Article
Chemistry, Applied
Changsheng Chen, Jinmei He, Jie Huang, Xiuming Yang, Lanlan Liu, Song Wang, Shizhao Ji, Bin Chu, Weiqiang Liu
Summary: This study presents a scaffold design inspired by fetal dermis for scarless dermal regeneration. The scaffold adopts a two-compartment architecture with a porous structure at the bottom and a parallel fibers network on top. The scaffold shows favorable physical properties and biocompatibility, promoting fibroblasts proliferation and minimizing inflammatory reaction. It provides a promising template for dermal regeneration in tissue engineering.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Chemistry, Physical
Rifky Ismail, Tezara Cionita, Yin Ling Lai, Deni Fajar Fitriyana, Januar Parlaungan Siregar, Athanasius Priharyoto Bayuseno, Fariz Wisda Nugraha, Rilo Chandra Muhamadin, Agustinus Purna Irawan, Agung Efriyo Hadi
Summary: There has been a growing number of studies on developing hydroxyapatite (HA) for use in biocomposites. This study explores the use of HA derived from green mussel shells in biocomposites and investigates the effect of composition on mechanical properties and degradation rate. The findings suggest that increasing the HA and PLA content improves the mechanical properties of the biocomposites but also increases the degradation rate.
Article
Engineering, Manufacturing
J. Jamari, D. F. Fitriyana, P. S. Ramadhan, S. Nugroho, R. Ismail, A. P. Bayuseno
Summary: This research aimed to construct interference screws using 3D printing filaments (HA, PLA, and PCL) at different nozzle temperatures. Various tests were conducted to characterize the screws, including density tests, torsion tests, fracture analysis, and biodegradable tests. A finite element model was also established and compared with a commercial screw. The study found that the interference screw prepared in this study had the best fit for implants in terms of density within the range of cortical bone density. However, the commercial screw outperformed the interference screw in terms of torque efficiency in the clamping failure area and showed faster deterioration.
MATERIALS AND MANUFACTURING PROCESSES
(2023)
Article
Polymer Science
Luca Magazzini, Sara Grilli, Seif Eddine Fenni, Alessandro Donetti, Dario Cavallo, Orietta Monticelli
Summary: Poly(glycolic acid) (PGA) has unique properties including high gas barrier properties, tensile strength, resistance to solvents, heat distortion temperature, stiffness, and biodegradability; combining PGA with other bioplastics can reduce costs and introduce new properties while maintaining green features. The presence of PGA in blends affects thermal properties and degradation behavior, accelerating the hydrolysis process, particularly in PLLA-based systems.
Article
Polymer Science
Julia Venturini Helaehil, Carina Basqueira Lourenco, Boyang Huang, Luiza Venturini Helaehil, Isaque Xavier de Camargo, Gabriela Bortolanca Chiarotto, Milton Santamaria-Jr, Paulo Bartolo, Guilherme Ferreira Caetano
Summary: Composite scaffolds made of polycaprolactone (PCL) mixed with bioceramics, such as hydroxyapatite (HA) and tricalcium phosphate (TCP), showed improved biological recognition and bioactivity. Electrical stimulation (ES) enhanced cell proliferation and differentiation. The study revealed that the combined use of PCL with HA or TCP scaffolds and ES improved bone regeneration.
Article
Materials Science, Multidisciplinary
Boqing Zhang, Ling Wang, Ping Song, Xuan Pei, Huan Sun, Lina Wu, Changchun Zhou, Kefeng Wang, Yujiang Fan, Xingdong Zhang
Summary: This study successfully combined PLLH/nHA composite with FDM technology to prepare porous bone repair scaffolds. The scaffolds showed good printing smoothness and accuracy, suitable mechanical properties, and good osteogenic properties.
MATERIALS & DESIGN
(2021)
Article
Chemistry, Physical
Heilwig Fischer, Claudius Steffen, Katharina Schmidt-Bleek, Georg N. Duda, Max Heiland, Carsten Rendenbach, Jan-Dirk Raguse
Summary: This study histologically evaluates the osteintegration of a CAD/CAM titanium scaffold used for cranioplasty and finds that bone formation primarily occurs at the edges of the implant, with no mineralization on the inner scaffold surface facing the brain. The study suggests that current alloplastic materials for cranioplasty may not provide adequate stimuli for bone formation and calls for further research on alternative approaches to improve osteintegration.
Article
Polymer Science
Elin Akerlund, Anna Diez-Escudero, Ana Grzeszczak, Cecilia Persson
Summary: The field of additive manufacturing, including 3D printing, has allowed for the production of patient-specific medical devices with high accuracy. This study focused on developing biocompatible and bioresorbable polymer-based composite filaments for 3D printing using a combination of polylactic acid, polycaprolactone, and hydroxyapatite. The materials were tested for their mechanical properties, thermal stability, chemical composition, and morphology. Results showed that the materials maintained their chemical composition and exhibited higher mechanical properties than human trabecular bone. The addition of hydroxyapatite significantly accelerated the degradation of the polymer, which can be beneficial for faster healing time.
Article
Dentistry, Oral Surgery & Medicine
Itsuka Arakawa, Nadin Al-Haj Husain, Murali Srinivasan, Sabrina Maniewicz, Samir Abou-Ayash, Martin Schimmel
Summary: The study aimed to compare CAD-CAM and conventional removable complete dentures in terms of treatment duration, financial costs, and adjustments. The results showed no significant differences between CAD-CAM and conventional dentures in treatment duration and adjustment frequency, but CAD-CAM dentures had significantly lower laboratory costs and overall costs.
JOURNAL OF PROSTHETIC DENTISTRY
(2022)
Article
Multidisciplinary Sciences
Ahmed Othman, Maximillian Sandmair, Vasilios Alevizakos, Constantin von See
Summary: This study analyzed the fracture resistance of 3D-printed temporary crowns compared to milled crowns using compression testing. The results showed that milled crowns had higher mechanical fracture strength than 3D-printed crowns, with no significant differences in travel distance until fracture. Therefore, both printed and milled temporary crowns can withstand masticatory forces and are safe for clinical use.
Article
Dentistry, Oral Surgery & Medicine
Claudia Dellavia, Elena Canciani, Gaia Pellegrini, Grazia Tommasato, Daniele Graziano, Matteo Chiapasco
Summary: This study demonstrated the successful use of customized CAD/CAM titanium mesh in combination with autologous bone chips and deproteinized bovine bone for alveolar bone regeneration. Histological analysis showed highly mineralized, well-structured newly formed tissue consisting of new lamellar bone, woven bone, osteoid matrix, and other components.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Multidisciplinary Sciences
Joyce Zhanzi Wang, Jonathon Lillia, Muhannad Farhan, Lei Bi, Jinman Kim, Joshua Burns, Tegan L. Cheng
Summary: This study analyzed the manual modification process of AFOs, aiming to inform digital workflows for AFO fabrication. Participant-specific modifications were found to be combined with universally applied modifications, with height having a moderate effect on plaster additions. The study demonstrated a reliable method for mapping and comparing pre- and post-modified casts for children's AFO fabrication.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Wei-Ting Chou, Chuan-Chung Chuang, Yi-Bing Wang, Hsien-Chung Chiu
Summary: This experimental study compared the internal fit of metal crowns fabricated by traditional casting and digital methods (CNC milling and 3D printing), showing that CNC milling method resulted in far superior marginal and internal fit compared to traditional casting and 3D printing methods.
Article
Polymer Science
Pierluigi Stipa, Stefania Marano, Roberta Galeazzi, Cristina Minnelli, Emiliano Laudadio
Summary: With the absence of specific therapeutic drugs for treating COVID-19, studies suggest that antimalarial quinine and its derivatives may inhibit the virus and cytokine storms. Quinine is considered safer, but dosage optimization and repurposing dosage forms are necessary. Biodegradable polymeric nanoparticles could provide a safer and controlled delivery system for quinine, potentially improving its efficacy against SARS-CoV-2.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Computer Science, Interdisciplinary Applications
Monika Dyavenahalli Shivegowda, Pawinee Boonyasopon, Sanjay Mavinkere Rangappa, Suchart Siengchin
Summary: Computer-aided design and manufacturing have become the most common trend, with designers using CAD to generate design concepts and engineers using CAM to produce goods. These two technologies are merged into unified CAD/CAM systems, which allow for easy management of the design and production process.
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.