Selective small-molecule inhibition of an RNA structural element

TheribBFMN riboswitch fromEscherichia colioperates at the transcriptional and translational level and regulates riboflavin biosynthesis

(2015) Danielle Pedrolli et al.   FEBS Journal

(Dis)similar Analogues of Riboswitch Metabolites as Antibacterial Lead Compounds

(2015) Daniel Matzner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clostridium difficile Infection

(2015) Daniel A. Leffler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unexpected versatility in bacterial riboswitches

(2015) J.R. Mellin et al.   TRENDS IN GENETICS

Tuning Riboswitch-Mediated Gene Regulation by Rational Control of Aptamer Ligand Binding Properties

(2014) Ambadas B. Rode et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Rfam 12.0: updates to the RNA families database

(2014) Eric P. Nawrocki et al.   NUCLEIC ACIDS RESEARCH

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Flavoenzyme Azobenzene Reductase AzoR from Escherichia coli Binds Roseoflavin Mononucleotide (RoFMN) with High Affinity and Is Less Active in Its RoFMN Form

(2013) Simone Langer et al.   BIOCHEMISTRY

A Decade of Riboswitches

(2013) Alexander Serganov et al.   CELL

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

Riboflavin Analogs as Antiinfectives: Occurrence, Mode of Action, Metabolism and Resistance

(2013) Danielle Biscaro Pedrolli et al.   CURRENT PHARMACEUTICAL DESIGN

The promise of riboswitches as potential antibacterial drug targets

(2013) Christina E. Lünse et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Flavoproteins Are Potential Targets for the Antibiotic Roseoflavin in Escherichia coli

(2013) S. Langer et al.   JOURNAL OF BACTERIOLOGY

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

(2013) Soumaya Zlitni et al.   Nature Chemical Biology

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

A highly specialized flavin mononucleotide riboswitch responds differently to similar ligands and confers roseoflavin resistance to Streptomyces davawensis

(2012) Danielle Biscaro Pedrolli et al.   NUCLEIC ACIDS RESEARCH

Recent Advances in Developing Small Molecules Targeting RNA

(2011) Lirui Guan et al.   ACS Chemical Biology

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The antibiotics roseoflavin and 8-demethyl-8-amino-riboflavin from Streptomyces davawensis are metabolized by human flavokinase and human FAD synthetase

(2011) Danielle B. Pedrolli et al.   BIOCHEMICAL PHARMACOLOGY

Pantethine Rescues Phosphopantothenoylcysteine Synthetase and Phosphopantothenoylcysteine Decarboxylase Deficiency in Escherichia coli but Not in Pseudomonas aeruginosa

(2011) C. J. Balibar et al.   JOURNAL OF BACTERIOLOGY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular sensing by the aptamer domain of the FMN riboswitch: a general model for ligand binding by conformational selection

(2011) Quentin Vicens et al.   NUCLEIC ACIDS RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The RFN riboswitch ofBacillus subtilisis a target for the antibiotic roseoflavin produced byStreptomyces davawensis

(2010) Eva Ott et al.   RNA Biology

Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression

(2010) Elaine R. Lee et al.   RNA Biology

Novel Riboswitch Ligand Analogs as Selective Inhibitors of Guanine-Related Metabolic Pathways

(2010) Jérôme Mulhbacher et al.   PLoS Pathogens

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch

(2009) Alexander Serganov et al.   NATURE

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES