Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury

Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice

(2015) Xiaochun Zhao et al.   BRAIN BEHAVIOR AND IMMUNITY

PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice

(2015) He Wu et al.   NEUROBIOLOGY OF AGING

Mouse Models of Intracerebral Hemorrhage in Ventricle, Cortex, and Hippocampus by Injections of Autologous Blood or Collagenase

(2014) Wei Zhu et al.   PLoS One

An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration

(2014) Roberta Azzarelli et al.   Nature Communications

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

Intercellular Signaling Pathway among Endothelia, Astrocytes and Neurons in Excitatory Neuronal Damage

(2013) Takako Takemiya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Induction of mitochondrial dysfunction by poly(ADP-ribose) polymer: Implication for neuronal cell death

(2013) Seung-Hoon Baek et al.   MOLECULES AND CELLS

Phospholipase Cɛ links G protein-coupled receptor activation to inflammatory astrocytic responses

(2013) Stephanie S. Dusaban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

(2013) Yu Zhou et al.   PROGRESS IN NEUROBIOLOGY

Inflammatory prostaglandin E2signaling in a mouse model of Alzheimer disease

(2012) Ju Shi et al.   ANNALS OF NEUROLOGY

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors

(2012) Begoña Villar-Cheda et al.   NEUROBIOLOGY OF DISEASE

Accumulating Microglia Phagocytose Injured Neurons in Hippocampal Slice Cultures: Involvement of p38 MAP Kinase

(2012) Takahiro Katayama et al.   PLoS One

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage

(2011) Qingyi Ma et al.   ANNALS OF NEUROLOGY

Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms

(2011) Yuri Ikeda-Matsuo et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain

(2011) Tao Wu et al.   Journal of Neuroinflammation

Efficacy of the lipid-soluble iron chelator 2,2′-dipyridyl against hemorrhagic brain injury

(2011) He Wu et al.   NEUROBIOLOGY OF DISEASE

Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: A postmortem study

(2010) He Wu et al.   BRAIN RESEARCH

Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors

(2010) Y Ikeda-Matsuo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure

(2010) Masatake Fujimura et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury

(2009) Da-Zhi Liu et al.   ANNALS OF NEUROLOGY

Prostanoid receptor antagonists: development strategies and therapeutic applications

(2009) RL Jones et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thrombin induces cyclooxygenase-2 expression and prostaglandin E2release via PAR1 activation and ERK1/2- and p38 MAPK-dependent pathway in murine macrophages

(2009) Huey-Ming Lo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia

(2009) Sofiyan Saleem et al.   JOURNAL OF NEUROIMMUNOLOGY

Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord

(2009) P. Duffy et al.   JOURNAL OF NEUROSCIENCE

Central control of fever and female body temperature by RANKL/RANK

(2009) Reiko Hanada et al.   NATURE

Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis

(2009) Lakshmi Thirumangalakudi et al.   NEUROSCIENCE LETTERS

Emerging roles of PGE2 receptors in models of neurological disease

(2009) Katrin Andreasson   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Relative Importance of Proteinase-Activated Receptor-1 Versus Matrix Metalloproteinases in Intracerebral Hemorrhage-Mediated Neurotoxicity in Mice

(2009) Mengzhou Xue et al.   STROKE

Patterns of Nogo-A, NgR, and RhoA expression in the brain tissues of rats with focal cerebral infarction

(2009) Wen Jiang et al.   Translational Research

PKC-δ/c-Src-mediated EGF receptor transactivation regulates thrombin-induced COX-2 expression and PGE2 production in rat vascular smooth muscle cells

(2008) Hsi-Lung Hsieh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis

(2008) Mayumi Ueta et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Neuroprotective Effect of Prostaglandin E2 EP1 Receptor Inhibition has a Wide Therapeutic Window, is Sustained in Time and is not Sexually Dimorphic

(2008) Takato Abe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia

(2008) Jun Li et al.   NEUROSCIENCE LETTERS

Effects of Thrombin on Neurogenesis After Intracerebral Hemorrhage

(2008) Shuxu Yang et al.   STROKE