Predicting Brain Occupancy from Plasma Levels using PET: Superiority of Combining Pharmacokinetics with Pharmacodynamics while Modeling the Relationship

Dopamine D2 Occupancy as a Biomarker for Antipsychotics: Quantifying the Relationship with Efficacy and Extrapyramidal Symptoms

(2010) Rik de Greef et al.   AAPS Journal

A population pharmacokinetic evaluation of the influence of CYP2D6 genotype on risperidone metabolism in patients with acute episode of schizophrenia

(2010) Igor Locatelli et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Application of PAMPA-models to predict BBB permeability including efflux ratio, plasma protein binding and physicochemical parameters

(2010) Jurgen Mensch et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Prediction of Repeat-Dose Occupancy from Single-Dose Data: Characterisation of the Relationship between Plasma Pharmacokinetics and Brain Target Occupancy

(2010) Sergio Abanades et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice

(2010) Katrin M. Kirschbaum et al.   NEUROPHARMACOLOGY

D2 receptor occupancy in conscious rat brain is not significantly distinguished with [3H]-MNPA, [3H]-(+)-PHNO, and [3H]-raclopride

(2010) Teng Peng et al.   SYNAPSE

Population Pharmacokinetics of Intramuscular Paliperidone Palmitate in Patients with Schizophrenia

(2009) Mahesh N. Samtani et al.   CLINICAL PHARMACOKINETICS

Mechanisms Underlying Psychosis and Antipsychotic Treatment Response in Schizophrenia: Insights from PET and SPECT Imaging

(2009) O. Howes et al.   CURRENT PHARMACEUTICAL DESIGN

Brain and Plasma Pharmacokinetics of Aripiprazole in Patients With Schizophrenia: An [18F]Fallypride PET Study

(2008) Gerhard Gründer et al.   AMERICAN JOURNAL OF PSYCHIATRY

Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients

(2008) Jung-Ryul Kim et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Striatal and Extrastriatal D2/D3-Receptor-Binding Properties of Ziprasidone

(2008) Ingo Vernaleken et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

Dose–Occupancy Study of Striatal and Extrastriatal Dopamine D2 Receptors by Aripiprazole in Schizophrenia with PET and [18F]Fallypride

(2008) Lawrence S Kegeles et al.   NEUROPSYCHOPHARMACOLOGY

Functional neuroimaging in schizophrenia: diagnosis and drug discovery

(2008) P MCGUIRE et al.   TRENDS IN PHARMACOLOGICAL SCIENCES