Monocyclic Peptides: Types, Synthesis and Applications

Peptides are considered to be appropriate tools in various biological fields. They can be primarily used for the rational design of bioactive molecules. They can act as ligands in the development of targeted therapeutics as well as diagnostics, can be used in the design of vaccines or can be employed in agriculture. Peptides can be classified in two broad structural classes: linear and cyclic peptides. Monocyclic peptides are a class of polypeptides with one macrocyclic ring that bears advantages, such as more selective binding and uptake by the target receptor, as well as higher potency and stability compared to linear types. This paper provides an overview of the categories, synthesis methods and various applications of cyclic peptides. The various applications of cyclic peptides include their use as pro-apoptotic and anti-microbial agents, their application as targeting ligands in drug delivery and diagnostic agents, as well as agricultural and therapeutics applications that are elaborated and discussed in this paper.

Automated summary

Peptides are versatile tools in biological fields and can be used for various purposes, such as drug design, diagnostics, vaccines, and agriculture. Cyclic peptides, in particular, offer advantages like selective binding, higher potency, and stability compared to linear peptides. This paper provides an overview of the categories, synthesis methods, and diverse applications of cyclic peptides, including their roles as pro-apoptotic and anti-microbial agents, targeting ligands in drug delivery, and in agricultural and therapeutic applications.