Article
Dentistry, Oral Surgery & Medicine
Ruojing Liu, Yi Gao, Li Huang, Bing Shi, Xing Yin, Shujuan Zou
Summary: This study aimed to investigate the potential effects of alpha-ketoglutarate (alpha-KG) on implant osseointegration in an osteoporotic mouse model. The results showed that the supplementation of alpha-KG in drinking water enhanced dental implant osseointegration in ovariectomized mice, with increased osteogenic and autophagic activity, and decreased osteoclast differentiation and cell apoptosis. Moreover, alpha-KG-treated bone-marrow-derived mesenchymal stem cells exhibited enhanced proliferation, survival, colony formation, and osteogenic differentiation, as well as autophagic activity. Therefore, systemic alpha-KG supplementation effectively prevents the failure of dental implant osseointegration in mice under an osteoporotic state.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Waqar Ahmad, Novin Pishevar, Leonard J. Cochrane, Andrew Reynolds, Joseph Kim, Ivan Korostenskij, Vincenza L. Geiser, Matthew D. Carson, Amy J. Warner, Peng Chen, Hai Yao, Alexander Alekseyenko, Jessica D. Hathaway-Schrader, Chad M. Novince
Summary: The aim of this study was to evaluate the impact of antibiotic prophylaxis on dental implant placement surgery-induced osteoimmune wound healing and osseointegration. The results showed that prophylactic antibiotics caused bacterial dysbiosis, suppressed helper T-cell immune response, reduced the number of osteoblasts and osteoclasts, and weakened the bone-implant interface. These findings suggest that antibiotic prophylaxis dysregulates the osteoimmune wound healing process induced by implant surgery.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biophysics
Cheng Zhang, Koichiro Hayashi, Kunio Ishikawa
Summary: This study investigates the effect of the dispersion state of osteoconductive ceramics (OCs) in implants on osseointegration ability. The findings show that composite implants made of carbonate apatite (CAp) granules with polylactic acid (PLA) exhibit improved bone maturation, higher bone-to-implant contact, and stronger adhesive shear strength compared to implants made with dispersed OC powder. This highlights the importance of the dispersion state of OCs in material development for enhancing osseointegration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Multidisciplinary Sciences
Lingxiao Wang, Zhenhua Gao, Yucheng Su, Qian Liu, Yi Ge, Zhaochen Shan
Summary: This study compared and verified the osseointegration performance of a novel implant in vivo, showing that the novel implants could promote bone formation better than traditional implants, but further improvements are still needed in some aspects.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ya-nan Wang, Lu Yu, Ting Wang, Shiyue Liu
Summary: This study investigated the effect of ApoE on bone marrow mesenchymal stem cells (BMMSCs) cultured on titanium surface and the osseointegration of titanium implants. The results showed that ApoE supplementation significantly promoted bone integration and inhibited adipogenesis. These findings reveal the potential mechanism of ApoE in improving the osseointegration of titanium implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Multidisciplinary
Tao Wang, Xu Chen, Yin Zhang, Tingjun Ye, Zhihong Liu, Lei Wang, Wenguo Cui, Guoqing Pan, Guilai Zuo, Lianfu Deng
Summary: A silicon-releasing coating for titanium substrates was fabricated using electron beam evaporation, which activated an anti-inflammatory macrophage phenotype and created an osteoimmune microenvironment conducive to interfacial osteogenesis. The mechanism of silicon-enhanced osteoimmunology established in this study provides both practical means and theoretical evidence to improve implant-to-bone osseointegration.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Chemistry, Analytical
Shouxun Lu, Benjamin Steven Vien, Matthias Russ, Mark Fitzgerald, Wing Kong Chiu
Summary: This paper investigates the feasibility of using vibration analysis technique for the osseointegration process. The results show that the vibrational behavior changes can be quantified using the energy index, which plays an important role in monitoring the osseointegration process.
Article
Biophysics
Kun Li, Zhen Tang, Kuangyu Song, Nicholas G. Fischer, Huihui Wang, Yunlin Guan, Yunyun Deng, Hao Cai, Sammer Ul Hassan, Zhou Ye, Ting Sang
Summary: A multifunctional nanocoating has been developed for titanium mini-implants to prevent bacterial infection and promote osseointegration. The nanocoating, consisting of antimicrobial peptides GL13K and silver nanoparticles (Ag-GL), showed excellent antibacterial properties without altering the surface morphology of the mini-implants. In vivo experiments demonstrated that the Ag-GL coating significantly enhanced osseointegration and new bone formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Junkai Zeng, Changjiang Gu, Feihui Zeng, Youzhuan Xie
Summary: This study developed a dual-functional coating to combat implant-associated infection. By loading two-dimensional silicene nanosheets onto the surface of implants and combining with photothermal therapy, efficient antibacterial effects and promotion of bone formation were achieved. In vivo experiments demonstrated significant improvement in bone-implant osseointegration with this coating.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biophysics
Xin Yang, Qiang Wang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Pingbo Chen, Congming Li, Lei Wang, Guohai Lu, Yaozeng Xu
Summary: In this study, a simply immersing method was used to fabricate dual-functional PEEK with antibacterial properties and enhanced bone integration. The modified PEEK demonstrated favorable biosafety, accelerated cell adhesion, and distribution, as well as wide antibacterial capabilities. The PEEK-PDA-Mn/Ag composite showed antibacterial and osseointegration-enhancing abilities in vivo.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Zhenzhen Wang, Yiming Niu, Xuejiao Tian, Na Yu, Xiaoyu Yin, Zhen Xing, Yurong Li, Lei Dong, Chunming Wang
Summary: A coating material has been developed to regulate inflammation around implants, promoting bone-implant integration under osteoporosis, representing a new strategy for designing immunomodulatory biomaterials for tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yu-Sung Choi, In-Seok Song, Moon-Young Kim, Ho-Kyung Lim, Li Chongyang, Ji Suk Shim
Summary: This study aimed to evaluate the effect of aging on the changes in implant stability over time following implant placement. The results showed that the stability of implants in elderly patients is not related to age, but rather to the engagement of the implant with the bone.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Lei Wang, Xin Yang, Weiwei Zheng, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Chao Wang, Haoran Lin, Pingbo Chen, Tingjun Ye, Xing Yang, Qiang Wang
Summary: A multifunctional coating integrated with bioactive Sr2+ and antibacterial Cu2+ was successfully fabricated on PEEK implants, which can regulate macrophage subtypes, promote osteogenic differentiation, and provide antibacterial properties, essential for long-term successful implantation.
MATERIALS TODAY ADVANCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Marta Liliana Musskopf, Amanda Finger Stadler, Tiago Fiorini, Umberto Demoner Ramos, Mariana de Sousa Rabelo, Rodrigo Nahas de Castro Pinto, Cristiano Susin
Summary: This study assessed the safety and efficacy of a new implant system using a minipig intraoral dental implant model. The results showed that the new implant system had higher bone-to-implant contact and histological performance, supporting its safety and efficacy. Further human studies should be conducted to validate these findings.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Engineering, Biomedical
Yuyu Zhao, Long Bai, Yi Zhang, Runhua Yao, Yonghua Sun, Ruiyue Hang, Xiangyang Chen, Huaiyu Wang, Xiaohong Yao, Yin Xiao, Ruiqiang Hang
Summary: Researchers developed a type I collagen decorated nanoporous network on titanium surfaces to regulate the osseointegration process of implants. The decorated network could modulate inflammation and angiogenesis, as well as promote osteogenesis, resulting in favorable osseointegration.
Article
Biochemistry & Molecular Biology
Zongliang Yue, Eric Zhang, Clark Xu, Sunny Khurana, Nishant Batra, Son Do Hai Deng, James J. Cimino, Jake Y. Chen
Summary: PAGER-CoV is a new web-based database that assists biomedical researchers in interpreting coronavirus-related functional genomic study results using a vast collection of PAGs. By exploring relationships between PAGs, users can gain deeper insights into the research information. This database can help researchers find molecular biology mechanisms and tailored therapeutics for treating COVID-19 patients.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Xiaoshan Mo, Junyu Qian, Yingqi Chen, Wentai Zhang, Peng Xian, Shuai Tang, Chao Zhou, Nan Huang, Huanzhong Ji, En Luo, Haijun Zhang, Guojiang Wan
Summary: The AL-embedded ZnP coating on biodegradable Zn effectively controlled its corrosion, reduced Zn2+ release rate, and maintained a uniform long-term degradation behavior in PBS, while also retaining a balanced osteo-functionality. This performance can be attributed to the organic-inorganic components and high quality of the coating.
Article
Dentistry, Oral Surgery & Medicine
H. Chen, R. Bi, Z. Hu, J. Chen, N. Jiang, G. Wu, Y. Li, E. Luo, S. Zhu
Summary: Selection and implementation of a plan for maxillary surgery is crucial for the outcome of two-jaw orthognathic surgery. Digital templates demonstrated the best performance in transferring the surgical plan, suggesting it as a reliable treatment option.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Engineering, Biomedical
Huanzhong Ji, Yiyao Wang, Hanghang Liu, Yao Liu, Xiaohui Zhang, Jiazhuang Xu, Zhongming Li, En Luo
Summary: The study developed a dual-delivery system that sequentially released substance P (SP) and alendronate (ALN) to promote bone regeneration and reduce bone resorption, improving implant osseointegration. The dual-delivery system increased BMSC migration, promoted osteogenic differentiation, and inhibited osteoclastogenesis. In a rat immediate implant model, the system showed enhanced peri-implant osteogenic property and osseointegration, suggesting a promising strategy for immediate implant osseointegration.
ACTA BIOMATERIALIA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Qiang Wang, Xiaoying Wang, Paloma Valverde, Dana Murray, Michel M. Dard, Thomas Van Dyke, Qiaobing Xu, Xin Xu, Nadeem Karimbux, Qisheng Tu, Jake Chen
Summary: Coating miR-335-5p lipidoid nanoparticles on Titanium SLActive surface can enhance osteogenic capacity and activity of BMSCs. This method effectively promotes interface compatibility between implants and bone tissue, as well as bone cell differentiation.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Surgery
Zhaokun Zhu, Ze He, Yue Tai, Yao Liu, Hanghang Liu, En Luo
Summary: This study investigates the application of CAD/CAM technologies in the treatment of dentofacial deformities secondary to condylar osteochondroma, and introduces a modified method to improve the accuracy of the operation. The results show that CAD/CAM technology can achieve more accurate and favorable treatment outcomes.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
WingYan Chow, Ze He, Yao Liu, Jian Song, ChunWei Xu, En Luo
Summary: In this study, the literature on condylar positioning techniques was reviewed, and the effectiveness of these techniques in preventing post-operative temporomandibular joint dysfunction and relapse was analyzed. The results showed that both computer-assisted and non-computer-assisted condylar positioning techniques are accurate in locating the pre-operative condyle position and preventing TMJ dysfunction and surgical relapse.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Gonggong Lu, Yang Xu, Quanying Liu, Manyu Chen, Huan Sun, Peilei Wang, Xing Li, Yuxiang Wang, Xiang Li, Xuhui Hui, En Luo, Jun Liu, Qing Jiang, Jie Liang, Yujiang Fan, Yong Sun, Xingdong Zhang
Summary: In this study, an instantly fixable and self-adaptive scaffold was engineered to promote cranial reconstruction by calcium chelation and interface integration, while also regulating macrophage M2 polarization and recruiting endogenous stem cells.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Tianyi Wang, Kehan Li, Hanghang Liu, En Luo
Summary: The Hippo pathway is a cellular regulatory pathway that regulates stem cells of oral origin, enamel formation, and periodontium regeneration. It interacts with several other pathways, including the BCL-2, ERK1/2, ROCK, TGF-beta/BMP, and Wnt/beta-catenin pathways.
Article
Surgery
Zhen Liu, Jianying Yang, Changhan Zhou, Yao Liu, En Luo
Summary: This study collected and analyzed publications related to craniomaxillofacial distraction osteogenesis (DO) from 2000 to 2021, exploring trends in research and comparing publications from different countries, institutions, and journals. The findings showcased the hotspots and frontiers in this field and provided a reference for future research.
FRONTIERS IN SURGERY
(2022)
Article
Engineering, Biomedical
Ze He, Shibo Liu, Zhongming Li, Jiazhuang Xu, Yao Liu, En Luo
Summary: Programmed core-shell nanofibers with sequential release of tea polyphenols and AdipoRon can control inflammation and promote bone regeneration to repair periodontitis-related alveolar bone defects.
MATERIALS TODAY BIO
(2022)
Article
Pharmacology & Pharmacy
Wei Qiu, Zhaodan Wang, Zehao Chen, Qian Sun, Hongle Wu, Zhao Chen, Kaiqi Luan, Zining Liu, Dian Ding, Qisheng Tu, Jake Chen, Buling Wu, Fuchun Fang
Summary: AdipoAI has the potential to alleviate diabetes-associated periodontitis by activating APN receptors and reducing tissue inflammation, which is crucial for the treatment of periodontitis.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Neurosciences
Radomir M. Slominski, Chander Raman, Jake Y. Chen, Andrzej T. Slominski
Summary: During oncogenesis, tumors can affect local and systemic homeostasis by producing cytokines, immune mediators, neurotransmitters, and other substances. They can control the central neuroendocrine and immune systems to promote their own growth and expansion.
TRENDS IN NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Xingwen Wu, Danting Zhu, Le Shi, Qisheng Tu, Youcheng Yu, Jake Chen
Summary: AdipoRon plays a role in bone wound healing in diet-induced obesity mice. Treatment with AdipoRon reduces body weight and improves fasting blood glucose level in obese mice, and promotes new bone formation in the defect area.
Review
Materials Science, Biomaterials
Linan Liu, Lichi Han, Qionghui Wu, Yue Sun, Kehan Li, Yao Liu, Hanghang Liu, En Luo
Summary: DNA dendrimers, with their highly branched configuration, are capable of achieving ultrasensitive detection of nucleic acids, proteins, and other substances, as well as serving as a delivery system for drugs and functional nucleic acids. Additionally, they are being utilized in protein engineering for efficient directed evolution of proteins.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
