Article
Engineering, Biomedical
Tianshu Chu, Qingye Li, Chun Dai, Xiang Li, Xiang Kong, Yangming Fan, Hongyan Yin, Jianjun Ge
Summary: In this study, a drug-loaded nanocellulose-gelatin hydrogel extravascular stent was developed to prevent restenosis of vein grafts. The stent showed excellent biocompatibility and the ability to resist restenosis by activating autophagy.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Analytical
Antonio Rodriguez, Pablo Barroso, Alberto Olmo, Alberto Yufera
Summary: Assessing the viability of bioimpedance sensing to detect atheromatous plaque formation in implantable stents was the focus of this study. Simulations in COMSOL Multiphysics were performed using both non-pathological and pathological models, taking into account the flow of blood. The results showed that the proposed bioimpedance sensing system could successfully detect the presence of atheromatous plaque based on the measured current intensity in the electrodes. This simple algorithm approach eliminates the need for complex image reconstruction and computational processing.
Article
Biology
Kiran Manjunatha, Nicole Schaaps, Marek Behr, Felix Vogt, Stefanie Reese
Summary: The persistence of in-stent restenosis pathology calls for the development of accurate computational models. This study enhances an existing finite element framework by incorporating endothelial effects and pharmacological influences, allowing for optimization of drug-eluting stent implantation parameters. The model provides insights into the effectiveness of drug embedment and release profiles and can serve as a tool for clinicians to personalize interventional procedures.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Biomedical
Jingdong Rao, Xiaohui Mou, Yongyi Mo, Ho-Pan Bei, Li Wang, Chuyang Y. Tang, Kai-Hang Yiu, Zhilu Yang, Xin Zhao
Summary: Stenting is the primary treatment for vascular obstruction-related cardiovascular diseases, but it causes endothelial injury. The DA-Cu-Arg-Hep coating can effectively reconstruct the damaged endothelium and prevent thrombosis and restenosis.
Article
Public, Environmental & Occupational Health
En-bo Zhan, Hong-wei Du
Summary: With the improvement of people's quality of life, cardiovascular diseases have become the most common diseases. This study investigates the relationship between coronary artery disease and cardiovascular disease through the analysis of coronary heart disease, which helps evaluate the disease risk and provides the best prevention and treatment plan to overcome cardiovascular disease. Nanocomposite hydrogel, as a material for artificial cartilage repair, shows excellent application value and similarity to natural chondrocytes. The research demonstrates that nanocomposite hydrogel stent implantation is an effective and safe treatment for coronary heart disease.
PREVENTIVE MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Wansong Hu, Jun Jiang
Summary: This article describes the relationship between in-stent restenosis (ISR) and hypersensitivity reactions in patients with coronary heart disease (CHD) after percutaneous transluminal coronary intervention (PCI). With the emergence of drug-eluting stents (DES), the efficacy and prognosis of CHD patients have greatly improved, but the components of DESs can still induce hypersensitivity reactions and lead to long-term adverse cardiovascular events.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Jing Wang, Hong-Lin Qian, Sheng-Yu Chen, Wei-Pin Huang, Dan-Ni Huang, Hong-Ye Hao, Ke-Feng Ren, Yun-Bing Wang, Guo-Sheng Fu, Jian Ji
Summary: MicroRNAs have been identified as potent gene medicine for regulating endothelial cells and smooth muscle cells in response to vascular injury. In this study, a microRNA-eluting cardiovascular stent was developed using a self-healing encapsulation process based on an amphipathic triblock copolymer network, effectively inhibiting in-stent restenosis.
BIOACTIVE MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Prakash Parthiban Selvakumar, Michael Scott Rafuse, Richard Johnson, Wei Tan
Summary: This article explores the application of regenerative medicine principles in stent design and summarizes the regenerative features and related methods of stent technology. Suggestions for future stent developments are provided, along with an analysis of their benefits and risks.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Emrah Erdogan, Retesh Bajaj, Alexandra Lansky, Anthony Mathur, Andreas Baumbach, Christos Bourantas
Summary: Advancements in stent technology and endovascular devices have improved the safety and effectiveness of second-generation drug-eluting stents. However, in-stent restenosis and stent thrombosis still pose challenges in percutaneous coronary intervention. Recent studies have highlighted the value of intravascular imaging in identifying causes of stent failure and guiding therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, Research & Experimental
K. B. Timizheva, M. M. Azova, A. Ait Aissa, A. Aghajanyan, L. Tskhovrebova, M. L. Blagonravov
Summary: Restenosis remains a main complication after percutaneous coronary interventions in patients with coronary heart disease. The study focused on polymorphic loci of genes related to endothelin and endothelial NO synthase, showing different associations with restenosis development in older patients and timing of in-stent restenosis. These results could provide valuable insights for assessing restenosis risk factors and guiding treatment choices for patients with coronary heart disease prior to elective surgical intervention.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Maobin Xie, Liming Lian, Xuan Mu, Zeyu Luo, Carlos Ezio Garciamendez-Mijares, Zhenrui Zhang, Arturo Lopez, Jennifer Manriquez, Xiao Kuang, Junqi Wu, Jugal Kishore Sahoo, Federico Zertuche Gonzalez, Gang Li, Guosheng Tang, Sushila Maharjan, Jie Guo, David L. Kaplan, Yu Shrike Zhang
Summary: This study demonstrates the rapid volumetric printing of unmodified silk sericin and silk fibroin inks, which exhibit shape-memory and tuneable mechanical properties. The inks are cytocompatible, providing expanded bioink libraries for volumetric additive manufacturing and offering potential for diverse biomedical applications.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Tarik Abdelkareem Mostafa Amer, Sathyadevi Palanisamy, Pamela Berilyn So, Priya Vijayaraghavan, Shey-Cherng Tzou, Tsai-Te Lu, Chia-Her Lin, Yun-Ming Wang
Summary: The use of MOF-based nanomaterials in bioapplications has increased due to their biocompatibility, drug degradation, tunable porosity, and intrinsic biodegradability. Bimetallic MOFs embedded with and without folic acid were synthesized and used for tissue sealing and repairing incisional wound sites in mice models. These materials displayed antibacterial properties and enhanced wound healing rates, and also showed potential for cell migration and angiogenesis.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Ioanna Samara, Christos S. Katsouras, Arsen Semertzioglou, Athanassios Vratimos, Amalia I. Moula, Constantinos A. Dimitriou, Michail Theofanis, Triantafyllia Papadimitropoulou, Vasileios Bouratzis, Georgia Karanasiou, Dimitrios Fotiadis, Lampros K. Michalis, Anargyros N. Moulas
Summary: This study evaluated the safety and efficacy of innovative retinoic acid (RA) eluting stents with bioabsorbable polymer. The results showed that RA eluting stents did not lead to thrombus formation and had an acceptable level of stenosis after 4 weeks of implantation. The dose of RA and type of polymer may play a role in the biocompatibility of the stents.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Guangqian Yang, Emile Mehanna, Chao Li, Hongyi Zhu, Chong He, Fang Lu, Ke Zhao, Yubin Gong, Zhao Wang
Summary: This study developed a deep learning method to automatically analyze stents with different thicknesses and vessels implanted with multiple stents, providing effective assistance for the evaluation of stent implantation and post-stent tissue coverage.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Engineering, Biomedical
Courtney Keiser, Kaspars Maleckis, Pauline Struczewska, Majid Jadidi, Jason MacTaggart, Alexey Kamenskiy
Summary: This study developed a method to assess the abrasiveness of peripheral arterial stents and applied it to several commercial devices. The results showed that the degree of stent abrasion was closely related to clinical outcomes, and this method can guide stent selection and development.
ACTA BIOMATERIALIA
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Arghya Paul
Article
Polymer Science
Sayantani Basu, Rea Johl, Settimio Pacelli, Stevin Gehrke, Arghya Paul
Article
Engineering, Biomedical
Settimio Pacelli, Aparna R. Chakravarti, Saman Modaresi, Siddharth Subham, Kyley Burkey, Cecilia Kurlbaum, Madeline Fang, Christopher A. Neal, Adam J. Mellott, Aishik Chakraborty, Arghya Paul
Summary: The study utilized polydopamine (pDA) treatment as a binding platform to create a versatile gelatin-alginate (Gel-Alg) hydrogel, effectively controlling stem cell adhesion and osteogenic differentiation, demonstrating the potential application value in tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Pharmacology & Pharmacy
Yasmeen Shamiya, Shruthi Polla Ravi, Ali Coyle, Subrata Chakrabarti, Arghya Paul
Summary: This article reviews emerging therapeutic nanoparticles for treating diabetic wounds and discusses their discrete delivery mechanisms and sites of action. The current challenges of these nanoengineered materials for successful clinical translation are critically assessed, along with their potential for growth in the clinical marketplace.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Shruthi Polla Ravi, Yasmeen Shamiya, Aishik Chakraborty, Cynthia Elias, Arghya Paul
Summary: Vaccines have been essential in training the immune system, but face challenges in manufacturing, large-scale production, and storage, with some showing suboptimal immunogenicity. A new class of biomimetic materials has emerged as an alternative vaccination strategy.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Cho-E Choi, Aishik Chakraborty, Ali Coyle, Yasmeen Shamiya, Arghya Paul
Summary: Considerable progress has been made in synthesizing intelligent, biodegradable hydrogels that undergo rapid changes in physicochemical properties once exposed to external stimuli. These advantageous properties of stimulus-triggered materials make them highly appealing to diverse biomedical applications. Of late, research on the incorporation of light-triggered nanoparticles (NPs) into polymeric hydrogel networks has gained momentum due to their ability to remotely tune hydrogel properties using facile, contact-free approaches, such as adjustment of wavelength and intensity of light source.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Harshavardhan Budharaju, Allen Zennifer, Swaminathan Sethuraman, Arghya Paul, Dhakshinamoorthy Sundaramurthi
Summary: DNA, with its outstanding features such as functional molecular recognition motifs and high precision molecular self-assembly, has emerged as a leading biomaterial for 3D bioprinting and other biomedical applications. Researchers are continuously exploring the interesting properties of DNA for various applications, including cell-laden tissue constructs. Advanced design approaches and cost-effective production methods have further enhanced the versatility and potential of DNA in bioprinting.
MATERIALS HORIZONS
(2022)
Article
Medicine, Research & Experimental
Aishik Chakraborty, Settimio Pacelli, Shana Alexander, Sebastian Huayamares, Zachary Rosenkrans, Filippo Elmi Vergel, Yuanyi Wu, Adrija Chakravorty, Arghya Paul
Summary: A mechanically tough nanocomposite hydrogel was prepared by utilizing the electrostatic interaction between nanosilicates and gelatin methacrylate. This hydrogel showed slower degradation rate and sustained release of the encapsulated drug metformin. The nanocomposite material also exhibited cell protective effects in vitro.
MOLECULAR PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Shruthi Polla Ravi, Yasmeen Shamiya, Aishik Chakraborty, Ali Coyle, Alap Ali Zahid, Jin Wang, Michael S. H. Boutilier, Emmanuel A. Ho, Arghya Paul
Summary: In this study, a biomimetic cell-derived nanoparticle (CDN) loaded with Dexamethasone was developed, which showed efficient cellular uptake and stem cell differentiation. These CDNs exhibited good cytocompatibility and stability, making them suitable for bone regeneration applications.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Ali Coyle, Arghya Paul
Summary: Biobased nanoparticles are promising tools for biomedical research, but their commercial application has not been fully realized. In this perspective, advanced designs of biobased nanoparticles, such as cell membrane nanoparticles, exosomes, and synthetic lipid-derived nanoparticles, are discussed along with their benefits and potential challenges. The future use of artificial intelligence and machine learning in preparing these particles is also critically assessed. This field of research has the potential to greatly impact the rational design of drug transporters and improve therapeutic outcomes.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Alap Ali Zahid, Aishik Chakraborty, Yasmeen Shamiya, Shruthi Polla Ravi, Arghya Paul
Summary: Exploring new avenues for clinical management of chronic wounds is crucial for eliminating socioeconomic burdens and health concerns. Engineered biomaterials with improved functionalities, such as bioadhesiveness, antimicrobial properties, proangiogenic attributes, and anti-inflammatory properties, have been developed to enhance wound healing. Different biomaterial templates, including hydrogels, cryogels, nanomaterials, and biomolecule-functionalized materials, have been utilized to fabricate smart patches, microneedles, electrospun scaffolds, and 3D-bioprinted structures, enabling effective wound healing.
MATERIALS HORIZONS
(2022)
Article
Materials Science, Multidisciplinary
Sayantani Basu, Aishik Chakraborty, Abdul-Rahman Imad Alkiswani, Yasmeen Shamiya, Arghya Paul
Summary: In this study, mechanically tough nanocomposite hydrogels were prepared using natural polymer DNA and two-dimensional nanosheets of WS2. The formation of double network polymeric hydrogels significantly improved the mechanical properties of the hydrogels, while maintaining biocompatibility. These tough DNA-based hydrogels have the potential for various biomedical applications, including drug delivery of proteins and growth factors.
MATERIALS ADVANCES
(2022)
Review
Materials Science, Biomaterials
Aishik Chakraborty, Avinava Roy, Shruthi Polla Ravi, Arghya Paul
Summary: The use of nanoparticles in 3D bioprinting can enhance the mechanical properties, introduce new functionalities, and provide responsiveness to external stimuli in hydrogel-based bioinks. This approach allows for the creation of intricate biostructures, bringing the field of bioprinting closer to printing complex tissue structures and organs.
BIOMATERIALS SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Aishik Chakraborty, Shruthi Polla Ravi, Yasmeen Shamiya, Caroline Cui, Arghya Paul
Summary: Apart from its role as a genetic material, DNA can also be utilized to construct materials with desired properties, such as hydrogels. Current chemical tools and strategies are being employed to harness the non-genetic functions of DNA.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Aparna R. Chakravarti, Settimio Pacelli, Arghya Paul
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.