期刊
BIOMATERIALS
卷 34, 期 26, 页码 6202-6228出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.05.012
关键词
HIV; Nanotechnology; Polymeric nanoparticles; Dendrimers; Prophylaxis; Vaginal delivery
资金
- National Institute of Health [1R56AI095115-01]
Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than 33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV infection have been reported. The situation demands development of effective prevention strategies to control the pandemic of AIDS. Due to lack of availability of an effective HIV vaccine, antiretroviral drugs and nucleic acid therapeutics like siRNA have been explored for HIV prophylaxis. Clinical trials shave shown that antiretroviral drugs, tenofovir and emtricitabine can offer some degree of HIV prevention. However, complete prevention of HIV infection has not been achieved yet. Nanotechnology has brought a paradigm shift in the diagnosis, treatment and prevention of many diseases. The current review discusses potential of various nanocarriers such as dendrimers, polymeric nanoparticles, liposomes, lipid nanocarriers, drug nanocrystals, inorganic nanocarriers and nanofibers in improving efficacy of various modalities available for HIV prophylaxis. (C) 2013 Elsevier Ltd. All rights reserved.
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