yunn Dou, Gwo-Bin Lee
Summary: Tuberculosis is a serious global public health issue and early diagnosis is challenging due to the slow growth of Mycobacterium tuberculosis. This study presents an integrated microfluidic system that can automatically detect live M. tuberculosis and distinguish dead bacteria. The system offers automation, high speed, low cost, low sample/reagent consumption, and reduced infection risk for medical staff.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Khaled Alsabbagh, Tim Hornung, Achim Voigt, Sahba Sadir, Taleieh Rajabi, Kerstin Lange
Summary: The microfluidic chip for electrochemical impedance spectroscopy (EIS) serves as a biosensor for label-free detection of proteins, with specific focus on cardiac troponin I as a diagnostic biomarker. The study demonstrates the successful functionalization of electrodes and specific antibody binding, showing promise for the specific detection of clinically relevant concentrations of cardiac markers.
Article
Microbiology
V Lorente-Leal, E. Liandris, M. Pacciarini, A. Botelho, K. Kenny, B. Loyo, R. Fernandez, J. Bezos, L. Dominguez, L. de Juan, B. Romero
Summary: This study evaluated the analytical and diagnostic performance of a real-time PCR technique targeting bovine tuberculosis, showing higher sensitivity and faster detection compared to traditional culture methods. Despite some cross-reactivity issues, this method is considered a valuable alternative to culture.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Microbiology
Yoshifumi Uwamino, Akio Aono, Yu Tomita, Kozo Morimoto, Masahiro Kawashima, Hirofumi Kamata, Yuka Sasaki, Hideaki Nagai, Naoki Hasegawa, Satoshi Mitarai
Summary: The Myco-Panel test accurately detects clinically common mycobacterial species that cause respiratory infections, providing useful information for patient management and rapid treatment initiation.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Applied
Hao Li, Min Long, Huiyu Su, Lei Tan, Xiaowen Shi, Yumin Du, Yan Luo, Hongbing Deng
Summary: This study demonstrates a piezoelectric biosensor with CMCS as the immobilization matrix for rapid, label-free, and cost-effective quantification of IgY.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Li Li, Zhengbo Chen
Summary: In this study, a high specificity, flexibility, and simplicity aptasensor strategy was designed using a triblock DNA probe. It was found that the polyA fragment could assemble on the gold electrode surface via polyA instead of traditional Au-S bonds, leading to improved hybridization stability. The electrochemical aptasensor showed good repeatability, stability, and specificity.
BIOELECTROCHEMISTRY
(2023)
Review
Infectious Diseases
Yuxin Fan, Jingjing Chen, Meixiao Liu, Xin Xu, Yu Zhang, Peng Yue, Wenjing Cao, Zhenhua Ji, Xuan Su, Shiyuan Wen, Jing Kong, Guozhong Zhou, Bingxue Li, Yan Dong, Aihua Liu, Fukai Bao
Summary: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, and the emergence of drug-resistant strains has made early diagnosis and drug sensitivity testing more challenging. Droplet digital PCR is a promising diagnostic technology with high sensitivity and no need for calibration, and it has the potential to improve diagnosis and monitoring of tuberculosis.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Chemistry, Analytical
Cansu Pinar Yenice, Nassif Chahin, Miriam Jauset-Rubio, Matthew Hall, Phil Biggs, Hans-Peter Dimai, Barbara Obermayer-Pietsch, Mayreli Ortiz, Ciara K. O'Sullivan
Summary: The detection of single nucleotide polymorphisms (SNPs) is increasingly important in various fields. This study presents a semi-automated system for solid-phase electrochemical melting curve analysis (e'MCA) to identify the allele present at a specific SNP site associated with an increased risk of bone fracture and predisposition to osteoporosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yunyun Ning, Cuiling Zhang, Chunyan Wang, Chuqing Zhou, Nana Gong, Qiang Wang, Ye Zhu
Summary: In this study, a highly sensitive and specific electrochemical strategy was proposed for accurate detection of miRNA-21. The strategy utilized DSN-assisted target recycling and DNA self-assembled FeNxC nanocatalytic network, and achieved ultrasensitive detection of miRNA-21.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Minglu Yan, Ruiduo Wang, Qiang Wang, Yansong Li, Beibei Liu, Yangyang Li, Man Jiang
Summary: This article presents a label-free, selective, and rapid optical fiber interferometer biosensor for detecting protamine. The thickness of the coating layer is found to be a key factor in the sensor's performance. The proposed biosensor exhibits high sensitivity and stability, making it suitable for protamine detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Meixing Li, Juan Cheng, Haitao Zheng, Jiawei Shi, Qingming Shen
Summary: A new electrochemical sensing strategy was developed for the precise detection of ultra-low abundance microRNA-21. The sensor utilized modified magnetic beads and hybridization chain reaction (HCR) to achieve signal amplification while avoiding modification fluctuation. The biosensor exhibited excellent specificity and reproducibility in complex sample analysis.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Thom Thi Nguyen, Nam Thi Pham, Dien Thi Nguyen, Phuc Xuan Nguyen, Kim Ngan Thi Nguyen, Thu Trang Thi Nguyen, Viet Van Pham, Thanh Nguyen Le Huynh, Hoang Thai Nguyen, Anh Tuan Nguyen, Bang Nghia Duong, Hai Viet Le, Lam Dai Tran
Summary: Metal oxide and conducting polymers were used to fabricate a novel electrochemical sensing interface for methanol electrooxidation. The composite electrode exhibited excellent sensing parameters and demonstrated high electrochemical and catalytic activities for methanol electrooxidation. Furthermore, the sensor showed good stability, repeatability, and reproducibility.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Applied
Thai Hoang Nguyen, Van Vien Nguyen, Ngan Tuan Nguyen, Thien Nguyen, Tuong Vy T. Nguyen, Hoang Long Ngo, Le Thanh Nguyen Huynh, Thanh Nhut Tran, Thi Thanh Nguyen Ho, Thanh Tung Nguyen, Viet Hai Le
Summary: Capacitive deionization (CDI) is an efficient, cost-effective, and environmentally friendly electrochemical desalination process. Nanoporous carbon aerogel (CA) has been considered the ideal electrode material. Waste corn stalks, a common agricultural waste, can be carbonized to provide a mesoporous structure due to its natural sponge-like porous channel structure. Carbon aerogels synthesized from waste corn stalks exhibited a high surface area of 370.37 m(2) g(-1), which can be further increased to 721.42 m(2) g(-1) through KOH activation. The CDI-utilized carbon aerogel electrodes made from waste biomass showed a promising green process with a higher NaCl removal capacity compared to activated carbon from the same source.
JOURNAL OF POROUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Vy Do Truc, Thien Vuong Nguyen, Tien Viet Vu, Tuan Anh Nguyen, Thanh Dung Ngo, The Tam Le, Trong Lu Le, Lan Thi Pham, Lam Dai Tran
Summary: This study explores the use of hybrid nanoparticles to enhance the antibacterial properties of single nanoparticles and their polymeric nanocomposite coatings. By combining different nanoparticles, such as nano-ZnO and silver nanoparticles, the advantages of each individual particle can be utilized. The results show that the hybrid nanoparticles and their nanocomposite coatings exhibit high antibacterial activity against E. coli, especially under visible light exposure. This research demonstrates the potential of hybrid nanoparticles in improving the antibacterial performance of materials and the benefit of visible light irradiation in enhancing bactericidal efficiency.
Article
Materials Science, Textiles
Tuong Vy T. Nguyen, Ngan Tuan Nguyen, Van Vien Nguyen, Thien Nguyen, Hoang Long Ngo, Le Thanh Nguyen Huynh, Huu Chi Le, Thanh Nhut Tran, Thi Thanh Nguyen Ho, Thanh Tung Nguyen, Viet Hai Le, Thai Hoang Nguyen
Summary: Carbon aerogel was prepared from waste corn stalk by a four-step process, using different amounts of urea as gelation agent to investigate their effect on the properties of carbon aerogel and its electrochemical performance. The ACCA-1.5 sample had the highest BET surface area of 713 m(2) g(-1), with 76.88% micropores, the highest specific capacitance of 67.2 F g(-1), and the highest SAC value of 22.19 mg g(-1) after 1415 s. These results suggest an effective method to utilize cheap and abundant waste biomass for fabricating electrodes in desalination processes.
FIBERS AND POLYMERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Thien Vuong Nguyen, Vy Do Truc, Tuan Anh Nguyen, Thi Lan Pham, Dai Lam Tran
Summary: This study aims to explore how ZnO-Ag hybrid nanoparticles can provide self-cleaning behavior to UV-curable acrylate urethane coating. It is the first work reporting the self-cleaning organic nanocoating for indoor and outdoor applications under visible light irradiation. Self-cleaning tests of dirty UVACU coatings were conducted with artificial dirty mixture or methylene blue under visible light and UV irradiation. The results showed that the cross-linked UVACU/ZnO-Ag nanocomposite coatings significantly removed methylene blue from the coating surface, indicating the self-cleaning property provided by ZnO-Ag nanoparticles.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Electrochemistry
Hoang Anh Nguyen, Thi Nam Pham, Nguyen Thao Trang Le, Le Thanh Nguyen Huynh, Thi Thu Trang Nguyen, Quoc Khuong Vo, Thai Hoang Nguyen, Viet Hai Le, Thi Thu Trang Nguyen, Thi Thom Nguyen, Dai Lam Tran, Trong Lu Le
Summary: This study aimed to prepare TiO2@CNTs composites via a simple sol-gel route and investigate their electrochemical performance in a neutral aqueous electrolyte of 1 M Na2SO4. The synergistic effects between TiO2 and CNTs in the composite electrode resulted in a significantly high specific capacitance of 227 F•g(-1) at a scan rate of 10 mV•s(-1). EIS analysis revealed both the pseudocapacitance process and the superior electrochemical performance of TiO2@CNTs-5%. The calculated ionic diffusion coefficients for TiO2@CNTs-5%, TiO2@CNTs-3%, and TiO2@CNTs-1% were 1.47 x 10(-17) cm(2)•s(-1), 1.12 x 10(-17) cm(2)•s(-1), and 0.71 x 10(-17) cm(2)•s(-1), respectively. Furthermore, TiO2@CNT electrodes were used to assemble a symmetrical supercapacitor with an excellent capacitance of 97.3 F•g(-1) at a current rate of 1 A•g(-1). The device showed long-term stability after 5000 cycles without degradation, and the energy density of TiO2@CNTs ranged from 15 to 43.8 Wh•kg(-1) in the power density range of 1800-18,000 W•kg(-1).
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Canh Minh Thang Nguyen, Khanh Linh Thi Nguyen, Van Vien Nguyen, Hoang Anh Nguyen, Viet Hai Le, Van Viet Pham, Le Thanh Nguyen Huynh, Thai Hoang Nguyen
Summary: Nowadays, the global environmental issue of arsenic pollution requires the development of effective detection techniques for various mediums. This study successfully fabricated gold nanoparticles/Fluorine doped Tin Oxide coated glass electrodes using the electrophoretic technique for highly sensitive As(III) detection. The electrodes showed superior electrochemical performance and demonstrated linear responses in the range of 1-50 ppb with a limit of detection of 0.81 ppb As(III) using anodic stripping voltammetry. The study confirms the promising use of electrophoretic deposition of nanomaterials for preparing working electrodes in various electrochemical analyses.
Article
Infectious Diseases
Muhammed Rabiu Sahal, Gaetan Senelle, Kevin La, Tukur Wada Panda, Dalha Wada Taura, Christophe Guyeux, Emmanuelle Cambau, Christophe Sola
Summary: In this article, an in-depth analysis is provided on the drug-resistance phenotypic characteristics of tuberculosis in Nigeria. The study also characterizes the genetic features of different lineages, such as L4, L5, and L6, through whole genome sequencing. The results indicate a high rate of drug-resistance in the L4.6.2.2 lineage and a diverse L5 lineage. The study highlights the importance of sequencing more tuberculosis genomes in Nigeria and West Africa for public health and academic reasons, as well as the need to gather historical knowledge on tuberculosis in the region.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Materials Science, Ceramics
Van Vien Nguyen, My Trang T. Dau, Canh Minh Thang Nguyen, Hoang Long Ngo, Thanh Tung Nguyen, Viet Hai Le, Le Thanh Nguyen Huynh, Thai Hoang Nguyen
Summary: Inorganic arsenic, a highly toxic substance, is widely present in the environment. Researchers have recently developed an anodic stripping voltammetry method to detect trace amounts of inorganic arsenic. In this study, gold nanoparticles coated on fluorine-doped tin oxide glass electrodes were successfully fabricated and used for arsenic(III) detection.
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Thi Lan Pham, Van Dat Doan, Quang Le Dang, Tuan Anh Nguyen, Thi Lan Huong Nguyen, Thi Dieu Thuy Tran, Thi Phuong Lan Nguyen, Thi Kieu Anh Vo, Trung Huy Nguyen, Dai Lam Tran
Summary: In this study, stable silver nanoparticles (BioAgNPs) were successfully biosynthesized using an aqueous extract from Syzygium nervosum buds as a reducing and stabilizing agent. The BioAgNPs were predominantly spherical with an average size of 10-30 nm. The outstanding stability of the BioAgNPs solution was attributed to the protective organic layer and the highly negatively charged surface of the nanoparticles. The BioAgNPs exhibited good antibacterial activity against various bacterial strains and also demonstrated catalytic activity in converting 2-NP, 3-NP, and 4-NP into aminophenols. The BioAgNPs formulations effectively suppressed anthracnose disease in tea plants without affecting plant growth.
Article
Chemistry, Multidisciplinary
Thanh Chung Pham, Dong Joon Lee, Do Hun Kim, Juyoung Yoon, Tran Dai Lam, Hwan Myung Kim, Songyi Lee
Summary: A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
X. T. Nguyen, A. O. Bulanov, V. V. Lukov, G. Borodkin, T. T. T. Nguyen, L. D. Tran, H. D. Vu, B. N. Duong, V. A. Lazarenko, I. N. Shcherbakov
Summary: This study focuses on the properties of the formyl derivative of 2-oxaindane series spiropyran under its condensation reaction. The results show that the products are thermodynamically stable enamine-ketone tautomeric forms in both DMSO solution and solid state. The compounds were evaluated for their cytotoxic activity and showed moderate activity against various human cell lines, while exhibiting weak or no antioxidant activity.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Manh B. Nguyen, Pham Thi Lan, Nguyen Tuan Anh, Nguyen Ngoc Tung, Shaoliang Guan, Valeska P. Ting, T. -Thanh-Bao Nguyen, Huan V. Doan, Mai Thanh Tung, Tran Dai Lam
Summary: This study investigates the advanced integration of a ternary heterogeneous Z-scheme photocatalyst, TiO2/CuInS2/OCN (OCN: O-g-C3N4), with carbon quantum dot (CQD) to enhance the degradation efficiency of reactive yellow 145 (RY145) dye in water. The findings demonstrate that the novel catalyst integration significantly improves RY145 degradation efficiency and possesses superior stability.
Article
Multidisciplinary Sciences
Le Thanh Nguyen Huynh, Hoang Anh Nguyen, Hoang Vinh Pham, Thanh Nhut Tran, Thi Thanh Nguyen Ho, Tan Le Hoang Doan, Viet Hai Le, Thai Hoang Nguyen
Summary: Capacitive deionization is a simple and cost-effective method for brackish water desalination. This study developed a composite coconut-shell-derived activated carbon and nano-carbonaceous material electrode for the removal of heavy metals. The activated electrode showed high specific capacitance and salt adsorption rate.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Cuong Van Le, My Thi Tra Nguyen, Nghia Tran Trung Le, Hung Khac Le, Tri Minh Bui, Dat Huu Ho, Viet Hai Le, Thi Thanh Nguyen Ho, Trong Liem Chau Pham, Le Thanh Nguyen Huynh, Thai Hoang Nguyen, Thanh Phong Mai, Nam Minh Hoang, Hieu Huu Nguyen
Summary: The composite TiO2/rGO, prepared by incorporating 1% rGO into TiO2 photoanode, significantly enhances the performance of DSSC; XPS, Raman spectroscopy, and FT-IR analysis confirm the formation of chemical bonds between titania and carbon in the composites.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)