Article
Oncology
Arne Van der Vreken, Inge Oudaert, Gamze Ates, Sylvia Faict, Philip Vlummens, Hatice Satilmis, Rong Fan, Anke Maes, Ann Massie, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Eline Menu
Summary: This study suggests an alternative combination treatment for multiple myeloma by targeting metabolic pathways. The combination of syrosingopine and metformin shows strong cytotoxic effects on multiple myeloma cell lines and patient samples, suppressing both glycolysis and oxidative phosphorylation. Furthermore, the combination treatment leads to a significant reduction in tumor burden in vivo.
JOURNAL OF PATHOLOGY
(2023)
Article
Medicine, General & Internal
Zi-Hao Wang, Wen-Bei Peng, Pei Zhang, Xiang-Ping Yang, Qiong Zhou
Summary: This review focuses on recent advances in the regulation of immune responses by lactate in the tumour microenvironment, as well as therapeutic strategies targeting lactate anabolism and transport. Lactate plays multifaceted roles in influencing immune responses, and a comprehensive understanding of how lactate and lactate-targeting therapies regulate immune responses in the TME may provide insights into the complex relationships between metabolism and antitumour immunity.
Review
Cell Biology
Qixin Duan, Shuang Zhang, Yang Wang, Dongming Lu, Yingming Sun, Yongyang Wu
Summary: The Warburg effect refers to the hyperactive glycolysis in tumor cells that provides energy for rapid growth and proliferation even under sufficient oxygen. Proton-coupled monocarboxylate transporters (MCTs) play a crucial role in the metabolic reprogramming and survival of tumor cells, as well as tumor angiogenesis, immune suppression, multidrug resistance, migration and metastasis, ferroptosis resistance, and autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ivan Ponce, Nelson Garrido, Nicolas Tobar, Francisco Melo, Patricio C. Smith, Jorge Martinez
Summary: The research revealed that increased tissue stiffness stimulates lactate production and glucose uptake by mammary fibroblasts, which is correlated with the expression of specific proteins. Additionally, mammary stromal cells cultured on stiff matrices generated factors that stimulated epithelial breast migration.
Review
Clinical Neurology
Atul Rawat, Brett M. Morrison
Summary: Cellular metabolism is crucial for cell survival, fate, function, and communication in the peripheral nervous system. Glucose and monocarboxylates are major energy sources utilized efficiently by peripheral nerves, through transporters such as glucose transporters 1 and 3 and monocarboxylate transporters 1 and 2. Connexins and pannexins also play important roles in supplying and regulating metabolic energy. Despite progress in understanding these pathways, there are still questions and discrepancies that require further research.
Article
Biochemistry & Molecular Biology
Ehsan Sohrabi, Masoumeh Moslemi, Ehsan Rezaie, Nahid Nafissi, Mansoor Khaledi, Hamed Afkhami, Javad Fathi, Ali Zekri
Summary: The study evaluated the expression of MCT3 (SLC16A8), MCT8 (SLC16A2), and MCT9 (SLC16A9) genes in breast cancer samples and compared to normal adjacent tissues. The results showed significantly lower expression of the MCT3 gene in breast cancer tissue, suggesting potential as a therapeutic target in breast cancer patients.
Article
Ophthalmology
Victor Calbiague Garcia, Yiyi Chen, Barbara Cadiz, Lan Wang, Francois Paquet-Durand, Oliver Schmachtenberg
Summary: In this study, lactate and glucose nanosensors were expressed in mouse retinal explants to study metabolite flux. The functional expression of monocarboxylate transporters (MCTs) in Muller cells of retinal explants was revealed through pharmacological manipulation and immunohistochemistry. The introduction of FRET nanosensors to measure key metabolites at the cellular level may contribute to a better understanding of retinal metabolism.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yi Rao, Seth T. Gammon, Margie N. Sutton, Niki M. Zacharias, Pratip Bhattacharya, David Piwnica-Worms
Summary: This study reveals that high concentrations of exogenous pyruvate inhibit intracellular LDH activity and glycolytic ECAR, with the extent of inhibition being highly dependent on pyruvate influx mediated by monocarboxylate transporter-1. These findings suggest that maintaining plasma pyruvate at submillimolar concentrations could minimize transient metabolic perturbations and enhance the accuracy of metabolic studies using hyperpolarized [1-C-13]pyruvate magnetic resonance spectroscopic imaging and stable isotope tracer experiments.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Vera Miranda-Goncalves, Celine S. Goncalves, Sara Granja, Joana Vieira de Castro, Rui M. Reis, Bruno M. Costa, Fatima Baltazar
Summary: The overexpression of MCT1 is associated with poor prognosis in GBM patients. Inhibiting MCT1 can slow down tumor growth and enhance response to temozolomide treatment in GBM.
Review
Public, Environmental & Occupational Health
Hamed Hatami, Atefe Sajedi, Seyed Mostafa Mir, Mohammad Yousef Memar
Summary: This article reviews the importance of glycolysis and lactate in cancer cells, highlighting their role in metastasis and invasion. Metabolic changes, including increased glycolysis, play a significant role in cancer cell survival and growth. Lactate dehydrogenase and monocarboxylate transporters are important proteins involved in lactate production and transport, aiding in immune system evasion and cancer cell expansion.
HEALTH SCIENCE REPORTS
(2023)
Article
Multidisciplinary Sciences
Vicente Medel, Nicolas Crossley, Ivana Gajardo, Eli Muller, L. Felipe Barros, James M. Shine, Jimena Sierralta
Summary: By analyzing gene expression data, we found that neuronal MCT2 lactate transporter is enriched in the cerebral cortex and negatively correlated with cortical thickness. MCT2 expression is associated with glucose utilization and brain function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Katia Monsorno, Kyllian Ginggen, Andranik Ivanov, An Buckinx, Arnaud L. Lalive, Anna Tchenio, Sam Benson, Marc Vendrell, Angelo D'Alessandro, Dieter Beule, Luc Pellerin, Manuel Mameli, Rosa Chiara Paolicelli
Summary: Microglia can import lactate as a metabolic fuel and lactate promotes lysosomal acidification in these cells. Loss of MCT4 in microglia leads to impaired synapse pruning and behavioral defects.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xin Jiang, Nieng Yan, Dong Deng, Chuangye Yan
Summary: The Warburg effect refers to the phenomenon in which cancer cells shift their glucose metabolism from aerobic respiration to lactic fermentation even in the presence of oxygen. Elevated expression levels of human glucose transporters (GLUTs) and human monocarboxylate transporters (MCTs) are observed to maintain metabolic homeostasis and prevent lactate accumulation. Inhibition of GLUTs and/or MCTs shows potential as therapeutic strategies for cancer treatment. Recent advances in the structural characterization of GLUTs and MCTs provide a comprehensive understanding of their transport and inhibition mechanisms, contributing to the development of anticancer therapies.
Article
Neurosciences
Chen Gao, Binni Yang, Yurong Li, Wenjuan Pei
Summary: Under high-altitude hypoxia environment, the adaptability to exercise-induced fatigue, brain lactate metabolism, and neuronal hypoxia injury were investigated. The study found that at the early stage of simulated high-altitude environment, the average exhaustive time and neuronal density of rats decreased rapidly, then gradually recovered with altitude acclimatization time. The expression of MCT2, MCT4, and lactate content in rat brain also increased gradually with altitude acclimatization time. The MCT-dependent mechanism was found to be involved in the adaptability of the body to central fatigue, providing a potential basis for medical intervention for exercise-induced fatigue under high-altitude hypoxia environment.
BRAIN RESEARCH BULLETIN
(2023)
Article
Multidisciplinary Sciences
Alexandra Poetzsch, Sara Zocher, Stefanie N. Bernas, Odette Leiter, Annette E. Ruenker, Gerd Kempermann
Summary: The study showed that L-lactate has a pro-proliferative effect on neural precursor cells, which is dependent on the active lactate transport by monocarboxylate transporters and is not linked to amplified mitochondrial respiration. L-lactate redirected glucose metabolism to the pentose phosphate pathway, as indicated by increased glucose-6-phosphate dehydrogenase activity and decreased glycolysis.
Article
Neurosciences
Svetlana Mastitskaya, Egor Turovsky, Nephtali Marina, Shefeeq M. Theparambil, Anna Hadjihambi, Sergey Kasparov, Anja G. Teschemacher, Andrew G. Ramage, Alexander Gourine, Patrick S. Hosford
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
NATURE COMMUNICATIONS
(2020)
Review
Neurosciences
Alex Vasilev, Roba Sofi, Ruman Rahman, Stuart J. Smith, Anja G. Teschemacher, Sergey Kasparov
Article
Biochemistry & Molecular Biology
Plamena R. Angelova, Minee L. Choil, Alexey Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Neurosciences
Barbara Vaccari Cardoso, Alexey V. Shevelkin, Chantelle Terrillion, Olga Mychko, Valentina Mosienko, Sergey Kasparov, Mikhail V. Pletnikov, Anja G. Teschemacher
Summary: Astrocytes control metabolic homeostasis and support neuronal function in the brain, with lactate playing a dual role as a metabolic and signaling molecule. Manipulating lactate levels can impact responsiveness to environmental novelty.
Article
Physiology
Sergii Snigirov, Sergiy Sylantyev
Summary: This study investigated the modulation of GABA(A) receptors in Actinia equina (Cnidaria: Anthozoa) by pH fluctuations and pharmacological activation, revealing changes in electrical charge transfer and whole-cell excitability. While behavioral reactions were influenced by GABA(A)Rs, alterations in pH did not significantly impact them, suggesting species resistance mechanisms to acidification.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Meeting Abstract
Nutrition & Dietetics
P. B. Martinez de Morentin, L. K. Heisler, S. Sylantyev
PROCEEDINGS OF THE NUTRITION SOCIETY
(2022)
Article
Multidisciplinary Sciences
Patrick S. Hosford, Jack A. Wells, Shereen Nizari, Isabel N. Christie, Shefeeq M. Theparambil, Pablo A. Castro, Anna Hadjihambi, L. Felipe Barros, Ivan Ruminot, Mark F. Lythgoe, Alexander Gourine
Summary: The study indicates that CO2 plays a crucial role in regulating neurovascular coupling by mediating signaling between neurons and cerebral blood vessels to adjust local brain blood flow based on neuronal activity. The neurovascular coupling mechanism ensures an adequate energy supply for the brain to meet demands.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Olga Kopach, Dmitri A. Rusakov, Sergiy Sylantyev
Summary: The study found that beta-Alanine can protect key physiological functions of brain cells in acute stroke-like conditions, suggesting its potential importance in acute stroke treatment and recovery facilitation.
CELL DEATH & DISEASE
(2022)
Article
Neurosciences
Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S. Nirujogi, Anna Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S. Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R. Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A. Rusakov, Dario R. Alessi, Tilo Kunath, Mathew H. Horrocks, Andrey Y. Abramov, Rickie Patani, Sonia Gandhi
Summary: Using human-induced pluripotent stem cells, researchers have discovered that protein misfolding leading to intraneuronal oligomer formation is one of the earliest critical events in Parkinson's disease. This leads to cellular stress and ultimately neuronal death.
NPJ PARKINSONS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Vincent Magloire, Leonid P. Savtchenko, Thomas P. Jensen, Sergyi Sylantyev, Olga Tyurikova, Nicholas Cole, Olga Tyurikova, Dimitri M. Kullmann, Matthew C. Walker, Jonathan S. Marvin, Loren L. Looger, Jeremy P. Hasseman, Ilya Kolb, Ivan Pavlov, Dmitri A. Rusakov
Summary: This study found that periodic epileptiform discharges are preceded by transient, region-wide waves of extracellular GABA. Neural network simulations suggest that this phenomenon is caused by a cycle of GABA-driven network inhibition and disinhibition. Additionally, reducing GABA uptake can slow down rhythmic activity. These findings uncover the important role of extrasynaptic, volume-transmitted GABA in pacing regenerative rhythmic activity in brain networks.
Article
Neurosciences
Renato W. Martins Sa, Shefeeq M. Theparambil, Karoline Martins dos Santos, Isabel N. Christie, Nephtali Marina, Barbara V. Cardoso, Patrick S. Hosford, Vagner R. Antunes
Summary: In this study, the authors aimed to determine the source of ATP that drives osmotically-induced increases in sympathetic outflow. They found that salt loading stimulated the release of ATP in the PVN, primarily from glial cells through a vesicle-mediated route. This finding provides insight into the neural control of circulation during osmotic challenges.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Olga Kopach, Sergyi Sylantyev, Lucie Bard, Piotr Michaluk, Janosch P. Heller, Ana Gutierrez del Arroyo, Gareth L. Ackland, Alexander V. Gourine, Dmitri A. Rusakov
Summary: Neutrophils, important white blood cells in acute inflammatory and adaptive immune responses, exhibit a swarming-pattern behavior controlled by calcium-dependent release of signaling molecules. This study found that stimulating one neutrophil can trigger a calcium signal and membrane current in neighboring neutrophils through an NMDA receptor. Additionally, glutamate released from neighboring neutrophils can induce glutamate release from neutrophils, providing evidence for positive-feedback inter-neutrophil communication.
Article
Neurosciences
Dhamyaa Abed Najm Al-Halboosi, Olena Savchenko, Lora K. Heisler, Sergiy Sylantyev
Summary: Obesity is a global health challenge caused by excessive calorie intake. The brain plays a crucial role in controlling food intake, and NAG neurons, which co-express NPY, AgRP, and GABA, are identified as hunger and food intake stimulators. Activation of 5-HT1BR leads to a decrease in food intake by suppressing NAG neuron activity and neurotransmitter release.
Article
Zoology
Sergii Snigirov, Yuriy Kvach, Yuliia Kutsokon, Veniamin Zamorov, Anastasiia Snigirova, Sergiy Sylantyev
Summary: Ichthyological data from the last two decades is used to create an inventory of fish species in the Lower Dniester, Dniester Estuary, and adjacent Black Sea area. A total of 110 species were found, representing various types of fish. The main species are settled, benthic, and demersal, with a preference for pelagic and phytophilic feeding habits. The dynamics of species composition and their importance for conservation are discussed.
ACTA ZOOLOGICA BULGARICA
(2022)