Article
Cell Biology
Haijiao Huang, Bo Jing, Feiyan Zhu, Wanxiang Jiang, Ping Tang, Liyang Shi, Huiting Chen, Guoru Ren, Shiyao Xia, Luoling Wang, Yiyuan Cui, Zhiwen Yang, Alexander J. Platero, Andrew P. Hutchins, Mina Chen, Paul F. Worley, Bo Xiao
Summary: The mechanism of how neuronal signaling affects brain myelination is still not well understood. Our study reveals that dysregulated neuronal RHEB-mTORC1-DLK1 axis impairs brain myelination. Neuronal Rheb cKO inhibits oligodendrocyte differentiation and myelination, with activated neuronal expression of Dlk1 gene. Neuronal Dlk1 cKO improves myelination deficit in neuronal Rheb cKO mice, indicating that activated neuronal Dlk1 expression contributes to impaired myelination caused by Rheb cKO. The effect of Rheb cKO on Dlk1 expression is mediated by mTORC1; neuronal mTor cKO, Raptor cKO, and pharmacological inhibition of mTORC1 also lead to elevated neuronal Dlk1 expression. We demonstrate that both a secreted form of DLK1 and a membrane-bound DLK1 inhibit the differentiation of cultured oligodendrocyte precursor cells into myelin protein-expressing oligodendrocytes. Furthermore, neuronal expression of Dlk1 in transgenic mice reduces the formation of mature oligodendrocytes and myelination. This study identifies Dlk1 as an inhibitor of oligodendrocyte myelination and provides a mechanism linking altered neuronal signaling with oligodendrocyte dysfunction.
Review
Immunology
Meihui Xu, Chi Ma, Ming Dong, Chunjie Guo, Simin Yang, Yue Liu, Xu Wang
Summary: This study aims to characterize the clinical symptoms, MRI findings, and prognosis of adult cerebral cortical encephalitis (CCE) with anti-MOG antibody. Two adult cases of CCE with anti-MOG antibody were presented and a systematic review of the literature was conducted. The majority of patients had a favorable prognosis after treatment, highlighting the importance of early detection and immunotherapy in improving outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Yi Hua, Xuke Yan, Liu Liu, Yilong Wang, Lu Xu, Peifang Jiang, Zhefeng Yuan, Feng Gao
Summary: This study retrospectively analyzed the clinical characteristics and follow-up data of 74 Chinese children with different clinical phenotypes of MOGAD. The results showed that the most common clinical phenotypes of MOGAD were ADEM and encephalitis, and recurrence may be related to age and sex, with a higher recurrence rate observed in females.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Lauren M. Webb, Laura Cacciaguerra, Karl N. Krecke, John J. Chen, Elia Sechi, Vyanka Redenbaugh, Divyanshu Dubey, Sean J. Pittock, Eoin P. Flanagan
Summary: This study aimed to assess marked central canal T2-hyperintensity in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) myelitis compared to myelitis patients with aquaporin-4-antibodypositive neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and multiple sclerosis (MS). The results showed that marked central canal T2-hyperintensity was more common in MOGAD and AQP4 + NMOSD myelitis, and it completely resolved on follow-up MRI, indicating it as a common transient radiological accompaniment in these conditions, but not in MS myelitis.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Tatsuhide Tanaka, Nobuhiko Ohno, Yasuyuki Osanai, Sei Saitoh, Truc Quynh Thai, Kazuya Nishimura, Takeaki Shinjo, Shoko Takemura, Kouko Tatsumi, Akio Wanaka
Summary: Single oligodendrocytes in the central nervous system produce myelin sheaths around multiple axons, and interfascicular oligodendrocytes (IOs) in the corpus callosum of adult mice have morphologically polarized cell bodies with processes of different thicknesses for myelinating axons. The myelin sheaths originating from specific IOs have biased thicknesses and are associated with axonal diameter. Despite potential axonal regulation of myelin sheath thickness, a single axon may also independently influence myelin thickness.
Review
Biochemistry & Molecular Biology
Wojciech Ambrosius, Slawomir Michalak, Wojciech Kozubski, Alicja Kalinowska
Summary: MOG-associated disease (MOGAD) is a rare inflammatory disorder of the central nervous system with various phenotypes, most commonly presenting as optic neuritis and ADEM. Diagnosis relies on detecting serum antibodies and MRI imaging, while treatment includes acute immunotherapy and immunosuppressive therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Kathrin Schanda, Patrick Peschl, Magdalena Lerch, Barbara Seebacher, Swantje Mindorf, Nora Ritter, Monika Probst, Harald Hegen, Franziska Di Pauli, Eva-Maria Wendel, Christian Lechner, Matthias Baumann, Sara Mariotto, Sergio Ferrari, Albert Saiz, Michael Farrell, Maria Isabel S. Leite, Sarosh R. Irani, Jacqueline Palace, Andreas Lutterotti, Tania Kuempfel, Sandra Vukusic, Romain Marignier, Patrick Waters, Kevin Rostasy, Thomas Berger, Christian Probst, Romana Hoeftberger, Markus Reindl
Summary: The study analyzed different isoforms of MOG and their binding patterns in patients with non-MS demyelinating diseases, identifying three distinct binding patterns. These patterns were found to be associated with non-MS demyelinating diseases and had unique immunologic characteristics without differences in clinical phenotypes or disease course. This novel finding could potentially improve MOG-IgG assays and enhance understanding of the pathophysiologic role of MOG-IgG.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Editorial Material
Medicine, General & Internal
Sohyeon Kim, Mi-Yeon Eun, Jae-Joon Lee, Hung Youl Seok
Summary: This study highlights the importance of recognizing the potential association between AHEM and MOGAD, especially when distinct MRI patterns are present.
Article
Clinical Neurology
Jaydip Ray Chaudhuri, Jui Jade Bagul, Alluri Swathi, Bhim Sen Singhal, N. Chakradhar Reddy, Kiran Kumar Vallam
Summary: This study presents a rare case of MOG antibody-associated disease presenting as intracranial hypertension and bilateral papilledema without typical clinical manifestations of MOGAD. The patient responded well to immunosuppressive therapy using rituximab.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Christian W. Keller, Joseph A. Lopez, Eva-Maria Wendel, Sudarshini Ramanathan, Catharina C. Gross, Markus Reindl, Russell C. Dale, Heinz Wiendl, Kevin Rostasy, Fabienne Brilot, Jan D. Luenemann
Summary: MOG-antibody associated diseases account for a significant portion of patients with acquired demyelinating disorders, with elevated systemic complement activation observed in both adult and pediatric cases across all clinical syndromes. Complement inhibition should be considered for therapeutic merit in patients with MOGAD.
ANNALS OF NEUROLOGY
(2021)
Article
Neurosciences
Jiayue Hong, Julia M. Kirkland, Jenica Acheta, Leandro N. Marziali, Brianna Beck, Haley Jeanette, Urja Bhatia, Grace Davis, Jacob Herron, Clemence Roue, Charly Abi-Ghanem, M. Laura Feltri, Kristen L. Zuloaga, Marie E. Bechler, Yannick Poitelon, Sophie Belin
Summary: In this study, the importance of YAP and TAZ in oligodendrocyte function was investigated. Deletion of these mechanotransducers in adult oligodendroglial cells did not affect animal viability or OL maturation and myelination. However, YAP and TAZ were found to play a critical role in the capacity of OLs to remyelinate axons, particularly during the early stage of repair.
Letter
Clinical Neurology
Patrick Lipps, Ana Beatriz Ayroza Galvao Ribeiro Gomes, Laila Kulsvehagen, Matthias Anthony Mutke, Jens Kuhle, Athina Papadopoulou, Anne-Katrin Probstel
Summary: This study investigates whether the proposed MOGAD diagnostic criteria can exclude other diseases, such as multiple sclerosis, and rely on results of cell-based assays.
Article
Immunology
Li Li, Wen Liu, Qifang Cai, Yuqing Liu, Wenjing Hu, Zhichao Zuo, Qiuhong Ma, Siping He, Ke Jin
Summary: This study retrospectively analyzed brain MRI images and clinical manifestations of pediatric patients with MOG antibody-associated encephalitis (MOG-E) and found that 54.5% of patients showed leptomeningeal enhancement (LME) on CE-FLAIR images. The results suggest that LME on CE-FLAIR images may be an early marker among patients with MOG-E, and including CE-FLAIR images in MRI protocols for children suspected of MOG-E at an early stage may be useful for the diagnosis of this disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jingsi Wang, Zhandong Qiu, Dawei Li, Xixi Yang, Yan Ding, Lehong Gao, Aihua Liu, Yang Song, Cunjiang Li, Ran Gao, Lin Wang, Liyong Wu, Longfei Jia, Dongmei Guo, Aihong Zhou, Jianping Jia, Liyuan Huang, Miao Qu, Li Gao, Huiqing Dong, Junwei Hao, Zheng Liu
Summary: The study describes the clinical and imaging features of patients with MOG-E in a medical center. Most patients had acute or subacute onset of encephalitic symptoms. MRI abnormalities were observed in all patients, with the most common lesion locations being cortical/subcortical, deep/periventricular white matter, and corpus callosum. The study suggests that chronically progressive encephalitis may be a new phenotype of MOGAD, and recommends testing for MOG-ab in subacute and chronic progressive dementia with leukodystrophy-like MRI lesions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Youssef Alqahtani, Mohammed Oshi, Naglaa M. Kamal, Mohammed Aljabri, Salma Abosabie, Waleed Elhaj, Sara A. Abosabie
Summary: This article reports a case of a healthy 12-year-old obese boy presenting with headache and bilateral asymmetric papilledema. The patient had an elevated intracranial pressure and pleocytosis, with a MOGA titer of 1:320. After 2 months of treatment, the patient showed significant improvement in symptoms, resolution of papilledema, and improved visual function.
Article
Neurosciences
Ainhoa Etxeberria, Kenton C. Hokanson, Dang Q. Dao, Sonia R. Mayoral, Feng Mei, Stephanie A. Redmond, Erik M. Ullian, Jonah R. Chan
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Feng Mei, Sonia R. Mayoral, Hiroko Nobuta, Fei Wang, Caroline Desponts, Daniel S. Lorrain, Lan Xiao, Ari J. Green, David Rowitch, Jennifer Whistler, Jonah R. Chan
JOURNAL OF NEUROSCIENCE
(2016)
Article
Medicine, General & Internal
Ari J. Green, Jeffrey M. Gelfand, Bruce A. Cree, Carolyn Bevan, W. John Boscardin, Feng Mei, Justin Inman, Sam Arnow, Michael Devereux, Aya Abounasr, Hiroko Nobuta, Alyssa Zhu, Matt Friessen, Roy Gerona, Hans Christian von Budingen, Roland G. Henry, Stephen L. Hauser, Jonah R. Chan
Article
Neurosciences
Tao Li, Jingjing Wang, Hongkai Wang, Yujian Yang, Shouyu Wang, Nanxin Huang, Fei Wang, Xing Gao, Jianqin Niu, Zhifang Li, Feng Mei, Lan Xiao
Article
Neurosciences
Fei Wang, Yu-Jian Yang, Nian Yang, Xian-Jun Chen, Nan-Xin Huang, Jun Zhang, Yi Wu, Zhi Liu, Xing Gao, Tao Li, Guang-Qiang Pan, Shu-Bao Liu, Hong-Li Li, Stephen P. J. Fancy, Lan Xiao, Jonah R. Chan, Feng Mei
Article
Multidisciplinary Sciences
Leonard Apeltsin, Shengzhi Wang, H. -Christian von Budingen, Marina Sirota
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Fei Wang, Shu-Yu Ren, Jing-Fei Chen, Kun Liu, Rui-Xue Li, Zhi-Fang Li, Bo Hu, Jian-Qin Niu, Lan Xiao, Jonah R. Chan, Feng Mei
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Jianqin Niu, Guangdan Yu, Xiaorui Wang, Wenlong Xia, Yuxin Wang, Kimberly K. Hoi, Feng Mei, Lan Xiao, Jonah R. Chan, Stephen P. J. Fancy
Summary: A study identifies an intrinsic factor, Rnf43, in controlling OL maturation in human white matter injury and brain injuries, promoting remyelination. Rnf43 is activated by Wnt signaling in OL progenitor cells and marks activated OPCs in MS and HIE. Inhibition of Fzd1 using UM206 promotes remyelination after demyelinating injury.
Article
Neurosciences
Jing-Fei Chen, Kun Liu, Bo Hu, Rong-Rong Li, Wendy Xin, Hao Chen, Fei Wang, Lin Chen, Rui-Xue Li, Shu-Yu Ren, Lan Xiao, Jonah R. Chan, Feng Mei
Summary: The study found a significant increase in new myelin formation rate in the APP/PS1 mouse model of Alzheimer's disease, despite a decrease in overall myelination levels in the cortex and hippocampus. Enhancing myelin renewal through genetic or pharmacological methods improved cognitive performance in memory-related tasks.
Article
Neurosciences
Feng Guo, Yi-Fan Zhang, Kun Liu, Xu Huang, Rui-Xue Li, Shu-Yue Wang, Fei Wang, Lan Xiao, Feng Mei, Tao Li
Summary: Chronic alcohol consumption can inhibit myelinogenesis in the adult mouse brain, potentially contributing to alcohol-related cognitive impairments.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Lin Chen, Shu-Yu Ren, Rui-Xue Li, Kun Liu, Jing-Fei Chen, Yu-Jian Yang, Yong-Bin Deng, Han-Zhi Wang, Lan Xiao, Feng Mei, Fei Wang
Summary: Exposure to chronic hypoxia inhibits myelinogenesis and causes motor coordination deficits in adult mice. Enhancing myelinogenesis protects brain functions against hypoxia-related deficits.
NEUROSCIENCE BULLETIN
(2021)
Review
Developmental Biology
Jing-Fei Chen, Fei Wang, Nan-Xing Huang, Lan Xiao, Feng Mei
Summary: Oligodendrocytes and myelin undergo dynamic changes in healthy and neurodegenerative brains, and may play an important role in modulating neuronal function and survival. Targeting oligodendroglial cells could have potential value in treating neurodegenerative diseases.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Bruce A. C. Cree, Jianqin Niu, Kimberly K. Hoi, Chao Zhao, Scott D. Caganap, Roland G. Henry, Dang Q. Dao, Daniel R. Zollinger, Feng Mei, Yun-An A. Shen, Robin J. M. Franklin, Erik M. Ullian, Lan Xiao, Jonah R. Chan, Stephen P. J. Fancy
Article
Medicine, Research & Experimental
Erica L. Eggers, Brady A. Michel, Hao Wu, Sheng-zhi Wang, Carolyn J. Bevan, Aya Abounasr, Natalie S. Pierson, Antje Bischof, Max Kazer, Elizabeth Leitner, Ariele L. Greenfield, Stanislas Demuth, Michael R. Wilson, Roland G. Henry, Bruce A. C. Cree, Stephen L. Hauser, H. -Christian von Budingen