期刊
BIOMATERIALS
卷 35, 期 20, 页码 5369-5380出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.03.038
关键词
Carbon nanotubes; Antibody; Ultrasound imaging; Drug delivery; Prostate cancer
资金
- Shanghai Natural Science Foundation [13ZR1430300]
- Shanghai Municipal Education Commission [14ZZ128]
- National Natural Science Foundation of China [21271130, 51102171]
- Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201212SIC]
Multiwalled carbon nanotubes (MWCNTs) are cut short and grafted with polyethylenimine (PEI) for further covalent conjugation to fluorescein isothiocyanate (FITC) and prostate stem cell antigen (PSCA) monoclonal antibody (mAb). The in vitro and in vivo toxicity data reveal that the as-prepared CNT-PEI(FITC)-mAb has good biocompatibility. Combined flow cytometry and confocal luminescence imaging experiments confirm that the CNT-PEI(FITC)-mAb can specifically target the cancer cells which over-express PSCA. The results of in vitro and in vivo ultrasound (US) imaging indicate that CNT-PEI(FITC)-mAb has great potential to be used as a targeted US contrast agent. The in vivo anti-cancer efficacy testing using PC-3 tumor-bearing mice as animal models demonstrates that CNT-PEI(FITC)-mAb can targetedly deliver drug to the tumors and suppress tumor growth. Findings from this study suggest that the CNT-PEI(FITC)-mAb could be used as a multifunctional platform for simultaneous US imaging and drug delivery applications. (c) 2014 Elsevier Ltd. All rights reserved.
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