Modifiers of solid RNP granules control normal RNP dynamics and mRNA activity in early development

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosyl Phosphatidylinositol Anchor Biosynthesis Is Essential for Maintaining Epithelial Integrity during Caenorhabditis elegans Embryogenesis

(2015) Yemima Budirahardja et al.   PLoS Genetics

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia

(2014) Sarah Mizielinska et al.   CURRENT OPINION IN NEUROLOGY

C9orf72; abnormal RNA expression is the key

(2014) Peter Heutink et al.   EXPERIMENTAL NEUROLOGY

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

(2014) Manal A. Farg et al.   HUMAN MOLECULAR GENETICS

Assemblages: Functional units formed by cellular phase separation

(2014) Jeffrey A. Toretsky et al.   JOURNAL OF CELL BIOLOGY

Direct Binding of Ataxin-2 to Distinct Elements in 3′ UTRs Promotes mRNA Stability and Protein Expression

(2014) Moe Yokoshi et al.   MOLECULAR CELL

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Contribution of ATXN2 intermediary polyQ expansions in a spectrum of neurodegenerative disorders

(2014) S. Lattante et al.   NEUROLOGY

The cytoplasmic poly(A) polymerases GLD-2 and GLD-4 promote general gene expression via distinct mechanisms

(2014) Marco Nousch et al.   NUCLEIC ACIDS RESEARCH

mRNP granules

(2014) J Ross Buchan   RNA Biology

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1

(2014) Christopher Rouya et al.   RNA

RNA and dynamic nuclear organization

(2014) J. Rinn et al.   SCIENCE

Determinants and implications of mRNA poly(A) tail size – Does this protein make my tail look big?

(2014) Aimee L. Jalkanen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects

(2014) Claudia Temme et al.   Frontiers in Genetics

Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation

(2014) Toshifumi Inada et al.   Frontiers in Genetics

Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena

(2014) Yo-Taro Shirai et al.   Frontiers in Genetics

Protein disorder, prion propensities, and self-organizing macromolecular collectives

(2013) Liliana Malinovska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Translation Repressors, an RNA Helicase, and Developmental Cues Control RNP Phase Transitions during Early Development

(2013) Arnaud Hubstenberger et al.   DEVELOPMENTAL CELL

Protein Aggregation Behavior Regulates Cyclin Transcript Localization and Cell-Cycle Control

(2013) ChangHwan Lee et al.   DEVELOPMENTAL CELL

The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans

(2013) M. Nousch et al.   JOURNAL OF CELL SCIENCE

A Role for Drosophila ATX2 in Activation of PER Translation and Circadian Behavior

(2013) Y. Zhang et al.   SCIENCE

Effects of stress and aging on ribonucleoprotein assembly and function in the germ line

(2013) Jennifer A. Schisa   Wiley Interdisciplinary Reviews-RNA

The cellular roles of Ccr4-NOT in model and pathogenic fungi—implications for fungal virulence

(2013) John C. Panepinto et al.   Frontiers in Genetics

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

(2012) Oliver D. King et al.   BRAIN RESEARCH

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

(2012) Tina W. Han et al.   CELL

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans

(2012) Arnaud Hubstenberger et al.   DEVELOPMENTAL BIOLOGY

ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans

(2012) M. S. Sengupta et al.   JOURNAL OF CELL SCIENCE

Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins

(2012) Purusharth Rajyaguru et al.   MOLECULAR CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence

(2012) Yuval Tabach et al.   NATURE

Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis

(2012) M. Nadler-Holly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

(2012) C. J. Decker et al.   Cold Spring Harbor Perspectives in Biology

FIMO: scanning for occurrences of a given motif

(2011) Charles E. Grant et al.   BIOINFORMATICS

Assembly of RNP granules in stressed and aging oocytes requires nucleoporins and is coordinated with nuclear membrane blebbing

(2011) Joseph R. Patterson et al.   DEVELOPMENTAL BIOLOGY

MPK-1 ERK Controls Membrane Organization in C. elegans Oogenesis via a Sex-Determination Module

(2011) Swathi Arur et al.   DEVELOPMENTAL CELL

In Vivo and Transcriptome-wide Identification of RNA Binding Protein Target Sites

(2011) Anna-Carina Jungkamp et al.   MOLECULAR CELL

The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation

(2011) C. McCann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB)

(2011) S. U. Heinrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis and function of nuclear bodies

(2011) Yuntao S. Mao et al.   TRENDS IN GENETICS

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

(2010) Kausik Si et al.   CELL

zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression

(2010) T. Guven-Ozkan et al.   DEVELOPMENT

The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules

(2010) E. Voronina et al.   DEVELOPMENT

Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells

(2010) U. Sheth et al.   DEVELOPMENT

A quantitative RNA code for mRNA target selection by the germline fate determinant GLD-1

(2010) Jane E Wright et al.   EMBO JOURNAL

P Granule Assembly and Function in Caenorhabditis elegans Germ Cells

(2010) D. Updike et al.   JOURNAL OF ANDROLOGY

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

(2010) Andrew C. Elden et al.   NATURE

A Genomewide RNAi Screen for Genes That Affect the Stability, Distribution and Function of P Granules in Caenorhabditis elegans

(2009) Dustin L. Updike et al.   GENETICS

An eIF4E-binding protein regulates katanin protein levels inC. elegansembryos

(2009) Wei Li et al.   JOURNAL OF CELL BIOLOGY

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Spinocerebellar ataxia 2 (SCA2)

(2008) Isabel Lastres-Becker et al.   CEREBELLUM

3′ UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline

(2008) Christopher Merritt et al.   CURRENT BIOLOGY

Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos

(2008) Christopher M. Gallo et al.   DEVELOPMENTAL BIOLOGY

Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway

(2008) Molly C. Jud et al.   DEVELOPMENTAL BIOLOGY

Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) duringCaenorhabditis elegansoogenesis

(2008) Peter R. Boag et al.   JOURNAL OF CELL BIOLOGY

Maternal mRNAs are regulated by diverse P body–related mRNP granules during earlyCaenorhabditis elegansdevelopment

(2008) Scott L. Noble et al.   JOURNAL OF CELL BIOLOGY

A role for Q/N-rich aggregation-prone regions in P-body localization

(2008) M. A. M. Reijns et al.   JOURNAL OF CELL SCIENCE

A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity

(2008) C. R. Stumpf et al.   RNA