Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Article
Biochemistry & Molecular Biology
Zifei Han, Shelli R. McAlpine, Robert Chapman
Summary: This study demonstrates the successful delivery of inhibitors to block the interaction between Hsp70 and HOP using polymer nanogels. The results show the effectiveness of these inhibitors in inhibiting Hsp70 and inducing cancer cell death.
BIOORGANIC CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Yujing Du, Zhao Chen, Ping Yan, Chunli Zhang, Xiaojiang Duan, Xueqi Chen, Meng Liu, Lei Kang, Xing Yang, Yan Fan, Jianhua Zhang, Rongfu Wang
Summary: The study identified heat shock protein 70 (HSP70) as the binding target for RRL, revealing a potential interaction between RRL and the nucleotide-binding domain (NBD) of HSP70. Clathrin-dependent endocytosis and macropinocytosis were suggested as vital internalization mechanisms of RRL. In vivo, Tc-99m-MAG3-RRL demonstrated satisfactory tumor accumulation and targeting, providing a promising probe for visualizing overexpressed HSP70 tumor sections.
MOLECULAR PHARMACEUTICS
(2021)
Article
Parasitology
Desmond O. Agwunobi, Tongxuan Wang, Meng Zhang, Tianhong Wang, Qingying Jia, Miao Zhang, Xinyue Shi, Zhijun Yu, Jingze Liu
Summary: In this study, genes of hsp70 and hsp90 cDNA were cloned and characterized from the tick Dermacentor silvarum, and their functions in cold stress were evaluated. Results showed that Dshsp70 and Dshsp90 play essential roles in the low-temperature adaptation of ticks. This study contributes to understanding the survival and acclimatization of overwintering ticks.
PARASITES & VECTORS
(2021)
Article
Biochemistry & Molecular Biology
Li-rong Yan, Shi-xuan Shen, Ang Wang, Han-xi Ding, Ying-nan Liu, Yuan Yuan, Qian Xu
Summary: The study showed differential expression of heat shock proteins (HSPs) in various cancers, with HSP expression levels generally associated with prognosis in multiple cancer types. While HSP gene mutations were generally linked to poor prognosis in cancers, copy number variations of HSPs had varying impacts on survival status in different cancers. HSPs were found to be involved in the activation and inhibition of multiple cancer-related pathways and closely correlated with immune cell infiltrations in different cancer types.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk
Summary: Summary Hyperthermia can improve the effects of radio- and chemotherapy, but its efficacy is limited by the heat stress response (HSR). In this study, we evaluated the HSP90 inhibitor ganetespib in promoting the effects of radiotherapy or cisplatin combined with hyperthermia. Our results showed that ganetespib could enhance the efficacy of hyperthermia when combined with radiation.
Article
Oncology
Jan Hrudka, Karolina Jelinkova, Hana Fiserova, Radoslav Matej, Vaclav Mandys, Petr Waldauf
Summary: Heat shock proteins (HSPs) are cytoprotective chaperones that play a critical role in maintaining cellular homeostasis. Overexpression of HSPs in cancer cells is associated with shorter overall survival and poorer prognosis. However, only HSP70 expression was found to have a significant impact on colorectal cancer prognosis in this study, with stage dependency.
Article
Biochemistry & Molecular Biology
Mingzu Guo, Wenxi Xu, Yoshinari Yamamoto, Takuya Suzuki
Summary: The study found that curcumin can increase the expression of HSP70 in intestinal Caco-2 cells through transcriptional activation, possibly enhancing cell integrity. The effects of curcumin are regulated by various signaling pathways. This discovery is expected to contribute to a deeper understanding of the regulation of intestinal HSP70 by dietary components.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Medicine, Research & Experimental
Seung Yeob Hyun, Huong Thuy Le, Hye-Young Min, Honglan Pei, Yijae Lim, Injae Song, Yen T. K. Nguyen, Suckchang Hong, Byung Woo Han, Ho-Young Lee
Summary: The HSP system was found to be activated in CSCs, especially HSP70. Evo was identified to induce apoptosis in both CSC and non-CSC populations in various cancer cell lines. Mechanistically, Evo disrupted the HSP system by binding the N-terminal ATP-binding pocket of HSP70 and causing its ubiquitin-mediated degradation.
Review
Biochemistry & Molecular Biology
Xin Xie, Nan Zhang, Xiang Li, He Huang, Cheng Peng, Wei Huang, Leonard J. Foster, Gu He, Bo Han
Summary: Hsp90 is a crucial molecular chaperone that plays a critical role in biological pathways and cellular operations. It is closely linked to cancer and has been studied as a potential drug target. Combining Hsp90 inhibitors with other tumor inhibitors has shown synergistic antitumor effects, making the development of Hsp90 dual-target inhibitors a promising strategy in cancer treatment.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wene Wei, Jiahui Zhou, Lipeng Chen, Haizhou Liu, Fuyong Zhang, Jilin Li, Shufang Ning, Shirong Li, Chen Wang, Yi Huang, Chang Zou, Litu Zhang
Summary: The study showed that plasma Hsp90 alpha levels were significantly higher in colorectal cancer patients and were associated with disease progression, certain tumor biomarkers, and immune cells. However, plasma Hsp90 alpha failed to demonstrate a prognostic value in progression-free survival for colorectal cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Neurosciences
Zhongting Zhao, Zheng Li, Fangning Du, Yixin Wang, Yue Wu, Kah-leong Lim, Lin Li, Naidi Yang, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Misfolding, aggregation, and abnormal degradation of proteins are believed to be key factors in the pathogenesis of PD. Heat shock protein 70 (Hsp70) and Parkin, an E3 ubiquitin ligase, have been found to play important roles in PD pathogenesis. This review focuses on the dysregulation of Hsp70 and Parkin, their interaction, and their potential therapeutic applications in PD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Xiude Ren, Tao Li, Wei Zhang, Xuejun Yang
Summary: Heat-shock protein 90 (HSP90) is an important molecule chaperone associated with tumorigenesis and malignancy. It plays a role in the malignant behaviors of cancer cells, but currently there are no effective single-agent treatments. Combining HSP90 inhibitors with other anticancer therapies may be a better strategy.
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
Chuanbei Tian, Yaying Li, Yixia Wu, Wenqiang Chu, Huai Liu
Summary: In fluctuating climatic environments, heat acclimation in predatory mites is a superior adaptation strategy for effective agricultural pest management. The sustained accumulation of HSP70 proteins results in predatory mites with thermotolerance advantage, promoting their biological control function to pests. The divergent constitutive regulation of HSP70 to a thermal environment allows predators to adapt flexibly to extreme stress.
PEST MANAGEMENT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Yu-Min Choi, So-Young Lee, Bum-Joon Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
So-Young Lee, Soo-Bin Yang, Yu-Min Choi, Song-Ji Oh, Byung-Jun Kim, Yoon-Hoh Kook, Bum-Joon Kim
Article
Immunology
Yu-Min Choi, Hong Kim, Seoung-Ae Lee, So-Young Lee, Bum-Joon Kim
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Microbiology
Ji Yeon Lee, Byoung-Jun Kim, Hyeon-Kyoung Koo, Junghyun Kim, Jee-min Kim, Yoon-Hoh Kook, Bum-Joon Kim
Article
Oncology
Soo-Bin Yang, Mi-Hyun Lee, Bo-Ram Kim, Yu-Min Choi, Bum-Joon Kim
Summary: Recent studies have shown that a tumor necrosis factor (TNF)/inducible nitric oxide synthase (iNOS)-producing dendritic cell (Tip-DC) may activate CD8+ T cells in tumor microenvironments. The development of a new immunotherapeutic agent, such as Poly6, has gained attention in enhancing Tip-DC activity for anticancer immune response. Poly6 treatment has demonstrated potential in activating an antitumor immune response in mice, suggesting its use as an adjuvant for cancer immunotherapy.
Article
Medicine, General & Internal
Ji Yeon Lee, Byoung-Jun Kim, Jee-min Kim, Junghyun Kim, Joon-Sung Joh, Ina Jeong, Yoon-Hoh Kook, Bum-Joon Kim
Article
Immunology
Hyein Jeong, Yu-Min Choi, Hyejun Seo, Bum-Joon Kim
Summary: In this study, a novel DNA vaccine candidate against SARS-CoV-2 called W4P-RBD was developed and shown to induce robust humoral and cell-mediated immune responses in vaccinated mice, suggesting its potential as a protective measure against SARS-CoV-2 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Hyein Jeong, Dong Hyun Kim, Yu-Min Choi, HyeLim Choi, Donghyun Kim, Bum-Joon Kim
Summary: The study showed that HBV rt269I type is more prone to overall genome mutations compared to rt269L type in genotype C2 infections, especially in the Pol region and MHR, leading to lower HBV DNA replication, HBsAg and HBeAg secretion, potential NAr variants and HCC. Furthermore, rt269L type may contribute to liver disease progression through immune escape or enhanced persistent infection in chronic patients of genotype C2.
Article
Virology
Yu-Min Choi, Hyein Jeong, Uni Park, Nam-Hyuk Cho, Bum-Joon Kim
Summary: Poly6, a hepatitis B virus hexamer peptide, shows an anti-SARS-CoV-2 effect with an estimated inhibitory concentration of 2.617 mu M in human bronchial epithelial cells, mediated through an IFN-I dependent manner. It also inhibits IL-6 production enhanced by SARS-CoV-2 in an IFN-I dependent manner, indicating its potential as a COVID-19 drug with potent antiviral and anti-inflammatory activities.
Article
Immunology
Byoung-Jun Kim, Hyein Jeong, Hyejun Seo, Mi-Hyun Lee, Hyun Mu Shin, Bum-Joon Kim
Summary: This study developed a novel vaccine candidate that induced strong immune responses in mice, showing potential efficacy against SARS-CoV-2 infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hyein Jeong, So-Young Lee, Hyejun Seo, Bum-Joon Kim
Summary: The rSmeg-hMIF-hIL-7 vaccine demonstrated strong anti-tumor immune response in mice by inhibiting MIF-dependent tumorigenesis promotion and enhancing cytotoxic T cell recruitment into tumor microenvironments. It also showed enhanced anticancer effect with immune checkpoint inhibitors, suggesting its potential as an adjuvant for cancer immunotherapy. This study is the first to demonstrate the anticancer potential of an immunotherapeutic vaccine targeting immune response against MIF.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Microbiology
Mi-Hyun Lee, Bum-Joon Kim
Summary: This review presents the current status of COVID-19 vaccine development based on recombinant viral and bacterial delivery systems, and discusses the use of licensed live vaccines to prevent COVID-19 infections.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Oncology
Hyein Jeong, So-Young Lee, Hyejun Seo, Dong Hyun Kinnar, Duhyung Lee, Bum-Joon Kim
Summary: The study demonstrates the potential of TBCM as an immunoadjuvant for DC-based cancer immunotherapy. TBCM can activate DCs and induce a strong anticancer immune response, inhibiting tumor growth and metastasis through functional cytotoxic T lymphocyte-mediated oncolytic activity and inhibition of cancer proliferation- and metastasis-related genes.
Article
Immunology
Bo-Ram Kim, Byoung-Jun Kim, Yoon-Hoh Kook, Bum-Joon Kim
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.