Design and synthesis of novel 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives as potential high selectivity and low toxicity topoisomerase I inhibitors for hepatocellular carcinoma
出版年份 2022 全文链接
标题
Design and synthesis of novel 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives as potential high selectivity and low toxicity topoisomerase I inhibitors for hepatocellular carcinoma
作者
关键词
Camptothecin, Fluorine, Cinnamic acid, Antitumor activity, Synthesis
出版物
BIOCHEMICAL PHARMACOLOGY
Volume 200, Issue -, Pages 115049
出版商
Elsevier BV
发表日期
2022-04-23
DOI
10.1016/j.bcp.2022.115049
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2021) Hyuna Sung et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets
- (2021) Antonino Lauria et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise
- (2021) Noura Khaiwa et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells – involvement of carbonyl reductase 1
- (2020) Paulina Koczurkiewicz-Adamczyk et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Trastuzumab-deruxtecan: an investigational agent for the treatment of HER2-positive breast cancer
- (2020) Rupert Bartsch EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery
- (2019) Ying Qu et al. JOURNAL OF CONTROLLED RELEASE
- Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poisons with Potent Anticancer Activity
- (2019) Biswajit Kundu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antibody-drug conjugates of 7-ethyl-10-hydroxycamptothecin: Sacituzumab govitecan and labetuzumab govitecan
- (2019) Wenjuan Dong et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade
- (2019) Xiaoxia Liang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study
- (2019) Kenji Tamura et al. LANCET ONCOLOGY
- RJT-101, a novel camptothecin derivative, is highly effective in the treatment of melanoma through DNA damage by targeting topoisomerase 1
- (2019) Chengxiang Lian et al. BIOCHEMICAL PHARMACOLOGY
- Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin
- (2019) Cheng-Jie Yang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
- (2019) Shanu Modi et al. NEW ENGLAND JOURNAL OF MEDICINE
- New cinnamic acid-pregenolone hybrids as potential antiproliferative agents: Design, synthesis and biological evaluation
- (2019) Yong-Xi Ge et al. STEROIDS
- (S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity
- (2019) Mengqiu Song et al. Cancers
- Trans -cinnamic acid attenuates UVA-induced photoaging through inhibition of AP-1 activation and induction of Nrf2-mediated antioxidant genes in human skin fibroblasts
- (2018) You-Cheng Hseu et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes
- (2018) Subhendu K. Das et al. JOURNAL OF MEDICINAL CHEMISTRY
- Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer
- (2018) Afroz S. Mohammad et al. PHARMACEUTICAL RESEARCH
- Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo
- (2018) Hongzhi Du et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Enzymatic modification of chitosan by cinnamic acids: Antibacterial activity against Ralstonia solanacearum
- (2016) Caifeng Yang et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Synthesis, in vitro and in vivo antitumor activity of scopoletin-cinnamic acid hybrids
- (2015) Linhu Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Applications of Fluorine in Medicinal Chemistry
- (2015) Eric P. Gillis et al. JOURNAL OF MEDICINAL CHEMISTRY
- Perspectives on Biologically Active Camptothecin Derivatives
- (2015) Ying-Qian Liu et al. MEDICINAL RESEARCH REVIEWS
- Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38
- (2013) Vaskor Bala et al. JOURNAL OF CONTROLLED RELEASE
- A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors
- (2013) Zhenyuan Miao et al. JOURNAL OF MEDICINAL CHEMISTRY
- AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,
- (2011) Coral Ho et al. HEPATOLOGY
- Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents
- (2010) Yong Qian et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Antitumor Agents 286. Design, Synthesis, and Structure−Activity Relationships of 3′R,4′R-Disubstituted-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DSP) Analogues as Potent Chemosensitizers to Overcome Multidrug Resistance
- (2010) Ting Zhou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis and Development of Novel Camptothecin Drugs
- (2008) Siong Liew et al. CURRENT PHARMACEUTICAL DESIGN
- Next generation topoisomerase I inhibitors: Rationale and biomarker strategies
- (2007) Beverly A. Teicher BIOCHEMICAL PHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search