Article
Pharmacology & Pharmacy
Fu Guangtao, Wen Zhenkang, Deng Zhantao, Li Mengyuan, Li Qingtian, Ma Yuanchen, Chen Yuanfeng, Zheng Qiujian
Summary: The study suggests that icariin attenuates wear particle-induced inflammation and osteolysis by down-regulating the ERα-mediated NF-kappa B signaling pathway in macrophages.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Zhaoyang Yin, Ge Gong, Xinhui Liu, Jian Yin
Summary: Joint replacement surgery is the most effective treatment for end-stage arthritis, but aseptic loosening caused by periprosthetic osteolysis is a common complication. Inflammation induced by wear particles and its effect on macrophages/osteoclasts play a key role in this process. Researchers have developed intervention approaches to regulate macrophage/osteoclast activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Halldor Bergvinsson, Vasilis Zampelis, Martin Sundberg, Jon Tjornstrand, Gunnar Flivik
Summary: This study compared the wear characteristics and clinical outcomes of vitamin E infused highly cross-linked polyethylene cups with regular ultra-high molecular weight polyethylene cups. The results showed reduced wear and good clinical outcomes in the vitamin E infused cups up to 5 years.
Article
Cell Biology
Hao Chai, Zai Hang Zhang, Jing Yi Fang, Chang She, De Chun Geng, Wei Xu
Summary: This study investigated the effects of titanium particles on MLO-Y4 osteocytic cells and their impact on osteoblastic cells. The results showed that titanium particles increased osteocytic marker expression, apoptosis, and the expression of inflammatory factors. The particles also inhibited the differentiation of osteoblastic cells through direct cell-to-cell contact. Silencing of SOST/sclerostin attenuated these effects. These findings highlight the extensive impact of titanium particles on osteocytic cells and the importance of SOST/sclerostin in cell interaction.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
John Patrick Connors, John W. W. Stelzer, Patrick M. M. Garvin, Ian J. J. Wellington, Olga Solovyova
Summary: Periprosthetic osteolysis is a common complication of joint replacement surgery, caused by wear-induced particulate debris. Advances in understanding the mechanism of osteolysis and developing strategies for prevention and treatment are being made. Therapeutic agents targeting proinflammatory mediators have shown promise, but the delay in diagnosis and treatment remains challenging.
BIOENGINEERING-BASEL
(2022)
Article
Orthopedics
Ramakanth R. Yakkanti, Justin L. Ocksrider, Anand A. Patel, Matthew P. Kolevar, Rebecca D. Moore, Clare M. Rimnac, Matthew J. Kraay, Timothy M. Wright, Elexis C. Baral, Raymond P. Robinson
Summary: This study identified excessive wear and a potential risk of osteolysis associated with a uniquely designed moderately cross-linked polyethylene liner used in total hip arthroplasty.
JOURNAL OF ARTHROPLASTY
(2022)
Review
Orthopedics
Byung-Ho Yoon, Jung -Wee Park, Young-Kyun Lee, Kyung-Hoi Koo, Chong Bum Chang
Summary: This systematic meta-analysis compares the long-term efficacy of highly cross-linked polyethylene (HXLPE) and conventional polyethylene (CPE) in preventing radiological osteolysis and revision surgery. The results demonstrate that HXLPE dramatically reduces the rate of osteolysis and wear-related revision surgery.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Biochemistry & Molecular Biology
Supriya Jagga, Ashish Ranjan Sharma, Yeon Hee Lee, Ju-Suk Nam, Sang-Soo Lee
Summary: The study found that Ti particles can activate the NF kappa B signaling pathway and induce COX-2 and inflammatory cytokines in FLSs, ultimately promoting osteoclast formation. Additionally, conditioned medium collected from Ti particle-stimulated FLSs contains factors that can suppress markers of osteogenesis in osteoprogenitors, affecting the WNT and BMP signaling pathways and hindering osteoblastic activity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Orthopedics
Richard S. Page, Angela C. Alder-Price, Sophia Rainbird, Stephen E. Graves, Richard N. de Steiger, Yi Peng, Carl Holder, Michelle F. Lorimer, Stephen D. Gill
Summary: This study compared the revision rates of primary stemmed anatomic total shoulder arthroplasty using crosslinked polyethylene (XLPE) and non-XLPE. The results showed that non-XLPE had a higher risk of revision than XLPE, particularly for larger head sizes. The study suggests that the type of polyethylene is an important determinant of revision risk in shoulder arthroplasty.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Article
Cell Biology
Jun Ren, Yonghong Tao, Meixi Peng, Qiaoling Xiao, Yipei Jing, Junpeng Huang, Jing Yang, Can Lin, Minghui Sun, Li Lei, Zesong Yang, Zailin Yang, Ling Zhang
Summary: Activation of GPER in combination with VEN could synergistically enhance the anti-leukemic activity, providing a potential therapeutic regimen for AML.
CELL DEATH & DISEASE
(2022)
Review
Orthopedics
Hannah Prock-Gibbs, Cyrus Anthony Pumilia, Teerin Meckmongkol, John Lovejoy, Aadil Mumith, Melanie Coathup
Summary: The study compared the incidence of osteolysis, aseptic loosening, and revision following the use of HXLPE or CPE in medium to long-term follow-up in primary THA. Results showed that HXLPE liners reduced the incidence of these complications compared to CPE, regardless of age and implant fixation method.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Cell Biology
Daniela Nahmias Blank, Esther Hermano, Amir Sonnenblick, Ofra Maimon, Ariel M. Rubinstein, Emmy Drai, Bella Maly, Israel Vlodavsky, Aron Popovtzer, Tamar Peretz, Amichay Meirovitz, Michael Elkin
Summary: Breast cancer and obesity are two conditions that have a significant impact on health. Obesity is a significant risk factor for estrogen receptor positive breast cancer. This study found that macrophages in the obesity-associated breast cancer microenvironment can increase the expression of estrogen receptors in tumor cells, potentially influencing hormone-related cancer progression and therapy resistance.
Article
Engineering, Biomedical
Christina Polan, Christina Brenner, Monika Herten, Gero Hilken, Florian Grabellus, Heinz-Lothar Meyer, Manuel Burggraf, Marcel Dudda, Willi Jahnen-Dechent, Christian Wedemeyer, Max Daniel Kauther
Summary: Particle-induced osteolysis is a major cause of prosthetic loosening. In this study, the influence of fetuin-A on particle-induced osteolysis was investigated using fetuin-A-deficient mice. The results showed that fetuin-A deficiency led to increased bone resorption, eroded surface areas, and osteoclast numbers. Fetuin-A deficiency also caused changes in bone metabolism parameters. These findings suggest that fetuin-A deficiency may be a risk factor for particle-induced osteolysis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Fenna Brunken, Tristan Senft, Maria Herbster, Borna Relja, Jessica Bertrand, Christoph H. Lohmann
Summary: Aseptic loosening is mainly caused by wear particles induced inflammatory response and subsequent bone loss. This study investigated the activation of the NLRP3 inflammasome by different metal particles in in vitro and in vivo conditions. The results showed that CoCrMo particles induced more inflammasome formation compared to TiAlV particles. Additionally, NRLP3 inflammasome activation was increased only by CoNiCrMo particles. These findings suggest that different alloys activate different inflammatory pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Mechanical
Annsley Mace, Jeremy L. Gilbert
Summary: The effects of potential, normal load, and cycles on volume abraded and fretting currents were studied for CoCrMo, Ti-6Al-4 V, and 316 L SS in a phosphate buffered saline solution. The tribocorroded regions were examined using microscopy and spectroscopy. Fretting currents were compared to the predictions of the Gilbert 2020 model. The currents varied as expected based on the alloy, potential, and load. The charge released decreased over time due to oxidation wear track, but it was linearly related to the volume removed. The average fretting corrosion currents during the initial 100 cycles indicated that only a small fraction (5-16%) of the wear volume was due to electrochemical processes, with the majority attributed to plastic deformation and metal wear particle generation. The highest currents occurred at the beginning and then steadily dropped to less than half of the initial value due to rapid filling of the oxide wear track.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Surgery
Ramin Fallahzadeh, Franck Verdonk, Ed Ganio, Anthony Culos, Natalie Stanley, Ivana Maric, Alan L. Chang, Martin Becker, Thanaphong Phongpreecha, Maria Xenochristou, Davide De Francesco, Camilo Espinosa, Xiaoxiao Gao, Amy Tsai, Pervez Sultan, Martha Tingle, Derek F. Amanatullah, James Huddleston, Stuart B. Goodman, Brice Gaudilliere, Martin S. Angst, Nima Aghaeepour
Summary: By combining high-fidelity accelerometry and advanced immune profiling, it is possible to accurately track individualized physical recovery trajectories in patients after surgery and link them to preoperative immune status.
Article
Orthopedics
Kevin Lawson, Katherine L. Hwang, Spencer Montgomery, Derek F. Amanatullah, James I. Huddleston, William J. Maloney, Stuart B. Goodman
Summary: The modified Wagner Cone demonstrates excellent clinical outcomes in patients with challenging proximal femoral anatomy. Subsidence is minor, stops by 3 months, and does not compromise clinical outcome.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Mathew J. Whittaker, Prerna Arora, James I. Huddleston III, Stuart B. Goodman, William J. Maloney, Derek F. Amanatullah
Summary: It is unclear if extended trochanteric osteotomy (ETO) is effective in the setting of periprosthetic joint infection (PJI). Concerns exist regarding persistent infection with cerclage fixation, but limited evidence supports this theory. The study found no significant differences in operative time, blood loss, rate of repeat revision surgery, or postoperative complications between retaining or exchanging cerclage fixation in PJI patients. ETO remains a powerful tool for femoral component revision even in the presence of PJI.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Rit Apinyankul, Katherine Hwang, Nicole Alexandriadria Segovia, Derek F. Amanatullah, James I. Huddleston, William J. Maloney, Stuart B. Goodman
Summary: Revision of both femoral and tibial components of a total knee arthroplasty (TKA) for aseptic loosening has favorable outcomes. Revision of only one loose component with retention of others has shorter operative time and lower cost; however, the implant survivorship and clinical outcomes of these different operations are unclear.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Junichi Kushioka, Masakazu Toya, Huaishuang Shen, Hirohito Hirata, Ning Zhang, Ejun Huang, Masanori Tsubosaka, Qi Gao, Victoria Teissier, Xueping Li, Takeshi Utsunomiya, Stuart B. Goodman
Summary: This study investigated the therapeutic effect of NF-kappa B decoy oligodeoxynucleotides (ODN), mesenchymal stem cells (MSCs), and genetically-modified NF-kappa B sensing interleukin-4 over-secreting MSCs (IL4-MSCs) on chronic inflammation in aged mice. The results demonstrated that MSCs and IL4-MSCs were effective in reducing osteoclast-like cells and increasing the M2/M1 ratio, with IL4-MSCs being more effective in mitigating inflammation. This study suggests potential therapeutic strategies for treating wear particle-associated inflammatory osteolysis after arthroplasty in the elderly.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Zhong Alan Li, Shilpa Sant, Sung Kwon Cho, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Michael S. Gold, Hang Lin
Summary: Synovial joint disorders like osteoarthritis and rheumatoid arthritis are common worldwide, but current clinical management does not fully restore joint function. Organ-on-chip (OoC) technology, which can culture multiple human cell-derived tissues/organs, shows potential in developing better therapies for joint diseases.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Orthopedics
Harsh N. Shah, Andrew A. Barrett, Andrea K. Finlay, Prerna Arora, Michael J. Bellino, Julius A. Bishop, Michael J. Gardner, Matthew D. Miller, James I. Huddleston, William J. Maloney, Stuart B. Goodman, Derek F. Amanatullah
Summary: The aim of this study was to compare the restoration of hip biomechanics between non-arthroplasty surgeons (NAS) and elective arthroplasty surgeons (EAS) through lateral offset, leg length, and acetabular component position. Retrospective review of 131 patients who underwent THA for femoral neck fracture by 7 EAS and 20 NAS was conducted. Results showed that NAS under-restored lateral femoral offset compared to the uninjured side, indicating a risk for under-restoration. However, there was no association found between surgeon type and other biomechanical factors. This study highlights the importance of considering lateral femoral offset in THA for femoral neck fractures, especially when performed by surgeons without regular experience in elective THA.
Article
Cell & Tissue Engineering
Victoria Teissier, Qi Gao, Huaishuang Shen, Jiannan Li, Xueping Li, Elijah Ejun Huang, Junichi Kushioka, Masakazu Toya, Masanori Tsubosaka, Hirohito Hirata, Hossein Vahid Alizadeh, Chima V. Maduka, Christopher H. Contag, Yunzhi Peter Yang, Ning Zhang, Stuart B. Goodman
Summary: This study investigated the effect of interactions between MSCs and macrophages on acute and chronic inflammation caused by contaminated polyethylene particles. It was found that exposure to polyethylene particles impaired mitochondrial metabolism and induced glycolytic reprogramming in MSCs, but the presence of macrophages helped restore mitochondrial function.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Surgery
Henry C. Cousins, Eli M. Cahan, Joshua T. Steere, William J. Maloney, Stuart B. Goodman, Matthew D. Miller, James I. Huddleston, Derek F. Amanatullah
Summary: Surgical team communication is crucial for operative efficiency, and factors such as team turnover and surgeon-staff preferences play a significant role. This retrospective analysis of total joint arthroplasties found that turnover among nonsurgical staff was associated with longer operative duration, while the presence of surgeon-preferred staff improved efficiency.
Article
Biochemistry & Molecular Biology
Meagan J. Makarczyk, Sophie Hines, Haruyo Yagi, Zhong Alan Li, Alyssa M. Aguglia, Justin Zbikowski, Anne-Marie Padget, Qi Gao, Bruce A. Bunnell, Stuart B. Goodman, Hang Lin
Summary: Osteoarthritis (OA) is a common joint disease that causes pain and disability. The miniJoint model, which mimics the nature of OA in humans, was used to explore the potential of co-treatment with anti-inflammation and chondroinducing agents. The study demonstrated that the combined treatment with BMP-7 and NF-kappa B ODNs reduced inflammation and promoted glycosaminoglycan formation in cartilage, indicating the potential for developing disease-modifying OA drugs.
Review
Engineering, Biomedical
Emmanuel Gibon, Yuya Takakubo, Stefan Zwingenberger, Jiri Gallo, Michiaki Takagi, Stuart B. Goodman
Summary: The use of biomaterials and implants in orthopedic indications has revolutionized patient care by decreasing pain and improving function. Chronic inflammation and the foreign body response have adverse effects on implant integration. Strategies to mitigate these responses can enhance implant longevity and improve pain relief and overall function.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Rheumatology
Akshay Pandey, Malachia Hoover, Mamta Singla, Yudhishtar Bedi, Hunter Storaci, Stuart B. Goodman, Charles Chan, Nidhi Bhutani
Summary: This study investigates how the DNA hydroxymethylase Tet1 regulates the function of adult skeletal stem cells (SSCs) in osteoarthritis (OA). It was found that loss of Tet1 expands the SSC pool and enhances their chondrogenic potential. Inhibiting Tet1 also enhances chondrogenesis in human SSCs and chondroprogenitors. Furthermore, the use of melatonin, a hormone, can mimic the inhibition ability of Tet1 and improve cartilage health.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Immunology
Xueping Li, Huaishuang Shen, Mao Zhang, Victoria Teissier, Ejun Elijah Huang, Qi Gao, Masanori Tsubosaka, Masakazu Toya, Junichi Kushioka, Chima V. Maduka, Christopher H. Contag, Simon Kwoon-Ho Chow, Ning Zhang, Stuart B. Goodman
Summary: This study revealed the dysfunctional bioenergetic activity of bone marrow-derived macrophages (Mφ) and mesenchymal stromal cells (MSCs) exposed to contaminated polyethylene particles (cPE), which may impair the immunoregulatory properties of cells in the bone niche. The underlying molecular defect related to disordered mitochondrial function could represent a potential therapeutic target during the resolution of inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Masakazu Toya, Ning Zhang, Masanori Tsubosaka, Junichi Kushioka, Qi Gao, Xueping Li, Simon Kwoon-Ho Chow, Stuart B. Goodman
Summary: Novel minimally invasive strategies are needed for bone healing in complex fractures and bone defects in the elderly. This study investigated the potential use of CCL2 as a therapeutic target for local cell therapy, as MSCs and macrophages play important roles in bone regeneration and inflammation. Acute stimulation with CCL2 was found to facilitate osteogenesis and macrophage migration in co-culture of MSCs and macrophages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuxi Sun, Tatiana Boyko, Owen Marecic, Danielle Struck, Randall K. Mann, Tom W. Andrew, Michael Lopez, Xinming Tong, Stuart B. Goodman, Fan Yang, Michael T. Longaker, Charles K. F. Chan, George P. Yang
Summary: Failure to form bone properly or integrate surgical implants can result in complications and additional interventions in orthopedic surgeries. The role of skeletal stem cells (SSCs) in bone formation is understood, but little is known about the regulation of Bone, Cartilage, Stromal, Progenitors (BCSPs). This study demonstrates that Del1 is a key regulator of BCSP expansion and its knockout leads to reduced bone formation. Del1 promotes BCSP proliferation and prevents apoptosis, making it a potential therapeutic target for improving bone formation and implant success.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.