Article
Chemistry, Multidisciplinary
Chun-gong Li, Qinqin Yang, Dong Chen, Hongliang Zhu, Jiachen Chen, Runjin Liu, Qi Dang, Xiang Wang
Summary: The stability and efficiency of heparin grafting on pDA/PEI coatings were investigated in this study, revealing that pDA/PEI coatings could better remain on substrates in a 1.0M NaOH solution and achieve higher heparin grafting density.
Article
Medicine, General & Internal
Karlin R. Karlmark, Marina El Haddad, Xavier-Come Donato, Gabriel Martin, Florence Bretelle, Nathalie Lesavre, Jean-Francois Cocallemen, Marielle Martin, Christophe Picard, Tiffany Albentosa, Jean Roudier, Raoul Desbriere, Nathalie C. Lambert
Summary: During pregnancy, there is a bidirectional exchange of cells between the mother and fetus through the placenta, leading to transgenerational transfer of cells. Research has found that cord blood samples may contain grandmother cells, which could be associated with an increased risk of aneuploidies and related invasive prenatal procedures, as well as affecting HLA compatibility.
Article
Multidisciplinary Sciences
Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi-Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Vasquez-Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, Christopher E. Gillies, Asa K. Hedman, Sile Hu, Tinchi Lin, Rajesh Mikkilineni, Rion K. Pendergrass, Corran Pickering, Bram Prins, Denis Baird, Chia-Yen Chen, Lucas D. Ward, Aimee M. Deaton, Samantha Welsh, Carissa M. Willis, Nick Lehner, Matthias Arnold, Maria A. Woerheide, Karsten Suhre, Gabi Kastenmueller, Anurag Sethi, Madeleine Cule, Anil Raj, Lucy Alnylam Human Genetics, Eugene AstraZeneca Genomics Initiative, Mary Helen Biogen Biobank Team, Eric B. Bristol Myers Squibb, Joanna M. M. Genentech Human Genetics, Hyun Min GlaxoSmithKline Genomic Sci, Mark I. Pfizer Integrative Biology, Paul Population Analytics Janssen Data Sci, Slave Regeneron Genetics Ctr, Lucy Burkitt-Gray, Eugene Melamud, Mary Helen Black, Eric B. Fauman, Joanna M. M. Howson, Hyun Min Kang, Mark I. Mccarthy, Paul Nioi, Slave Petrovski, Robert A. Scott, Erin N. Smith, Sandor Szalma, Dawn M. Waterworth, Lyndon J. Mitnaul, Joseph D. Szustakowski, Bradford W. Gibson, Melissa R. Miller, Christopher D. Whelan
Summary: The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium that characterizes the plasma proteomic profiles of over 54,000 UK Biobank participants. The study provides detailed insights into proteomic disease signatures, genetic associations, and biological mechanisms, offering a valuable resource for drug discovery and biomarker development.
Article
Chemistry, Physical
Fengli Liang, Po-hung Tseng, Qiang Sun, Mengran Li, Wei Zhou, Lian X. Liu, Hao Wang, Zhonghua Zhu
Summary: This study presents a novel method to assemble SrCo0.4Fe0.5W0.1O3-δ cathode directly onto YSZ electrolyte using a highly efficient microwave plasma technique, achieving intimate contact and notably high ORR performance. The method is also effective in assembling other MIEC perovskite cathodes, enhancing cathode performance significantly.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Food Science & Technology
Sara Alvarez, Shihan Weng, Carlos Alvarez, Ismael Marcet, Manuel Rendueles, Mario Diaz
Summary: This study successfully described a new method to prepare water-insoluble edible films from bovine and porcine blood plasma, without the use of crosslinkers, for the production of sustainable packaging materials. The new films showed superior visual appearance, microstructure, and mechanical properties compared to the control film.
FOOD PACKAGING AND SHELF LIFE
(2021)
Article
Biophysics
Chi-Hsien Liu, Cheng-Han Lin, Yi-Jun Chen, Wei-Chi Wu, Chun-Chao Wang
Summary: Nucleic acids have potential for treating diseases but face challenges in cellular uptake. This study developed a new carrier, MNP-CA-PEI, for efficient delivery of nucleic acids into cells, enhancing gene silencing efficiency. The nanoparticles could be magnetically triggered to deliver DNA plasmids and siRNA, improving gene knockdowns in different cell lines.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Shuangquan Wu, Biao Chen, Qifa Ye
Summary: In this study, chitin/zeolite composite nanofibrous microspheres (CZ) were developed as efficient and specific blood ammonia adsorbent for the treatment of hyperammonemia. The CZ exhibited rapid and good affinity for ammonia in both aqueous solution and hyperammonemia plasma. It also demonstrated good compatibility with cells and blood components, making it a potential candidate for clinical use.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Noralyn Manucat-Tan, Rafaa Zeineddine Abdallah, Harsimran Kaur, Daniel Saviane, Mark R. Wilson, Amy R. Wyatt
Summary: Fibrinogen in blood plasma may have a role in antioxidant defense, as it reacts with the biological oxidant hypochlorite to form high molecular weight assemblies with potential antioxidant properties. Unlike hypochlorite-modified albumin, hypochlorite-modified fibrinogen does not induce reactive oxygen species production or cell death in immune cells. The interaction of hypochlorite with fibrinogen in plasma may reduce the accumulation of other hypochlorite-modified species, indicating a novel role for fibrinogen in blood plasma antioxidant defense.
Article
Immunology
Marina El Haddad, Karlin R. Karlmark, Xavier-Come Donato, Gabriel V. Martin, Florence Bretelle, Nathalie Lesavre, Jean-Francois Cocallemen, Marielle Martin, Christophe Picard, Jean Roudier, Raoul Desbriere, Nathalie C. Lambert
Summary: The study found that factors influencing the presence of maternal cells in cord blood samples included high concentrations of pregnancy-associated protein in maternal serum during the first trimester and feto-maternal HLA compatibility. Samples with maternal microchimerism were enriched in CD56+ cells, which may have an influence on the hematopoietic composition of fetal cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Chemical
Juanjuan Liu, Xiaolong Lu, Guiming Shu, Ke Li, Xiao Kong, Shuyun Zheng, Tao Li, Jun Yang
Summary: A novel heparin/PEI dual-sided functional PVDF plasma separation membrane structure is proposed. Bilirubin is removed using this membrane via one-step anti-coagulation-adsorption. The inner side of the membrane prolongs clotting time while the outer side adsorbs and removes bilirubin.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Brianna M. Vickerman, Colin P. O'Banion, Xianming Tan, David S. Lawrence
Summary: Protein therapeutics have high selectivity and potency, but are often limited by short half-lives and off-target effects. This study introduces a targeted protein delivery system using engineered red blood cells and light-triggered hemolysis for drug release. The strategy shows spatiotemporal control and successful delivery of therapeutic proteins in vitro and in vivo.
ACS CENTRAL SCIENCE
(2021)
Article
Genetics & Heredity
Egil Ferkingstad, Patrick Sulem, Bjarni A. Atlason, Gardar Sveinbjornsson, Magnus I. Magnusson, Edda L. Styrmisdottir, Kristbjorg Gunnarsdottir, Agnar Helgason, Asmundur Oddsson, Bjarni V. Halldorsson, Brynjar O. Jensson, Florian Zink, Gisli H. Halldorsson, Gisli Masson, Gudny A. Arnadottir, Hildigunnur Katrinardottir, Kristinn Juliusson, Magnus K. Magnusson, Olafur Th. Magnusson, Run Fridriksdottir, Saedis Saevarsdottir, Sigurjon A. Gudjonsson, Simon N. Stacey, Solvi Rognvaldsson, Thjodbjorg Eiriksdottir, Thorunn A. Olafsdottir, Valgerdur Steinthorsdottir, Vinicius Tragante, Magnus O. Ulfarsson, Hreinn Stefansson, Ingileif Jonsdottir, Hilma Holm, Thorunn Rafnar, Pall Melsted, Jona Saemundsdottir, Gudmundur L. Norddahl, Sigrun H. Lund, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Kari Stefansson
Summary: Genome-wide association studies of plasma protein levels in Icelanders have identified numerous associations with diseases and other traits, providing valuable insights into disease pathogenesis and potential drug targets. Through integration of proteomics, genomics, and transcriptomics, this research offers a resource for improving disease understanding and aiding drug discovery and development.
Article
Multidisciplinary Sciences
Cecilia Primo, Catherine Navarre, Francois Chaumont, Bruno Andre
Summary: This research discovered that TORC1 activity in tobacco cells is strongly influenced by the activity of plasma membrane H+-ATPases. When H+-ATPases are stimulated by fusicoccin, TORC1 activity can be activated. These results suggest that plant H+-ATPases play an important role in TOR signaling.
Article
Medicine, General & Internal
Dibyadyuti Datta, Paul Bangirana, Robert O. Opoka, Andrea L. Conroy, Katrina Co, Caitlin Bond, Yi Zhao, Keisuke Kawata, Andrew J. Saykin, Chandy C. John
Summary: Plasma tau levels were elevated in children with CM or SMA and associated with mortality and persistent NCI in children with CM younger than 5 years.
Article
Biology
Steffen M. Recktenwald, Greta Simionato, Marcelle G. M. Lopes, Fabia Gamboni, Monika Dzieciatkowska, Patrick Meybohm, Kai Zacharowski, Andreas von Knethen, Christian Wagner, Lars Kaestner, Angelo D'Alessandro, Stephan Quint
Summary: The flow properties and shape of red blood cells in COVID-19 patients are significantly impaired, but these changes are reversible when suspended in healthy plasma. The study also reveals a new role of red blood cells in maintaining plasma equilibrium. These findings provide a framework for further investigations into the treatment of COVID-19 and other infectious diseases.
Article
Engineering, Environmental
Yi Zhang, Jian Li, Zhen Wang, Ming-Ze Xu, Zhi Zeng, Jin-peng Huang, Yan-Qing Guan
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Nanoscience & Nanotechnology
Xiang Zhou, Zhentao Li, Lihui Tan, Yi Zhang, Yanpeng Jiao
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Engineering, Environmental
Xin Liu, Wenfu Lin, Peng Xiao, Mingjin Yang, Li-Peng Sun, Yi Zhang, Wei Xue, Bai-Ou Guan
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Materials Science, Biomaterials
Li Liu, Mingchao Li, Mingze Xu, Zhen Wang, Zhi Zeng, Yunqing Li, Yi Zhang, Rong You, Chu-Hua Li, Yan-Qing Guan
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Engineering, Environmental
Xiang Zhou, Xiuhong Huang, Bincheng Wang, Lihui Tan, Yi Zhang, Yanpeng Jiao
Summary: The study presented a novel micromotor system that utilized NIR light and gas propulsion to overcome multiple biological barriers in tumor treatment, achieving precise active drug delivery.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biophysics
Xiang Wang, Xin Yan, Bin-cheng Wang, Wei Xue, Chang-ren Zhou, Yi Zhang, Zong-hua Liu
Summary: This study introduces a novel blood lead adsorbent that allows for selective adsorption with real-time monitoring, possessing the ability to resist blood components and be used for treatment and monitoring of lead poisoning.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Materials Science, Composites
Zhi Zeng, Han-bo Feng, Meng-en Hao, Yi Zhang
Summary: A transdermal delivery system for colchicine using a one-pot approach in a microemulsion was proposed in this study, which achieved in situ encapsulation of colchicine during nano-hydroxyapatite formation. The optimal formulation showed high transdermal flux, enhanced drug loading efficiency, and tunable sustained-release behavior, combining the advantages of microemulsion and nano-Hap for controlled drug release. This composite system holds promise as a vehicle for transdermal delivery of colchicine to produce desirable pharmacological effects.
COMPOSITES COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Hua Zhang, Haijie Zhao, Yan Huang, Guodong Sun, Yi Zhang
Summary: Researchers have incorporated mTOR signaling inhibitor rapamycin into a shell-core theranostic nanoplatform to enhance the synergistic effect of chemotherapy and immunotherapy. This nano-platform, with responsive properties regulated by intracellular processes, demonstrates improved blood compatibility, effective tumor accumulation and microenvironment-selective endocytosis.
APPLIED MATERIALS TODAY
(2022)
Article
Materials Science, Multidisciplinary
Xiuhong Huang, Licheng Lin, Xing Yang, Zhentao Li, Yi Wan, Lihua Li, Yanpeng Jiao, Yi Zhang, Changren Zhou
Summary: This study proposes a method using a complex of chitooligosaccharides and europium ions to monitor wound healing, modulate inflammation, and promote vascularization in pressure ulcer injuries. The complex not only monitors wound healing through fluorescence changes, but also demonstrates anti-inflammatory activity and promotes vascularization. The simple construction enables visual monitoring and multi-stage adaptive wound repair.
APPLIED MATERIALS TODAY
(2022)
Article
Biophysics
Xin Liu, Fan Wang, Li Liu, Tiantian Li, Xiangyu Zhong, Hongsheng Lin, Yi Zhang, Wei Xue
Summary: In this study, a nano-spray assisted photothermal imaging system was developed for in vitro cell discrimination and in vivo visualization of tumor position and border in real-time during surgery. Compared to conventional imaging techniques, this approach has the advantages of low cost, convenience, no radiation hazard, and avoiding the adverse effects risk of oral or intravenous contrast agent.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Shuo Liu, Xiaozhen Zhan, Zhenni Lin, Zonghua Liu, Jie Yang, Yi Zhang
Summary: In this study, bacteria-like tumor vaccines with cascade reaction properties were designed to target all key steps of the immune response. The vaccines demonstrated promising anti-tumor effectiveness by effectively loading the antigen, activating and entering antigen presenting cells, escaping the lysosomes, and inducing a potent and continuous anti-tumor cellular immune response.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Wei Wang, Jiexuan Cai, Nai-Kei Wong, Meijing Hong, Jianbin Deng, Long Jin, Yang Ran, Yi Zhang, Yaqi Zhou, Bai-Ou Guan
Summary: In this study, two fluorescent probes were successfully synthesized for the detection of NTR activity in cell and in vivo models. One probe showed high selectivity for NTR, strong fluorescence enhancement, and low detection limit in the presence of NADH. The other tumor-targeting probe efficiently detected NTR activity in cancer cells. The liposome-encapsulated probe was successfully applied to visualize NTR during liver inflammation in mice.
Article
Chemistry, Physical
Zhen Wang, Qian Hu, Zhi Zeng, Xiao-Zhen Wang, Yan-Qing Guan, Yi Zhang
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2020)
Article
Materials Science, Biomaterials
Cheng-guang Wu, Xiang Wang, Yun-feng Shi, Bin-cheng Wang, Wei Xue, Yi Zhang
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Li Liu, Bo Yang, Lan-Qing Wang, Jin-Peng Huang, Wu-Ya Chen, Qing Ban, Yi Zhang, Rong You, Liang Yin, Yan-Qing Guan
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.