Review
Chemistry, Multidisciplinary
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi
Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.
Article
Polymer Science
Neha Parveen, Afsana Sheikh, Mohammed A. S. Abourehab, Ritu Karwasra, Surender Singh, Prashant Kesharwani
Summary: Pancreatic cancer is the fourth leading cause of death worldwide, with low survival rates. The difficulties in early detection and the unique characteristics of pancreatic cancer contribute to ineffective therapies and widespread metastasis. Novel approaches, such as combining nanotechnology with cancer targeting, have shown potential in improving treatment efficacy and reducing cytotoxic effects.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Camila Beatriz Barros Araujo, Ingrid Larissa da Silva Soares, Diego Paulo da Silva Lima, Rafaella Moreno Barros, Bolivar Ponciano Goulart de Lima Damasceno, Joao Augusto Oshiro-Junior
Summary: Nanofibers have potential clinical applications in tissue regeneration due to their similar structure to the extracellular matrix, high surface-to-volume ratio, and flexibility. Polyvinyl alcohol (PVA) nanofibers have shown versatility in drug release and tissue regeneration, with different compositions modifying the pharmacokinetics of active ingredients. PVA/PCL and PVA/CS blends were found to be compatible and had slow degradation, making them suitable for prolonged biodegradation and guiding regeneration in bone and cartilage tissues.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Pharmacology & Pharmacy
M. Zegre, E. Poljanska, L. A. Caetano, L. Goncalves, A. Bettencourt
Summary: The treatment of bone infections involves high doses of antibiotics, either systemically or locally. Recent research has focused on developing drug delivery systems that can target the infected bone specifically, reducing the amount of drugs needed and their potential toxicity. Biodegradable polymeric platforms, such as micro- and nanoparticles, scaffolds, and hydrogels, are being studied as alternative options to the current gold standard treatment, poly(methyl methacrylate) (PMMA) cement.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Zhaofeng Li, Wei Zhang, Zhong Zhang, Huile Gao, Yi Qin
Summary: Bone metastases are recognized as common metastases that affect patient quality of life and survival. Nanomedicine, as a new treatment strategy, shows great potential for the treatment of bone metastases.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Pharmacology & Pharmacy
Amir Barzegar Behrooz, Zahra Talaie, Amir Syahir
Summary: Aggressive glioblastoma (GBM) is a primary brain tumor with no known treatment. However, drug delivery based on nanotechnology holds the potential to address the challenges of treating GBM. Combination therapies have shown better efficacy in GBM treatment, and nanotechnology can enhance the effectiveness of combination treatments.
Review
Polymer Science
Azeez Yusuf, Awatif Rashed Z. Almotairy, Hanan Henidi, Ohoud Y. Alshehri, Mohammed S. Aldughaim
Summary: Nanotechnology has experienced rapid development in the past four decades and has revolutionized various aspects of everyday life. It has had significant impacts on fields like medicine and food industry, leading to improvements in shelf life of food, drug delivery, and development of specific therapeutics.
Article
Chemistry, Multidisciplinary
Pradip Das, Silvia Pujals, Lamiaa M. A. Ali, Magali Gary-Bobo, Lorenzo Albertazzi, Jean-Olivier Durand
Summary: In this study, the degradation of biodegradable periodic mesoporous organosilica nanoparticles (nanoPMOs) triggered by glutathione and the multivalency of antibody-conjugated nanoPMOs were quantified using direct stochastic optical reconstruction microscopy (dSTORM). The impact of these properties on cancer cell targeting, drug loading and release capability, and anticancer activity were also investigated. The higher spatial resolution of dSTORM imaging enabled the characterization of structural properties of fluorescent and biodegradable nanoPMOs. The quantification of nanoPMOs' biodegradation using dSTORM imaging demonstrated their excellent structure-dependent degradation behavior at a higher glutathione concentration. The surface functionality of anti-M6PR antibody-conjugated nanoPMOs, as quantified by dSTORM imaging, played a key role in prostate cancer cell labeling and the higher biodegradability and cancer cell-targeting properties of nanorods conjugated with oriented antibody effectively delivered the anticancer drug doxorubicin to cancer cells, exhibiting potent anticancer effects.
Review
Biochemistry & Molecular Biology
Ta-Hsin Tsung, Yu-Chien Tsai, Hsin-Pei Lee, Yi-Hao Chen, Da-Wen Lu
Summary: Ocular drug delivery is a challenging field due to anatomical and physiological barriers of the eye. Biodegradable polymers have shown promise for efficient and controlled drug delivery in ocular diseases. This review provides an overview of biodegradable polymer-based drug-delivery systems for various ocular diseases, highlighting their potential for sustained drug release, improved bioavailability, and targeted therapy. The safety considerations and future directions of this field are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yongzhuo Huang
Summary: There is a close relationship between cancer metabolism and immunity. Targeting cancer metabolism shows promise as a therapeutic approach for cancer immunotherapy. The Warburg effect, characterized by abnormal glucose metabolism, can modify cancer cells and create a suppressive immune microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Multidisciplinary
Nishant Kumar, Sajid Fazal, Eijiro Miyako, Kazuaki Matsumura, Robin Rajan
Summary: Cancer is a leading cause of death globally, causing physical, emotional, and financial strain on individuals, families, and healthcare systems. The development of nanoparticle-based drug delivery systems and synthetic biodegradable polypeptides and polymers offers new hope for cancer treatment, overcoming challenges such as harmful side effects and drug resistance. Additionally, immunotherapies and bacteria-based therapies show promising selectivity and efficacy in treating various cancers.
Review
Pharmacology & Pharmacy
Likang Xiao, Jiarui Cui, Zhuang Sun, Yunke Liu, Jia Zheng, Yonghui Dong
Summary: The article reviews the current treatment of osteoarthritis (OA) and summarizes the research advances of nanotechnology in OA treatment, including nano drug delivery systems, nano-scaffolds, and nanoparticle lubricants. The opportunities and potential challenges of nanotechnology in OA treatment are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ines Vasconcelos, Tiago Santos
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to an invading pathogen. Nanotechnology-based solutions, such as nanoscale-engineered materials and nanoparticle-based sensors, show promise in improving sepsis diagnosis and management with targeted drug delivery and faster diagnostic methods.
Review
Biotechnology & Applied Microbiology
Yajing Sun, Qingshan Yang, Xue Xia, Xiaozhe Li, Weimin Ruan, Meng Zheng, Yan Zou, Bingyang Shi
Summary: Researchers are focusing on developing polymeric nanoparticles targeted at mitochondria to enhance the efficiency of cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Abdulrahman A. Halwani
Summary: Nanotechnology has a significant impact on medicine and drug delivery, addressing the limitations of conventional pharmaceutical agents. Many nanotechnology applications have been developed and nanotechnology-based medicines are now on the market. Nanotechnology attracts increasing investment worldwide. Pharmaceutical nanomedicine products are projected to play a major role in the global pharmaceutical market and healthcare system.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.