Review
Biotechnology & Applied Microbiology
Rebecca Powell, Despoina Eleftheriadou, Simon Kellaway, James B. Phillips
Summary: This review discusses the physical processes by which natural biomaterials mimic the function of the extracellular matrix and regulate cellular behavior, as well as highlights representative cases of controllable cell microenvironments developed through the combination of cell biology and tissue engineering principles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Medicine, Research & Experimental
Lingchi Kong, Xin Gao, Yun Qian, Wei Sun, Zhengwei You, Cunyi Fan
Summary: This review integrates the current understanding of the biomechanical microenvironment associated with peripheral nerve function and regeneration, introduces promising tissue engineering strategies based on biomechanical modulation, and provides suggestions and prospects for future directions.
Review
Pharmacology & Pharmacy
Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Raziyeva, Laura Tabyldiyeva, Kamila Berikova, Dias Zhumagul, Kamila Temirkhanova, Arman Saparov
Summary: Chitosan, a biopolymer derived from chitin, has great potential for tissue regeneration and controlled drug delivery. It possesses qualities such as biocompatibility, low toxicity, and antimicrobial activity, making it attractive for biomedical applications. Chitosan can be fabricated into different structures, including nanoparticles, scaffolds, hydrogels, and membranes, which can be customized for specific outcomes. It has been shown to stimulate tissue regeneration and repair in various tissues and organs, and is an efficient carrier for medications, genes, and bioactive compounds.
Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Materials Science, Biomaterials
Xiangyun Yao, Zhiwen Yan, Xu Wang, Huiquan Jiang, Yun Qian, Cunyi Fan
Summary: Graphene and its derivatives have extraordinary electrochemical and mechanical properties, leading to extensive research in tissue engineering and regenerative medicine. Reduced graphene oxide (rGO) shares structural and functional similarities with graphene, influencing neurogenic differentiation of stem cells.
REGENERATIVE BIOMATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj, Rajamanikkam Yuvashree, Gopal Hariprabu, Raghunandhakumar Subramanian, Palraju Murali, Deepak Nallaswamy Veeraiyan, Lakshmi Thangavelu
Summary: Zebrafish serves as an excellent biomaterial testing platform for rapid characterization of the biological properties of new biomaterials, particularly in bone tissue engineering applications, surpassing technical difficulties and cost issues associated with rodent models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
Zhirong Liu, Xingyi Wan, Zhong Lin Wang, Linlin Li
Summary: Electroactive biomaterials have the potential to mimic cell microenvironments and regulate cell and tissue behaviors for tissue regeneration. Electrical stimulation can impact various biological processes and is crucial for nerve, bone, and cardiac tissue regeneration.
ADVANCED MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
V. K. Anupama Devi, Anjaneyulu Udduttula, Amit Kumar Jaiswal
Summary: Biomedical uses for natural polysaccharides of marine origin, including fucoidan derived from brown algae, are gaining popularity. Despite being less researched compared to other biomaterials, fucoidan is more accessible and cost-effective. This review provides an overview of its history, sources, and characteristics, with a focus on its application in bone tissue engineering. The global research status of fucoidan, especially for bone tissue engineering, is examined, making this study a comprehensive manual for understanding its research status.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Fatemeh S. Hosseini, Amir Abbas Abedini, Feiyang Chen, Taraje Whitfield, Chinedu C. Ude, Cato T. Laurencin
Summary: Successful regeneration of critical-size bone defects remains a significant challenge in regenerative engineering. The use of oxygen-generating biomaterials can improve tissue growth and overcome the hypoxic regions in large matrices. This article reviews recent advances in oxygen-releasing and delivery methods for bone regenerative engineering.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Xinyu Song, Ling Xu, Wenjie Zhang
Summary: Critical-size bone defect repair is challenging, and current therapies have limitations. Extracellular vesicle (EV)-based strategies offer a promising approach for tissue regeneration due to their complex composition and low immunogenicity. Optimizing the synthesis of biomimetic EVs can enhance their bioactivity and improve bone regeneration. Integrating nanoparticles into bone graft biomaterials can maximize the therapeutic efficacy of EVs. This review summarizes the role of EVs in bone regeneration, discusses strategies for optimizing biomimetic synthetic EVs, and explores the use of bone graft biomaterials for EV delivery to repair bone defects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Medicinal
Teerawat Sukpaita, Suwabun Chirachanchai, Atiphan Pimkhaokham, Ruchanee Salingcarnboriboon Ampornaramveth
Summary: This review provides an overview of chitosan-based biomaterials for bone tissue engineering and their applications in treating bone defects. The focus is on the characteristics of chitosan, scaffold fabrication processes, advantages and disadvantages, and future directions in the field.
Review
Biotechnology & Applied Microbiology
Bin Lv, Juntao Wu, Yuan Xiong, Xudong Xie, Ze Lin, Bobin Mi, Guohui Liu
Summary: Bone regeneration is a pathophysiological process that requires the involvement of multiple systems, and the immune system plays a crucial role in it. Researchers have applied various therapeutic strategies, such as intervention of surface characteristics or local delivery systems, to create an ideal microenvironment for bone tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bruno Zwingenberger, Corina Vater, Roland L. Bell, Julia Bolte, Elisabeth Mehnert, Ronny Bruenler, Dilbar Aibibu, Stefan Zwingenberger
Summary: The study found that CHS scaffolds exhibited higher osteogenic properties in vitro, but resulted in lower bone-healing outcomes compared to CBA and MCM in vivo. Future improvements on CHS scaffolds are needed for better mechanical stability and osteoconductivity.
Article
Polymer Science
Krishnamurithy Genasan, Mohammad Mehrali, Tarini Veerappan, Sepehr Talebian, Murali Malliga Raman, Simmrat Singh, Sasikumar Swamiappan, Mehdi Mehrali, Tunku Kamarul, Hanumantha Rao Balaji Raghavendran
Summary: The study investigated the physicochemical, biocompatible, and osteoinductive properties of gellan-chitosan incorporated with different percentages of calcium silicate in human bone-marrow mesenchymal stromal cells (hBMSCs). Results showed that the 40% calcium silicate incorporation exhibited the most promising osteogenic potential in hBMSCs, making it a potential biomaterial for treating critical bone defects.
Review
Cell Biology
Elia Bosch-Rue, Leire Diez-Tercero, Barbara Giordano-Kelhoffer, Luis M. Delgado, Begona M. Bosch, Mireia Hoyos-Nogues, Miguel Angel Mateos-Timoneda, Phong A. Tran, Francisco Javier Gil, Roman A. Perez
Summary: Bone is the most studied tissue in tissue regeneration field, with tissue engineering seeking to mimic successful regeneration pathways. The use of inorganic ions has therapeutic effects and lower biological risks, with biomaterials playing a key role in controlling their release.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Yunping Zhu, Xiaoyan Zhao, Xiaowei Zhang, Hongkai Liu, Qiang Ao
Summary: The impact of different protease hydrolysis on H. pluvialis protein was studied, showing that enzyme hydrolysates had higher essential amino acid, hydrophobic, sulphur, and aromatic amino acid contents compared to HP. Alcalase hydrolysate had the highest degree of hydrolysis and peptide yield, with higher alpha-helix content. Trypsin-derived hydrolysate exhibited the best antioxidant properties among all hydrolysates. This suggests the potential of HP hydrolysates as natural functional ingredients in food production.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Neurosciences
Lei Han, Kenneth Lap-Kei Wu, Pui-Yi Kwan, Oscar Wing-Ho Chua, Daisy Kwok-Yan Shum, Ying-Shing Chan
Summary: Chemogenetic activation of 5-HT neurons projecting to the medial vestibular nucleus led to deficits in vestibular-related tasks in rats. The effects were mediated by the 5-HT1A receptor and were attenuated through a presynaptic mechanism in the vestibular nucleus. These results highlight the role of the 5-HT1A receptor as a gain controller in vestibular-related brainstem circuits for posture and balance.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Pharmacology & Pharmacy
Shawn Zheng Kai Tan, Chi Him Poon, Ying-Shing Chan, Lee Wei Lim
Summary: The study identified the critical time point during memory consolidation stage to disrupt fear memory via prelimbic cortex deep brain stimulation. The disruption was partially modulated by the inactivation of the ventral hippocampus and the transient changes in ventral hippocampus dopamine (D-2) receptors expression upon prelimbic cortex deep brain stimulation. Wide-scale changes of various neurotransmitters and their metabolites in ventral hippocampus were also observed, confirming its important role in response to prelimbic cortex deep brain stimulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Yuchen Hua, Jinjie Wu, Hongfeng Wu, Cheng Su, Xiangfeng Li, Qiang Ao, Qin Zeng, Xiangdong Zhu, Xingdong Zhang
Summary: The study reveals that HANPs can induce TLR4 signaling activation and synergize with LPS to promote macrophage polarization toward M1 phenotype, as well as to abolish immune tolerance in response to repeated LPS stimulation.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Yang Liu, Lu Yu, Di Zhang, Xiaoning He, Rabia Javed, Qiang Ao
Summary: Alveolar ridge augmentation can use various bone graft materials, including autogenous bone, allograft, xenograft, and alloplastic material. ATR, an acellular tooth root, shows good biocompatibility and can be used as a new tooth-derived bone graft material for alveolar ridge augmentation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell Biology
Yat-Ping Tsui, Guy Lam, Kenneth Lap-Kei Wu, Maximilian Tak-Sui Li, Kin-Wai Tam, Daisy Kwok-Yan Shum, Ying-Shing Chan
Summary: A two-step protocol was developed to derive highly enriched populations of oligodendrocyte precursors (OPs) from bone marrow stromal cells of young adult rats (aMSCs). These OPs were capable of forming compact myelin both in vitro and in vivo, showing promising potential for cell therapy in myelin disorders.
Article
Materials Science, Biomaterials
Shuang Lin, Yuanjia He, Meihan Tao, Aijun Wang, Qiang Ao
Summary: The translated content discusses the issue of poor biocompatibility of synthetic prostheses and proposes a novel xenogeneic rib cartilage graft as an alternative. By improving the decellularization protocol and using trypsin instead of an ionic detergent, the resulting decellularized graft demonstrated better structural components, mechanics, and excellent biocompatibility and biosecurity. Functional assessment in a rabbit model showed improved degradation rate and morphology maintenance compared to traditional decellularized rib cartilage, indicating great potential for future investigations and clinical applications of rhinoplasty prostheses.
REGENERATIVE BIOMATERIALS
(2021)
Review
Engineering, Biomedical
Meihan Tao, Tianrang Ao, Xiaoyan Mao, Xinzhu Yan, Rabia Javed, Weijian Hou, Yang Wang, Cong Sun, Shuang Lin, Tianhao Yu, Qiang Ao
Summary: This review discusses the definitions of sterilization and disinfection, the effects on dECM, and various methods for sterilization and disinfection. It also proposes recommendations for selecting appropriate sterilization or disinfection methods and validating them.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Medicinal
Hengtong Zhang, Xixi Wu, Liang Quan, Qiang Ao
Summary: Oceans have great potential in developing high-value bioactive substances and biomaterials. Marine biomaterials are characterized by excellent biological activity and unique chemical structure, making them suitable for applications in tissue engineering and regenerative medicine.
Review
Polymer Science
Liang Quan, Yuan Xin, Xixi Wu, Qiang Ao
Summary: Self-healing hydrogels have the ability to automatically repair damage and avoid premature failure caused by mechanical damage. Researchers can design hydrogels to meet the needs of different tissues.
Article
Multidisciplinary Sciences
Wing Shan Yu, Luca Aquili, Kah Hui Wong, Amy Cheuk Yin Lo, Leanne Lai Hang Chan, Ying-Shing Chan, Lee Wei Lim
Summary: Noninvasive visual stimulation is a novel concept that may be applicable for treating dementia. This study found that transcorneal electrical stimulation (TES) improved memory performance in aged mice and a mouse model of Alzheimer's disease, and reduced plaque deposition in the hippocampus of male 5XFAD mice. The findings suggest that TES shows promise as a potential treatment for cognitive dysfunction.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shabnam Anjum, Farheen Rahman, Prashant Pandey, Dilip Kumar Arya, Mahmood Alam, Paruvathanahalli Siddalingam Rajinikanth, Qiang Ao
Summary: This review examines the application of electrospun nanofibrous scaffolds in bone tissue engineering, demonstrating their potential for bone tissue regeneration. Nanofibrous scaffolds provide a natural environment for cell adhesion and function, and drug/growth factor delivery is also highlighted as a significant application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kin-Wai Tam, Cheuk-Yin Wong, Kenneth Lap-Kei Wu, Guy Lam, Xiaotong Liang, Wai-Ting Wong, Maximilian Tak-Sui Li, Wing-Yui Liu, Sa Cai, Graham Ka-Hon Shea, Daisy Kwok-Yan Shum, Ying-Shing Chan
Summary: The in vitro derivation of Schwann cells from human bone marrow stromal cells offers a potential therapy for neural regeneration. In experiments with rats, Schwann-cell-like cells derived from human induced pluripotent stem-cell-derived sensory neurons were used to bridge nerve injuries. This approach resulted in significant improvement in motor function and myelinated axons in both peripheral and central nervous systems.
Article
Engineering, Biomedical
Ruiqi Wang, Yuchen Hua, Hongfeng Wu, Jingyu Wang, You-cai Xiao, Xuening Chen, Qiang Ao, Qin Zeng, Xiangdong Zhu, Xingdong Zhang
Summary: This study investigated the role of hydroxyapatite nanoparticles (HANPs) in manipulating the phenotype and function of macrophages in the tumor microenvironment. The results showed that the combination of HANPs and MPLA promoted cytokine secretion and polarization of macrophages towards a tumoricidal M1 phenotype. HANPs also induced immunogenic cell death in 4T1 breast tumor cells and activated macrophages towards an M1 type. In a tumor-bearing mice model, HANPs and MPLA synergistically delayed tumor growth.
ACTA BIOMATERIALIA
(2023)
Review
Pharmacology & Pharmacy
Yuan Xin, Liang Quan, Hengtong Zhang, Qiang Ao
Summary: Nanosystems-based antifungal agents have been effective in addressing drug resistance, drug release, and toxicity issues. Polymers, including polysaccharides, proteins, and polyesters, have gained significant attention as versatile materials for antifungal drug delivery. It is crucial for researchers to carefully select appropriate polymers based on specific scenarios when designing antifungal agent delivery nanosystems.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
