In VitroandIn VivoEvaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sickness

Pharmacokinetic Comparison To Determine the Mechanisms Underlying the Differential Efficacies of Cationic Diamidines against First- and Second-Stage Human African Trypanosomiasis

(2014) Sihyung Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics, Trypanosoma brucei gambiense Efficacy, and Time of Drug Action of DB829, a Preclinical Candidate for Treatment of Second-Stage Human African Trypanosomiasis

(2013) Tanja Wenzler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues

(2013) Laixing Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Antiprotozoal Activity of Dicationic m-Terphenyl and 1,3-Dipyridylbenzene Derivatives

(2013) Donald A. Patrick et al.   JOURNAL OF MEDICINAL CHEMISTRY

New WHO plan targets the demise of sleeping sickness

(2013) John Maurice   LANCET

Microbial growth and isothermal microcalorimetry: Growth models and their application to microcalorimetric data

(2013) O. Braissant et al.   THERMOCHIMICA ACTA

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

(2013) Nicola Baker et al.   TRENDS IN PARASITOLOGY

Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

(2013) Fabrice E. Graf et al.   PLoS Neglected Tropical Diseases

Antiparasitic agents: new drugs on the horizon

(2012) Pascal Mäser et al.   CURRENT OPINION IN PHARMACOLOGY

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

(2012) N. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models

(2012) Alison H. Harrill et al.   TOXICOLOGICAL SCIENCES

Isothermal Microcalorimetry, a New Tool to Monitor Drug Action against Trypanosoma brucei and Plasmodium falciparum

(2012) Tanja Wenzler et al.   PLoS Neglected Tropical Diseases

Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns

(2011) Christopher P. Ward et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of novel drugs for human African trypanosomiasis

(2011) Reto Brun et al.   Future Microbiology

Mechanisms Underlying Differences in Systemic Exposure of Structurally Similar Active Metabolites: Comparison of Two Preclinical Hepatic Models

(2011) G. Z. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward

(2011) Pere P. Simarro et al.   PLoS Neglected Tropical Diseases

Isolation of Trypanosoma brucei gambiense from Cured and Relapsed Sleeping Sickness Patients and Adaptation to Laboratory Mice

(2011) Patient Pati Pyana et al.   PLoS Neglected Tropical Diseases

Chemotherapy against human African trypanosomiasis: Is there a road to success?

(2010) CHRISTIAN BURRI   PARASITOLOGY

Diamidine Activity Against Trypanosomes: The State of the Art

(2010) M. Soeiro et al.   Current Molecular Pharmacology

New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289

(2009) T. Wenzler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

Antiparasitic compounds that target DNA

(2008) W. David Wilson et al.   BIOCHIMIE

Global metabolic responses of mice to Trypanosoma brucei brucei infection

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA