Article
Nanoscience & Nanotechnology
Xinchen Wu, Olivia Gauntlett, Tengfei Zhang, Sanika Suvarnapathaki, Colleen McCarthy, Bin Wu, Gulden Camci-Unal
Summary: Scaffold-based bone regeneration using eggshell microparticles in protein-derived hydrogels significantly promotes bone regeneration by inducing osteogenic differentiation and supporting tissue infiltration over a 12-week period.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Orthopedics
Cheol-Hee Jeong, Jooseong Kim, Hyun Sil Kim, Song-Yi Lim, Dawool Han, Aaron J. Huser, Sang Bae Lee, Yeonji Gim, Jeong Hyun Ji, Dohun Kim, Amaal M. Aldosari, Kyelim Yun, Yoon Hae Kwak
Summary: In this study, three types of OCPs were compared to commercially available 8-TCP for their potential to promote bone formation in rat tibias with defects. The results showed that OCP/Alg was equivalent to 8-TCP in promoting bone bridge formation and had better biodegradability. OCP/Col accelerated bone formation in defect repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Multidisciplinary Sciences
Dongseob Lee, Jungwon Lee, Yang-Jo Seol, Yong-Moo Lee, Ki-Tae Koo
Summary: This study investigated the early bone formation using collagenated biphasic calcium phosphate (CBCP) and the potential effects of polynucleotide (PDRN) on bone formation. The results showed that the use of CBCP/PDRN in the repair of bone defects around implants can facilitate bone growth.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Richard Frank Richter, Corina Vater, Margarete Korn, Tilman Ahlfeld, Martina Rauner, Winnie Pradel, Bernd Stadlinger, Michael Gelinsky, Anja Lode, Paula Korn
Summary: Calcium phosphate cements (CPC) are bone replacement materials with good bioactivity, but slow degradation. By combining CPC with mesoporous bioactive glass (MBG) particles, degradation can be enhanced. Functionalizing the MBG with hypoxia conditioned medium (HCM) can support new bone formation. This highly flexible material system has potential for clinical translation.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Ye Li, Kegong Xie, Chong Wang, Chengliang Yang, Ke Huang, Feng Li, Chuanchuan Zheng, Jian Chen, Shujun Dong, Guangfeng Deng, Gege Huang, Qiaoyan Lu, Jia Liu, Kai Li, Yujin Tang, Liqiang Wang
Summary: The study developed a porous CFZ/β-tricalcium phosphate/poly lactic-co-glycolic acid scaffold for treating critical-sized bone defects, showing promising results in promoting bone and blood vessel growth, and demonstrating for the first time that CFZ-loaded scaffolds could treat nonunion of bone defect by activating the Wnt/β-catenin signaling pathway.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Sanika Suvarnapathaki, Xinchen Wu, Tengfei Zhang, Michelle A. Nguyen, Anastasia A. Goulopoulos, Bin Wu, Gulden Camci-Unal
Summary: Recent innovations in bone tissue engineering have introduced biomaterials that generate oxygen to substitute vasculature. This study demonstrates a novel oxygen-generating tissue scaffold with predictable oxygen release kinetics and modular material properties. The scaffolds showed consistent tissue viability, metabolic activity, and osteogenic differentiation in both in vitro and in vivo experiments.
BIOACTIVE MATERIALS
(2022)
Article
Cell & Tissue Engineering
Bart van Oirschot, Antonios G. Mikos, Qian Liu, Jeroen J. J. P. van den Beucken, John A. Jansen
Summary: The aim of this preclinical study was to test the applicability of CPC-PLGA-CMC as a bone substitute material for GBR procedures. The study showed that CPC-PLGA-CMC can be used as a bone-grafting material and stimulates bone regeneration to a comparable extent as with BioOss particles. Importantly, CPC-PLGA-CMC degrades faster compared to BioOss, is easier to apply into a bone defect, and does not need the use of an additional GBR membrane.
TISSUE ENGINEERING PART A
(2023)
Article
Materials Science, Multidisciplinary
Zhiming Zhang, Zijie Rong, Guofeng Wu, Yihan Wang, Zhiwen Tan, Juan Zheng, Yanglei Jin, Zhihao Liang, Chun Liu, Jiasong Guo, Lixin Zhu
Summary: The study introduced a controlled-oxygen-generating composite scaffold to enhance seed cell survival and improve bone defect reconstruction.
APPLIED MATERIALS TODAY
(2021)
Review
Engineering, Multidisciplinary
Muhammad Aqib, Aneela Anwar, Humayun Ajaz, Samina Akbar, Ahsan Manzoor, Maham Abid, Zohaib Waheed, Qudsia Kanwal
Summary: In recent years, calcium phosphate cement has been widely used in biomedical applications due to its excellent biocompatibility, bioactivity, self-setting qualities, minimal setting degree, suitable toughness, and versatility in shape. Brushite, a type of calcium phosphate, is particularly attractive for bone repair and can also potentially serve as a drug delivery device. The addition of metal ions, such as magnesium, zinc, and strontium, into the calcium phosphate structure has become a major research focus. This paper provides a comprehensive analysis of the advancements and prospects of metal-doped brushite cement, including its impact on physical and chemical properties, as well as its potential applications in regenerative medicine.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Veterinary Sciences
Ahmed Abdelrahiem Sadek, Mahmoud Abd-Elkareem, Hani Nasser Abdelhamid, Samia Moustafa, Kamal Hussein
Summary: The UiO-66 nanomaterial demonstrates excellent cytocompatibility and stimulates osteoblast functions, indicating its potential as a biomaterial for bone tissue engineering. In vivo experiments show enhanced osteogenesis and healing of bone defects, making UiO-66 a promising candidate for bone repair.
BMC VETERINARY RESEARCH
(2022)
Article
Materials Science, Ceramics
Zilgma Irbe, Dagnija Loca
Summary: Premixed calcium phosphate cement pastes have been proposed as biomaterials for bone tissue repair and regeneration, with alpha-Tricalcium phosphate (alpha-TCP) based cements setting to form calcium deficient hydroxyapatite. The use of mixture of basic and acidic potassium phosphate salts showed the best overall results in terms of cohesion, pH value, hydrolysis, and compressive strength of the cement.
CERAMICS INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mohamed Abdelrasoul, Ahmed Abd El-Fattah, Gehan Kotry, Omneya Ramadan, Marwa Essawy, Jahangir Kamaldin, Sherif Kandil
Summary: This study evaluated the effectiveness of a novel biodegradable bioactive hydrogel template loaded with melatonin in periodontal regenerative therapy. The results showed that the melatonin-loaded template accelerated bone formation and improved its quality, leading to complete periodontal regeneration.
Article
Orthopedics
Jacob T. Landeck, William R. Walsh, Rema A. Oliver, Tian Wang, Mallory R. Gordon, Edward Ahn, Colin D. White
Summary: An injectable calcium phosphate-based bone void filler containing hyaluronic acid was formulated for prolonged working time during injection into difficult-to-access bony defects. The material demonstrated biocompatibility and osteoconductivity in vivo, with new bone formation and normal bone architecture observed up to 26 weeks. The findings suggest that this material is suitable for minimally invasive percutaneous delivery applications.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Materials Science, Ceramics
Ziyu Wang, Qinghui Li, Shangxuan Ren, Hengshuo Zhang, Jie Chen, Aimin Li, Yunzhen Chen
Summary: In this study, Monetite (MC) was combined with amorphous calcium phosphate (ACP) at different ratios to form new types of bone cements. The results showed that MC75 (75% MC and 25% ACP) had better biocompatibility and osteogenic induction ability, and it met the clinical application requirements, making it a promising bone cement for repairing bone defects.
CERAMICS INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yujia Yan, JingLin Li, Hualing Zhu, Jun Liu, Jiayin Ren, Ling Zou
Summary: The study evaluated the root anatomy, canal morphology, and relationship between roots and maxillary sinus of maxillary second premolars in a western Chinese population using CBCT. Single-rooted teeth were prevalent, with most having Type I or Type II canal morphology. The distance from root tip to maxillary sinus floor increased with age.
Letter
Dentistry, Oral Surgery & Medicine
Kai Xia, Liyuan Yu, Jun Liu
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2021)
Article
Cell & Tissue Engineering
Jingjing Shao, Shibo Liu, Min Zhang, Shujiang Chen, Shuaiqi Gan, Chenfeng Chen, Wenchuan Chen, Lei Li, Zhimin Zhu
Summary: This study aimed to investigate the role of HIF1 alpha in aged bone and its regulation of osteogenesis and angiogenesis. The results showed that HIF1 alpha exhibited different effects in aged bone and may be associated with the ROS-mediated HIF1 alpha-p53 relationship.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Orthopedics
Shizhou Wu, Michael D. Weir, Lei Lei, Jun Liu, Hockin H. K. Xu
Summary: An injectable CPC-chitosan paste containing graphene oxide was developed for promising endodontic therapy, showing excellent antibacterial effects against E. faecalis biofilms and strong support for human dental pulp stem cells. The study results indicate a great potential for this paste in root canal treatment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Cell & Tissue Engineering
Kai Xia, Li-Yuan Yu, Xin-Qi Huang, Zhi-He Zhao, Jun Liu
Summary: This review summarizes the role of long noncoding RNAs (lncRNAs) in the osteo-/adipogenic differentiation of mesenchymal stromal cells (MSCs) and the pathogenesis of degenerative bone diseases. It highlights the potential of lncRNAs as diagnostic and therapeutic targets for bone diseases.
WORLD JOURNAL OF STEM CELLS
(2022)
Article
Biotechnology & Applied Microbiology
Xiao Zheng, Shuaiqi Gan, Cheng Su, Zheng Zheng, Yihan Liao, Jingjing Shao, Zhimin Zhu, Wenchuan Chen
Summary: This study investigated the expression and function of lncRNAs in hUCMSC osteogenic differentiation. A total of 343 differentially expressed lncRNAs were identified. Bioinformatic analysis showed their involvement in intracellular function and phosphatidylinositol signaling system pathway. The impact of lncRNA H19 on osteogenic differentiation was validated through the construction of competing endogenous RNA networks.
Article
Engineering, Biomedical
Christopher J. Panebianco, Sanjna Rao, Warren W. Hom, James H. Meyers, Tiffany Y. Lim, Damien M. Laudier, Andrew C. Hecht, Michael D. Weir, Jennifer R. Weiser, James C. Iatridis
Summary: This study developed an injectable composite biomaterial using degradable oxidized alginate microbeads for delivering annulus fibrosus cells to injured intervertebral discs. The composite material achieved a balance between biomechanical and biological demands, providing promising results for cell delivery and repair.
Article
Dentistry, Oral Surgery & Medicine
Rashed AlSahafi, Heba Mitwalli, Abdullah Alhussein, Mary Anne S. Melo, Frederico Martinho, Christopher D. Lynch, Thomas W. Oates, Hockin H. K. Xu, Michael D. Weir
Summary: This study investigated the efficacy of a novel resin cement containing DMAHDM and NACP in inhibiting saliva microcosm biofilm. The results showed that the cement exhibited strong antibacterial action and continuous ion release, indicating its potential for remineralization.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Liyuan Yu, Kai Xia, Jing Zhou, Zhiai Hu, Xing Yin, Chenchen Zhou, Shujuan Zou, Jun Liu
Summary: The circRNA circ_0003204 is found to regulate osteogenic differentiation of human adipose-derived stem cells (hASCs) through the miR-370-3p/HDAC4 axis, playing an important role in bone defect repair.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hanan Filemban, Ghalia Bhadila, Xiaohong Wang, Mary Ann S. Melo, Thomas W. Oates, Gary D. Hack, Christopher D. Lynch, Michael D. Weir, Jirun Sun, Hockin H. K. Xu
Summary: This study developed a bioactive low-shrinkage-stress composite with antibacterial and remineralizing properties. After thermal cycling, the composite demonstrated good mechanical properties and maintained its strong antibacterial activity. This material shows great potential in inhibiting recurrent caries and increasing restoration longevity.
JOURNAL OF DENTISTRY
(2022)
Article
Cell & Tissue Engineering
Yifan Wang, Guanyin Zhu, Fang Pei, Yigan Wang, Jun Liu, Caixia Lu, Zhihe Zhao
Summary: Using RNA-seq, this study investigated the differential expression of miRNAs in dental, periodontal, and alveolar bone tissue of orthodontic tree shrews under tension. The results showed that miR-149 could modulate osteoblast differentiation under orthodontic mechanical tension through targeting ASAP3.
STEM CELLS INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Zheng Zheng, Yanjin He, Li Long, Shuaiqi Gan, Shujiang Chen, Min Zhang, Jia Xu, Ruijie Fu, Yihan Liao, Zhimin Zhu, Hang Wang, Wenchuan Chen
Summary: Non-thermal atmospheric plasma (NTAP) modification of hydrophilic titanium surfaces has been shown to enhance osteogenic responses. This study investigated the role of PI3K/Akt signaling pathway in regulating osteogenic activities on NTAP-treated titanium surfaces. The results demonstrated that the PI3K/Akt pathway is involved in the amelioration of osteogenesis induced by NTAP modification.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Wen Zhou, Hong Chen, Michael D. Weir, Thomas W. Oates, Xuedong Zhou, Suping Wang, Lei Cheng, Hockin H. K. Xu
Summary: This review provides an overview of cutting-edge research on the development of new bioactive restorations to inhibit secondary caries in enamel and dentin under biofilms. Novel bioactive materials are categorized based on their remineralization and antibacterial biofunctions. However, there is still a need for new intelligent and pH-responsive materials, and the evaluation should be performed using more clinically relevant biofilm-based secondary caries models.
JOURNAL OF DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ghalia Y. Bhadila, Bashayer H. Baras, Abdulrahman A. Balhaddad, Mary Ann Williams, Thomas W. Oates, Michael D. Weir, Hockin H. K. Xu
Summary: This study reviewed different recurrent caries models used to evaluate restorative materials and compared their methodology and parameters. Specific recommendations for future investigations were also provided.
JOURNAL OF DENTISTRY
(2023)
Article
Materials Science, Biomaterials
Shizhou Wu, Lei Lei, Chongyun Bao, Jin Liu, Michael D. Weir, Ke Ren, Abraham Schneider, Thomas W. Oates, Jun Liu, Hockin H. K. Xu
Summary: The study developed an antibacterial CPC-chitosan-penicillin-alginate microbead scaffold with strong antibacterial effects on S. aureus. This scaffold demonstrated good biocompatibility, supported stem cell viability, and had injectability and good strength for osteogenesis.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.