Article
Plant Sciences
Joji Abraham, Singarayer Florentine
Summary: Despite COVID-19 vaccination efforts, ongoing personal and social caution is necessary; pharmaceutical industry aims to develop antiviral and anti-inflammatory drugs to alleviate COVID-19 symptoms; research on licorice phytochemicals shows potential for natural interventions against COVID-19 symptoms.
Review
Biochemistry & Molecular Biology
Camila dos Santos Leite, Gabriel Alves Bonafe, Juliana Carvalho Santos, Carlos Augusto Real Martinez, Manoela Marques Ortega, Marcelo Lima Ribeiro
Summary: Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), pose a significant health burden globally. Licorice, a traditional Chinese medicine, exhibits anti-inflammatory and antioxidant properties that may have therapeutic potential for intestinal disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Parasitology
Michela Maestrini, Marcelo Beltrao Molento, Mario Forzan, Stefania Perrucci
Summary: This study evaluated the in vitro anthelmintic activity of liquorice root extract and glycyrrhetinic acid against sheep gastrointestinal nematodes. The results suggest that these compounds may have different mechanisms of action, with glycyrrhetinic acid showing higher efficacy than liquorice root extract. The findings encourage further in vivo studies to evaluate the potential use of these compounds as natural dewormers in ruminants.
Article
Biochemistry & Molecular Biology
Anping Li, Zhongmin Zhao, Shaoyong Zhang, Zhijun Zhang, Yanping Shi
Summary: The study showed that glabridin exhibits significant fungicidal activity against various phytopathogenic fungi, especially being effective against Sclerotinia sclerotiorum. Glabridin exerts its fungicidal activity by inducing reactive oxygen species accumulation and affecting the expression levels of phosphatidylserine decarboxylase. These findings suggest the potential of glabridin as a candidate for fungicidal agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Christian Schmid, Anne Brockhoff, Yaron Ben Shoshan-Galeczki, Maximilian Kranz, Timo D. Stark, Rukiye Erkaya, Wolfgang Meyerhof, Masha Y. Niv, Corinna Dawid, Thomas Hofmann
Summary: This study used a sensomics approach to investigate the molecular features contributing to the bitter, sweet, and licorice sensations of licorice roots, identifying 28 key phytochemicals with distinct structural features that affect taste perception and sweet receptor stimulation.
Review
Biochemistry & Molecular Biology
Yuliya Markina, Tatiana Kirichenko, Alexander M. Markin, Irina Y. Yudina, Antonina Starodubova, Igor A. Sobenin, Alexander N. Orekhov
Summary: Cardiovascular diseases associated with atherosclerosis are the leading cause of death in developed countries. Licorice has shown promising anti-atherosclerotic effects, including anti-inflammatory, antioxidant, and anti-platelet actions, making it a potential atheroprotective agent.
Review
Multidisciplinary Sciences
Md. Kamrul Hasan, Iffat Ara, Muhammad Shafiul Alam Mondal, Yearul Kabir
Summary: Nature is a great source of therapeutic compounds, with licorice being a medicinal herb that contains beneficial compounds with various pharmacological benefits.
Article
Immunology
Hannah J. Loghry, Noelle A. Sondjaja, Sarah J. Minkler, Michael J. Kimber
Summary: Lymphatic filariasis (LF) is a mosquito-borne disease caused by filarial nematodes including Brugia malayi. Current control strategies rely on mass drug administration programs, but established infections are incurable. This study found that parasite-derived galectins have immunomodulatory effects and induce immune phenotypes consistent with chronic LF infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Kakuki Kato, Asako Horiba, Hiroaki Hayashi, Hajime Mizukami, Kazuyoshi Terasaka
Summary: This study investigates the transport mechanism of glycyrrhizin (GL) in plants using cultured cells of Glycyrrhiza glabra. The results indicate that GL uptake by cultured cells is mediated by a H+-symporter in the plasma membrane and an ATP-binding cassette transporter.
Article
Multidisciplinary Sciences
Shivani Choudhary, Melanie Abongwa, Sudhanva S. Kashyap, Saurabh Verma, Gunnar R. Mair, Daniel Kulke, Richard J. Martin, Alan P. Robertson
Summary: In this study, a GluCls subunit from Brugia malayi was cloned and its pharmacological properties were investigated. The results showed that the receptor was regulated by the natural ligand L-glutamate and ivermectin, and had dual effects when exposed to nodulisporic acid. Furthermore, the unique pharmacological characteristics of this GluCls subunit could explain the variation in drug sensitivities observed in different nematode parasites.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Sophie Hermann, Marc Orlik, Petra Boevink, Elke Stein, Andrea Scherf, Ina Kleeberg, Annegret Schmitt, Adam Schikora
Summary: The study demonstrates that licorice leaf extract can be an effective alternative to conventional pesticides, acting as a fungicide and bactericide and modulating the plant immune system to combat pathogen infections.
Article
Microbiology
Alexander F. Flynn, Rebekah T. Taylor, Marzena E. Pazgier, Sasisekhar Bennuru, Alyssa R. Lindrose, Spencer L. Sterling, C. Paul Morris, Brynna Gleeson, Tim K. Maugel, Thomas B. Nutman, Edward Mitre
Summary: Lymphatic filariasis is a global disease caused by parasitic nematodes that affect millions of people. Identifying new drug and vaccine targets in adult filariae could aid elimination efforts. Bma-LAD-2 was identified as an essential protein for adult Brugia malayi, making it a potential therapeutic target.
Article
Multidisciplinary Sciences
Fana B. Mersha, Colleen M. McClung, Minyong Chen, Cristian I. Ruse, Jeremy M. Foster
Summary: N-linked glycosylation is an important modification of eukaryotic proteins. This study investigated the N-linked glycoproteome of the filarial parasite Brugia malayi using an enhanced N-glyco FASP protocol. The results showed variations in N-glycosylation at the protein and glycosite levels, particularly in proteins involved in host parasite interactions. These findings highlight potential therapeutic targets and biomarkers.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Christopher C. Evans, Katelin E. Greenway, Elyssa J. Campbell, Michael T. Dzimianski, Abdelmoneim Mansour, John W. McCall, Andrew R. Moorhead
Summary: This study found that dogs can serve as competent laboratory hosts for Brugia malayi, similar to cats. This has important implications for research on filarial diseases and the potential for zoonotic transmission in endemic regions.
Article
Veterinary Sciences
Sumas Loymek, Achinya Phuakrod, Kati Zaelai, Witsaroot Sripumkhai, Prapakorn Vongjaroensanti, Sirichit Wongkamchai
Summary: The study found varying prevalence of canine microfilaremia in three provinces of Thailand, with Brugia pahangi and Dirofilaria immitis being the predominant species. The lower prevalence in Samut Sakhon could be attributed to the successful efforts of the Soi Dog foundation. Effective disease control and prevention strategies are needed in Chanthaburi and Narathiwat to reduce the risks of zoonotic transmission.
VETERINARY SCIENCES
(2021)
Article
Chemistry, Physical
Pratibha Kumari, Renu Gautam, Harshit Yadav, Vikas Kushwaha, Avinash Mishra, Shilpi Gupta, Veena Arora
Article
Parasitology
Vikas Kushwaha, Kirti Saxena, Richa Verma, Shiv K. Verma, Deepali Katoch, Neeraj Kumar, Brij Lal, P. Kalpana Murthy, Bikram Singh
PARASITES & VECTORS
(2016)
Correction
Parasitology
Vikas Kushwaha, Kirti Saxena, Richa Verma, Shiv K. Verma, Deepali Katoch, Neeraj Kumar, Brij Lal, P. Kalpana Murthy, Bikram Singh
PARASITES & VECTORS
(2017)
Article
Parasitology
Richa Verma, Vikas Kushwaha, Smriti Pandey, Jagadeshwar Reddy Thota, Preeti Vishwakarma, Naveen Parmar, Pawan Kumar Yadav, Prachi Tewari, Susanta Kar, Praveen Kumar Shukla, Puvvada Kalpana Murthy
PARASITOLOGY RESEARCH
(2018)
Article
Parasitology
Vikas Kushwaha, Prachi Tewari, Payal Mandal, Anurag Tripathi, P. Kalpana Murthy
PARASITOLOGY RESEARCH
(2019)
Article
Chemistry, Medicinal
Vikas Kushwaha, Subha Rastogi, Madan Mohan Pandey, Kirti Saxena, Sayyada Khatoon, Ajay Kumar Singh Rawat, P. Kaplana Murthy
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Mohd Saeed, Vikas Kushwaha, Syed Mohd Faisal, Richa Verma, Irfan Ahmad, Huma Mustafa, Magdah Ganash, Mohammad Amjad Kamal, Ghulam Md Ashraf
PROTEIN AND PEPTIDE LETTERS
(2020)
Article
Parasitology
Vikas Kushwaha, Amogh A. Sahasrabuddhe, P. Kalpana Murthy
ACTA PARASITOLOGICA
(2020)
Correction
Immunology
Shiv K. Verma, Sujith K. Joseph, Richa Verma, Vikas Kushwaha, Naveen Parmar, Pawan K. Yadav, Jagadeshwar Reddy Thota, Susanta Kar, P. Kalpana Murthy
Article
Biochemical Research Methods
Vikas Kushwaha, Sukhbir Kaur
Summary: This study demonstrates that immunization with cross-reactive molecule HSP60 of filarial parasite B. malayi in BALB/c mice enhances the immune response, resulting in a significant decrease in parasite burden, and a strong Th1 immune response which protects the host from Visceral Leishmaniasis.
Review
Parasitology
Vikas Kushwaha, Sukhbir Kaur
Summary: Coinfection is less common worldwide but more prevalent than single infection. Neglected tropical diseases such as lymphatic filariasis and visceral leishmaniasis have a significant impact on individuals living in tropical and subtropical regions. The challenges in managing LF/VL coinfection highlight the need for further research and data to address this issue.
Article
Tropical Medicine
Vikas Kushwaha, Sukhbir Kaur
Summary: The study demonstrated that rBmHSP60 possesses immunostimulatory potential, effectively enhancing Th1 immune responses, and can be utilized as an immunoprophylactic agent against leishmaniasis. Results indicated that BmHSP60 exposure upregulated the expression of iNOS, STAT1, STAT4, and Th1 cytokines.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2021)
Article
Plant Sciences
Subha Rastogi, Madan Mohan Pandey, Ajay Kumar Singh Rawat, Vikas Kushwaha, P. Kalpana Murthy
INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE
(2019)
Meeting Abstract
Public, Environmental & Occupational Health
Vikas Kushwaha
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2018)
Correction
Parasitology
Richa Verma, Sujith K. Joseph, Vikas Kushwaha, Vikash Kumar, M. I. Siddiqi, Preeti Vishwakarma, Rahul Shivahare, Suman Gupta, P. K. Murthy
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)