Article
Multidisciplinary Sciences
Lihi Radomir, Matthias P. Kramer, Michal Perpinial, Nofar Schottlender, Stav Rabani, Keren David, Anna Wiener, Hadas Lewinsky, Shirly Becker-Herman, Rina Aharoni, Ron Milo, Claudia Mauri, Idit Shachar
Summary: Regulatory B (Breg) cells suppress excessive inflammation primary via the production of interleukin 10 (IL-10). Here the authors show that the function and homeostasis of mouse and human IL-10(+) Breg cells are negatively regulated by the cell surface receptor, SLAMF5, to impact experimental autoimmunity, thereby hinting SLAMF5 as a potential target for immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Junichi Ishikawa, Akira Suto, Kazuya Abe, Yuki Hayashi, Kensuke Suga, Shigeru Tanaka, Takahiro Kageyama, Arifumi Iwata, Kazumasa Suzuki, Kotaro Suzuki, Hiroshi Nakajima
Summary: Murine IL-17-producing γδT (γδT17) cells consist of natural γδT17 (nγδT17) cells and inducible γδT17 cells. IL-21 is dispensable for the fetal thymic development of nγδT17 cells, but required for the peripheral maintenance of Vδ4(+)nγδT17 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ashley A. Brate, Alexander W. Boyden, Isaac J. Jensen, Vladimir P. Badovinac, Nitin J. Karandikar
Summary: This study identifies a disease-suppressing subset of CD8 T cells with unique phenotypic properties, including a CXCR3(+) subpopulation and increased degranulation and coproduction of IFN-gamma and IL-10. Understanding the functional characteristics of this regulatory subset provides insights into potential novel immunotherapeutic approaches for MS.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Gil-Ran Kim, Won-Ju Kim, Sangho Lim, Hong-Gyun Lee, Ja-Hyun Koo, Kyung-Ho Nam, Sung-Min Kim, Sung-Dong Park, Je-Min Choi
Summary: The study demonstrates that a novel chimeric CTLA-4 signaling peptide can induce regulatory T cells effectively in vivo, showing potential therapeutic effects for autoimmune diseases such as multiple sclerosis.
Article
Immunology
Xiaomei Liu, Feng Zhou, Weixiao Wang, Guofang Chen, Qingxiu Zhang, Ruixue Lv, Zijun Zhao, Xiangyang Li, Qian Yu, Jessica M. Meves, Hui Hua, Xiaocui Li, Xiaotian Wang, Hong Sun, Dianshuai Gao
Summary: IL-9 regulated lncRNA Gm13568 affects the production of inflammatory cytokines in active astrocytes through the Notch1/STAT3 pathway, influencing the pathogenesis of EAE.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Zhihui Zhang, Kai Zhang, Mi Zhang, Xiaomin Zhang, Rongxin Zhang
Summary: This study demonstrates the important immunosuppressive effect of parthenolide (PTL) on autoimmune inflammation. PTL can alleviate clinical symptoms by inhibiting inflammatory cell infiltration, reducing inflammation, and demyelination. It also regulates the immune response by inhibiting the reactivation of specific T cells and the differentiation of CD4(+) T cells into pathogenic Th17 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Eryn Bugbee, Angela A. Wang, Jennifer L. Gommerman
Summary: The IL-10/IL-10 receptor axis has an important role in reducing neuroinflammation in animal models of Multiple Sclerosis (MS), and increased IL-10 is associated with a positive response to MS disease modifying therapy. Identification of environmental factors impacting the IL-10/IL-10 receptor axis could have therapeutic potential. This review discusses the impact of IL-10 receptor signaling on neuroinflammation, environmental factors and intestinal microbes that affect the IL-10/IL-10 receptor axis, and proposes a hypothetical model for the role of B cells in conveying environmental information to the inflamed central nervous system.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jorge H. Tabares-Guevara, Julio C. Jaramillo, Laura Ospina-Quintero, Christian A. Piedrahita-Ochoa, Natalia Garcia-Valencia, David E. Bautista-Erazo, Erika Caro-Gomez, Camila Covian, Angello Retamal-Diaz, Luisa F. Duarte, Pablo A. Gonzalez, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis, Jose R. Ramirez-Pineda
Summary: The use of natural IL-10-inducing small molecules can potentially address chronic inflammatory diseases by modulating the effector/regulatory balance of the immune system, showcasing a promising immunopharmacological potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Alba Sanchez-Fernandez, Stephanie Zandee, Jesus Amo-Aparicio, Marc Charabati, Alexandre Prat, Cecilia Garlanda, Elan Z. Eisenmesser, Charles A. Dinarello, Ruben Lopez-Vales
Summary: This study demonstrates that IL-37 reduces inflammation and protects against neurological deficits and myelin loss in EAE mice by acting via IL1-R5/IL1-R8. Administration of recombinant human IL-37 exerts therapeutic actions in EAE mice, but IL-37 transcripts are not up-regulated in peripheral blood mononuclear cells and brain lesions of MS patients.
Article
Cell Biology
Ka Man Tse, Alexis Vandenbon, Xiaotong Cui, Takashi Minot, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, Makoto Kinoshita, Tatsusada Okuno, Osamu Takeuchi
Summary: This study developed a therapeutic strategy to suppress inflammatory responses by targeting Regnase-1, a ribonuclease involved in immune reactions. By using antisense phosphorodiamidate morpholino oligonucleotides to alter Regnase-1's binding to stem-loop structures, this strategy enhanced Regnase-1 expression and reduced proinflammatory transcripts. In animal models, intratracheal administration of Regnase-1-targeting MOs improved respiratory distress and fibrosis, while intracranial treatment attenuated the development of autoimmune encephalomyelitis.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dirk Reinhold, Karina Guttek, Annika Reddig, Linda Voss, Claudia Schubert, Sascha Kahlfuss, Kurt Grungreiff, Burkhart Schraven, Annegret Reinhold
Summary: The study found that zinc aspartate can inhibit T cell activation, cytokine production, and induce apoptosis, suggesting that it may be beneficial for treating T cell-mediated autoimmune diseases.
Review
Immunology
Aaron H. S. Heng, Caleb W. Han, Caitlin Abbott, Shaun R. McColl, Iain Comerford
Summary: Pro-inflammatory CD4(+) T helper cells play a crucial role in autoimmune diseases. Recent research has revealed the heterogeneity of chemokine receptors expressed by these cells, which are responsible for recruiting different subsets of pro-inflammatory Th cells in autoimmune inflammation. Understanding these receptors may lead to potential therapeutic targets for intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Jenny Linnoila, Negin Jalali Motlagh, Grace Jachimiec, Chih-Chung Jerry Lin, Enrico Kullenberg, Gregory Wojtkiewicz, Rudolph Tanzi, John W. Chen
Summary: The study aimed to find optimal conditions for active immunization models of NMDAR encephalitis. The results showed that different induction methods led to mice with different phenotypes and immune responses. Ventral induction demonstrated characteristics of autoimmune encephalitis earlier and is suitable for short-term studies, while dorsal induction requires further improvement and enhancement of immune response, making it suitable for long-term longitudinal studies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ulas Ceylan, Steffen Haupeltshofer, Laura Kaemper, Justus Dann, Bjorn Ambrosius, Ralf Gold, Simon Faissner
Summary: Clozapine regulates microglial function and attenuates chronic EAE, even in a therapeutic treatment paradigm. This well-defined generic medication might be considered as a promising add-on therapeutic for further development in progressive MS.
FRONTIERS IN IMMUNOLOGY
(2021)