期刊
BIOMATERIALS
卷 34, 期 4, 页码 1281-1288出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.10.025
关键词
Infection; Drug delivery; Hydrogels; Controlled drug release
资金
- National Institute of Deafness and Communicative Disorders (NIDCD) [R21DC009986]
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R21DC009986] Funding Source: NIH RePORTER
We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases. (C) 2012 Elsevier Ltd. All rights reserved.
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