Article
Nanoscience & Nanotechnology
Hyerim Kim, Yunji Joo, Yun-Min Kook, Na Ly Tran, Sang-Heon Kim, Kangwon Lee, Seung Ja Oh
Summary: This study developed an inflammation-responsive hydrogel that can control drug release based on the state of inflammation. By modulating epigenetics, it effectively treats disease dynamics in wound healing and improves therapeutic outcomes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Pardis Pakshir, Fereshteh Younesi, Kelli-Anne Wootton, Kyle Battiston, Greg Whitton, Bernadette Ilagan, Dimitra Louka, Matthew Statham, Gillian Mackey, Adam Daley, Ian Parrag, Wendy Naimark, Boris Hinz
Summary: The researchers successfully suppressed foreign body reactions and fibrotic encapsulation using a thin coating strategy with novel low molecular weight corticosteroid dimers, achieving long-term stability of implanted medical materials. The coatings demonstrated a slow and sustained release profile of dexamethasone in a rat subcutaneous implantation model.
Article
Engineering, Mechanical
Xinxing Li, Hongxia Wang, Jianfeng Shi, Boqun Han, Naifei Ren
Summary: Dry sliding wear tests were conducted on TC11 alloy under different sliding velocities, revealing the formation of tribo-layers on the wear surfaces at different speeds. The formation of these layers depended on factors such as wear debris generation, movement, aggregation, transfer, and tribo-chemistry. Conditions favorable for the formation of tribo-oxide layers included small wear debris and relatively high contact surface temperature, which effectively protected the titanium alloy matrix and reduced wear. The protective effect of the tribo-oxide layer on the matrix improved with a higher content of oxides.
SURFACE TOPOGRAPHY-METROLOGY AND PROPERTIES
(2021)
Article
Chemistry, Multidisciplinary
Shuaidong Huo, Zhihuan Liao, Pengkun Zhao, Yu Zhou, Robert Goestl, Andreas Herrmann
Summary: Mechanochemistry-based strategies provide new avenues to improve drug selectivity and overcome side effects and drug resistance. In this study, a mechano-responsive nanoswitch was constructed for the selective activation of drugs to inhibit cancer cell proliferation.
Article
Materials Science, Coatings & Films
Chi-Wai Chan, James Quinn, Issam Hussain, Louise Carson, Graham C. Smith, Seunghwan Lee
Summary: The study applied fibre laser nitriding in open air to improve wear resistance of Ti6A14V alloy, reducing wear debris generation. By modulating the nitriding process between pulsed and CW modes, crack-free and homogenous laser-nitrided surfaces were created. Experimental findings showed significantly improved wear resistance and reduced wear debris generation with nano-sized wear particles showing less toxicity and antimicrobial properties.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Chemistry, Physical
Pablo Lozano, Marta Pena, Mariano Herrero-Climent, Jose Vicente Rios-Santos, Blanca Rios-Carrasco, Aritza Brizuela, Javier Gil
Summary: This study investigated the removal of bacterial biofilm on dental implants using implantoplasty and analyzed the stress, corrosion resistance, and titanium ion release of different materials. The results showed that debris had the poorest corrosion resistance and released the highest amount of titanium ions, with observed pitting in the physiological environment.
Article
Engineering, Mechanical
Song Zhao, Fanyue Meng, Bingli Fan, Yu Dong, Jibo Wang, Xiaowen Qi
Summary: This research investigates the wear mechanism of TC4 titanium alloys in self-lubricating spherical plain bearings, revealing that the main wear forms are a combination of abrasive wear and adhesive wear. The accumulated debris generated during the friction process is the main cause of surface damage to the titanium alloys.
Article
Engineering, Mechanical
Jianfei Wang, Weihai Xue, Siyang Gao, Shu Li, Deli Duan
Summary: Surface textures with different orientations on Ti-6Al-4V alloys affect fretting wear behavior, leading to variations in COF curves and system deformation. Groove spacing influences wear debris formation and movement during fretting tests, providing potential for new tribology design for fretting friction pairs.
Review
Pharmacology & Pharmacy
Ilker S. Bayer
Summary: Polysaccharides are complex molecules with exceptional properties and can be chemically modified. They have increased application in drug encapsulation and release in nanoscale synthesis due to their biocompatibility and biodegradability. This review focuses on studying sustained drug release from nanoscale polysaccharides, particularly drug release kinetics and mathematical modeling. It highlights the importance of modeling in predicting the behavior of specific polysaccharide matrices and reducing experimental trial and error.
Review
Nanoscience & Nanotechnology
Tiantian Liang, Rongtao Zhang, Xianbin Liu, Qian Ding, Siqiong Wu, Chunhong Li, Yan Lin, Yun Ye, Zhirong Zhong, Meiling Zhou
Summary: Macrophages play a crucial role in drug delivery systems, prolonging drug circulation and release, enhancing stability and targeting ability. However, further research and optimization are needed for their potential applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Medicine, Research & Experimental
Giovanna Pepe, Chiara Sfogliarini, Loris Rizzello, Giuseppe Battaglia, Christian Pinna, Gianenrico Rovati, Paolo Ciana, Electra Brunialti, Federica Mornata, Adriana Maggi, Massimo Locati, Elisabetta Vegeto
Summary: The research found that tamoxifen and its active metabolite have estrogen antagonist effects and regulate immune activation genes, while also enhancing cell phagocytosis and modifying the expression of inflammatory cytokines. These effects may be mediated through different mechanisms within the cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Oishani Chaterjee, Debjeet Sur
Summary: Macrophages are mature form of monocytes that can shift from one phenotype to another through the process of macrophage polarization. Different phenotypes of macrophages have different functions with M1 macrophages being responsible for immune responses and M2 macrophages having healing properties. Maintaining macrophage homeostasis is important to avoid tissue damage and ensure proper wound healing and angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yunshan Zhang, Tuo Huang, Wanwan Lv, Kai Yang, Cuiling Ouyang, Minxin Deng, Rongyuan Yi, Hui Chu, Jian Chen
Summary: In this study, TiO2 nanotubes of different sizes were grown using anodization method and their drug loading and release profile as well as antitumor efficiency were investigated. The larger TiO2 nanotubes showed improved drug-loading capacity and cell-killing ability compared to smaller ones. These findings suggest that larger TiO2 nanotubes have potential as therapeutic carriers for improved cancer treatment outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Liza L. Ramenzoni, Laura B. Flueckiger, Thomas Attin, Patrick R. Schmidlin
Summary: This study found that exposure to higher concentrations of titanium and zirconia particles under sterile lipopolysaccharide (LPS) inflammation significantly increased cytotoxicity. Macrophages exposed to TiO2 particles showed up to approximately 3.5-fold higher upregulation than ZrO2 from 12 to 48 hours, but pro-inflammatory gene expression induced by both TiO2 and ZrO2 particles was further enhanced when exposed to LPS.
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Article
Surgery
Ramin Fallahzadeh, Franck Verdonk, Ed Ganio, Anthony Culos, Natalie Stanley, Ivana Maric, Alan L. Chang, Martin Becker, Thanaphong Phongpreecha, Maria Xenochristou, Davide De Francesco, Camilo Espinosa, Xiaoxiao Gao, Amy Tsai, Pervez Sultan, Martha Tingle, Derek F. Amanatullah, James Huddleston, Stuart B. Goodman, Brice Gaudilliere, Martin S. Angst, Nima Aghaeepour
Summary: By combining high-fidelity accelerometry and advanced immune profiling, it is possible to accurately track individualized physical recovery trajectories in patients after surgery and link them to preoperative immune status.
Article
Orthopedics
Kevin Lawson, Katherine L. Hwang, Spencer Montgomery, Derek F. Amanatullah, James I. Huddleston, William J. Maloney, Stuart B. Goodman
Summary: The modified Wagner Cone demonstrates excellent clinical outcomes in patients with challenging proximal femoral anatomy. Subsidence is minor, stops by 3 months, and does not compromise clinical outcome.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Mathew J. Whittaker, Prerna Arora, James I. Huddleston III, Stuart B. Goodman, William J. Maloney, Derek F. Amanatullah
Summary: It is unclear if extended trochanteric osteotomy (ETO) is effective in the setting of periprosthetic joint infection (PJI). Concerns exist regarding persistent infection with cerclage fixation, but limited evidence supports this theory. The study found no significant differences in operative time, blood loss, rate of repeat revision surgery, or postoperative complications between retaining or exchanging cerclage fixation in PJI patients. ETO remains a powerful tool for femoral component revision even in the presence of PJI.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Rosa S. Valtanen, Katherine L. Hwang, Derek F. Amanatullah, James I. Huddleston, William J. Maloney, Stuart B. Goodman
Summary: This study retrospectively analyzed long-term follow-up data of patients who underwent revision total hip arthroplasty (THA) using a cementless modular stem. The results demonstrated long-term clinical success and safety of the cementless modular revision stem for complex revision operations.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Engineering, Biomedical
Masanori Tsubosaka, Masahiro Maruyama, Elaine Lui, Seyedsina Moeinzadeh, Elijah Ejun Huang, Junichi Kushioka, Hirohito Hirata, Charu Jain, Hunter W. W. Storaci, Calvin Chan, Masakazu Toya, Qi Gao, Victoria Teissier, Huaishuang Shen, Xueping Li, Ning Zhang, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. B. Goodman, Yunzhi Peter Yang
Summary: Core decompression with genetically modified MSCs or pMSCs combined with a three-dimensional printed FGS improves steroid-induced osteonecrosis in rabbits. The FGS delivers cells to a specific location and improves bone volume and osteoclastogenesis. However, the combined effect of GM MSCs or pMSCs and the FGS was not superior to the effect of each alone.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Orthopedics
Jason R. Saleh, Allison Mitchell, Stephanie T. Kha, Rachel Outterson, Aiden Choi, Lamara Allen, Tony Chang, Amy L. Ladd, Stuart B. Goodman, Paige Fox, Loretta Chou
Summary: There are increasing opportunities in orthopaedic surgery to address climate change and promote sustainability. Orthopaedic surgeons can play an active role in reducing environmental impact in areas such as operating-room waste, carbon emissions, anesthetic gases, and water usage. Further studies are needed to quantify and decrease the environmental impact and promote sustainable resource use.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Materials Science, Biomaterials
Chima V. Maduka, Mohammed Alhaj, Evran Ural, Maxwell M. Kuhnert, Oluwatosin M. Habeeb, Anthony L. Schilmiller, Kurt D. Hankenson, Stuart B. Goodman, Ramani Narayan, Christopher H. Contag
Summary: The stereochemistry of polylactide (PLA) affects its thermal and physicochemical properties, including degradation profiles. However, the role of PLA stereochemistry and its immune responses in vivo and in vitro remains unclear. In this study, a bioenergetic model was used to investigate the immune cellular responses to different PLA stereochemistries. The findings provide mechanistic explanations for the diverse immune responses to PLA and emphasize the importance of immunometabolism in the biocompatibility of biomaterials used in medicine.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemical Research Methods
Malachia Y. Hoover, Thomas H. Ambrosi, Holly M. Steininger, Lauren S. Koepke, Yuting Wang, Liming Zhao, Matthew P. Murphy, Alina A. Alam, Elizabeth J. Arouge, M. Gohazrua K. Butler, Eri Takematsu, Suzan P. Stavitsky, Serena Hu, Debashis Sahoo, Rahul Sinha, Maurizio Morri, Norma Neff, Julius Bishop, Michael Gardner, Stuart Goodman, Michael Longaker, Charles K. F. Chan
Summary: A refined flow cytometric approach has been developed to isolate purified human skeletal stem cells (hSSCs) and establish functional assays that accurately recapitulate their physiological behavior within the skeleton.
Review
Materials Science, Multidisciplinary
Amit Bandyopadhyay, Indranath Mitra, Stuart B. Goodman, Mukesh Kumar, Susmita Bose
Summary: The increasing demand for joint replacement surgeries, musculoskeletal repairs, and orthodontics worldwide drives the need for evolving technologies in healthcare. Although metallic orthopaedic materials have a shared application history with the aerospace industry, their suitability in bone tissue replacements and regenerative therapies remains unchallenged due to their superior mechanical properties. However, improvement in biocompatibility is crucial for the development of the next generation of metallic biomaterials.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Cell & Tissue Engineering
Victoria Teissier, Qi Gao, Huaishuang Shen, Jiannan Li, Xueping Li, Elijah Ejun Huang, Junichi Kushioka, Masakazu Toya, Masanori Tsubosaka, Hirohito Hirata, Hossein Vahid Alizadeh, Chima V. Maduka, Christopher H. Contag, Yunzhi Peter Yang, Ning Zhang, Stuart B. Goodman
Summary: This study investigated the effect of interactions between MSCs and macrophages on acute and chronic inflammation caused by contaminated polyethylene particles. It was found that exposure to polyethylene particles impaired mitochondrial metabolism and induced glycolytic reprogramming in MSCs, but the presence of macrophages helped restore mitochondrial function.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Surgery
Henry C. Cousins, Eli M. Cahan, Joshua T. Steere, William J. Maloney, Stuart B. Goodman, Matthew D. Miller, James I. Huddleston, Derek F. Amanatullah
Summary: Surgical team communication is crucial for operative efficiency, and factors such as team turnover and surgeon-staff preferences play a significant role. This retrospective analysis of total joint arthroplasties found that turnover among nonsurgical staff was associated with longer operative duration, while the presence of surgeon-preferred staff improved efficiency.
Article
Materials Science, Biomaterials
Chima Maduka, Oluwatosin M. Habeeb, Maxwell M. Kuhnert, Maxwell Hakun, Stuart B. Goodman, Christopher H. Contag
Summary: Total joint arthroplasties (TJAs) are effective in treating end-stage arthritis, but the challenge is to ensure their long-term viability. Altering immune cell metabolism can reduce inflammation and enhance the integration of artificial joints with bone, preventing loosening.
BIOMATERIALS ADVANCES
(2023)
Article
Medicine, Research & Experimental
Vidyani Suryadevara, Mohammad Javad Hajipour, Lisa C. Adams, Nour Mary Aissaoui, Ali Rashidi, Louise Kiru, Ashok J. Theruvath, Ching-Hsin Huang, Masahiro Maruyama, Masanori Tsubosaka, Jennifer K. Lyons, Wei (Emma) Wu, Raheleh Roudi, Stuart B. Goodman, Heike E. Daldrup-Link
Summary: This study developed an efficient labeling method for MSCs using MegaPro nanoparticles, which showed better effectiveness in tracking MSCs compared to ferumoxytol nanoparticles. MegaPro-labeled MSCs demonstrated enhanced MRI tracking without affecting cell viability or differentiation.
Article
Orthopedics
Cory Knecht, Landon Polakof, Jonathan Behrens, Stuart B. Goodman
Summary: Metal-on-metal hip arthroplasty was widely used in the 1990s and early 2000s. Although it had lower wear rate compared to polyethylene, metal ion particles were found to be smaller and more abundant. Research shows the relationship between these articulations and adverse local tissue reactions.
Article
Biochemistry & Molecular Biology
Issei Shinohara, Masanori Tsubosaka, Masakazu Toya, Max L. Lee, Junichi Kushioka, Masatoshi Murayama, Qi Gao, Xueping Li, Ning Zhang, Simon Kwoon-Ho Chow, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman
Summary: Local cell therapy using mesenchymal stem cells (MSCs) has gained attention for treating joint diseases and fractures. This study investigated the utility of C-C motif chemokine ligand 2 (CCL2) as a therapeutic target for this therapy. The results showed that overexpression of CCL2 promoted macrophage chemotaxis and osteogenesis, as well as angiogenesis, through crosstalk between MSCs and macrophages. These findings suggest that CCL2 may be a useful target for local cell therapy in areas of bone loss.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.