Article
Biochemistry & Molecular Biology
Alok Mishra, Anshuman Srivastava, Ankit Pateriya, Manendra Singh Tomar, Anand Kumar Mishra, Ashutosh Shrivastava
Summary: Breast cancer is the most common cancer among females, and endocrine therapy for ER-positive breast cancer can result in acquired resistance. The metabolic state of cancer cells plays a crucial role in their susceptibility to chemotherapeutic drugs, and understanding metabolic pathway alterations in TAMR cancer may offer potential therapeutic strategies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Sheila Almaraz Postigo, Juan Carlos Montero
Summary: In this study, the researchers found that Neuregulins (NRGs) regulate estrogen receptor α (ERα) in breast cancer cells through multiple mechanisms. NRGs activate the PI3K/AKT/mTOR, ERK1/2, and ERK5 pathways, leading to phosphorylation of ERα and down-regulation of its expression. NRGs also confer resistance to fulvestrant in breast cancer cells. However, this resistance can be reversed by simultaneously inhibiting these three pathways.
Article
Pharmacology & Pharmacy
Faten Shehadeh-Tout, Heloisa H. Milioli, Suraya Roslan, Patric J. Jansson, Mahendiran Dharmasivam, Dinny Graham, Robin Anderson, Tharushi Wijesinghe, Mahan Gholam Azad, Des R. Richardson, Zaklina Kovacevic
Summary: This study investigates a new class of anti-cancer agents for the treatment of ER-positive breast cancer. These agents inhibit multiple growth factor receptors and down-stream signaling, leading to decreased expression of hormone receptors and key resistance pathways. In vivo experiments demonstrate that these agents effectively inhibit ER-positive breast cancer growth. This represents an innovative non-hormonal, multi-modal therapeutic approach.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Coralie Poulard, Thuy Ha Pham, Youenn Drouet, Julien Jacquemetton, Ausra Surmielova, Loay Kassem, Benoite Mery, Christine Lasset, Jonathan Reboulet, Isabelle Treilleux, Elisabetta Marangoni, Olivier Tredan, Muriel Le Romancer
Summary: Endocrine therapies targeting estrogen signaling have improved management of estrogen receptor alpha (ERα)-positive breast cancers. However, resistance to treatment remains a challenge. This study identifies nuclear PRMT5 expression as a predictive marker of sensitivity to tamoxifen in breast cancer patients, and reveals the mechanism of tamoxifen stimulating ERα methylation by PRMT5. This biomarker could be used to enhance response to tamoxifen in ERα-positive breast tumors.
EMBO MOLECULAR MEDICINE
(2023)
Review
Oncology
Nivida Shete, Jordan Calabrese, Debra A. Tonetti
Summary: Estrogen is a key driver of estrogen-receptor-positive breast cancers, and drugs that block estrogen signaling are commonly used for treatment. Surprisingly, estrogen was previously used to treat breast cancer before the introduction of tamoxifen. This review focuses on the insights, molecular mechanisms, and potential clinical application of this counterintuitive therapeutic approach.
Article
Biochemistry & Molecular Biology
Shaimaa Hamza, Ekaterina E. E. Garanina, Mohammad Alsaadi, Svetlana F. F. Khaiboullina, Gulcin Tezcan
Summary: NLRP3 may contribute to the growth and propagation of breast cancer, and the effects of ER-alpha, PR, and HER2 on NLRP3 activation in breast cancer are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chih-Jung Chen, Ting-Hao Chen, Jason Lei, Ji-An Liang, Po-Sheng Yang, Chiun-Sheng Huang, Chia-Ming Hsieh, Ling-Ming Tseng, Liang-Chih Liu, Skye Hung-Chen Cheng, Kuan-Hui Shih
Summary: This study compared the biomarker expression and breast cancer subtyping results obtained by immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR). The results showed concordance between the two methods, and RT-PCR performed similarly to IHC in predicting 5-year survival.
BIOSCIENCE REPORTS
(2022)
Article
Endocrinology & Metabolism
Partha Das, Aritra Gupta, Kartiki V. Desai
Summary: High expression of JMJD6 is associated with poor prognosis and resistance to endocrine therapy in ER+ breast cancer. JMJD6 upregulates genes related to cell proliferation and downregulates ER target genes. Blocking ER alone may not eliminate proliferation of JMJD6-expressing ER+ cells. Immunostaining for JMJD6 could be developed as a potential marker for predicting endocrine therapy resistance.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Michael B. Stout, Rebecca L. Scalzo, Elizabeth A. Wellberg
Summary: Tamoxifen, a selective estrogen receptor modulator, is commonly used in preclinical studies and treatment of ER-positive breast cancer. Activation of Cre-ER transgenes in mice requires tamoxifen administration through various methods and doses, leading to inconsistent metabolic effects compared to anecdotal reports and expected outcomes.
Article
Oncology
Iris Noordhoek, Kai Treuner, Hein Putter, Yi Zhang, Jenna Wong, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Cornelis J. H. van de Velde, Catherine A. Schnabel, Gerrit-Jan Liefers
Summary: This study found that BCI (H/I) as a biomarker could predict the benefit of extended endocrine therapy in patients with early-stage HR+ breast cancer, providing important clinical implications for treatment decisions.
CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Ingrid Espinoza, Lin Yang, Travis Vander Steen, Luciano Vellon, Elisabet Cuyas, Sara Verdura, Lester Lau, Javier A. Menendez, Ruth Lupu
Summary: CCN1 promotes angiogenesis, tumor growth, and chemoresistance in endothelial and breast cancer cells by binding to its integrin receptor α(v)β(3). It also controls tissue regeneration by engaging its integrin receptor α(6)β(1) to induce fibroblast senescence. In estrogen receptor-positive breast cancer cells, CCN1 drives an endocrine resistance phenotype through its interaction with ER α.
Article
Multidisciplinary Sciences
Raksha Bhat, Hariprasad Thangavel, Noor Mazin Abdulkareem, Suhas Vasaikar, Carmine De Angelis, Leon Bae, Maria Letizia Cataldo, Sarmistha Nanda, Xiaoyong Fu, Bing Zhang, Rachel Schiff, Meghana Trivedi
Summary: This study reveals that the expression of NPY1R gene and protein in breast cancer is associated with subtypes and changes with the transition of molecular subtypes. In ER+ BC cells, NPY1R expression increases in response to estrogen stimulation and decreases in cells resistant to endocrine therapies. In addition, high NPY1R gene expression is associated with better relapse-free survival and overall survival.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Javier A. Menendez, Adriana Papadimitropoulou, Travis Vander Steen, Elisabet Cuyas, Bharvi P. Oza-Gajera, Sara Verdura, Ingrid Espinoza, Luciano Vellon, Inderjit Mehmi, Ruth Lupu
Summary: The study highlights the critical role of fatty acid synthase (FASN) in HER2-driven tamoxifen resistance and suggests that FASN inhibition could be a novel therapeutic approach to restore tamoxifen sensitivity in endocrine-resistant breast cancer.urther research using next-generation FASN inhibitors may be therapeutically relevant in countering resistance to tamoxifen in FASN-overexpressing ER+/HER2+ breast carcinomas.
Article
Multidisciplinary Sciences
Tomoka Hisada, Naoto Kondo, Yumi Wanifuchi-Endo, Satoshi Osaga, Takashi Fujita, Tomoko Asano, Yasuaki Uemoto, Sayaka Nishikawa, Yusuke Katagiri, Mitsuo Terada, Akiko Kato, Hiroshi Sugiura, Katsuhiro Okuda, Hiroyuki Kato, Masayuki Komura, Satoshi Morita, Satoru Takahashi, Tatsuya Toyama
Summary: Co-expression of LLGL2 and SLC7A5 mRNA has a significant impact on predicting prognosis and response to tamoxifen therapy in ER alpha-positive breast cancer patients, making it a promising biomarker for early breast cancer patients.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Darcie D. Seachrist, Lindsey J. Anstine, Ruth A. Keri
Summary: The review discusses the role of FOXA1 in regulating gene activity, cell biology, and the response of breast cancers to hormone therapies. It also highlights the potential for future studies to explore the roles of FOXA1 independent of its regulation of nuclear receptors.
Article
Environmental Sciences
Mariana Segovia-Mendoza, Carmen T. Gomez de Leon, Rocio Garcia-Becerra, Javier Ambrosio, Karen E. Nava-Castro, Jorge Morales-Montor
ENVIRONMENTAL RESEARCH
(2020)
Article
Engineering, Chemical
Galia Lara-Sotelo, Lorenza Diaz, Rocio Garcia-Becerra, Euclides Avila, Heriberto Prado-Garcia, Gabriela Morales-Guadarrama, Maria de Jesus Ibarra-Sanchez, Jose Esparza-Lopez, Fernando Larrea, Janice Garcia-Quiroz
Summary: Breast cancer is the most common neoplasm in women worldwide, with 5-fluorouracil being a conventional chemotherapeutic agent, but may cause severe side effects. Research shows that using alpha-mangostin together with 5-fluorouracil can increase the anticancer effect, potentially allowing for reducing the dosage of 5-fluorouracil in breast cancer patients.
Article
Biochemistry & Molecular Biology
Mitzi Garcia-Olivares, Sandra Romero-Cordoba, Elizabeth Ortiz-Sanchez, Rocio Garcia-Becerra, Mariana Segovia-Mendoza, Claudia Rangel-Escareno, Ali Halhali, Fernando Larrea, David Barrera
Summary: Calcitriol and TGF-β play important roles in biological pathways such as cell proliferation, differentiation, and invasion, with their cellular effects depending on genetic targets and cell types. Combinatory treatment of calcitriol and TGF-β in human prostate cancer cell lines affects the expression of a set of genes and pathways, leading to inhibition of cell growth and improvement in cancer signaling.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fernando Hernandez-Borja, Itzel Mercado-Sanchez, Yolanda Alcaraz, Marco A. Garcia-Revilla, Clarisa Villegas Gomez, David Ordaz-Rosado, Nancy Santos-Martinez, Rocio Garcia-Becerra, Miguel A. Vazquez
Summary: The study focused on analyzing high substituted pyridine as a capping group, which includes synthesis and docking experiments, and the new compounds showed inhibitory effects on cell proliferation and gene expression.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Cell Biology
Gabriela Morales-Guadarrama, Rocio Garcia-Becerra, Edgar Armando Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Lorenza Diaz
Summary: In solid tumors, vasculogenic mimicry (VM) involves the formation of vascular structures by cancer cells, contributing to tumor neovascularization, promoting metastasis, and driving resistance to antiangiogenic therapy. Various factors, including hypoxia and specific genes, play a role in this process.
Review
Biochemistry & Molecular Biology
Mariana Segovia-Mendoza, Janice Garcia-Quiroz, Lorenza Diaz, Rocio Garcia-Becerra
Summary: Vitamin D3 deficiency may increase the risk of breast cancer development, and calcitriol has been shown to inhibit cancer cell proliferation through various mechanisms and enhance the efficacy of anticancer drugs, although a standardized treatment regimen for breast cancer patients has not been fully established.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Janice Garcia-Quiroz, Nohemi Cardenas-Ochoa, Rocio Garcia-Becerra, Gabriela Morales-Guadarrama, Edgar A. Mendez-Perez, Clara Santos-Cuevas, Gerardo J. Ramirez-Nava, Mariana Segovia-Mendoza, Heriberto Prado-Garcia, Euclides Avila, Fernando Larrea, Lorenza Diaz
Summary: The study found that the combination of multikinase inhibitor dovitinib and natural anticancer hormone calcitriol synergistically inhibited tumor growth in TNBC, leading to a significant reduction in the dose of dovitinib while maintaining its antiproliferative potency. The dual treatment induced cell death and DNA damage, inhibited tumor growth, and decreased angiogenesis in TNBC tumors, suggesting a beneficial convergence of independent antitumor mechanisms of dovitinib and calcitriol.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Rubi Hernandez-Rojas, Carolina Jimenez-Arellano, Marisol de la Fuente-Granada, David Ordaz-Rosado, Rocio Garcia-Becerra, Pedro Valencia-Mayoral, Lourdes Alvarez-Arellano, Pilar Eguia-Aguilar, Marco A. Velasco-Velazquez, Aliesha Gonzalez-Arenas
Summary: Medulloblastoma is the most common and aggressive pediatric intracranial tumor. The expression and phosphorylation of estrogen receptor beta (ER beta) are associated with Medulloblastoma development. Protein kinases C (PKCs) alpha and delta have been identified as potential regulators of ER beta through phosphorylation. The activation of ER beta by PKC alpha and PKC delta promotes proliferation and invasion of Medulloblastoma cells.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Morales-Guadarrama, Edgar A. Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Rocio Garcia-Becerra, Alejandro Zentella-Dehesa, Fernando Larrea, Lorenza Diaz
Summary: The study found that in triple-negative breast cancer cell lines, calcitriol and curcumin partially inhibited the endothelial cell-induced process of vasculogenic mimicry (VM). Calcitriol promoted morphological changes in the cells, while curcumin reduced the 3D structure of VM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Janice Garcia-Quiroz, Bismarck Vazquez-Almazan, Rocio Garcia-Becerra, Lorenza Diaz, Euclides Avila
Summary: Chronic infection of high-risk human papillomaviruses (HPV) and chronic inflammation are closely associated with the occurrence and progression of various neoplasms, including cervical cancer. This article reviews the general mechanisms of HPV-driven cervical carcinogenesis, as well as the involvement of cyclooxygenase-2 (COX-2)/prostaglandin E-2 (PGE(2)) and downstream effectors in this pathology. The research also highlights the interaction between chronic HPV infection and PGE(2) signaling, which weakens immune response and promotes the development of cervical cancer. Furthermore, the article provides an update on current therapeutic and preventive options for targeting PGE(2)-derived inflammation and HPV infection in cervical cancer, including nonsteroidal anti-inflammatory drugs, prophylactic and therapeutic vaccines, immunomodulators, antivirals, and nanotechnology.
Article
Biochemistry & Molecular Biology
Lorenza Diaz, Samantha V. Bernadez-Vallejo, Rafael Vargas-Castro, Euclides Avila, Karla A. Gomez-Ceja, Rocio Garcia-Becerra, Mariana Segovia-Mendoza, Heriberto Prado-Garcia, Galia Lara-Sotelo, Javier Camacho, Fernando Larrea, Janice Garcia-Quiroz
Summary: Cervical cancer, mainly caused by HPV infection, is the fourth most common cancer among women worldwide. This study found that alpha-mangostin (AM) inhibits cell proliferation, induces cell cycle arrest and cell death in different cervical cancer cell lines. AM also decreases the expression of HPV oncogenes (E6, E7) and KCNH1 gene, and inhibits tumor growth in mice. These findings suggest that AM could be a potential adjuvant for the treatment and prevention of cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Euclides Avila, Bryan Javier Noriega-Mejia, Jocelyn Gonzalez-Macias, Ulises Cortes-Hernandez, Janice Garcia-Quiroz, Rocio Garcia-Becerra, Lorenza Diaz
Summary: Vitamin D and the vitamin D endocrine system play a crucial role in regulating calcium homeostasis and have antitumoral effects in various human cancers, including cervical cancer. Studies have shown an inverse relationship between cervical neoplasia and vitamin D levels. This review supports the idea that the vitamin D endocrine system has a preventive role in cervical cancer, particularly in the early stages, by suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, and potentially clearing HPV-dependent lesions. However, vitamin D seems to have little effectiveness in advanced cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Morales-Guadarrama, Edgar A. Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Maria J. Ibarra-Sanchez, Jose Esparza-Lopez, Rocio Garcia-Becerra, Fernando Larrea, Lorenza Diaz
Summary: This study investigates the role of endothelial cells in vasculogenic mimicry (VM) in triple-negative breast cancer (TNBC) and the involvement of the FGFR/PI3K/Akt pathway. Results show that endothelial cells play a predominant role in inducing VM, and the FGFR/PI3K/Akt pathway is implicated in this process. Targeting this pathway may hold promise for treating and preventing VM in TNBC tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nancy Santos-Martinez, Lorenza Diaz, Victor M. Ortiz-Ortega, David Ordaz-Rosado, Heriberto Prado-Garcia, Euclides Avila, Fernando Larrea, Rocio Garcia-Becerra
Summary: Calcitriol induces ER alpha expression in ER-negative breast cancer cells through binding of the VDR-RXR complex to VDREs in the ER alpha gene promoter region, including downregulation of chromatin-remodeling enzymes. Co-treatment of calcitriol with inhibitors of histone deacetylase and DNA methyltransferase significantly increases ER alpha expression, providing new mechanistic insights into the actions of calcitriol in ER-negative breast cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Santiago Garcia, Itzel Mercado-Sanchez, Luis Bahena, Yolanda Alcaraz, Marco A. Garcia-Revilla, Juvencio Robles, Nancy Santos-Martinez, David Ordaz-Rosado, Rocio Garcia-Becerra, Miguel A. Vazquez