Article
Biochemistry & Molecular Biology
Somayeh Mojtabavi, Mohammad Reza Khoshayand, Mohammad Reza Fazeli, Mohammad Ali Faramarzi, Nasrin Samadi
Summary: The in-vitro study using a combination of laccase and cinnamic acid showed significant inhibition of pathogenic microorganisms growth and biofilm formation, as well as teeth whitening effects. The combination also successfully removed teeth discoloration caused by coffee without causing surface damage. The study further demonstrated the redox potential values of phenolic monomers/oligomers are related to their biological activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Ioanna-Chrysoula Tsopka, Dimitra Hadjipavlou-Litina
Summary: Cinnamic acid and its derivatives have been studied for their various biological properties such as anti-inflammatory, antioxidant, anticancer, antihypertensive, and antibacterial effects. Hybrids of cinnamic derivatives with other bioactive molecules have been synthesized and evaluated as nitric oxide (NO) donors, incorporating NO donor groups to enhance their biological properties for the treatment of several diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Takeshi Nishimura, Saki Makigawa, Jun Sun, Kozue Kodama, Hiromi Sugiyama, Kenji Matsumoto, Takayuki Iwata, Naoya Wasano, Arihiro Kano, Miyo Terao Morita, Yoshiharu Fujii, Mitsuru Shindo
Summary: In this study, a highly potent gravitropic bending inhibitor with no concomitant growth inhibition was described. Through structure-activity relationship study, a 4-phenylethynyl analog was found to be the most effective in inhibiting gravitropic bending, even more potent than the known inhibitor NPA. The analog affected auxin distribution in root tips, suggesting a novel mechanism of action different from previously reported auxin transport inhibitors.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Li Lu, Xin Zhang, Yu Kang, Zhuang Xiong, Kun Zhang, Xuetao Xu, Liping Bai, Hongguang Li
Summary: A series of thirty coumarin derivatives were synthesized and evaluated for their anti-tyrosinase activity. Compound 5l showed excellent anti-tyrosinase activity and inhibited melanin content and cellular tyrosinase activity without toxicity. It has the potential to relieve tyrosinase-related hyperpigmentation.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Engineering, Chemical
Xinyang Yu, Ruirui Zhang, Yuhui Zeng, Chen Cheng, Zhiqiang Huang, Jinliang Wang, Guichun He, Haolin Wang
Summary: This study introduced a novel collector CHA for malachite flotation, which demonstrated improved selectivity compared to traditional BA and effective separation of malachite from calcite. Various experimental techniques were used to explore the adsorption mechanism of CHA on malachite surfaces, showing increased hydrophobicity and changes in elemental concentrations.
MINERALS ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Yin-Peng Bai, Cheng-Jie Yang, Nan Deng, Mi Zhang, Zhi-Jun Zhang, Lei Li, Yong Zhou, Xiong-Fei Luo, Chuan-Rui Xu, Bao-Qi Zhang, Yue Ma, Ying-Qian Liu
Summary: A series of new 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives were synthesized and found to exhibit promising cytotoxic activity against various human tumor cell lines, particularly against liver cancer, colorectal cancer, ovarian cancer, and intrahepatic cholangiocarcinoma. Among them, compound XJS-11 showed broad-spectrum inhibitory activities against different tumor cell lines and demonstrated selectivity for cancer cells over normal liver cells. Mechanistically, XJS-11 induced cell cycle arrest and cell apoptosis in liver cancer cells by inhibiting Top I activity. XJS-11 also showed good antitumor effects in xenograft and primary HCC mouse models without causing significant toxicity.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Seung-Hyun Jeong, Ji-Hun Jang, Da-Hwa Jung, Guk-Yeo Lee, Yong-Bok Lee
Summary: This study aimed to investigate the pharmacokinetic properties of ephedrine, paeoniflorin, and cinnamic acid in rats after administration of Socheongryong-tang, revealing differences in pharmacokinetic parameters between single and multiple doses, especially in paeoniflorin and cinnamic acid. The results suggest that multiple doses of SCRT significantly increased plasma concentrations of paeoniflorin and cinnamic acid, highlighting the importance of pharmacokinetic comparison studies for herbal medicines.
Article
Biochemistry & Molecular Biology
Jianping Li, Xiaofeng Min, Xi Zheng, Shaohua Wang, Xuetao Xu, Jinbao Peng
Summary: Tyrosinase inhibitors, including cinnamic acid-eugenol esters, especially c27, showed definite inhibitory activity against tyrosinase, which is crucial in melanin production. Compound c27 exhibited the strongest tyrosinase inhibitory activity and could potentially be used as a lead compound in finding tyrosinase inhibitors.
Article
Chemistry, Physical
Kamila Gryko, Monika Kalinowska, Piotr Ofman, Renata Choinska, Grzegorz Swiderski, Renata Swislocka, Wlodzimierz Lewandowski
Summary: The research studied the structural, antioxidant properties, and biodegradability of several acids using various experimental methods, as well as their impact on the environment. The results indicate that these acids exhibit antioxidant properties and can influence transformation processes in biological wastewater treatment.
Article
Biochemistry & Molecular Biology
P. Naresh, A. Selvaraj, P. Shyam Sundar, S. Murugesan, S. Sathianarayananan, Krishnan Namboori P. K., S. Jubie
Summary: Dengue virus enters the cell through receptor-mediated endocytosis and membrane fusion mediated by viral protein. This study identified novel inhibitors through molecular modeling and molecular dynamics simulations, demonstrating their potential in inhibiting dengue virus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Dalia E. Ali, Rania A. El Gedaily, Shahira M. Ezzat, Maged A. El Sawy, Meselhy R. Meselhy, Essam Abdel-Sattar
Summary: Plant resins from Eucalyptus trees contain bioactive compounds with high medicinal values. This study investigated the chemistry and anti-inflammatory activity of these resins and found that 1,6-dicinnamoyl-O-alpha-D-glucopyranoside (C5) showed significant inhibition against COX-2, TNF-alpha, NF-kappa B, and NO.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Organic
Sarah K. Watt, Janique G. Charlebois, Christopher N. Rowley, Jeffrey W. Keillor
Summary: This study provides a detailed mechanism of the reaction between acrylamide and cysteine, which is important for the development of targeted enzyme inhibitors.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Infectious Diseases
Neveen A. Abdelaziz, Walid F. Elkhatib, Mahmoud M. Sherif, Mohammed A. S. Abourehab, Sara T. Al-Rashood, Wagdy M. Eldehna, Nada M. Mostafa, Nooran S. Elleboudy
Summary: This study evaluated the modulatory effect of combining cinnamic and gallic acids with various antibiotics against multidrug-resistant Acinetobacter baumannii and found that it can reduce resistance and down-regulate the expression of biofilm-related genes.
Article
Nanoscience & Nanotechnology
Ha Cam Anh, Nguyen Phung Anh, Nguyen Tri, Hoang Tien Cuong, Nguyen Thi Thuy Van, Luu Cam Loc
Summary: The influence of the calcination mode of sol-gel synthesis on the crystallization properties of ferric pseudobrookite Fe2TiO5 (FTO) was investigated. It was found that the calcination temperature and time affected the crystallinity and crystal size of the pseudobrookite. The pseudobrookite showed the ability to absorb visible and UV light and exhibited excellent catalytic performance in the photo-Fenton process with high conversion rate and stability.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2022)
Article
Food Science & Technology
Min Wang, Lin Yue, Lingyu Zhao, Imran Mahmood Khan, Yin Zhang, Zhouping Wang
Summary: Chitosan derivatives were chemically modified and used to synthesize nanoparticles, which were then applied to stabilize oil-in-water emulsions. The nanoparticles exhibited good properties and the emulsions showed promising stability and potential for bioactive compound delivery.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Entomology
Ruchir Mishra, Joanna C. Chiu, Gang Hua, Nilesh R. Tawari, Michael J. Adang, Ashfaq A. Sial
Article
Immunology
Pramod Kumar Gupta, M. G. R. Rajan, Savita Kulkarni
INTERNATIONAL IMMUNOPHARMACOLOGY
(2017)
Article
Chemistry, Analytical
N. Lakshminarayanan, Sharmila Banerjee, M. G. R. Rajan
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2017)
Article
Chemistry, Inorganic & Nuclear
Arun M. Bhusari, N. Lakshminarayanan, Yogita P. Pawar, Surendra H. Moghe, M. G. R. Rajan, Mariam S. Degani
Article
Plant Sciences
H. Janmanchi, A. Raju, M. S. Degani, M. K. Ray, M. G. R. Rajan
SOUTH AFRICAN JOURNAL OF BOTANY
(2017)
Article
Genetics & Heredity
Jason D. Gillman, Won-Seok Kim, Bo Song, Nathan W. Oehrle, Nilesh R. Tawari, Shanshan Liu, Hari B. Krishnan
G3-GENES GENOMES GENETICS
(2017)
Article
Chemistry, Analytical
Bharti Jain, Savita Kulkarni, Sharmila Banerjee, M. G. Ramakrishna Rajan
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2019)
Article
Biochemical Research Methods
Jothivel Kumarasamy, Samar Kumar Ghorui, Chandrakala Gholve, Bharti Jain, Yogesh Dhekale, Gagan Deep Gupta, Archana Damle, Sharmila Banerjee, M. G. R. Rajan, Savita Kulkarni
Summary: Single-domain antibodies (SdAbs) have been used in various biomedical applications, but their use in immunoradiometric assays (IRMA) for thyroglobulin (Tg) has not been reported. This study demonstrates the production of SdAbs against human-Tg using a hybrid immunization/directed-evolution approach. The T7 phage display system shows potential as an alternative for constructing single-domain antibody display libraries. Additionally, the SdAbs showed quantitative-binding properties in IRMA for thyroglobulin, with serum Tg values correlating significantly with those obtained using conventional methods.
JOURNAL OF IMMUNOLOGICAL METHODS
(2021)
Article
Multidisciplinary Sciences
Dharanesh Gangaiah, Shrinivasrao P. Mane, Nilesh R. Tawari, Nallakannu Lakshmanan, Valerie Ryan, Alyssa Volland, Dwi Susanti, Milind Patel, Abraham Abouzeid, Emily B. Helmes, Arvind Kumar
Summary: This study isolated, identified, and evaluated the safety of two novel L. reuteri strains. Genomic sequencing and in vitro assays confirmed their species identity, absence of known genetic sequences of concern, susceptibility to antibiotics, and lack of harmful by-products. In vivo experiments using a bird model demonstrated the safety of these strains. These findings provide evidence for their potential probiotic applications in humans and animals.
Article
Biochemistry & Molecular Biology
Chandrakala Gholve, J. Kumarasamy, Archana Damle, Savita Kulkarni, Meera Venkatesh, Sharmila Banerjee, M. G. R. Rajan
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
S. Gawandi, S. Gangawane, A. Chakrabarti, S. Kedare, K. Bantwal, V. Wadhe, A. Kulkarni, S. Kulkarni, M. G. R. Rajan
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Bharti Jain, Savita Kulkarni, M. G. R. Rajan
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
(2017)
Article
Chemistry, Inorganic & Nuclear
Tapas Das, Ajit Shinto, Koramadai K. Kamaleshwaran, Haladhar D. Sarma, Sahiralam Khan Mohammed, Arpit Mitra, Sangita Lad, M. G. R. Rajan, Sharmila Banerjee
APPLIED RADIATION AND ISOTOPES
(2017)
Article
Biochemistry & Molecular Biology
Chandrakala Gholve, J. Kumarasamy, Savita Kulkarni, M. G. R. Rajan
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2017)
Article
Biochemical Research Methods
Nilesh R. Tawari, Justine Jia Wen Seow, Dharuman Perumal, Jack L. Ow, Shimin Ang, Arun George Devasia, Pauline C. Ng
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
