Article
Endocrinology & Metabolism
Wout Verbeure, Eveline Deloose, Joran Toth, Jens F. Rehfeld, Lukas Van Oudenhove, Inge Depoortere, Jan Tack
Summary: This study investigated the effects of bitter tastants on hunger ratings and hormone plasma levels, finding that infusing bitter tastants into the stomach was more effective in reducing hunger sensations. Quinine hydrochloride showed the best performance when infused 60 minutes before food intake.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Wolfgang W. Wicha, Thomas C. Marbury, James A. Dowell, Jared L. Crandon, Cathie Leister, James Ermer, Steven P. Gelone
Summary: This study evaluated the pharmacokinetics of IV Lefamulin in subjects with different degrees of hepatic impairment compared to healthy subjects. The results showed that Lefamulin was well tolerated in all hepatic function groups. Differences in Lefamulin and BC-8041 pharmacokinetics were small relative to overall variability, suggesting that any changes may be compensated by increases in renal clearance and decreased protein binding.
Article
Biochemistry & Molecular Biology
Kamil Brzoska, Malgorzata Szczygiel, Agnieszka Drzal, Martyna Sniegocka, Dominika Michalczyk-Wetula, Eva Biela, Martyna Elas, Lucyna Kapka-Skrzypczak, Hanna Lewandowska-Siwkiewicz, Krystyna Urbanska, Marcin Kruszewski
Summary: Gold nanoparticles (AuNPs) were investigated for their potential anticancer effects in tumor growth and metastasis. The results showed that AuNPs did not inhibit tumor growth but caused significant vasodilation in the tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Yang Song, Kefei Wang, Xiaoyi Wei, Tongyuan Wei, Tianhao Xiao, Minjie Wei
Summary: A method for quantifying palmatine in rat plasma and tissue samples was developed, showing that the liver and kidney may be the targeting organs of palmatine, and the plasma binding rate of palmatine is higher in humans than in rats.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Veterinary Sciences
Raquel Diez, M. Jose Diez, Juan J. Garcia, Jose M. Rodriguez, Cristina Lopez, Nelida Fernandez, Matilde Sierra, Ana M. Sahagun
Summary: This study aimed to establish the pharmacokinetic parameters of Menbutone in sheep after intravenous and intramuscular administration. The results indicated that the absorption of Menbutone after intramuscular administration was rapid and complete.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Mohamed Elbadawy, Ahmed Soliman, Amira Abugomaa, Adel Alkhedaide, Mohamed Mohamed Soliman, Mohamed Aboubakr
Summary: After administering cefquinome to turkeys via intravenous or intramuscular injection, the drug was rapidly absorbed with a considerable bioavailability. These findings can guide the establishment of optimal dosage regimens to eradicate bacterial infections in turkeys.
Article
Chemistry, Physical
Kamil Brzoska, Maria Wojewodzka, Malgorzata Szczygiel, Agnieszka Drzal, Martyna Sniegocka, Dominika Michalczyk-Wetula, Eva Biela, Martyna Elas, Malgorzata Kucinska, Hanna Piotrowska-Kempisty, Lucyna Kapka-Skrzypczak, Marek Murias, Krystyna Urbanska, Marcin Kruszewski
Summary: This study analyzed the impact of different silver nanoparticles on the development and metastatic potential of breast cancer using a mouse model. The results showed that citrate-coated silver nanoparticles had a significant effect on reducing tumor volume and lung metastases in mice treated intragastrically. However, no effect on lung metastases was observed after intravenous administration of silver nanoparticles. The findings suggest that the anticancer activity of silver nanoparticles may depend on the activation of the immune system.
Article
Agriculture, Dairy & Animal Science
Jun-Cheng Chen, Fang Yang, Ming-Hui Duan, Ze-En Li, Yan Dai, Mei Zhang, Fan Yang
Summary: This study aimed to determine the pharmacokinetics of meloxicam in pigeons. The results showed that meloxicam was effectively and quickly absorbed after oral and intramuscular administration, with high bioavailability. After intravenous administration, the elimination was faster. Formulating a dosing regimen for pigeons presented a significant challenge due to the lack of a precise analgesic threshold and notable differences in analgesic thresholds among various animal species. Higher doses or shorter dosing intervals are recommended for treating pain in pigeons, but further research is required to verify these recommendations.
Article
Veterinary Sciences
Irene Sartini, Beata Lebkowska-Wieruszewska, Anna Gajda, Konrad Pietruk, Malgorzata Gbylik-Sikorska, Andrzej Lisowski, Tae Won Kim, Amnart Poapolathep, Mario Giorgi
Summary: In this study, the pharmacokinetics of propacetamol, a prodrug form of paracetamol, were investigated in Labrador dogs. The study found that direct intravenous injection of APAP may be a better option for pain relief in dogs.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Lisa Ebner, O. Odette, Bradley Simon, Ignacio Lizarraga, Joe Smith, Sherry Cox
Summary: The pharmacokinetics of butorphanol after IV and IM administration in donkeys were studied. The results showed that the elimination half-life of butorphanol in healthy donkeys was shorter compared to the values from equine literature.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jun-Cheng Chen, Fang Yang, Guang-Hui Li, Ming-Hui Duan, Ze-En Li, Yan Dai, Mei Zhang, Fan Yang
Summary: This study investigated the pharmacokinetics of danofloxacin in Gushi chickens after oral and intravenous administration of a 5 mg/kg dose. Results showed that the peak concentration was reached at 4 hours after oral administration, with a bioavailability of 40.12%. The area under the concentration-time curve (AUC) was higher for IV administration compared to oral administration. The findings suggest that a 5 mg/kg BW dose of danofloxacin can effectively treat infections in Gushi chickens.
Article
Medicine, Research & Experimental
Cong Yi-Jun, Chen Wei-Ya, Wei Jia-Xing, Liu Chun-Yu, Yang Fei-Fei, Liao Yong-Hong
Summary: This study evaluated the aerosolization performance and pulmonary fate of Chuankezhi injection (CKZ), a traditional Chinese medicine for respiratory diseases. The results showed that nebulization therapy of CKZ has promising pharmacokinetics, lung distribution, and anti-inflammatory effects, making it a potential alternative to injectable CKZ.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Juan Sebastian Galecio, Pedro Marin, Veronica Hernandis, Maria Botia, Elisa Escudero
Summary: This study investigated the disposition kinetics of tildipirosin in dairy goats and found that it had a significantly longer persistence in milk and somatic cells compared to plasma. It is recommended to use tildipirosin when other antibiotics have failed and to avoid using milk from treated animals or treat goats during the dry-off period.
Article
Rheumatology
Kazuki M. Matsuda, Ayumi Yoshizaki, Ai Kuzumi, Satoshi Toyama, Kentaro Awaji, Tomomi Miyake, Shinichi Sato
Summary: This study aims to summarize the current knowledge on the efficacy of IVIG against GI symptoms of SSc and identify future research directions. The results indicate that IVIG administration can lead to remarkable improvement in GI symptoms, including IPO, and previous reports also support its efficacy. However, further studies with objective and quantitative measures are needed to evaluate short-term outcomes.
Article
Veterinary Sciences
Juan Sebastian Galecio, Elisa Escudero, Elena Badillo, Pedro Marin
Summary: This study aimed to investigate the pharmacokinetics and safety of tildipirosin in horses. The results showed that tildipirosin had extensive distribution and high bioavailability in horses, and did not cause significant cardiotoxicity. However, it could lead to mild local reactions and myolysis.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Xiaohua Zhu, Kurt S. Van Horn, Megan M. Barber, Sihyung Yang, Michael Zhuo Wang, Roman Manetsch, Karl A. Werbovetz
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Donald A. Patrick, Tanja Wenzler, Sihyung Yang, Patrick T. Weiser, Michael Zhuo Wang, Reto Brun, Richard R. Tidwell
BIOORGANIC & MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Xiaohua Zhu, Abdelbasset A. Farahat, Meena Mattamana, April Joice, Trupti Pandharkar, Elizabeth Holt, Moloy Banerjee, Jamie L. Gragg, Laixing Hu, Arvind Kumar, Sihyung Yang, Michael Zhuo Wang, David W. Boykin, Karl A. Werbovetz
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Correction
Chemistry, Medicinal
Kurt S. Van Horn, Xiaohua Zhu, Trupti Pandharkar, Sihyung Yang, Brian Vesely, Manu Vanaerschot, Jean-Claude Dujardin, Suman Rijal, Dennis E. Kyle, Michael Zhuo Wang, Karl A. Werbovetz, Roman Manetsch
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Microbiology
Tanja Wenzler, Sihyung Yang, Donald A. Patrick, Olivier Braissant, Mohamed A. Ismail, Richard R. Tidwell, David W. Boykin, Michael Zhuo Wang, Reto Brun
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2014)
Article
Microbiology
Sihyung Yang, Tanja Wenzler, Patrik N. Miller, Huali Wu, David W. Boykin, Reto Brun, Michael Zhuo Wang
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2014)
Article
Biochemical Research Methods
Sihyung Yang, Kuan-Wei Peng, Michael Zhuo Wang
BIOMEDICAL CHROMATOGRAPHY
(2015)
Article
Chemistry, Medicinal
Kurt S. Van Horn, Xiaohua Zhu, Trupti Pandharkar, Sihyung Yang, Brian Vesely, Manu Vanaerschot, Jean-Claude Dujardin, Suman Rijal, Dennis E. Kyle, Michael Zhuo Wang, Karl A. Werbovetz, Roman Manetsch
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Wujian Ju, Sihyung Yang, John H. Ansede, Chad E. Stephens, Arlene S. Bridges, Robert D. Voyksner, Mohamed A. Ismail, David W. Boykin, Richard R. Tidwell, James Edwin Hall, Michael Zhuo Wang
JOURNAL OF PHARMACEUTICAL SCIENCES
(2014)
Review
Pharmacology & Pharmacy
Sihyung Yang, Young Sun Lee, Euichaul Oh
Article
Chemistry, Medicinal
Sihyung Yang, Yao Chen, Mei Feng, Larry Rodriguez, Judy Qiju Wu, Michael Zhuo Wang
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Robert W. Busby, Xiaokun Cai, Sihyung Yang, Luis Ramos, Lata Venkatarangan, Helen Shen, Stephen Wax, Abu J. M. Sadeque, Cyril De Colle
Summary: Metopimazine (MPZ) is a drug used for the treatment of acute nausea and vomiting. It undergoes high first-pass metabolism to produce metopimazine acid (MPZA). This study identified human liver microsomal amidase as the primary enzyme responsible for the formation of MPZA. The involvement of cytochrome P450 enzymes in MPZ metabolism was found to be negligible. This differentiation from other D2 antagonists used for gastroparesis treatment highlights the importance of liver amidase in MPZ metabolism.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Parasitology
Mei Feng, Yiru Jin, Sihyung Yang, Arline M. Joachim, Yu Ning, Luis M. Mori-Quiroz, Jacob Fromm, Chamani Perera, Kai Zhang, Karl A. Werbovetz, Michael Zhuo Wang
Summary: Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly disease have significant limitations. The ergosterol biosynthetic pathway has been identified as a drug target in Leishmania. However, remarkable differences in the efficacy of antifungal azoles that inhibit ergosterol biosynthesis have been reported for the treatment of leishmaniasis. To better understand the sterol biosynthetic pathway in Leishmania and elucidate the mechanism underlying the differential efficacy of antifungal azoles, we developed a new LC-MS/MS method to study sterol profiles in promastigotes of three Leishmania species, including two L. donovani, one L. major and one L. tarentolae strains. A combination of distinct precursor ion masses and LC retention times allowed for specific detection of sixteen intermediate sterols between lanosterol and ergosterol using the newly developed LC-MS/MS method. Although both posaconazole and fluconazole are known inhibitors of fungal lanosterol 14 alpha-demethylase (CYP51), only posaconazole led to a substantial accumulation of lanosterol in azole-treated L. donovani promastigotes. Furthermore, a key intermediate sterol accumulated by 40- and 7-fold when these parasites were treated with posaconazole and fluconazole, respectively, which was determined as 4 alpha,14 alpha-dimethylzymosterol by high resolution mass spectrometry and NMR spectroscopy. The identification of 4 alpha,14 alpha-dimethylzymosterol supports a branched ergosterol biosynthetic pathway in Leishmania, where lanosterol C4- and C14-demethylation reactions occur in parallel rather than sequentially. Our results suggest that selective inhibition of leishmanial CYP51 is insufficient to effectively prevent parasite growth and dual inhibitors of both CYP51 and the unknown sterol C4-demethylase may be required for optimal antiparasitic effect.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2022)
Article
Microbiology
April C. Joice, Sihyung Yang, Abdelbasset A. Farahat, Heidi Meeds, Mei Feng, Junan Li, David W. Boykin, Michael Zhuo Wang, Karl A. Werbovetz
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Pharmacology & Pharmacy
Yuan Ji, Rosanne Varkevisser, Dragan Opacic, Alexandre Bossu, Marion Kuiper, Jet D. M. Beekman, Sihyung Yang, Azinwi Phina Khan, Dobromir Dobrev, Niels Voigt, Michael Zhuo Wang, Sander Verheule, Marc A. Vos, Marcel A. G. van der Heyden
BRITISH JOURNAL OF PHARMACOLOGY
(2017)