Article
Immunology
Diego Scheggia, Jennifer Stanic, Maria Italia, Filippo La Greca, Elisa Zianni, Alberto Benussi, Barbara Borroni, Monica Di Luca, Fabrizio Gardoni
Summary: Autoantibodies targeting the GluA3 subunit of AMPARs have been found in patients with Rasmussen's encephalitis and epilepsy, and associated with learning and attention deficits. The presence of anti-GluA3 IgG in FTD patients suggests a novel pathogenic role in chronic neurodegenerative diseases. In vivo preclinical data provide insights into autoimmune encephalitis associated with anti-GluA3 IgG and indicate an additional pathological mechanism affecting excitatory synapses in FTD patients.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Maria Italia, Elena Ferrari, Monica Di Luca, Fabrizio Gardoni
Summary: AMPARs play a crucial role in excitatory synaptic transmission in the mammalian brain, with the GluA3 subunit being widely expressed and functionally relevant. Modulation of GluA3 through pharmacological means may offer a new approach for addressing altered glutamatergic synapses associated with neurodegenerative and neurodevelopmental disorders.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Pharmacology & Pharmacy
Fritz Markwardt
Summary: Patch clamp investigations help understand the molecular function of single ion channels. The human P2X7 receptor is an ATP-gated ion channel involved in inflammatory and nociceptive reactions. Specific residues and domains play crucial roles in ion channel function.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Valerio Farfariello, Dmitri Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan B. Parys, Loic Lemonnier, Natalia Prevarskaya
Summary: This study reveals the mechanism of how alterations in mitochondrial function and calcium signaling contribute to cellular senescence and tumor growth. The downregulation of TRPC3 protein in senescent fibroblasts leads to increased mitochondrial calcium load and oxidative phosphorylation, promoting cellular senescence. The downregulation of TRPC3 in stromal cells also affects secretome and tumor progression, highlighting its importance in cancer development.
NATURE COMMUNICATIONS
(2022)
Article
Computer Science, Artificial Intelligence
Yuechen Tao, Bo Li, Baochun Li, Lei Chen
Summary: In this paper, a mathematical model is developed to capture the performance of payment channel networks (PCNs). The impact of factors such as channel capacity and transactions on PCN performance and performance gap are examined. The analytical characterization provides important insights on the design of PCNs.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Thermodynamics
Mingjing Chen, Deqi Chen, Haidong Liu, Hanzhou Liu, Lei Zhong, Jian Deng
Summary: In this study, the mechanisms of droplet formation and fragmentation during the reflood process were investigated through visualization experiments and quantitative analysis. Based on these findings, a prediction model was established and compared with experimental data.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2024)
Article
Instruments & Instrumentation
Kiyoshi Kinefuchi, Daisuke Nakata, Giulio Coral, Suyalatu, Hitoshi Sakai, Ryudo Tsukizaki, Kazutaka Nishiyama
Summary: A novel single-piece thin multi-layer tungsten resistive heater was successfully fabricated and tested as an electrothermal thruster, showing high heating efficiency and reliability. Efficiency of the heater decreased with temperature due to thermal conduction and radiation heat losses, crucial for improving heater performance at high temperatures above 2000 K.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2021)
Article
Chemistry, Physical
Yunsong Yu, Chen Zhang, Jingfeng Zhang, Chenyang Zhou, Zaoxiao Zhang, Geoff G. X. Wang
Summary: The newly developed single atom fluid in solvent mixture exhibits remarkable thermoelectric properties, with significant influence from temperature, pressure, and nickel weight fraction, and has wide industrial application value.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Editorial Material
Endocrinology & Metabolism
Erika Cecon, Celine Legros, Jean A. Boutin, Ralf Jockers
Summary: Melatonin has been associated with a multitude of effects at varying concentrations, with over fifteen proposed targets. The current guidelines aim to provide a framework for improving and rationalizing the characterization of melatonin targets and effects, acting as mandatory guidelines for manuscripts submitted to the Journal of Pineal Research.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Xiao Yang, Yang Zhao, Hairong Qi, George T. Tabler
Summary: This study investigated the frequency ranges of six common sounds in commercial broiler houses and their relation with bird age. The behavioral frequencies of wing flapping and dustbathing decreased over time. The research provides valuable information for monitoring animal behavior and equipment operation using sound signal in commercial broiler houses.
Article
Neurosciences
Peter C. Petersen, Joshua H. Siegle, Nicholas A. Steinmetz, Sara Mahallati, Gyorgy Buzsaki
Summary: CellExplorer is an open-source MATLAB-based framework designed for processing, visualizing, and standardizing features of neurons, such as physiological metrics, neuron type classification, and synaptic connections. Its powerful graphical interface allows users to explore computed features quickly and relate their data to a growing public collection of neurons.
Article
Health Care Sciences & Services
Keren Nitzan, Roni Toledano, Shiran Shapira, Nadir Arber, Ravid Doron
Summary: The study found that CD24 knockout mice exhibited better cognitive performance and less anxiety-like behavior compared to wild-type mice, with no effect on depression-like behavior. This phenotype remained constant from childhood to adulthood.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Genetics & Heredity
Sebastian Preissl, Kyle J. Gaulton, Bing Ren
Summary: This article discusses cell type-specific gene regulation and its changes during development and disease. Single-cell epigenomic methods and data analysis tools provide a deeper understanding of gene regulatory programs and their roles in different environments and diseases.
NATURE REVIEWS GENETICS
(2022)
Article
Cell Biology
Tingting Yang, Zixuan Yuan, Chenxi Liu, Ting Liu, Wei Zhang
Summary: Mechanical receptors in the pharynx of fruit flies play a crucial role in controlling meal size, particularly with high viscosity foods. These receptors transmit mechanical force information to the brain, in conjunction with gustatory signals, influencing feeding behavior through neural circuits.
Article
Multidisciplinary Sciences
Tiago A. Schieber, Laura C. Carpi, Panos M. Pardalos, Cristina Masoller, Albert Diaz-Guilera, Martin G. Ravetti
Summary: This article introduces the concept of Diffusion Capacity, which measures the potential of a network node to diffuse information and provides insights for improving network efficiency. The method considers the network topology, diffusion process, and initial conditions, and thoroughly describes the role of individual nodes and identifies structural modifications that can enhance diffusion mechanisms. Applied to a global climate network, the research reveals a significant decrease in diffusion capacity around 2000, suggesting a loss of the planet's diffusion capacity contributing to more frequent climatic events.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jessica R. Barson, Kinning Poon, Hui Tin Ho, Mohammad I. Alam, Lilia Sanzalone, Sarah F. Leibowitz
Article
Biochemistry & Molecular Biology
Kinning Ponn, Mohammad Alam, Olga Karatayev, Jessica R. Barson, Sarah F. Leibowitz
JOURNAL OF NEUROCHEMISTRY
(2015)
Article
Neurosciences
K. Poon, D. Abramova, H. T. Ho, S. Leibowitz
Article
Behavioral Sciences
Kinning Poon, Jessica R. Barson, Hui T. Ho, Sarah F. Leibowitz
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2016)
Article
Endocrinology & Metabolism
Kinning Poon, Jessica R. Barson, Shawn E. Fagan, Sarah F. Leibowitz
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2012)
Article
Biochemistry & Molecular Biology
Kinning Poon, Hui T. Ho, Jessica R. Barson, Sarah F. Leibowitz
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Multidisciplinary Sciences
Kinning Poon, Sushma Mandava, Karen Chen, Jessica R. Barson, Sylvie Buschlen, Sarah F. Leibowitz
Article
Physiology
Edward Y. Shi, Christine L. Yuan, Matthew T. Sipple, Jayasri Srinivasan, Christopher P. Ptak, Robert E. Oswald, Linda M. Nowak
JOURNAL OF GENERAL PHYSIOLOGY
(2019)
Article
Chemistry, Medicinal
Christine L. Yuan, Edward Y. Shi, Jayasri Srinivasan, Christopher P. Ptak, Robert E. Oswald, Linda M. Nowak
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Physiology
Elisa Carrillo, Sana A. Shaikh, Vladimir Berka, Ryan J. Durham, Douglas B. Litwin, Garam Lee, David M. MacLean, Linda M. Nowak, Vasanthi Jayaraman
JOURNAL OF GENERAL PHYSIOLOGY
(2020)
Review
Endocrinology & Metabolism
Kinning Poon
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Fabiola Pacheco Valencia, Amanda F. Marino, Christos Noutsos, Kinning Poon
Summary: Prenatal exposure to a high-fat diet increases hypothalamic neurogenesis events in embryos and programs the offspring to be prone to obesity. This study investigates the effects of oleic and palmitic acids, abundant in a high-fat diet, on the hypothalamic neuronal transcriptome and how these changes affect neurogenesis events. The results show that oleic acid stimulates proliferation and palmitic acid stimulates apoptosis in hypothalamic neurons, with both fatty acids impacting migration. Potential signaling pathways affected by these fatty acids are also uncovered.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biology
Sangeeta Nischal, Maria Zulema Cabail, Kinning Poon
Summary: Due to the COVID-19 pandemic, undergraduate biology courses in New York shifted to remote learning. A study found that using a multi-modal approach with take-home experiments and virtual labs enhanced students' conceptual understanding, hands-on experience, writing skills, and critical thinking.
JOURNAL OF BIOLOGICAL EDUCATION
(2022)
Article
Behavioral Sciences
Kinning Poon, Jessica R. Barson, Huanzhi Shi, Guo Qing Chang, Sarah F. Leibowitz
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2017)
Review
Nutrition & Dietetics
Kinning Poon, Sarah F. Leibowitz
FRONTIERS IN NUTRITION
(2016)