Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
M. A. Sunil, V. S. Sunitha, Prasanthkumar Santhakumaran, Mohind C. Mohan, Midhun Sebastian Jose, E. K. Radhakrishnan, Jyothis Mathew
Summary: The study demonstrated that catechin inhibited several inflammatory mediators in LPS-stimulated RAW 264.7 cells while also up-regulating IL-10 production. Furthermore, catechin down-regulated the mRNA expression of COX-2, iNOS, TNF-α, NF-κB, and p38 MAPK.
INFLAMMOPHARMACOLOGY
(2021)
Article
Engineering, Chemical
Ji-Woong Park, Woong Kim, Chul Yung Choi, Seok-Jun Kim
Summary: The study found that RLE effectively suppressed the inflammatory response induced by LPS in BV-2 cells, suggesting its potential use as a preventive agent against diseases triggered by microglial inflammatory responses.
Article
Immunology
Donghui Bai, Yujie Sun, Qiong Li, Haihua Li, Yuerun Liang, Ximing Xu, Jiejie Hao
Summary: This study found that leonurine, extracted from Herba leonuri, has a protective effect on asthma by regulating the p38 MAPK/NF-κB signaling pathway to reduce inflammation and mucus overproduction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Jing Tang, Chenjuan Yao, Yingqi Liu, Jiaming Yuan, Li Wu, Kazuo Hosoi, Shali Yu, Chunyan Huang, Haiyan Wei, Gang Chen
Summary: In this study, it was elucidated that BCL-2, as a pro-apoptotic factor, plays a role in As2O3-induced apoptosis in BEAS-2B cells through NF-kappa B and p38 MAPK signaling pathways. The upregulation, nuclear localization, and phosphorylation of BCL-2 during apoptosis were found to be crucial factors in As2O3-induced cell death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Yun-yun Zhang, Lu Wang, Hua Guo, Ting-ting Han, Yan-hua Chang, Xiao-chuan Cui
Summary: Levetiracetam improves cognitive impairment in streptozotocin-induced diabetic rats by suppressing microglia activation. In vitro experiments suggest that levetiracetam inhibits microglia polarization via the JNK/MAPK/NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Sheng Wang, Cai-Li Xu, Tao Luo, Hua-Qiao Wang
Summary: Jatrorrhizine (JAT), an alkaloid from Huanglian, has a neuroprotective effect against neurodegenerative diseases by inhibiting the MAPK/NF-kappa B/NLRP3 pathway in microglia. It may serve as a potential therapeutic approach for neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Hana Lee, Jun-Ho Jang, Seok-Jun Kim
Summary: Inflammatory reaction in the brain, caused by microglia activation, is associated with the development of neurodegenerative diseases like Alzheimer's and Parkinson's. Malonic acid has anti-inflammatory effects on microglia, reducing pro-inflammatory responses and regulating specific pathways. This study suggests that malonic acid could be a potential therapeutic candidate for neuroinflammatory diseases.
ANIMAL CELLS AND SYSTEMS
(2021)
Article
Medicine, Research & Experimental
Amir Mohamed Abdelhamid, Mahmoud E. Youssef, Eslam E. Abd El-Fattah, Naglaa A. Gobba, Ahmed Gaafar Ahmed Gaafar, Samuel Girgis, Ahmed Shata, Abdel-Moneim Hafez, Eman El-Ahwany, Noha A. Amin, Mohamed Awad Shahien, Marwa A. Abd-Eldayem, Magdy Abou-Elrous, Sameh Saber
Summary: The study investigated the hepatoprotective effects of metformin and empagliflozin combined therapy in a hepatic fibrosis model in mice induced by carbon tetrachloride. Results showed that the combination therapy exhibited complementary effects in preventing hepatic inflammation and fibrosis, particularly in diabetic patients, by enhancing antifibrotic effect and AMPK-induced NF-kappa B inactivation.
Article
Biochemistry & Molecular Biology
Dae-Kyum Kim, Jin-Won Huh, Hyeonseung Yu, Yeji Lee, Yongxin Jin, Un-Hwan Ha
Summary: This study investigated the impact of DnaJ on IL-1 beta expression in macrophages and found that DnaJ modulates macrophages to secrete IL-1 beta by activating NF-kappa B and MAPK signaling pathways. ERK was identified as a positive mediator for IL-1 beta expression, while p38 acted as a negative mediator. Furthermore, the reciprocal actions of MAPKs were found to regulate the activation of inflammasome-related molecules. The study also explored the involvement of CD91/CD40 in ERK signaling-mediated IL-1 beta production from DnaJ-treated macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Xin Guo, Yun-Da Yao, Jun-Li Kang, Fu-Kang Luo, Xi-Jun Mu, Yan-Yu Zhang, Ming-Tai Chen, Meng-Nan Liu, Chi-Chou Lao, Zi-Hao Tan, Yu-Feng Huang, You-Hua Xu, Ying Xie, Peng Wu, Hua Zhou
Summary: This study isolated an active compound, IT24, from Iris tectorum and demonstrated its anti-inflammatory effects. IT24 exerts its anti-inflammatory effects by inhibiting mPGES-1 and the p38/JNK pathway, and has potential as an mPGES-1 inhibitor for the prevention and treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Hai-Qiao Wang, Zhong Wan, Qiqiang Zhang, Tong Su, Dan Yu, Fei Wang, Chao Zhang, Wei Li, Dongliang Xu, Hai Zhang
Summary: This study identified schisandrin B as the most effective component for attenuating liver fibrosis and proved that CB2 is a potential target for anti-liver fibrosis. The findings showed that schisandrin B improves CCl4-induced liver fibrosis by suppressing the NF-kappa B and p38 MAPK pathways.
Article
Neurosciences
Jian-wei Ge, Shi-ji Deng, Zhi-wei Xue, Pin-yi Liu, Lin-jie Yu, Jiang-nan Li, Sheng-nan Xia, Yue Gu, Xin-yu Bao, Zhen Lan, Yun Xu, Xiao-lei Zhu
Summary: The research suggests that imperatorin can suppress neuroinflammation, alleviate ischemic injury, and exert protective effects by downregulating the MAPK and NF-kappa B signaling pathways.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Chariya Hahnvajanawong, Thitiporn Sahakulboonyarak, Thidarut Boonmars, Vichai Reutrakul, Anusak Kerdsin, Parichart Boueroy
Summary: Evidence suggests that isomorellin can inhibit cell viability, migration, and invasion of CCA cells by affecting focal adhesion kinase and other proteins, regulating nuclear factor kappa B expression, and downregulating MMP-2, uPA, and COX-2.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zheng Zhao, Christoph Heier, Huimin Pang, Yu Wang, Feifei Huang, Pingan Chang
Summary: Phospholipase PNPLA7 suppresses M1 polarization of LPS-challenged macrophages by modulating SIRT1/NF-κ B and p38 MAPK-dependent pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Ravikanth Velagapudi, Izabela Lepiarz, Abdelmeneim El-Bakoush, Folashade O. Katola, Harsharan Bhatia, Bernd L. Fiebich, Olumayokun A. Olajide
MOLECULAR NUTRITION & FOOD RESEARCH
(2019)
Article
Cell Biology
Ravikanth Velagapudi, Ayokulehin M. Kosoko, Olumayokun A. Olajide
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2019)
Article
Immunology
Olumayokun A. Olajide, Idowu S. Akande, Carlos da Silva Maia Bezerra Filho, Izabela Lepiarz-Raba, Damian Pergentino de Sousa
INFLAMMOPHARMACOLOGY
(2020)
Review
Immunology
Olumayokun A. Olajide, Satyajit D. Sarker
INFLAMMOPHARMACOLOGY
(2020)
Article
Chemistry, Medicinal
Gabriel Mengheres, Craig R. Rice, Olumayokun A. Olajide, Karl Hemming
Summary: A series of novel isoflavone/benzo-o-sultam hybrids were synthesized and evaluated for their potential anti-inflammatory and neuroprotective effects in LPS-activated BV2 microglia. The most potent hybrid compound showed promising results by reducing NO production to 41% and TNF-alpha to 34% in the cells.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Cell Biology
Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Izabela Lepiarz-Raba, Alaa A. Al-Hindawi
Summary: The study found that SARS-CoV-2 spike glycoprotein S1 stimulated PBMCs to release pro-inflammatory cytokines through mechanisms involving activation of NF-kappa B, p38 MAPK, and NLRP3 inflammasome. The clinical benefits of dexamethasone in COVID-19 may be due to its anti-inflammatory activity in reducing SARS-CoV-2 cytokine storm.
Article
Neurosciences
Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Oyinkansola D. Adegbola, Alaa A. Al-Hindawi
Summary: The study found that the spike protein S1 of SARS-CoV-2 can induce neuroinflammation in BV-2 microglia through activation of NF-kappa B and p38 MAPK. These findings contribute to our understanding of the mechanisms underlying CNS pathologies of SARS-CoV-2.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Izabela Lepiarz-Raba, Alaa A. Al-Hindawi, Mutalib A. Aderogba, Hazel L. Sharp, Robert J. Nash
Summary: The study demonstrates that Garcinia kola seed extract and garcinoic acid can reduce the production of inflammatory cytokines in immune cells induced by SARS-CoV-2 spike protein S1, potentially offering therapeutic benefits in reducing cytokine storm in severe coronavirus infections.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Owolabi W. Banjo, Atsushi Kato, Yana B. Penkova, George W. J. Fleet, Robert J. Nash
Summary: This study found that idoBR1, a cucumber-derived iminosugar amino acid, could dose-dependently reduce the inflammatory responses in LPS-activated microglia cells. These findings suggest that idoBR1 may have anti-inflammatory effects and could be further investigated for its potential in other neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Folashade A. Ogunrinade, Victoria U. Iwuanyanwu, Satyajit D. Sarker, Olumayokun A. Olajide
Summary: Skimmianine reduces the production of pro-inflammatory mediators in LPS-activated BV-2 microglia and inhibits neuroinflammation by targeting the NF-kappa B activation pathway.
Article
Pharmacology & Pharmacy
Folashade A. Ogunrinade, Stephanie T. Guetchueng, Folashade O. Katola, Mutalib A. Aderogba, Idowu S. Akande, Satyajit D. Sarker, Olumayokun A. Olajide
Summary: The root extract of Zanthoxylum zanthoxyloides has shown effectiveness in reducing neuroinflammation in BV-2 microglia stimulated with LPS and hemozoin by regulating cytokine levels, inhibiting iNOS and COX-2 proteins, and preventing microglia-mediated damage to neurons. The extract targets NF-kappa B and NLRP3 inflammasome activation, and skimmianine was identified as an anti-inflammatory compound in Z. zanthoxyloides.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Tayo Famojuro, Taiwo O. Elufioye, Olumayokun A. Olajide, Michael Dybek, Adeboye Adejare
Summary: This study identified potential cytotoxic compounds from Caesalpinia benthamiana, with the new monoterpenoid benthamiacone exhibiting the highest activity across different cancer cell lines. The compounds showed activity against human adenocarcinoma cells, with significant reductions in live carcinoma cells and increases in dead carcinoma cells observed in cell proliferation and caspase-3/7 green detection assays.
AVICENNA JOURNAL OF PHYTOMEDICINE
(2021)
Article
Chemistry, Organic
Gabriel Mengheres, Olumayokun Olajide, Karl Hemming
Meeting Abstract
Pharmacology & Pharmacy
Alaa Al-Hindawi, Olumayokun Olajide, Karl Hemming
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Meeting Abstract
Pharmacology & Pharmacy
I. Lepiarz, M. B. Navarro, F. A. Javid, K. Hemming, O. A. Olajide
BRITISH JOURNAL OF PHARMACOLOGY
(2019)