Article
Engineering, Aerospace
Michael Inggs
Summary: This document summarizes the achievements in synthetic aperture radar (SAR) technology during the 50-year existence of the Aerospace and Electronic Systems Society. Advances in radar technology, driven by the digital revolution, have led to the widespread application of SAR in various fields. The development of coherent radar during World War II enabled the formation of large synthetic apertures, resulting in microwave images with high resolution that are unaffected by time and weather. The article traces the history of SAR technology from airborne platforms to satellites and discusses its achievements. SAR technology has now entered the phase of commercial exploitation, with a significant increase in available systems.
IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE
(2023)
Article
Chemistry, Organic
Renate Melngaile, Melita Videja, Janis Kuka, Artis Kinens, Dzintars Zacs, Janis Veliks
Summary: Here we describe a direct method for the preparation of the fluorocyclopropylidene group from aldehydes and ketones via Julia-Kocienski olefination using a newly developed reagent. The utility of this method is demonstrated by the synthesis of a fluorocyclopropyl-containing analogue of ibuprofen, showing its potential in tuning the biological properties of drugs through bioisosteric replacement.
Article
Chemistry, Physical
Sachin Kumar, Vijay Kumar Bhardwaj, Rahul Singh, Pralay Das, Rituraj Purohit
Summary: The over-expression of BRD3-BD2 protein contributes to breast cancer development, while BCH molecules show potential as therapeutic agents for cancers associated with the overexpression of BRD3-BD2 protein.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2022)
Article
Geosciences, Multidisciplinary
Anirudh Rao, Jungkyo Jung, Vitor Silva, Giuseppe Molinario, Sang-Ho Yun
Summary: This article proposes a framework that combines remote-sensing data, supplementary datasets, and machine-learning algorithms to assess building damage caused by earthquakes in a semi-automated manner. The framework integrates building inventory data, earthquake ground shaking intensity maps, and InSAR images to classify the damage state of buildings using ensemble models. Case studies of four recent earthquakes demonstrate the successful identification of damaged buildings using both multi-class and binary classification approaches.
NATURAL HAZARDS AND EARTH SYSTEM SCIENCES
(2023)
Article
Chemistry, Medicinal
Ioannis P. Papanastasiou, Markos-Orestis Georgiadis, Christos Iliopoulos-Tsoutsouvas, Carol A. Paronis, Christina A. Brust, Ngan K. Tran, Lipin Ji, Xiaoyu Ma, JodiAnne T. Wood, Nikolai Zvonok, Fei Tong, Laura M. Bohn, Spyros P. Nikas, Alexandros Makriyannis
Summary: This study merged the features of nabilone and AM2389 and optimized the C3 side chain. Among the nabilone analogs, AM8936 exhibited balanced and potent agonist activity on the CB1 receptor, making it a potential candidate for further development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Kishor D. Mane, Anirban Mukherjee, Gourab Kanti Das, Gurunath Suryavanshi
Summary: An atom economical and environmentally benign protocol has been developed for the regioselective C(sp2)-H bond functionalization of indolizines. The protocol utilizes acetic acid as a metal-free catalyst to produce a wide range of synthetically useful indolizine derivatives.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Remote Sensing
Yan Wang, Yuhan Wen, Xinliang Chen, Hui Kuang, Yujie Fan, Zegang Ding, Tao Zeng
Summary: This paper proposes a method for parametric reconstruction of arc-shaped structures in SAR imaging by using anisotropic phase feature, which can reconstruct disappeared arc-shaped structures through three observations.
INTERNATIONAL JOURNAL OF REMOTE SENSING
(2021)
Article
Remote Sensing
Bokun Tian, Xiaoling Zhang, Xinxin Tang, Shunjun Wei, Jun Shi
Summary: This study investigates the use of joint sparse recovery (JSR) algorithm for coprime adjacent array (CAA) sparse imaging in three-dimensional imaging with linear array synthetic aperture radar (LASAR). Simulation and experimental results show that the JSR algorithm achieves higher imaging quality and computational efficiency compared to other algorithms.
INTERNATIONAL JOURNAL OF REMOTE SENSING
(2021)
Review
Chemistry, Multidisciplinary
Shubhankar Samanta, Sk Asraf Ali, Anirban Bera, Soumen Giri, Khokan Samanta
Summary: Isoindolinones play important roles in natural products, drug molecules, materials science, and medicinal chemistry. Transition-metal-free synthetic methods for isoindolinones and their fused analogues are environmentally friendly and have industrial advantages.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Chao Liu, Mohammad Tayeb Al Qaseer, Reza Zoughi
Summary: The proposed method extracts complex permittivity from SAR images of multilayered structures by compensating for various issues through calibration and optimization processes, showing potential for accurate nondestructive evaluation purposes.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Biochemistry & Molecular Biology
Zahra Abdulkarim Homoud, Muhammad Taha, Fazal Rahim, Naveed Iqbal, Muhammad Nawaz, Rai Khalid Farooq, Abdul Wadood, Munther Alomari, Imadul Islam, Shatha Algheribe, Ashfaq Ur Rehman, Khalid Mohammed Khan, Nizam Uddin
Summary: Acetylcholinesterase and butyrylcholinesterase are both valid therapeutic targets for ameliorating the cholinergic deficit in Alzheimer's disease. This study describes the synthesis of indole-based sulfonamide derivatives and their inhibitory activity against the enzymes. Compound 9 showed strong potential as an inhibitor.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Dumitrela Diaconu, Vasilichia Antoci, Violeta Mangalagiu, Dorina Amariucai-Mantu, Ionel I. Mangalagiu
Summary: Two new classes of hybrid quinoline-imidazole/benzimidazole derivatives were designed and synthesized to evaluate their anticancer and antimicrobial activity. The results showed that certain compounds exhibited excellent nonselective or selective anticancer activity against different cancer cell lines, as well as good antimicrobial activity against Gram-negative bacteria and one compound against Gram-positive bacteria. These findings suggest that these compounds have the potential to be candidates for future drug development.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Hao Chen, Feng Ming, Liang Li, Guikun Liu
Summary: This paper presents a method to estimate the sampling time delay error, amplitude error, and phase error between channels in DBF-SAR based on external calibration data. The method successfully estimates these errors by calculating the statistical average of position deviation and maximizing image contrast.
Article
Astronomy & Astrophysics
R. D. Jeffries, R. J. Jackson, A. S. Binks
Summary: Through astrometric and spectroscopic analysis of IC 4665 members, it was found that the positions of low-mass stars and the lithium depletion among K and early M stars in the cluster do not match the reported LDB age. Re-analysis of the data suggests that the LDB of IC 4665 has not been detected and the reported LDB age should be interpreted as a lower limit. A comparison with other young clusters with better-established LDB ages indicates that IC 4665 has an age range of 55 +/- 3 Myr, bracketed by clusters IC 2602 and IC 2391.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Article
Engineering, Electrical & Electronic
Josaphat Tetuko Sri Sumantyo, Ming Yam Chua, Cahya Edi Santosa, Good Fried Panggabean, Tomoro Watanabe, Bambang Setiadi, Fransiskus Dwikoco Sri Sumantyo, Kengo Tsushima, Karna Sasmita, Agus Mardiyanto, Edy Supartono, Eko Tjipto Rahardjo, Gunawan Wibisono, Muh Aris Marfai, Retnadi Heru Jatmiko, Sudaryatno, Taufik Hery Purwanto, Barandi Sapta Widartono, Muhammad Kamal, Daniele Perissin, Steven Gao, Koichi Ito
Summary: This article introduces and develops an airborne broadband C-band circularly polarized synthetic aperture radar (SAR) system, demonstrating its good performance in ground and flight tests. It discusses circularly polarized scattering characteristics, image analysis and classification, and potential applications in environmental and disaster monitoring.
IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING
(2021)
Article
Multidisciplinary Sciences
John A. Howe, Hao Wang, Thierry O. Fischmann, Carl J. Balibar, Li Xiao, Andrew M. Galgoci, Juliana C. Malinverni, Todd Mayhood, Artjohn Villafania, Ali Nahvi, Nicholas Murgolo, Christopher M. Barbieri, Paul A. Mann, Donna Carr, Ellen Xia, Paul Zuck, Dan Riley, Ronald E. Painter, Scott S. Walker, Brad Sherborne, Reynalda de Jesus, Weidong Pan, Michael A. Plotkin, Jin Wu, Diane Rindgen, John Cummings, Charles G. Garlisi, Rumin Zhang, Payal R. Sheth, Charles J. Gill, Haifeng Tang, Terry Roemer
Article
Biochemistry & Molecular Biology
Thierry O. Fischmann, Catherine K. Smith, Todd W. Mayhood, Joseph E. Myers, Paul Reichert, Anthony Mannarino, Donna Carr, Hugh Zhu, Jesse Wong, Rong-Sheng Yang, Hung V. Le, Vincent S. Madison
Article
Chemistry, Medicinal
Lianyun Zhao, Yingxin Zhang, Chaoyang Dai, Timothy Guzi, Derek Wiswell, Wolfgang Seghezzi, David Parry, Thierry Fischmann, M. Arshad Siddiqui
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2010)
Article
Chemistry, Medicinal
Michael P. Dwyer, Kamil Paruch, Marc Labroli, Carmen Alvarez, Kerry M. Keertikar, Cory Poker, Randall Rossman, Thierry O. Fischmann, Jose S. Duca, Vincent Madison, David Parry, Nicole Davis, Wolfgang Seghezzi, Derek Wiswell, Timothy J. Guzi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Chemistry, Medicinal
Marc Labroli, Kamil Paruch, Michael P. Dwyer, Carmen Alvarez, Kartik Keertikar, Cory Poker, Randall Rossman, Jose S. Duca, Thierry O. Fischmann, Vincent Madison, David Parry, Nicole Davis, Wolfgang Seghezzi, Derek Wiswell, Timothy J. Guzi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Chemistry, Medicinal
Zhaoyang Meng, Jeffrey P. Ciavarri, Andrew McRiner, Yinyan Zhao, Lianyun Zhao, Panduranga Adulla Reddy, Xingmin Zhang, Thierry O. Fischmann, Charles Whitehurst, M. Arshad Siddiqui
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2013)
Article
Chemistry, Medicinal
Xiaohua Huang, Cliff C. Cheng, Thierry O. Fischmann, Jose S. Duca, Matthew Richards, Praveen K. Tadikonda, Panduranga Adulla Reddy, Lianyun Zhao, M. Arshad Siddiqui, David Parry, Nicole Davis, Wolfgang Seghezzi, Derek Wiswell, Gerald W. Shipps
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2013)
Article
Biochemistry & Molecular Biology
Thierry O. Fischmann, Alan Hruza, Jose S. Duca, Lata Ramanathan, Todd Mayhood, William T. Windsor, Hung V. Le, Thimothy J. Guzi, Michael P. Dwyer, Kamil Paruch, Ronald J. Doll, Emma Lees, David Parry, Wolfgang Seghezzi, Vincent Madison
Article
Biochemistry & Molecular Biology
Andrew D. Ferguson, Payal R. Sheth, Andrea D. Basso, Sunil Paliwal, Kimberly Gray, Thierry O. Fischmann, Hung V. Le
Article
Instruments & Instrumentation
Vincent Madison, Andrew J. Prongay, Zhuyan Guo, Nanhua Yao, John Pichardo, Thierry Fischmann, Corey Strickland, Joseph Myers, Patricia C. Weber, Brian M. Beyer, Richard Ingram, Zhi Hong, Winifred W. Prosise, Lata Ramanathan, S. Shane Taremi, Taisa Yarosh-Tomaine, Rumin Zhang, Mary Senior, Rong-Sheng Yang, Bruce Malcolm, Ashok Arasappan, Frank Bennett, Stephane L. Bogen, Kevin Chen, Edwin Jao, Yi-Tsung Liu, Raymond G. Lovey, Anil K. Saksena, Srikanth Venkatraman, Viyyoor Girijavallabhan, F. George Njoroge
JOURNAL OF SYNCHROTRON RADIATION
(2008)
Article
Chemistry, Medicinal
Kamil Paruch, Michael P. Dwyer, Carmen Alvarez, Courtney Brown, Tin-Yau Chan, Ronald J. Doll, Kerry Keertikar, Chad Knutson, Brian McKittrick, Jocelyn Rivera, Randall Rossman, Greg Tucker, Thierry Fischmann, Alan Hruza, Vincent Madison, Amin A. Nomeir, Yaolin Wang, Paul Kirschmeier, Emma Lees, David Parry, Nicole Sgambellone, Wolfgang Seghezzi, Lesley Schultz, Frances Shanahan, Derek Wiswell, Xiaoying Xu, Quiao Zhou, Ray A. James, Vidyadhar M. Paradkar, Haengsoon Park, Laura R. Rokosz, Tara M. Stauffer, Timothy J. Guzi
ACS MEDICINAL CHEMISTRY LETTERS
(2010)
Article
Chemistry, Medicinal
Xiaohua Huang, Cliff C. Cheng, Thierry O. Fischmann, Jose S. Duca, Xianshu Yang, Matthew Richards, Gerald W. Shipps
ACS MEDICINAL CHEMISTRY LETTERS
(2012)
Article
Immunology
Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland, Laurence Fayadat-Dilman
Summary: Research has shown that self-association of antibodies can be modulated through single point mutations, affecting both self-interaction and target binding. Different experimental methods can be used to assess and validate antibody self-interaction, aiding in the correction of self-association issues.
Article
Chemistry, Medicinal
Michael P. Dwyer, Kamil Paruch, Carmen Alvarez, Ronald J. Doll, Kerry Keertikar, Jose Duca, Thierry O. Fischmann, Alan Hruza, Vincent Madison, Emma Lees, David Parry, Wolfgang Seghezzi, Nicole Sgambellone, Frances Shanahan, Derek Wiswell, Timothy J. Guzi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2007)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)