期刊
BIOMATERIALS
卷 32, 期 34, 页码 8783-8796出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.08.010
关键词
Antibacterial; Polyethylenimine (PEI); Keratoprosthesis; PMMA; Titanium; Corneal cytotoxicity
资金
- MEEI B-KPro Fund
- Institute for Soldier Nanotechnologies at MIT through the U.S. Army Research Office [DAAD-19-D-0002]
- NIH [EY017381]
The biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, we observed that HMPEI-derivatized materials exert an inhibitory effect on biofilm formation by Staphylococcus aureus clinical isolates, as compared to the parent poly(methyl methacrylate) (PMMA) and titanium. There was no additional corneal epithelial cell cytotoxicity of HMPEI-coated PMMA compared to that of control PMMA in tissue cultures in vitro. Likewise, no toxicity or adverse reactivity was detected with HMPEI-derivatized PMMA or titanium compared to those of the control materials after intrastromal or anterior chamber implantation in rabbits in vivo. (C) 2011 Elsevier Ltd. All rights reserved.
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