Article
Chemistry, Multidisciplinary
Ivana Predarska, Mohamad Saoud, Dijana Draca, Ibrahim Morgan, Teodora Komazec, Thomas Eichhorn, Ekatarina Mihajlovic, Dusko Dunderovic, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Evamarie Hey-Hawkins, Goran N. Kaluderovic
Summary: Platinum(IV) conjugates based on a cisplatin scaffold containing derivatives of caffeic and ferulic acid demonstrated higher or comparable activity with respect to cisplatin against different human breast cancer cell lines, while showing superior antiproliferative activity upon immobilization in mesoporous silica nanoparticles. Mechanistic investigations revealed that these compounds induce apoptotic cell death causing strong caspase activation in a mouse breast cancer cell line.
Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Mariana Segovia-Mendoza, Janice Garcia-Quiroz, Lorenza Diaz, Rocio Garcia-Becerra
Summary: Vitamin D3 deficiency may increase the risk of breast cancer development, and calcitriol has been shown to inhibit cancer cell proliferation through various mechanisms and enhance the efficacy of anticancer drugs, although a standardized treatment regimen for breast cancer patients has not been fully established.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Suxing Jin, Yan Guo, Zijian Guo, Xiaoyong Wang
Summary: Monofunctional platinum(II) complexes are a class of non-traditional anticancer agents hopeful to overcome the defects of current platinum drugs, with designs aiming to visualize cellular distribution, reduce side effects, improve tumor selectivity, or inhibit cancer cells through non-DNA targets.
Article
Oncology
Hana Dostalova, Radek Jorda, Eva Reznickova, Vladimir Krystof
Summary: Small molecule Bruton's tyrosine kinase (BTK) inhibitors, including ibrutinib, have shown potential as effective treatments for haemato-oncological diseases. Recent studies have identified HER2 as an off-target kinase of BTK inhibitors, suggesting that these drugs may be repurposed for HER2-positive breast cancer. In this study, we investigated the anticancer effects of zanubrutinib, evobrutinib, tirabrutinib and acalabrutinib in different BCa cell lines and found that zanubrutinib effectively inhibits the HER2 signalling pathway and reduces cell proliferation. These findings support the potential use of zanubrutinib in HER2-amplified solid tumours.
INVESTIGATIONAL NEW DRUGS
(2023)
Article
Chemistry, Multidisciplinary
Yerbol Tagay, Sina Kheirabadi, Zaman Ataie, Rakesh K. Singh, Olivia Prince, Ashley Nguyen, Alexander S. Zhovmer, Xuefei Ma, Amir Sheikhi, Denis Tsygankov, Erdem D. Tabdanov
Summary: The principal cause of death in cancer patients is metastasis, which is conventionally linked to actomyosin-driven cell locomotion. However, this study identifies a complementary mechanism of metastatic locomotion powered by dynein-generated forces. These findings provide new insights into the fundamental understanding of cell locomotion mechanisms and expand the spectrum of clinical targets against metastasis.
Review
Medicine, Research & Experimental
Hadi Shabani, Mohammad Hossein Karami, Jalili Kolour, Zeinab Sayyahi, Mohammad Amir Parvin, Shahrad Soghala, Sadegh Shojaei Baghini, Mahsa Mardasi, Ali Chopani, Pooria Moulavi, Tahereh Farkhondeh, Majid Darroudi, Mahboubeh Kabiri, Saeed Samarghandian
Summary: The rising incidence of breast cancer is a major concern in the medical community. Medicinal herbs, particularly Nigella Sativa, contain compounds that can control cancer development. Thymoquinone (TQ), derived from Nigella sativa Linn, has been proven to have anti-cancer properties and can interfere with tumorigenic processes. This review discusses the cytotoxic effects of TQ for breast cancer treatment and the encapsulation of TQ in nanocarriers to enhance its efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Tugce Boztepe, Guillermo R. Castro, Ignacio E. Leon
Summary: Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Multidisciplinary
Yibin Yu, Chong Huang, Fen Chen, Weisan Pan, Ling Zhang
Summary: Integration of diagnostic and therapeutic modalities into a single nanoplatform (HPCT nanomicelles) for breast cancer was achieved in this study. The nanomicelles comprised hyaluronan-b-poly(ecaprolactone) (HA-PCL), curcumin (Cur), and tocopheryl polyethylene glycol succinate (TPGS). Efficient drug loading, stability, and hyaluronidase-sensitive release were observed in the HPCT nanomicelles. In vivo SPECT/CT imaging confirmed the active targeting ability of the HAbased nanomicelles to breast cancer, while pharmacodynamic studies showed desirable anti-tumor efficacy with good biosafety. The 99mTc-HPCT nanomicelles, integrating imaging and therapeutic modalities, have great potential as an all-in-one theranostic nanoplatform for breast cancer.
MATERIALS & DESIGN
(2023)
Review
Chemistry, Medicinal
Christian Rafael Quijia, Marlus Chorilli
Summary: Piperine has been shown to inhibit the growth and spread of breast cancer cells through mechanisms such as altering signaling pathways and inducing cell cycle arrest and apoptosis. Combining piperine with other phytochemicals and utilizing nanotechnology can enhance its effectiveness in treating breast cancer.
PHYTOTHERAPY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Davood Dalil, Saeid Iranzadeh, Soroush Kohansal
Summary: This study summarized the latest research findings on the antitumor effect of cryptotanshinone (CPT) in breast cancer, revealing its significant impact and various mechanisms. The findings provide essential evidence for future research and clinical applications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Robert Czarnomysy, Anna Muszynska, Jakub Rok, Zuzanna Rzepka, Krzysztof Bielawski
Summary: Transition metal coordination compounds, when conjugated with drug carriers such as dendrimers, can enhance their bioavailability, exhibit higher cytotoxic activity against breast cancer cells, and induce apoptosis and autophagy through various pathways, thus overcoming drug resistance and increasing cellular accumulation in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Kang Fang, Yanting Sun, Jingxian Yang, Xiaochun Hu, Mengyao Chen, Ruihao Li, Xinda Yang, Ting Fan, Junjie Wu, Xiaohan Tong, Chunyan Dong, Shuo Shi
Summary: An acid and glutathione (GSH) dual-controlled nanoplatform is designed to strengthen the antitumor efficacy and avoid toxicity to normal cells of cisplatin and triptolide through the synergy of 1+1 apoptosis and 1+1 ferroptosis. The nanosystem shows superior specificity and therapeutic outcomes while reducing the toxicity to normal cells/tissues.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Christopher Barnett, Fanny Joubert, Alexandra Iliopoulou, Raul Sanchez Alvarez, George Pasparakis
Summary: Photochemical internalization (PCI) is a minimally invasive drug delivery technology that enhances the therapeutic activity of anticancer drugs and nanomicron formulations against breast and pancreatic cancer cells. Various drugs, including vinca alkaloids, taxanes, and anti-metabolites, were tested in a 3D PCI in vitro model and showed significantly enhanced therapeutic efficiency. Particularly, vinca alkaloids and selected nanoformulations demonstrated impressive performance across potency, efficacy, and synergy in a cell viability assay. This study provides a systematic guide for the development of future PCI-based therapeutic modalities for precision oncology.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Javier E. Lopez-Hernandez, Nazia Nayeem, Jose P. Ceron-Carrasco, Afruja Ahad, Aiman Hafeez, Ignacio E. Leon, Maria Contel
Summary: This study describes new heterometallic binuclear and trinuclear platinum(IV)-gold(I) compounds that exhibit cytotoxicity and selectivity against a small panel of cancer cell lines. One trinuclear compound accumulates in the nucleus and mitochondria, induces apoptosis, and shows antimigratory and antiangiogenic properties against triple-negative breast cancer (TNBC) cell lines, as well as potent cytotoxic effect against TNBC 3D spheroids.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Applied
Angelo Cichelli, Ylenia Riciputi, Lorenzo Cerretani, Maria F. Caboni, Nicola d'Alessandro
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Gloria Formoso, Caterina Pipino, Maria Pompea Antonia Baldassarre, Piero Del Boccio, Mirco Zucchelli, Nicola D'Alessandro, Lucia Tonucci, Angelo Cichelli, Assunta Pandolfi, Natalia Di Pietro
APPLIED SCIENCES-BASEL
(2020)
Article
Chemistry, Multidisciplinary
Giuseppe Scioli, Lucia Tonucci, Pietro Di Profio, Antonio Proto, Raffaele Cucciniello, Nicola d'Alessandro
SUSTAINABLE CHEMISTRY AND PHARMACY
(2020)
Article
Chemistry, Applied
Sara Pantalone, Lucia Tonucci, Angelo Cichelli, Lorenzo Cerretani, Ana Maria Gomez-Caravaca, Nicola d'Alessandro
Summary: The study found that phenolic compounds from olive by-products can reduce the acrylamide content in food, with tyrosyl acetate showing the best inhibitory performance.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Chemistry, Applied
Francesca Pietropaoli, Sara Pantalone, Angelo Cichelli, Nicola d'Alessandro
Summary: This review aims to reveal the toxicological characteristics of AA, describe the most interesting mitigation techniques for each food category, and focus on compliance with EU legislation in various consumer products in Europe.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Chemistry, Multidisciplinary
Andrea Mascitti, Giuseppe Scioli, Lucia Tonucci, Valentino Canale, Raimondo Germani, Pietro Di Profio, Nicola d'Alessandro
Summary: The deoxydehydration reaction of glycerol and 1,2-propanediol in ionic liquids catalyzed by methyltrioxorhenium (MTO) and Re2O7 was studied. The ability of ionic liquids to improve the catalytic performance of the rhenium catalyst was examined by conducting experiments using various cations and anions. The results showed that a specific anion, bis(trifluoromethylsulfonyl)imide (TFSI), and a cation with a single aromatic ring were more suitable for the reaction. The presence of ionic liquids also prevented the inertization process of the catalyst, allowing for the readdition of fresh polyol.
Article
Food Science & Technology
Michele Ciulla, Valentino Canale, Rafal Damian Wolicki, Vincenzo Ferrone, Giuseppe Carlucci, Antonella Fontana, Gabriella Siani, Nicola D'Alessandro, Pietro Di Profio
Summary: This paper compares extraction methods using subcritical solvents, dimethyl ether (sC-DME) and n-butane (sC-nB), and finds that sC-DME exhibits higher selectivity and better yield for caffeine. It also discusses technical implementations to optimize subcritical solvent usage and demonstrates that extraction processes based on sub-critical solvents are easy to operate and efficient, and can be easily automated.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Lucia Tonucci, Andrea Mascitti, Anna M. Ferretti, Francesca Coccia, Nicola d'Alessandro
Summary: This study reports a pathway to obtain a bio-adipic acid using metal nanoparticles as catalysts for the hydrogenation reactions of dicarboxylic acids in water at room pressure and temperature. Among the metal nanoparticles tested, Rh NPs showed the best selectivity for adipic acid.
Article
Environmental Sciences
Fabio Girardi, Andrea Mascitti, Nicola D'Alessandro, Lucia Tonucci, Giuseppe Augusto Marzo, Romolo Remetti
Summary: This study aims to investigate the impact of the Fenton reaction, an oxidative treatment, on the biochemical methane potential of solid residues from olive oil production. The experiment reveals that the Fenton treatment improves the speed of methane production, reduces the bacteriostatic effect of phenols, decreases the H2S content in the produced biogas, and enhances methane production in the first four weeks of the test.
WASTE AND BIOMASS VALORIZATION
(2023)