Article
Endocrinology & Metabolism
Xenia G. Borggaard, Jean-Paul Roux, Jean-Marie Delaisse, Pascale Chavassieux, Christina M. Andreasen, Thomas L. Andersen
Summary: The study found that patients treated with bisphosphonates had fewer quiescent pores/osteons compared to placebo-treated patients, indicating that new cortical remodeling events need to be activated. Additionally, the contribution of eroded pores in the resorption-reversal phase was higher in bisphosphonate-treated patients, while the contribution of mixed eroded-formative pores and formative pores was lower in these patients compared to placebo.
Article
Biotechnology & Applied Microbiology
Daniele Boaretti, Francisco C. Marques, Charles Ledoux, Amit Singh, Jack J. Kendall, Esther Wehrle, Gisela A. Kuhn, Yogesh D. Bansod, Friederike A. Schulte, Ralph Mueller
Summary: Bone remodeling is regulated by the interaction between different cells and tissues at multiple scales. In this study, we established a 3D multiscale micro-MPA model to simulate trabecular bone remodeling and evaluated its morphometry. Our results showed that changes in the levels of osteoprotegerin (OPG) and receptor activator of nuclear factor kB ligand (RANKL) were correlated with bone volume fraction (BV/TV), while changes in sclerostin (Scl) levels had minimal impact on BV/TV.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Pengbin Yin, Ming Chen, Man Rao, Yuan Lin, Mingming Zhang, Ren Xu, Xueda Hu, Ruijing Chen, Wei Chai, Xiang Huang, Haikuan Yu, Yao Yao, Yali Zhao, Yi Li, Licheng Zhang, Peifu Tang
Summary: This study reveals the presence of lipid-associated macrophages and pro-inflammatory CD4+ T cells in the aging process of muscles and bones. The findings also suggest that exosomes produced by degenerated myocytes can communicate with Th17 cells in the bone, leading to the upregulation of aging-related genes. Overall, this study provides important insights into the synchronized aging of muscles and bones.
Article
Construction & Building Technology
Yanming Liu, Shu Jian Chen, Kwesi Sagoe-Crentsil, Wenhui Duan
Summary: In this study, a digital concrete model was used to analyze the pore structure of cement, showing promising results for future research. The model provided a new approach to studying the microstructural properties of cementitious materials and has the potential to transform traditional analytical processes.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Endocrinology & Metabolism
Cassandra Smith, Danielle Hiam, Alexander Tacey, Xuzhu Lin, Mary N. Woessner, Navabeh Zarekookandeh, Andrew Garnham, Paul Chubb, Joshua R. Lewis, Marc Sim, Markus Herrmann, Gustavo Duque, Itamar Levinger
Summary: Bone and muscle are closely linked, and hormones secreted during bone remodeling may be related to muscle mass and strength maintenance. The relationship between bone turnover markers and muscle function in older adults is unclear. This study found that higher levels of bone turnover markers were associated with better muscle function in older adults.
Article
Endocrinology & Metabolism
Hailey C. Cunningham, Sophie Orr, Deepa K. Murugesh, Allison W. Hsia, Benjamin Osipov, Lauren Go, Po Hung Wu, Alice Wong, Gabriela G. Loots, Galateia J. Kazakia, Blaine A. Christiansen
Summary: Mechanical unloading causes rapid loss of bone structure and strength, which gradually recovers after resuming normal loading. However, it is not well established how this adaptation to unloading and reloading changes with age. In this study, they examined bone adaptation during unloading and subsequent reloading in mice of different ages, and found important differences in bone adaptation between young and old mice, as well as osteocyte deficient mice. These findings suggest a period of vulnerability in skeletal health in older subjects during and following a period of disuse.
Article
Biochemistry & Molecular Biology
Leticia Ferreira Montarele, Dimitrius Leonardo Pitol, Bruno Fiorelini Pereira, Sara Feldman, Valeria Paula Sassoli Fazan, Joao Paulo Mardegan Issa
Summary: This study investigated the effects of topical melatonin treatment and its association with rhBMP-2 on bone repair. The results showed a positive effect of the combination treatment on bone repair, suggesting its potential as a new safe alternative technique.
Article
Neurosciences
Hao Guan, Mingxia Liu
Summary: Domain adaptation is an important technique in machine learning-based medical data analysis to reduce distribution differences between different datasets. The Domain Adaptation Toolbox for Medical data analysis (DomainATM) is an open-source software package implemented in MATLAB, offering a collection of popular data adaptation algorithms for medical image analysis. It provides researchers with the capability to perform fast feature-level and image-level adaptation, visualization, and performance evaluation of adaptation methods. Users can also develop and test their own adaptation methods through scripting, enhancing the utility and extensibility of DomainATM. The software, source code, and manual are available online.
Article
Computer Science, Artificial Intelligence
Yufan He, Aaron Carass, Lianrui Zuo, Blake E. Dewey, Jerry L. Prince
Summary: Deep neural networks have shown success in medical image analysis tasks, but performance drop on unseen test domains is a challenge. Existing solutions focus on retraining models or harmonizing test domain data with network training data, limited by lack of source training data and high training costs.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Biophysics
Ivan Giorgio, Francesco dell'Isola, Ugo Andreaus, Anil Misra
Summary: The study proposes a variational approach based on a generalized principle of virtual work to estimate the mechanical response and changes in living bone tissue during remodeling. It explains the adaptive regulation of bone substructure in the context of orthotropic material symmetry. The research focuses on the gradual adjustment of bone tissue as a structural material in response to evolving loading conditions, postulating a feedback mechanism involving multiple stimulus signals.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Geriatrics & Gerontology
Jelena Jadzic, Jovana Mijucic, Slobodan Nikolic, Marija Djuric, Danijela Djonic
Summary: The burden of age-associated fragility fractures of the pelvis has increased over time. Microstructural analysis may be necessary to explain the decline in pubic bone strength in the elderly. Changes in trabecular and cortical microarchitecture of the pubic bone can lead to decreased bone strength and increased fragility, particularly in elderly women.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Medicine, General & Internal
Barbara Alexandra do Amaral Couto, Juliana Campos Hasse Fernandes, Mariana Saavedra-Silva, Hernan Roca, Rogerio Moraes Castilho, Gustavo Vicentis de Oliveira Fernandes
Summary: Objective: This study reviewed the literature on local or systemic administration of antisclerostin and its effects on osseointegration of dental/orthopedic implants and bone remodeling potential. Materials and Methods: An extensive search was conducted to identify relevant case reports, case series, clinical trials, and animal studies. Results: 19 articles were included, showing that antisclerostin administration positively impacted bone-implant contact, bone mineral density, bone area/volume, and bone thickness in the osseointegration group, and increased bone mineral density, trabecular bone, and bone formation in the bone remodeling group. Conclusion: More studies are needed to better evaluate the effects of antisclerostin on osseointegration of dental implants, but the findings suggest that it can accelerate and stimulate bone remodeling and neoformation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gerontology
Bryant Carlson, Jacklyn N. Kohon, Paula C. Carder, Dani Himes, Eiji Toda, Katsuya Tanaka
Summary: This study analyzes states' climate adaptation plans in the United States and assesses how they address the impact of climate change on older adults.
Article
Materials Science, Multidisciplinary
Aditya Kumar, Arash Yavari
Summary: This paper presents a formulation of large-deformation mechanics of remodeling. Remodeling is a type of anelasticity with material evolutions that preserve mass and volume. The time dependence of the energy function is achieved through one or more remodeling tensors, which can be considered as internal variables of the theory. The governing equations of remodeling solids are derived using a two-potential approach and the Lagrange-d'Alembert principle. The study includes both isotropic and anisotropic solids, as well as a particular remodeling of fiber-reinforced solids. The importance of material and loading parameters on fiber remodeling is explored through parametric studies.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Article
Chemistry, Analytical
Bahar Uddin Mahmud, Guan Yue Hong, Abdullah Al Mamun, Em Poh Ping, Qingliu Wu
Summary: 3D object segmentation is a fundamental and challenging topic in computer vision, with applications in various fields. Traditional techniques using hand-made features and design methods have limitations in handling large amounts of data and achieving high accuracy. Deep learning techniques, especially convolutional neural networks, have emerged as the preferred method for 3D segmentation tasks.
Review
Engineering, Biomedical
Pingping Han, Guillermo A. Gomez, Georg N. Duda, Saso Ivanovski, Patrina S. P. Poh
Summary: The dynamics of cell mechanics and epigenetic signatures play a crucial role in cell behavior and fate, affecting the outcomes of tissue regeneration. While 2D geometric substrates have been widely used to study cell mechanics in response to the extracellular microenvironment, there is limited knowledge about cell mechanobiology and epigenetics in 3D biomaterial matrices. This review explores the potential of additive manufacturing for incorporating multi length-scale geometry features on scaffolds, and discusses how scaffold geometry influences cell and nuclear mechanosensing and epigenetic modifications, ultimately impacting tissue regeneration outcomes.
ACTA BIOMATERIALIA
(2023)
Article
Orthopedics
Philippe Moewis, Rene Kaiser, Adam Trepczynski, Christoph von Tycowicz, Leonie Krahl, Ansgar Ilg, Johannes Holz, Georg N. Duda
Summary: This study aimed to analyze knee kinematics in patients with patient-specific episealer implants and found that these implants led to knee kinematics similar to healthy knees, with a medial pivot and high degree of femoral rollback during flexion. However, compared to healthy knees, the episealer implants showed higher femoral rollback and axial external rotation, suggesting possible post-operative muscle weakness and insufficient stabilization at high flexion.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Martin Textor, Arnd Hoburg, Rex Lehnigk, Carsten Perka, Georg N. N. Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Summary: This study found that loose bodies (LBs) from patients with osteochondritis dissecans (OCD) contain sufficient viable and functional chondrocytes that can be used for autologous chondrocyte implantation (ACI) without affecting their phenotype during prolonged in vitro expansion. The chondrocyte populations from LBs (LB-CH) showed no significant differences in cell yield per isolation and expression of chondrocyte progenitor cell markers compared to control chondrocytes from non-weight-bearing joint regions. LB-CH exhibited comparable viability, proliferation rates, and chondrogenic differentiation potential to control chondrocytes, and had a higher ability to form a hyaline cartilage matrix compared to bone marrow mesenchymal stromal cells (BMSCs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Alexander Paping, Clara Basler, Kerstin Melchior, Loreen Ehrlich, Mario Thiele, Georg N. Duda, Wolfgang Henrich, Thorsten Braun
Summary: The study aimed to evaluate the reliability of intraoperative ultrasound in identifying histologically confirmed uterine scar tissue. The results showed that intraoperative ultrasound was more accurate in identifying scar tissue compared to preoperative ultrasound. This is important for studying uterine wound healing and preventing uterine wall rupture.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Maurizio Pesce, Georg N. Duda, Giancarlo Forte, Henrique Girao, Angel Raya, Pere Roca-Cusachs, Joost P. G. Sluijter, Carsten Tschope, Sophie Van Linthout
Summary: A growing body of evidence suggests that the mechanical functions of cardiac fibroblasts, as a necessary component, play an active role in myocardial growth and homeostasis. This review describes cell mechanosensation as a regulator of cardiac maturation and disease, and provides evidence that changes in the mechanical properties of the myocardium can occur due to disease-induced remodeling of the cardiac extracellular matrix.
NATURE REVIEWS CARDIOLOGY
(2023)
Review
Rheumatology
Georg N. N. Duda, Sven Geissler, Sara Checa, Serafeim Tsitsilonis, Ansgar Petersen, Katharina Schmidt-Bleek
Summary: Bone has the ability to regenerate and restore its prior mechanical function without scarring, even in challenging conditions. However, many bone injuries still heal unsatisfactorily. The mechanisms leading to impaired healing involve excessive immune reactions and mechanical conditions that affect the regulation of scar-free healing. This review discusses the complex processes involved in bone regeneration, particularly the early healing phase, and the importance of controlling inflammation and tissue organization for successful regeneration. Various therapies, including immunotherapy and mechanobiology-based approaches, are being investigated for promoting bone regeneration.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Cell Biology
Tazio Maleitzke, Tamara Dietrich, Alexander Hildebrandt, Jerome Weber, Jessika Appelt, Denise Jahn, Ellen Otto, Dario Zocholl, Shan Jiang, Anke Baranowsky, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller
Summary: The study found that procalcitonin (PCT) is applied as a sensitive biomarker to exclude bacterial infections in patients with rheumatoid arthritis (RA) flare-ups. Little is known about the pathophysiological role of PCT in RA. The study revealed that the lack of PCT protected Calca-deficient mice from joint inflammation.
INFLAMMATION RESEARCH
(2023)
Review
Cell Biology
Lisa-Marie Burkhardt, Christian H. Bucher, Julia Loeffler, Charlotte Rinne, Georg N. Duda, Sven Geissler, Tim J. Schulz, Katharina Schmidt-Bleek
Summary: Patients with musculoskeletal diseases face a lower quality of life and higher medical expenses. The interaction between immune cells and mesenchymal stromal cells plays a crucial role in bone regeneration. Excessive accumulation of adipocytes has been linked to low-grade inflammation and impaired bone regeneration. This review discusses the features of bone marrow adipocytes and explores the potential therapeutic approach of targeting peroxisome proliferator-activated receptor gamma (PPARG) to enhance bone regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Tobias Winkler, Louisa Bell, Alwina Bender, Adam Trepczynski, Georg N. Duda, Alexander J. D. Baur, Philipp Damm
Summary: This study assessed the status of periarticular muscles in long-term follow-up after TKA and found that fatty infiltration reduction may lead to increased tibio-femoral joint contact forces. Functional muscle recovery after surgery is important for reducing joint loads and improving long-term outcomes of TKA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Luis Becker, Friederike Schoemig, Lea Marie-Sophie Cordes, Georg N. Duda, Matthias Pumberger, Hendrik Schmidt
Summary: A study was conducted with 523 participants, including 120 with low back pain and 356 without symptoms. It was found that participants with low back pain had reduced pelvic and lumbar range of motion and increased finger-floor distance compared to the asymptomatic control group. Lumbar flexibility assessment should take into account the correlation of pelvic and lumbar motion.
Editorial Material
Cell Biology
Georg N. Duda, David W. Grainger, Robert E. Guldberg, Gady Goldsobel, Glenn D. Prestwich, Brenna Rauw, Hans-Dieter Volk
Summary: Translational impact assessment is crucial in determining the potential of biomedical research discoveries to be transformed into practical, beneficial products for human health. However, measuring translational success is challenging as it goes beyond commercial achievements and may vary from case to case. Prioritizing societal impact is essential in a globalized society.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph Knosalla
Summary: Pulmonary hypertension worsens prognosis in left heart disease. Increased stiffness of the pulmonary artery may contribute to this by causing right ventricular dysfunction and lung vascular remodeling. Targeting extracellular matrix remodeling may be a therapeutic approach for pulmonary hypertension in left heart disease.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
L. Gabel, K. Kent, S. Hosseinitabatabaei, A. J. Burghardt, M. B. Leonard, F. Rauch, B. M. Willie
Summary: The purpose of this review is to summarize current approaches and provide recommendations for imaging bone in pediatric populations using high-resolution peripheral quantitative computed tomography (HR-pQCT). Three established protocols for HR-pQCT imaging in children and adolescents are presented, along with their advantages and disadvantages. The review also outlines special cases and provides tips for acquiring and processing scans to minimize motion artifacts and account for growing bone.
CURRENT OSTEOPOROSIS REPORTS
(2023)
Article
Endocrinology & Metabolism
Michael Indermaur, Daniele Casari, Tatiana Kochetkova, Bettina M. Willie, Johann Michler, Jakob Schwiedrzik, Philippe Zysset
Summary: Osteogenesis imperfecta (OI) is a genetic bone disease that leads to an increased risk of fractures. This study investigated the tensile properties of healthy and OI bone extracellular matrix (ECM). The results showed that OI bone ECM exhibited similar tensile properties to healthy bone, and the mechanical properties were primarily influenced by the orientation of mineralized collagen fibers (MCF) and the degree of bone mineralization (DBM).
Article
Rheumatology
Marcel Niemann, Melanie Ort, Luis Lauterbach, Mathias Streitz, Andreas Wilhelm, Gerald Gruetz, Florian N. Fleckenstein, Frank Graef, Antje Blankenstein, Simon Reinke, Ulrich Stoeckle, Carsten Perka, Georg N. Duda, Sven Geissler, Tobias Winkler, Tazio Maleitzke
Summary: This study compared the leukocyte and cytokine distributions of different PRP products and assessed the effect of pro-inflammatory cytokines on chondrocytes. The results showed that all three PRP products contained elevated levels of leukocytes, and the nSTRIDE APS product had significantly higher concentrations of the pro-inflammatory cytokines IFN-gamma and TNF-alpha. Furthermore, treatment with IFN-gamma and TNF-alpha negatively affected chondrocyte proliferation and cartilage formation. These findings suggest that both the individual's immune profile and the concentration method impact the composition of PRP products.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.