Article
Polymer Science
Rong Li, Zhenfei Bao, Pei Wang, Yunyun Deng, Junping Fan, Xin Zhu, Xinyu Xia, Yiming Song, Haiyan Yao, Dongfang Li
Summary: In this study, a pH-responsive carbon nanotube-modified nano-drug delivery system (CNTs/Gel/Cp) was constructed to release cisplatin steadily and effectively. The system uses gelatin-modified carbon nanotubes (CNTs/Gel) to load cisplatin, preventing premature inactivation and maintaining a desirable concentration. The CNTs/Gel/Cp system exhibits antitumor properties comparable to cisplatin and provides a theoretical and experimental basis for the clinical application of modified carbon nanotubes as a new drug delivery system.
Article
Materials Science, Biomaterials
Qiaoying Wang, Changqiang Wu, Xiaoting Li, Dixiao Yang, Liangjun Shi
Summary: The study developed an effective drug delivery system using biocompatible polymer mPEG-PAsp for co-loading chemotherapy drugs PTX and CP, which demonstrated synergistic anti-tumor efficacy. The results suggested that mPEG-PAsp nano-micelles are promising alternatives for carrying and improving the delivery of therapeutic drugs with different water solubilities.
REGENERATIVE BIOMATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Joseph A. Stapleton, Eric M. Hofferber, Jakob Meier, Ivon Acosta Ramirez, Nicole M. Iverson
Summary: This work develops a platform for the immobilization of SWNT sensors with increased fluorescence yield, longevity, fluorescence distribution, and fast reaction times.
ACS APPLIED NANO MATERIALS
(2021)
Article
Environmental Sciences
Conrado M. S. Neto, Felipe C. Lima, Renata P. Morais, Lucas R. M. de Andrade, Renata de Lima, Marco V. Chaud, Matheus M. Pereira, Ricardo L. C. de Albuquerque Junior, Juliana C. Cardoso, Aleksandra Zielinska, Eliana B. Souto, alvaro S. Lima, Patricia Severino
Summary: In this study, Multi-Walled Carbon Nanotubes (MWCNT) were functionalized with rutin through three steps and then investigated for their physicochemical properties. The formation of rutin-functionalized MWCNT occurred through hydrogen bonds and exhibited a tubular shape in a three-dimensional structure. Mild cytotoxicity was observed in 3T3 fibroblasts, indicating a dose-effect relationship and the formation of aggregates of filamentous structures on the cells.
Review
Energy & Fuels
Jin-Myung Choi, Jiye Han, Tushar Rane, Soyeon Kim, Ick Soo Kim, Il Jeon
Summary: This review discusses the fundamentals of utilizing SWCNTs in PSCs, including their characteristics as electron-transporting layer, hole-transporting layer, photoactive layer, and interfacial materials. It also presents strategies to improve PSCs performance through defect control and enhancement of electrical and morphological properties.
JOURNAL OF PHYSICS-ENERGY
(2022)
Article
Chemistry, Physical
Mehdi Meran, Handan Emisoglu-Kulahli
Summary: This study used molecular dynamics simulations to investigate the encapsulation dynamics and interaction mechanisms of catechin derivatives within single-walled carbon nanotubes (SWNTs). The strength of the 7C-7C stacking interactions between catechin derivatives and SWNTs was assessed by analyzing the distance evolution between aromatic rings, mean square displacement (MSD), and diffusion coefficient (D) values. The results showed that the interaction strength varied depending on the specific derivative and concentration. The study provides insights into the interactions of catechin derivatives with SWNTs, enhancing our understanding of supermolecular structure development and enabling potential applications in drug delivery and biosensors.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Cecilia Espindola, Alejandro Javier Correa, Manuel Lopez-Lopez, Pilar Lopez-Cornejo, Eva Bernal, Jose Antonio Lebron, Francisco Jose Ostos, Mohammed Rafii-El-Idrissi Benhnia, Maria Luisa Moya
Summary: Research on flavonoids has grown significantly since their first therapeutic evidence in 1937. They have shown effective antioxidant activity in a wide range of human diseases. However, their applications have been limited due to their low solubility, poor absorption, and rapid metabolism. Encapsulating flavonoids in nanocarriers, such as carbon nanotubes, can improve their oral absorption and stability. This study investigated the encapsulation of 7-hydroxyflavone (7-HF) in different types of carbon nanotubes and studied its release at different pHs, simulating biological barriers.
Review
Chemistry, Multidisciplinary
Yu Han, Panyue Wen, Junjie Li, Kazunori Kataoka
Summary: Cisplatin is a successful chemotherapy drug, but its resistance and toxicity limit its clinical application. Targeted nanomedicine offers hope for maximizing efficacy and minimizing toxicity. This article reviews the recent progress and challenges in managing cisplatin resistance and toxicity and highlights future directions for development.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Maryam Zarghami Dehaghani, Farrokh Yousefi, S. Mohammad Sajadi, Muhammad Tajammal Munir, Otman Abida, Sajjad Habibzadeh, Amin Hamed Mashhadzadeh, Navid Rabiee, Ebrahim Mostafavi, Mohammad Reza Saeb
Summary: Chemotherapy is a common method for killing cancer cells, but faces barriers such as toxicity and side effects. Nano-based drug delivery systems, using nanotubes like CNT and BNNT, provide a promising solution. Theoretical analysis shows that BNNT provides more stable encapsulation for anti-cancer drugs, leading to potential advancements in drug delivery technology.
Review
Medicine, Research & Experimental
Lu Tang, Jing Li, Ting Pan, Yue Yin, Yijun Mei, Qiaqia Xiao, Ruotong Wang, Ziwei Yan, Wei Wang
Summary: Despite advancements in medicine, cancer remains a leading cause of death worldwide. Traditional treatment strategies often come with severe adverse effects and limited efficacy. Nanotechnology, particularly carbon nanomaterials, has shown great promise in cancer therapy due to their unique properties. Developing carbon-based nanoplatforms is critical for improving cancer theranostics. This review introduces the use of graphene, graphdiyne, fullerene, carbon nanotubes, and carbon quantum dots in cancer treatment, as well as their diagnostic potential.
Article
Chemistry, Multidisciplinary
Min-Ken Li, Adnan Riaz, Martina Wederhake, Karin Fink, Avishek Saha, Simone Dehm, Xiaowei He, Friedrich Schoeppler, Manfred M. Kappes, Han Htoon, Valentin N. Popov, Stephen K. Doom, Tobias Hertel, Frank Hennrich, Ralph Krupke
Summary: This work demonstrates that electroluminescence excitation is selective towards neutral defect-state configurations with the lowest transition energy, which, combined with gate control, leads to high spectral purity.
Article
Materials Science, Multidisciplinary
Gang Chen, Yuna Qian, Hang Zhang, Aftab Ullah, Xiaojun He, Zaigang Zhou, Hicham Fenniri, Jianliang Shen
Summary: Nanotechnologies offer potential solutions to the obstacles in cancer therapy, with hybrid nanomaterials showing great promise in a wide range of potential applications for cancer treatment. By combining the unique properties of different classes of nanomaterials, versatile new nanomaterials can be created to target and kill tumor tissues and cells synergistically.
APPLIED MATERIALS TODAY
(2021)
Article
Materials Science, Multidisciplinary
Karolina Z. Milowska, Maciej Krzywiecki, Mike C. Payne, Dawid Janas
Summary: Carbon nanomaterials such as graphene and carbon nanotubes have attracted significant interest due to their extraordinary properties, with the potential to play a key role in future applications. The sensitivity of carbon nanostructures to chemical stimuli allows for enhanced charge propagation capabilities, as seen in the impact of bromine addition on the electrical and thermoelectric properties of single-walled carbon nanotube films. Experimental results show a two orders of magnitude enhancement in thermoelectric capabilities through sonication-assisted introduction of Br2 into the SWCNT network, with computational analyses revealing the dopant's influence on electronic and charge transport properties.
MATERIALS & DESIGN
(2022)
Article
Pharmacology & Pharmacy
Bhavna Yadav, Mahima Chauhan, Saurabh Shekhar, Abhitinder Kumar, Abhishesh Kumar Mehata, Amit Kumar Nayak, Rohit Dutt, Vandana Garg, Vikas Kailashiya, Madaswamy S. Muthu, Sonali, Rahul Pratap Singh
Summary: Extensive research in pharmaceutical and biomedical fields confirms that lung cancer remains a highly fatal disease and the leading cause of death worldwide for both men and women. The limited potential for effective treatment using existing therapies underscores the urgent need for the development of precise and sustainable solutions to combat lung cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Alejandro Lopez-Moreno, Susana Ibanez, Sara Moreno-Da Silva, Luisa Ruiz-Gonzalez, Natalia Martin Sabanes, Eduardo Peris, Emilio M. Perez
Summary: Mechanically interlocked derivatives of carbon nanotubes (MINTs) are interesting and stable nanotube products. This study explores the encapsulation of single-walled carbon nanotubes within a palladium-based metallosquare, revealing the sensitivity of MINT formation to structural variations of the metallo-assemblies. The study also demonstrates the potential application expansion of MINTs through supramolecular coordination complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.