Article
Biochemistry & Molecular Biology
Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Bruna Lopes, Patricia Sousa, Justina Prada, Isabel Pires, Giulia Ronchi, Stefania Raimondo, Ana L. Luis, Stefano Geuna, Artur Severo P. Varejao, Ana Colette Mauricio
Summary: Cell secretome is of great interest in Regenerative Medicine. This study analyzed the secretome collected from Olfactory Mucosa Mesenchymal Stem Cells and Olfactory Ensheathing Cells and applied it to promote peripheral nerve regeneration. The results showed that this therapeutic combination had beneficial effects on nerve and muscle regeneration, but further research is needed to address irregularities in the outcomes.
Article
Engineering, Biomedical
Philip J. Hanwright, Chenhu Qiu, Jennifer Rath, Yang Zhou, Nicholas von Guionneau, Karim A. Sarhane, Thomas G. W. Harris, Gregory P. Howard, Harsha Malapati, Michael J. Lan, Sashank Reddy, Ahmet Hoke, Hai-Quan Mao, Sami H. Tuffaha
Summary: This study demonstrates the potential of a novel nanoparticle delivery system for targeted and sustained release of IGF-1, leading to improved motor recovery through amelioration of denervation-induced muscle atrophy and SC senescence and enhanced axonal regeneration.
Article
Engineering, Biomedical
Fangguo Liang, Yusheng Yang, Yuyong Chen, Jiajun Xie, Shencai Liu, Zilin Tan, Liangjie Tian, Zhiqiang Yu, Zhanjun Shi, Peigen Xie, Hong Ding, Qinfeng Yang
Summary: In this study, an electroconductive hydrogel loaded with sustained-release analgesic microspheres was designed as a promising therapeutic approach for diabetic peripheral nerve injury. In vitro and in vivo experiments demonstrated that this treatment strategy can enhance nerve regeneration, functional recovery, and pain relief in diabetic patients.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Environmental
Zhenwei Yi, Fangke Zhan, Yijia Chen, Ran Zhang, Haodong Lin, Liming Zhao
Summary: A water-soluble conductive material was synthesized by grafting polyaniline onto carboxymethyl chitosan, and dual cross-linked hydrogels with injectable, self-healing, and conductive properties were created. The hydrogel showed good biocompatibility, elastic modulus, and electrical conductivity, promoting the proliferation and migration of Schwann cells and enhancing nerve conduction velocity in sciatic nerve injury.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Shuhui Yang, Jinjin Zhu, Changfeng Lu, Yi Chai, Zheng Cao, Jiaju Lu, Zhe Zhang, He Zhao, Yin-Yuan Huang, Shenglian Yao, Xiangdong Kong, Peixun Zhang, Xiumei Wang
Summary: The AFG/fSAP hydrogel, with synergistic topographical and biochemical cues, successfully repaired a 15-mm peripheral nerve defect in rats through enhancing alignment and neurotrophin secretion. It showed satisfactory morphological and functional recovery, comparable to autografts, and activated regeneration-associated gene expression and signaling pathways.
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Aline Yen Ling Wang, Kuan-Hung Chen, Hsiu-Chao Lin, Charles Yuen Yung Loh, Yun-Ching Chang, Ana Elena Avina, Chin-Ming Lee, I-Ming Chu, Fu-Chan Wei
Summary: Vascularized composite allotransplantation is a strategy for reconstructing unique defects like amputated limbs. To ensure the function of transplanted limbs, the recovery of the anastomosed nerves is crucial. Tacrolimus has been shown to promote nerve recovery but has risks of systemic complications. A mixed thermosensitive hydrogel was developed for sustained release of tacrolimus, which improved functional recovery of injured nerves without adverse effects.
Article
Chemistry, Multidisciplinary
Mouyuan Sun, Dongqi You, Ning Zhan, Chao Liu, Xiaoting Zhang, Lining Lin, Jingyu Zhang, Yiting Lou, Yuewei Chen, Chundi Liu, Huiming Wang, Yong He, Mengfei Yu
Summary: A 4D oriented dynamic scaffold based on shape memory polymer is constructed to accelerate peripheral nerve regeneration and functional recovery. It can regulate neuronal behavior and fate in a non-invasive way and promote the formation of functionalized regenerating nerve fascicles with comparable therapeutic effects on autologous nerve transplantation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Immunology
Li-peng Zhang, Jun-xiang Liao, Yi-yi Liu, Hong-lang Luo, Wen-jun Zhang
Summary: Neurological diseases are destructive and current clinical drugs lack therapeutic effect in repairing tissue injury and rebuilding neurological function. Cell therapy, particularly the use of olfactory ensheathing cells, has shown good achievements in nerve injury applications through mechanisms such as neuroprotection, immune regulation, axon regeneration, improvement of nerve injury microenvironment, and myelin regeneration.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Xiaoxuan Tang, Qiaoyuan Li, Tingting Huang, Han Zhang, Xiaoli Chen, Jue Ling, Yumin Yang
Summary: This review mainly discusses the beneficial impact of T-cell subsets in the repair of both peripheral nervous system and central nervous system injuries and introduces studies on various therapies based on T-cell regulation. Further discoveries in T-cell mechanisms and multifunctional biomaterials will provide novel strategies for nerve regeneration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jung Il Lee, Ji Hun Park, Yeong-Rim Kim, Kihak Gwon, Hae Won Hwang, Gayoung Jung, Joo-Yup Lee, Jeong-Yun Sun, Jong Woong Park, Jae Ho Shin, Myoung-Ryul Ok
Summary: This study demonstrates the use of NO-releasing silica nanoparticles to enhance revascularization and improve nerve regeneration in a rat model of peripheral nerve injury, suggesting a potential therapeutic strategy for promoting functional recovery after nerve damage.
NEURAL REGENERATION RESEARCH
(2022)
Article
Engineering, Biomedical
Long Chen, Xiongbo Song, Zhicheng Yao, Conglai Zhou, Junjun Yang, Qiming Yang, Junrong Chen, Jiarui Wu, Zeyu Sun, Liling Gu, Yi Ma, Shin-Jae Lee, Chi Zhang, Hai-Quan Mao, Li Sun
Summary: An engineered composite membrane, Gel nanofiber-dAM, consisting of gelatin nanofiber membrane and decellularized amniotic membrane, showed improved mechanical properties and biocompatibility, promoting axon regeneration and reducing fibrotic response in peripheral nerve injury repair. It exhibits great potential for clinical translation in surgical treatment of PNI as a fully natural materials-derived off-the-shelf matrix.
Article
Neurosciences
Karim A. Sarhane, Benjamin R. Slavin, Nicholas Hricz, Harsha Malapati, Yi-nan Guo, Michael Grzelak, Irene Aran Chang, Heather Shappell, Nicholas von Guionneau, Alison L. Wong, Ruifa Mi, Ahmet Hoke, Sami H. Tuffaha
Summary: The study found that the detrimental effects of muscle denervation on functional recovery are more significant than the effects of SC denervation, with SC denervation having negligible impact on functional outcome. Further research is needed to investigate whether longer periods of SC denervation have negative effects on functional recovery.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Engineering, Biomedical
Xianhao Dong, Siyang Liu, Yueyue Yang, Shan Gao, Wenlei Li, Jiasong Cao, Ye Wan, Ziqi Huang, Guanwei Fan, Quan Chen, Hongjun Wang, Meifeng Zhu, Deling Kong
Summary: Research on nerve conduits composed of oriented microfiber-bundle cores and randomly organized nanofiber sheaths has shed light on the regulatory role of microfiber orientation in promoting peripheral nerve regeneration, elucidating a cascade of biological responses and ultimately enhancing nerve regeneration outcomes.
Article
Surgery
Peter J. Nicksic, D'Andrea T. Donnelly, Weifeng Zeng, Allison J. Seitz, Samuel O. Poore, Aaron J. Suminski, Aaron M. Dingle
Summary: The study demonstrates that trigeminal nerve stimulation (TNS) or peripheral nerve stimulation (PNS) can improve functional outcomes of peripheral nerve injury in rats. This finding is important in translating the therapy as a non-invasive treatment for high, mixed nerve injuries in humans.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Cell Biology
Shi-Qin Lv, Wutian Wu
Summary: ISP and PAP4 promote nerve regeneration and motor functional recovery after peripheral nerve injury in rats, suggesting their potential therapeutic effects in treating such injuries.
NEURAL REGENERATION RESEARCH
(2021)
Article
Cell & Tissue Engineering
Teng Ma, Lei Zhu, Yafeng Yang, Xin Quan, Liangliang Huang, Zhongyang Liu, Zhen Sun, Shu Zhu, Jinghui Huang, Zhuojing Luo
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Engineering, Biomedical
Liangliang Huang, Lei Zhu, Xiaowei Shi, Bing Xia, Zhongyang Liu, Shu Zhu, Yafeng Yang, Teng Ma, Pengzhen Cheng, Kai Luo, Jinghui Huang, Zhuojing Luo
ACTA BIOMATERIALIA
(2018)
Article
Medicine, General & Internal
Chao Zheng, Xisheng Lin, Xiaolong Xu, Cheng Wang, Jinru Zhou, Bo Gao, Jing Fan, Weiguang Lu, Yagian Hu, Qiang Jie, Zhuojing Luo, Liu Yang
Article
Biochemistry & Molecular Biology
Liangliang Huang, Bing Xia, Xiaowei Shi, Jianbo Gao, Yujie Yang, Feng Xu, Fengyu Qi, Chao Liang, Jinghui Huang, Zhuojing Luo
Article
Medicine, Research & Experimental
Bo Gao, Ruoxian Deng, Yu Chai, Hao Chen, Bo Hu, Xiao Wang, Shouan Zhu, Yong Cao, Shuangfei Ni, Mei Wan, Liu Yang, Zhuojing Luo, Xu Cao
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Nanoscience & Nanotechnology
Jianbo Gao, Bing Xia, Shengyou Li, Liangliang Huang, Teng Ma, Xiaowei Shi, Kai Luo, Yujie Yang, Laihe Zhao, Hao Zhang, Beier Luo, Jinghui Huang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Neurosciences
Bing Xia, Jianbo Gao, Shengyou Li, Liangliang Huang, Teng Ma, Laihe Zhao, Yujie Yang, Jinghui Huang, Zhuojing Luo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Jianhua Zhou, Shengyou Li, Jianbo Gao, Yawei Hu, Shaochu Chen, Xinle Luo, Hao Zhang, Zhuojing Luo, Jinghui Huang
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Nanoscience & Nanotechnology
Liangliang Huang, Jianbo Gao, Heran Wang, Bing Xia, Yujie Yang, Feng Xu, Xiongfei Zheng, Jinghui Huang, Zhuojing Luo
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Clinical Neurology
Yu-Jie Yang, Xin Huang, Xiao-Ning Gao, Bing Xia, Jian-Bo Gao, Chen Wang, Xiao-Ling Zhu, Xiao-Juan Shi, Hui-Ren Tao, Zhuo-Jing Luo, Jing-Hui Huang
Summary: The study evaluated the impact and feasibility of an optimized ERAS pathway in surgically treated AIS patients. The ERAS pathway was found to improve perioperative outcomes by providing stronger analgesia, faster ambulation, and earlier discharge for AIS patients.
WORLD NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Chang Liu, Jianbo Gao, Xinxin Cui, Zhipeng Li, Lei Chen, Yuan Yuan, Yaolei Zhang, Liangwei Mei, Lan Zhao, Dan Cai, Mingliang Hu, Botong Zhou, Zihe Li, Tao Qin, Huazhe Si, Guangyu Li, Zeshan Lin, Yicheng Xu, Chenglong Zhu, Yuan Yin, Chenzhou Zhang, Wenjie Xu, Qingjie Li, Kun Wang, M. Thomas P. Gilbert, Rasmus Heller, Wen Wang, Jinghui Huang, Qiang Qiu
Summary: The suite of adaptations associated with the extreme stature of giraffes is mainly related to cardiovascular, bone growth, vision, hearing, and circadian functions. The giraffe FGFRL1 gene plays a key role in resistance to hypertension and increased bone mineral density, contributing to giraffe's adaptations to their tall stature.
Article
Medicine, Research & Experimental
Xiaolong Xu, Di Wang, Chao Zheng, Bo Gao, Jing Fan, Pengzhen Cheng, Baohua Liu, Liu Yang, Zhuojing Luo
Article
Medicine, Research & Experimental
Bing Xia, Jianbo Gao, Shengyou Li, Liangliang Huang, Lei Zhu, Teng Ma, Laihe Zhao, Yujie Yang, Kai Luo, Xiaowei Shi, Liangwei Mei, Hao Zhang, Yi Zheng, Lei Lu, Zhuojing Luo, Jinghui Huang
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.