Nucleic acid tool enzymes-aided signal amplification strategy for biochemical analysis: status and challenges

A multiple amplification strategy for nucleic acid detection based on host–guest interaction between the β-cyclodextrin polymer and pyrene

(2015) Xiaochen Guo et al.   ANALYST

Multiple amplification detection of microRNA based on the host–guest interaction between β-cyclodextrin polymer and pyrene

(2015) Xiaochen Guo et al.   ANALYST

Exonuclease III-Assisted Target Recycling Amplification Coupled with Liposome-Assisted Amplification: One-Step and Dual-Amplification Strategy for Highly Sensitive Fluorescence Detection of DNA

(2015) Fulin Zhou et al.   ANALYTICAL CHEMISTRY

Ultrasensitive Electrochemical Detection of Nucleic Acids Based on the Dual-Signaling Electrochemical Ratiometric Method and Exonuclease III-Assisted Target Recycling Amplification Strategy

(2015) Erhu Xiong et al.   ANALYTICAL CHEMISTRY

DNA-based biosensors for Hg2+ determination by polythymine–methylene blue modified electrodes

(2015) Cristina Tortolini et al.   BIOSENSORS & BIOELECTRONICS

Highly sensitive fluorescence assay of DNA methyltransferase activity by methylation-sensitive cleavage-based primer generation exponential isothermal amplification-induced G-quadruplex formation

(2015) Qingwang Xue et al.   BIOSENSORS & BIOELECTRONICS

Ultrasensitive homogeneous electrochemical strategy for DNA methyltransferase activity assay based on autonomous exonuclease III-assisted isothermal cycling signal amplification

(2015) Wei Li et al.   BIOSENSORS & BIOELECTRONICS

Nicking enzyme and graphene oxide-based dual signal amplification for ultrasensitive aptamer-based fluorescence polarization assays

(2015) Yong Huang et al.   BIOSENSORS & BIOELECTRONICS

Label-free molecular beacon-based quadratic isothermal exponential amplification: a simple and sensitive one-pot method to detect DNA methyltransferase activity

(2015) Qingwang Xue et al.   CHEMICAL COMMUNICATIONS

Highly sensitive detection of CpG methylation in genomic DNA by AuNP-based colorimetric assay with ligase chain reaction

(2015) Fengxia Su et al.   CHEMICAL COMMUNICATIONS

Sensitive detection of DNA methyltransferase activity by transcription-mediated duplex-specific nuclease-assisted cyclic signal amplification

(2015) Yan Zhang et al.   CHEMICAL COMMUNICATIONS

Ultrasensitive electrochemical detection of breast cancer cells based on DNA-rolling-circle-amplification-directed enzyme-catalyzed polymerization

(2015) Qinglin Sheng et al.   CHEMICAL COMMUNICATIONS

Highly sensitive and selective detection of miRNA: DNase I-assisted target recycling using DNA probes protected by polydopamine nanospheres

(2015) Yi Xie et al.   CHEMICAL COMMUNICATIONS

A new mode for highly sensitive and specific detection of DNA based on exonuclease III-assisted target recycling amplification and mismatched catalytic hairpin assembly

(2015) Chenyang Tao et al.   CHEMICAL COMMUNICATIONS

Highly sensitive DNA methylation analysis at CpG resolution by surface-enhanced Raman scattering via ligase chain reaction

(2015) Yuling Wang et al.   CHEMICAL COMMUNICATIONS

Signal amplification by enzymatic tools for nucleic acids

(2015) Peng Miao et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Duplex-specific nuclease-mediated bioanalysis

(2015) Xiaopei Qiu et al.   TRENDS IN BIOTECHNOLOGY

Enzyme-mediated single-nucleotide variation detection at room temperature with high discrimination factor

(2015) Tongbo Wu et al.   Chemical Science

An exonuclease III-aided “turn-on” fluorescence assay for mercury ions based on graphene oxide and metal-mediated “molecular beacon”

(2015) Ying Zhou et al.   RSC Advances

Microarray-based resonance light scattering assay for detecting DNA methylation and human DNA methyltransferase simultaneously with high sensitivity

(2014) Lan Ma et al.   ANALYST

Label-free fluorescence detection of DNA methylation and methyltransferase activity based on restriction endonuclease HpaII and exonuclease III

(2014) Chunyan Gao et al.   ANALYST

Aptamer binding assays for proteins: The thrombin example—A review

(2014) Bin Deng et al.   ANALYTICA CHIMICA ACTA

Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles

(2014) Shuo Wu et al.   ANALYTICAL CHEMISTRY

Highly Sensitive and Homogeneous Detection of Membrane Protein on a Single Living Cell by Aptamer and Nicking Enzyme Assisted Signal Amplification Based on Microfluidic Droplets

(2014) Lu Li et al.   ANALYTICAL CHEMISTRY

Concatemeric dsDNA-Templated Copper Nanoparticles Strategy with Improved Sensitivity and Stability Based on Rolling Circle Replication and Its Application in MicroRNA Detection

(2014) Fengzhou Xu et al.   ANALYTICAL CHEMISTRY

Reagentless, Ratiometric Electrochemical DNA Sensors with Improved Robustness and Reproducibility

(2014) Yan Du et al.   ANALYTICAL CHEMISTRY

Visual and Highly Sensitive Detection of Cancer Cells by a Colorimetric Aptasensor Based on Cell-Triggered Cyclic Enzymatic Signal Amplification

(2014) Xianxia Zhang et al.   ANALYTICAL CHEMISTRY

A Highly Sensitive Target-Primed Rolling Circle Amplification (TPRCA) Method for Fluorescent in Situ Hybridization Detection of MicroRNA in Tumor Cells

(2014) Jia Ge et al.   ANALYTICAL CHEMISTRY

Disposable Strip Biosensor for Visual Detection of Hg2+ Based on Hg2+-Triggered Toehold Binding and Exonuclease III-Assisted Signal Amplification

(2014) Junhua Chen et al.   ANALYTICAL CHEMISTRY

Aptamers Facilitating Amplified Detection of Biomolecules

(2014) Feng Li et al.   ANALYTICAL CHEMISTRY

Exonuclease III-Aided Autocatalytic DNA Biosensing Platform for Immobilization-Free and Ultrasensitive Electrochemical Detection of Nucleic Acid and Protein

(2014) Shufeng Liu et al.   ANALYTICAL CHEMISTRY

A dual-signal amplification method for the DNA detection based on exonuclease III

(2014) Zhimin Cai et al.   BIOSENSORS & BIOELECTRONICS

Optical aptasensors for quantitative detection of small biomolecules: A review

(2014) Chunjing Feng et al.   BIOSENSORS & BIOELECTRONICS

Enzymatic cascade based fluorescent DNAzyme machines for the ultrasensitive detection of Cu(II) ions

(2014) Jing-Lin He et al.   BIOSENSORS & BIOELECTRONICS

Label-free picomolar detection of Pb2+ using atypical icosahedra gold nanoparticles and rolling circle amplification

(2014) Yi Peng et al.   BIOSENSORS & BIOELECTRONICS

Electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for determining the methylation level and position in the Hsp53 tumor suppressor gene

(2014) Hui Zhang et al.   CHEMICAL COMMUNICATIONS

Qualitative and quantitative detection of methylation at CpG sites using the fluorescein-dGTP incorporated asymmetric PCR assay strategy

(2014) Tingting Hong et al.   CHEMICAL COMMUNICATIONS

Enzyme-assisted target recycling (EATR) for nucleic acid detection

(2014) Yulia V. Gerasimova et al.   CHEMICAL SOCIETY REVIEWS

Sensitive detection of DNA methyltransferase activity based on rolling circle amplification technology

(2014) Pei Liu et al.   CHINESE CHEMICAL LETTERS

A ratiometric electrochemical aptasensor for sensitive detection of protein based on aptamer–target–aptamer sandwich structure

(2014) Peng Yu et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Theoretical Study of Silver-Ion-Mediated Base Pairs: The Case of C–Ag–C and C–Ag–A Systems

(2014) Mariagrazia Fortino et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Nanomaterials as signal amplification elements in DNA-based electrochemical sensing

(2014) Liang Wu et al.   Nano Today

Quadratic isothermal amplification for the detection of microRNA

(2014) Ruixue Duan et al.   Nature Protocols

Ligation-rolling circle amplification combined with γ-cyclodextrin mediated stemless molecular beacon for sensitive and specific genotyping of single-nucleotide polymorphism

(2014) Zhen Zou et al.   TALANTA

Highly sensitive label-free fluorescent detection of Hg2+ ions by DNA molecular machine-based Ag nanoclusters

(2013) Jinjin Yin et al.   ANALYST

An ultrasensitive electrochemical method for detection of Ag+ based on cyclic amplification of exonuclease III activity on cytosine–Ag+–cytosine

(2013) Gang Xu et al.   ANALYST

A colorimetric method for H1N1 DNA detection using rolling circle amplification

(2013) Yasi Xing et al.   ANALYST

A colorimetric method for protein assay via exonuclease III-assisted signal attenuation strategy and specific DNA–protein interaction

(2013) Tao Gao et al.   ANALYTICA CHIMICA ACTA

Application of Exonuclease III-Aided Target Recycling in Flow Cytometry: DNA Detection Sensitivity Enhanced by Orders of Magnitude

(2013) Jie Lu et al.   ANALYTICAL CHEMISTRY

Label-Free and Turn-on Aptamer Strategy for Cancer Cells Detection Based on a DNA–Silver Nanocluster Fluorescence upon Recognition-Induced Hybridization

(2013) Jinjin Yin et al.   ANALYTICAL CHEMISTRY

Label-Free Colorimetric Aptasensor Based on Nicking Enzyme Assisted Signal Amplification and DNAzyme Amplification for Highly Sensitive Detection of Protein

(2013) Yong Huang et al.   ANALYTICAL CHEMISTRY

Label-Free and Ultrasensitive Electrochemical Detection of Nucleic Acids Based on Autocatalytic and Exonuclease III-Assisted Target Recycling Strategy

(2013) Shufeng Liu et al.   ANALYTICAL CHEMISTRY

Sensitive Detection of DNA Methyltransferase Using Hairpin Probe-Based Primer Generation Rolling Circle Amplification-Induced Chemiluminescence

(2013) Ya-ping Zeng et al.   ANALYTICAL CHEMISTRY

Sensitive Detection of MicroRNA in Complex Biological Samples via Enzymatic Signal Amplification Using DNA Polymerase Coupled with Nicking Endonuclease

(2013) Bin-Cheng Yin et al.   ANALYTICAL CHEMISTRY

Conformation-Dependent Exonuclease III Activity Mediated by Metal Ions Reshuffling on Thymine-Rich DNA Duplexes for an Ultrasensitive Electrochemical Method for Hg2+ Detection

(2013) Feng Xuan et al.   ANALYTICAL CHEMISTRY

Sensitive detection of methylated DNA using the short linear quencher–fluorophore probe and two-stage isothermal amplification assay

(2013) Guichi Zhu et al.   BIOSENSORS & BIOELECTRONICS

Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification

(2013) Yuyu Tan et al.   BIOSENSORS & BIOELECTRONICS

A sensitive biosensing strategy for DNA detection based on graphene oxide and T7 exonuclease assisted target recycling amplification

(2013) Hai-Bo Wang et al.   CANADIAN JOURNAL OF CHEMISTRY

Homogeneous electrochemical aptamer-based ATP assay with signal amplification by exonuclease III assisted target recycling

(2013) Shufeng Liu et al.   CHEMICAL COMMUNICATIONS

Assistant DNA recycling with nicking endonuclease and molecular beacon for signal amplification using a target-complementary arched structure

(2013) Fenglei Gao et al.   CHEMICAL COMMUNICATIONS

Backbone-modified molecular beacons for highly sensitive and selective detection of microRNAs based on duplex specific nuclease signal amplification

(2013) Xiaoyan Lin et al.   CHEMICAL COMMUNICATIONS

A T7 exonuclease-assisted cyclic enzymatic amplification method coupled with rolling circle amplification: a dual-amplification strategy for sensitive and selective microRNA detection

(2013) Liang Cui et al.   CHEMICAL COMMUNICATIONS

Aptamers from Cell-Based Selection for Bioanalytical Applications

(2013) Weihong Tan et al.   CHEMICAL REVIEWS

Mechanism of the hairpin folding transformation of thymine-cytosine-rich oligonucleotides induced by Hg(II) and Ag(I) ions

(2013) Wei Ding et al.   EUROPEAN PHYSICAL JOURNAL E

Electrochemical biosensor for DNA damage detection based on exonuclease III digestions

(2013) Wei Wei et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

A DNA machine for sensitive and homogeneous DNA detection via lambda exonuclease assisted amplification

(2013) Lin Liu et al.   TALANTA

Pattern Recognition of Cancer Cells Using Aptamer-Conjugated Magnetic Nanoparticles

(2012) Suwussa Bamrungsap et al.   ACS Nano

A novel sensing platform using aptamer and RNA polymerase-based amplification for detection of cancer cells

(2012) Jingjin Zhao et al.   ANALYTICA CHIMICA ACTA

Optical Aptasensors for the Analysis of the Vascular Endothelial Growth Factor (VEGF)

(2012) Ronit Freeman et al.   ANALYTICAL CHEMISTRY

Ultrasensitive Electrochemical Detection of Nucleic Acids by Template Enhanced Hybridization Followed with Rolling Circle Amplification

(2012) Hanxu Ji et al.   ANALYTICAL CHEMISTRY

Signal Amplification of Graphene Oxide Combining with Restriction Endonuclease for Site-Specific Determination of DNA Methylation and Assay of Methyltransferase Activity

(2012) Wen Li et al.   ANALYTICAL CHEMISTRY

DNA Methylation Analysis Triggered by Bulge Specific Immuno-Recognition

(2012) Ryoji Kurita et al.   ANALYTICAL CHEMISTRY

Sensitive and Homogeneous Protein Detection Based on Target-Triggered Aptamer Hairpin Switch and Nicking Enzyme Assisted Fluorescence Signal Amplification

(2012) Liyun Xue et al.   ANALYTICAL CHEMISTRY

Engineering a unimolecular multifunctional DNA probe for analysis of Hg2+ and Ag+

(2012) Xiaoxiao He et al.   Analytical Methods

A sensitive signal-on assay for MTase activity based on methylation-responsive hairpin-capture DNA probe

(2012) Jing Su et al.   BIOSENSORS & BIOELECTRONICS

Ultrasensitive electrochemical detection of Pb2+ based on rolling circle amplification and quantum dotstagging

(2012) Shurong Tang et al.   BIOSENSORS & BIOELECTRONICS

A label-free electrochemical assay for methyltransferase activity detection based on the controllable assembly of single wall carbon nanotubes

(2012) Yonghong Wang et al.   BIOSENSORS & BIOELECTRONICS

Aptamer-based polymerase chain reaction for ultrasensitive cell detection

(2012) Jinzhao Song et al.   CHEMICAL COMMUNICATIONS

An electrochemical DNA biosensor based on the “Y” junction structure and restriction endonuclease-aided target recycling strategy

(2012) Qing Wang et al.   CHEMICAL COMMUNICATIONS

Cascade signal amplification strategy for the detection of cancer cells by rolling circle amplification and nanoparticles tagging

(2012) Caifeng Ding et al.   CHEMICAL COMMUNICATIONS

Signal amplification using functional nanomaterials for biosensing

(2012) Jianping Lei et al.   CHEMICAL SOCIETY REVIEWS

Amplified Fluorescence Aptamer-Based Sensors Using Exonuclease III for the Regeneration of the Analyte

(2012) Xiaoqing Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Gold Nanoparticle-Enabled Real-Time Ligation Chain Reaction for Ultrasensitive Detection of DNA

(2012) Wei Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

One-Step, Multiplexed Fluorescence Detection of microRNAs Based on Duplex-Specific Nuclease Signal Amplification

(2012) Bin-Cheng Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1

(2012) J. E. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cascade signal amplification for sensitive detection of cancer cell based on self-assembly of DNA scaffold and rolling circle amplification

(2012) Ying Li et al.   SENSORS AND ACTUATORS B-CHEMICAL

Ultrasensitive Colorimetric DNA Detection using a Combination of Rolling Circle Amplification and Nicking Endonuclease-Assisted Nanoparticle Amplification (NEANA)

(2012) Wei Xu et al.   Small

Amplified optical aptasensors through the endonuclease-stimulated regeneration of the analyte

(2012) Chun-Hua Lu et al.   Chemical Science

Nucleic Acids With Metal-Mediated Base Pairs and Their Applications

(2012) Philipp Scharf et al.   ChemPlusChem

Linear nicking endonuclease-mediated strand-displacement DNA amplification

(2011) Aric Joneja et al.   ANALYTICAL BIOCHEMISTRY

Linear molecular beacons for highly sensitive bioanalysis based on cyclic Exo III enzymatic amplification

(2011) Chaoyong James Yang et al.   BIOSENSORS & BIOELECTRONICS

Label-free optical detection of single-base mismatches by the combination of nuclease and gold nanoparticles

(2011) Meiying Liu et al.   BIOSENSORS & BIOELECTRONICS

A sensitive signal-on electrochemical assay for MTase activity using AuNPs amplification

(2011) Xiaoxiao He et al.   BIOSENSORS & BIOELECTRONICS

A label-free electrochemical DNA sensor based on exonuclease III-aided target recycling strategy for sequence-specific detection of femtomolar DNA

(2011) Di Wu et al.   BIOSENSORS & BIOELECTRONICS

Ultrasensitive fluorescence polarization DNA detection by target assisted exonuclease III-catalyzed signal amplification

(2011) Min Zhang et al.   CHEMICAL COMMUNICATIONS

Exonuclease-assisted cascaded recycling amplification for label-free detection ofDNA

(2011) Sai Bi et al.   CHEMICAL COMMUNICATIONS

Nicking enzyme based homogeneous aptasensors for amplification detection of protein

(2011) Ai-Xian Zheng et al.   CHEMICAL COMMUNICATIONS

DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer

(2011) Kathrin Mutze et al.   EUROPEAN JOURNAL OF CANCER

Applications and recent developments of multi-analyte simultaneous analysis by enzyme-linked immunosorbent assays

(2011) Hongyan Zhang et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Amplified Analysis of DNA by the Autonomous Assembly of Polymers Consisting of DNAzyme Wires

(2011) Fuan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration

(2011) H. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target-Responsive Structural Switching for Nucleic Acid-Based Sensors

(2010) Di Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

Folding-Based Electrochemical Biosensors: The Case for Responsive Nucleic Acid Architectures

(2010) Arica A. Lubin et al.   ACCOUNTS OF CHEMICAL RESEARCH

A methylation-stimulated DNA machine: an autonomous isothermal route to methyltransferase activity and inhibition analysis

(2010) Changfeng Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Ultrasensitive DNA Detection by Cascade Enzymatic Signal Amplification Based on Afu Flap Endonuclease Coupled with Nicking Endonuclease

(2010) Bingjie Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of Aptamers as Sensors

(2010) Eun Jeong Cho et al.   Annual Review of Analytical Chemistry

Electrochemical Impedance Spectroscopy

(2010) Byoung-Yong Chang et al.   Annual Review of Analytical Chemistry

Electrochemical biosensors

(2010) Niina J. Ronkainen et al.   CHEMICAL SOCIETY REVIEWS

Light and colour as analytical detection tools: A journey into the periodic table using polyamines to bio-inspired systems as chemosensors

(2010) Carlos Lodeiro et al.   CHEMICAL SOCIETY REVIEWS

Nanoparticle-based mass spectrometry for the analysis of biomolecules

(2010) Cheng-Kang Chiang et al.   CHEMICAL SOCIETY REVIEWS

Sensitive and Selective Amplified Fluorescence DNA Detection Based on Exonuclease III-Aided Target Recycling

(2010) Xiaolei Zuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes

(2010) F. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle Amplification

(2009) Wei Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of DNA Polymerases

(2009) Anthony J. Berdis   CHEMICAL REVIEWS

Functional Nucleic Acid Sensors

(2009) Juewen Liu et al.   CHEMICAL REVIEWS

Utility of Incorporating Genetic Variants for the Early Detection of Prostate Cancer

(2009) R. K. Nam et al.   CLINICAL CANCER RESEARCH

Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma

(2009) Akash M. Mehta et al.   GENES CHROMOSOMES & CANCER

Quantitative analysis of gene expression in a single cell by qPCR

(2009) Kiyomi Taniguchi et al.   NATURE METHODS

Electrochemical DNAzyme Sensor for Lead Based on Amplification of DNA−Au Bio-Bar Codes

(2008) Li Shen et al.   ANALYTICAL CHEMISTRY

DNAzymes for sensing, nanobiotechnology and logic gate applications

(2008) Itamar Willner et al.   CHEMICAL SOCIETY REVIEWS

The cancer biomarker problem

(2008) Charles L. Sawyers   NATURE

Enzymatic signal amplification of molecular beacons for sensitive DNA detection

(2008) Jianwei Jeffery Li et al.   NUCLEIC ACIDS RESEARCH

Discriminating single-base difference miRNA expressions using microarray Probe Design Guru (ProDeG)

(2008) Inhan Lee et al.   NUCLEIC ACIDS RESEARCH

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic Cleavage of Nucleic Acids on Gold Nanoparticles: A Generic Platform for Facile Colorimetric Biosensors

(2008) Weian Zhao et al.   Small