Review
Biochemistry & Molecular Biology
Siying Ren, Yue Chen, Likun Wang, Guofeng Wu
Summary: Intracerebral hemorrhage is a devastating form of stroke that induces cell death responsible for secondary brain injury. Iron-dependent cell death, known as ferroptosis, plays a crucial role in the occurrence and progression of intracerebral hemorrhage. Understanding and targeting the regulators and signaling pathways of ferroptosis could lead to potential treatments for intracerebral hemorrhage.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Clinical Neurology
Xiongjie Fu, Guoyang Zhou, Jianfeng Zhuang, Chaoran Xu, Hang Zhou, Yucong Peng, Yang Cao, Hanhai Zeng, Jianru Li, Feng Yan, Lin Wang, Gao Chen
Summary: Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity, mortality, and disability rates. Research indicates that the development of white matter injury (WMI) following ICH is complex and determines the prognosis of patients. Comprehensive treatment and understanding the relationship between WMI and other brain cells may reveal therapeutic targets for ICH.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Yuhua Gong, Jia Deng, Yingqing Wu, Xiaoyun Xu, Zongkun Hou, Shilei Hao, Bochu Wang
Summary: This study found that the mass effect after intracerebral hemorrhage significantly increased iron deposition in neuronal cells and promoted the iron uptake and ferroptosis. Additionally, the inhibition of the pERK1/2 pathway reversed the upregulation of iron uptake and ferroptosis.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Nemanja Novakovic, Zachary M. Wilseck, Thomas L. Chenevert, Guohua Xi, Richard F. Keep, Aditya S. Pandey, Neeraj Chaudhary
Summary: This study investigated the time course of red blood cell lysis in ICH patients using MRI, revealing correlations between perihematomal iron accumulation and white matter loss with erythrolysis extent and hematoma volume in the early and subacute periods after ICH. MRI may be a reliable tool for assessing hematoma lysis over time and its impact on surrounding tissues.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Heng Yang, Wei Ni, Pengju Wei, Sicheng Li, Xinjie Gao, Jiabin Su, Hanqiang Jiang, Yu Lei, Liangfu Zhou, Yuxiang Gu
Summary: Inhibition of HDACs can reduce neuroinflammation and white matter damage after ICH by modulating microglia/macrophage polarization, leading to improved neurological functional recovery.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Immunology
Jingwei Zheng, Jia'nan Lu, Shuhao Mei, Haijian Wu, Zeyu Sun, Yuanjian Fang, Shenbin Xu, Xiaoyu Wang, Ligen Shi, Weilin Xu, Sheng Chen, Jun Yu, Feng Liang, Jianmin Zhang
Summary: CeNP treatment alleviates white matter injury induced by ICH by modulating ROS-induced microglial polarization and astrocyte alteration. CeNP promotes remyelination and OPC differentiation, while inhibiting the expression of M1 microglia and A1 astrocyte. The findings suggest that CeNP could be a potential therapeutic strategy for white matter injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Critical Care Medicine
Mengying Yu, Dongqin Zhu, Zhixian Luo, Zhifang Pan, Yunjun Yang, Haoli Xu
Summary: This study aimed to investigate the correlation between white matter lesion (WML) severity and delayed intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH), as well as the association between WML and baseline IVH. The results showed that moderate-severe WML was an independent risk factor for both delayed IVH and baseline IVH.
NEUROCRITICAL CARE
(2022)
Article
Neurosciences
Jing Li, Jianhao Liang, Meiqin Zeng, Kaijian Sun, Yunhao Luo, Huaping Zheng, Feng Li, Wen Yuan, Hongwei Zhou, Junshan Liu, Haitao Sun
Summary: This study demonstrates that oxymatrine improves white matter injury and neurological deficits caused by intracerebral hemorrhage by modulating the gut microbiota.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Qingqing Bai, Shuoyang Wang, Dongmei Rao, Zhiming Zhou, Jianfei Wang, Qi Wang, Yu Qin, Zhaohu Chu, Shoucai Zhao, Dijing Yu, Yang Xu
Summary: In this study, the researchers investigated the impact of RIPK3 activation on neuronal necroptosis and the involvement of DAXX in the nuclear necroptosis pathway after ICH. The results showed that RIPK3 promoted neuronal necroptosis in ICH mice, partially through the DAXX signaling pathway. RIPK3 and AIF interacted with nuclear DAXX to aggravate ICH injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Xiongjie Fu, Guoyang Zhou, Xinyan Wu, Chaoran Xu, Hang Zhou, Jianfeng Zhuang, Yucong Peng, Yang Cao, Hanhai Zeng, Yin Li, Jianru Li, Liansheng Gao, Gao Chen, Lin Wang, Feng Yan
Summary: Our study revealed that inhibiting P2X4R can promote neurofunctional recovery after ICH, transform pro-inflammatory microglia induced by ICH into an anti-inflammatory phenotype, and alleviate ICH-induced WMI. Additionally, TrkB blockage can reverse the protective effects of WMI, suggesting that P2X4R plays a crucial role in regulating WMI and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Danmin Shen, Weihua Wu, Jing Liu, Ting Lan, Zhongnan Xiao, Kaiyuan Gai, Liye Hu, Zhaoli Luo, Chao Wei, Xiaotong Wang, Yabin Lu, Yamei Wang, Chenguang Zhang, Peipei Wang, Zhentao Zuo, Fei Yang, Qian Li
Summary: This study reveals that ferroptosis is the major form of OPC cell death in hemorrhagic stroke, and inhibiting ferroptosis can alleviate white matter injury caused by hemorrhage and promote neurological function recovery.
CELL DEATH & DISEASE
(2022)
Review
Neurosciences
Zhe Li, Yang Liu, Ruixue Wei, Suliman Khan, Ruiyi Zhang, Yan Zhang, Voon Wee Yong, Mengzhou Xue
Summary: This review summarizes recent progress in understanding the mechanisms by which deferoxamine may alleviate intracerebral hemorrhage (ICH) and discusses the potential clinical utility of deferoxamine.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jingyin Chen, Sravanthi Koduri, Shuhui Dai, Yasunori Toyota, Ya Hua, Neeraj Chaudhary, Aditya S. Pandey, Richard F. Keep, Guohua Xi
Summary: The study found that white matter fibers may persist within the hematoma after intracerebral hemorrhage, and macrophages/microglia may use these fibers as a scaffold to infiltrate into the hematoma and aid in hematoma clearance.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nemanja Novakovic, Joseph R. Linzey, Thomas L. Chenevert, Joseph J. Gemmete, Jonathan P. Troost, Guohua Xi, Richard F. Keep, Aditya S. Pandey, Neeraj Chaudhary
Summary: This study attempts to quantify white matter injury within and surrounding hematomas after mild to moderate ICH using DTI MRI, showing varying degrees of changes in white matter injury over time, with a correlation to hematoma size.
Article
Neurosciences
Ruming Deng, Wenjie Wang, Xiang Xu, Jiasheng Ding, Jiahe Wang, Siyuan Yang, Haiying Li, Haitao Shen, Xiang Li, Gang Chen
Summary: Mitochondrial damage is crucial in secondary brain injury caused by intracerebral hemorrhage (ICH), and MIC60 plays a significant role in maintaining mitochondrial structure and function. Overexpression of MIC60 can reduce neuronal death and functional impairments induced by ICH, suggesting that MIC60 may be a promising target for ICH therapy.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Immunology
Ruoyu Zhang, Chen Sun, Xuemei Chen, Yunze Han, Weidong Zang, Chao Jiang, Junmin Wang, Jian Wang
Summary: This review discusses the potential pathogenic role of ferroptosis in COVID-19-related brain injury and the possible routes by which SARS-CoV-2 could invade the brain. Understanding these mechanisms could lead to new treatment strategies to prevent or reduce brain-related complications of COVID-19.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Cell Biology
Ruoyu Zhang, Chen Sun, Yunze Han, Leo Huang, Honghui Sheng, Jing Wang, Yuqing Zhang, Jonathan Lai, Jiahao Yuan, Xuemei Chen, Chao Jiang, Fuyuan Wu, Junmin Wang, Xiaochong Fan, Jian Wang
Summary: This review summarizes the latest research progress of autophagy and NETosis in COVID-19 and provides an in-depth explanation of their underlying mechanisms. The relationship between autophagy and NETosis is explored, and potential treatment targets and options are discussed.
Review
Cell Biology
Chao Jiang, Hengtao Guo, Zhiying Zhang, Yali Wang, Simon Liu, Jonathan Lai, Tom J. Wang, Shize Li, Jing Zhang, Li Zhu, Peiji Fu, Jiewen Zhang, Jian Wang
Summary: Acute intracerebral hemorrhage (ICH) is a devastating type of stroke that causes significant brain damage. The destruction of neurons in ICH is caused by both primary and secondary injuries. Factors in the coagulation cascade and complement activation process contribute to the secondary brain injury. Although treatment options for direct damage are limited, various strategies can be used to treat secondary injury. Perihematomal edema (PHE) is a potential marker for secondary injury and is associated with poor outcomes after ICH. Therefore, understanding the underlying pathological mechanism, evolution, and potential therapeutic strategies for PHE is crucial.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Immunology
Dengpan Song, Chi-Tai Yeh, Jian Wang, Fuyou Guo
Summary: Intracerebral hemorrhage (ICH) is a dangerous neurological disorder with high mortality, disability, and recurrence rates. Currently, there are no effective therapies available. Pyroptosis, a recently discovered form of programmed cell death, plays a significant role in brain injury and poor prognosis after ICH. Inhibition of pyroptosis through targeting specific pathways can improve the prognosis of ICH. This review discusses the pathological pathways and regulatory mechanisms of pyroptosis after ICH and suggests intervention strategies to mitigate pyroptosis and brain dysfunction.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Chen Sun, Yunze Han, Ruoyu Zhang, Simon Liu, Jing Wang, Yuqing Zhang, Xuemei Chen, Chao Jiang, Junmin Wang, Xiaochong Fan, Jian Wang
Summary: COVID-19 infection triggers regulated necrosis under low apoptosis condition, releasing cytokines and cell contents, leading to severe inflammation. Understanding the mechanism of regulated necrosis in COVID-19 can help in assessing disease severity, prognosis, and guiding treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Peijun Jia, Junmin Wang, Xiuhua Ren, Jinxin He, Shaoshuai Wang, Yinpei Xing, Danyang Chen, Xinling Zhang, Siqi Zhou, Xi Liu, Shangchen Yu, Zefu Li, Chao Jiang, Weidong Zang, Xuemei Chen, Jian Wang
Summary: Post-stroke depression worsens neurological deficits and quality of life. Exposure to an enriched environment can improve outcomes after stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cell Biology
Li-Min Wang, Zhi-Hua Liu, Hong-Lei Ren, Xue-Mei Chen, Jun-Min Wang, Hui-Min Cai, Li-Ping Wei, Hui-Hong Tian, Jian Wang, Li-Juan Wang
Summary: This study successfully established a mouse model of recurrent ICH and found that mice with bilateral striatal hemorrhage showed worse neurological function, delayed recovery in locomotor function and cognitive dysfunction compared to mice with unilateral striatal hemorrhage, which could well simulate the clinical situation.
NEURAL REGENERATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yuanyuan Liu, Shuai Chen, Simon Liu, Kevin L. Wallace, Marietta Zille, Jiewen Zhang, Jian Wang, Chao Jiang
Summary: Stroke is a severe and life-threatening disease that requires more research on new treatment strategies. Infiltrated T lymphocytes play a crucial role in post-stroke inflammation and have conflicting roles as therapeutic targets. Understanding the mechanisms of the adaptive immune response associated with T lymphocytes is essential for developing effective treatments.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Shaoshuai Wang, Xiuhua Ren, Junmin Wang, Qinfeng Peng, Xiaoyu Niu, Chunhua Song, Changsheng Li, Chao Jiang, Weidong Zang, Marietta Zille, Xiaochong Fan, Xuemei Chen, Jian Wang
Summary: This study aimed to characterize brain tissue autofluorescence in three models of acute brain injury and establish a simple and effective method to block autofluorescence. The results showed that pretreatment with SBB could significantly reduce brain tissue autofluorescence without affecting specific fluorescence signals, improving the signal-to-noise ratio of fluorescence imaging.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Geriatrics & Gerontology
Yinrou Huang, Mengke Zhao, Xuemei Chen, Ruoyu Zhang, Anh Le, Michael Hong, Yufei Zhang, Lin Jia, Weidong Zang, Chao Jiang, Junmin Wang, Xiaochong Fan, Jian Wang
Summary: In this review, the biological properties and pathogenic functions of key metabolites in 12 central nervous system disorders are summarized. The changes in the metabolic pathway of tryptophan and potential therapeutic strategies targeting this pathway are discussed. This comprehensive review provides valuable guidance for future research on neuropsychiatric disorders.
Article
Geriatrics & Gerontology
Zhiying Zhang, Yinuo Li, Juyuan Shi, Li Zhu, Yinming Dai, Peiji Fu, Simon Liu, Michael Hong, Jiewen Zhang, Jian Wang, Chao Jiang
Summary: Modulators of the S1PR have potential therapeutic effects on stroke, but their mechanisms and value for ICH therapy need further exploration. This study found that siponimod could reduce brain injury and improve neurological function, as well as inhibit immunoinflammatory responses. These results provide preclinical evidence for future investigation of immunomodulators.
Article
Biochemistry & Molecular Biology
Chengli Liu, Kun Yao, Qi Tian, Yujia Guo, Guijun Wang, Peibang He, Jianfeng Wang, Jian Wang, Zhan Zhang, Mingchang Li
Summary: This study revealed the impact of CXCR4 and P-BTK on NLRP3-mediated pyroptosis and lipid peroxidation in SAH, both in vivo and in vitro. Inhibition of the CXCR4-BTK axis can attenuate NLRP3-mediated pyroptosis and lipid peroxidation by regulating NF-kappa B activation in EBI after SAH.
Article
Physiology
Li Zhu, Leo Huang, Anh Le, Tom J. Wang, Jiewen Zhang, Xuemei Chen, Junmin Wang, Jian Wang, Chao Jiang
Summary: Acute stroke is a major cause of morbidity and mortality worldwide. The immune-inflammatory response triggered by stroke occurs both locally and systemically. While stroke-induced immunosuppression may reduce brain injury, it also impairs brain repair as the immune-inflammatory response plays a dual role after acute stroke. Additionally, suppression of systemic immune-inflammatory response increases the risk of life-threatening bacterial infections following acute stroke. Hence, understanding the mechanisms behind stroke-induced immune-inflammatory response is crucial. Autonomic nervous system (ANS) activation is critical in regulating both local and systemic immune-inflammatory responses and may impact the prognosis of acute stroke. This review discusses the changes in sympathetic and parasympathetic nervous systems after stroke and their effects on the immune-inflammatory response. Moreover, the article summarizes how the ANS regulates immune-inflammatory response through neurotransmitters and their receptors in immune cells and organs after stroke. The review also explores potential therapeutic approaches to modulate ANS activation or immune-inflammatory response to promote neurological recovery after stroke.
COMPREHENSIVE PHYSIOLOGY
(2022)
Article
Clinical Neurology
Yinfeng Dong, Yanting Gu, Jianhua Lu, Jieru Wan, Shanshan Jiang, Raymond C. Koehler, Jian Wang, Jinyuan Zhou
Summary: This study investigated the potential of non-invasive APTw MRI techniques to assess TBI injury in different brain regions and predict long-term neurobehavior outcomes. The results suggest that APTw imaging can be used for detecting secondary injury and as a potential predictor of long-term outcomes from TBI.
NEUROTRAUMA REPORTS
(2022)
Review
Cell Biology
Chengli Liu, Jie Xie, Shanshan Sun, Hui Li, Tianyu Li, Chao Jiang, Xuemei Chen, Junmin Wang, Anh Le, Jiarui Wang, Zhanfei Li, Jian Wang, Wei Wang
Summary: This article reviews the recent research progress on hemorrhagic transformation (HT) in ischemic stroke patients treated with thrombolysis. It discusses the mechanisms, experimental models, and biomarkers of HT, as well as the limitations of different models. Furthermore, it investigates the molecular mechanism and clinical features of HT, and outlines neuroprotective strategies to improve HT. The authors suggest further efforts to reduce the risk of HT and improve the clinical prognosis of patients treated with thrombolysis.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)