Article
Engineering, Biomedical
Nan Zhang, Yiqian Huang, Pengfei Wei, Liya Sun, Wei Jing, Yunxia Xue, Yan Zhang, Bo Zhao, Ziang Yang
Summary: Hernia and life-threatening intestinal obstruction often occur due to abdominal wall injuries, which are difficult to regenerate due to the lack of suitable materials. In this study, a multi-therapeutic copper element was introduced to porcine small intestinal submucosa bio-patches, resulting in excellent antibacterial efficiency, cell compatibility, neovascularization, and collagen maturity. This bio-patch shows promise for preventing visceral adhesion, bacterial infection, and promoting soft tissue regeneration.
MATERIALS TODAY BIO
(2023)
Article
Andrology
Alessandro Fiorillo, Matteo Droghetti, Franco Palmisano, Lorenzo Bianchi, Pietro Piazza, Paolo Sadini, Martina Masetti, Enrico Molinaroli, Giorgio Gentile, Valerio Vagnoni, Alessandro Franceschelli, Fulvio Colombo
Summary: Porcine dermal and bovine pericardium xenografts have similar long-term outcomes in PEG treatment for PD, with comparable post-operative sexual life satisfaction among patients.
Article
Engineering, Biomedical
Zhengni Liu, Xuezhe Liu, Luhan Bao, Jiajie Liu, Xiaoqiang Zhu, Xiumei Mo, Rui Tang
Summary: The study focuses on using VEGF and TGF-β1 incorporated silk fibroin membrane as a functional mesh to repair abdominal wall defects in a rat model. This membrane demonstrated independent distribution and sequential release of the two regulators, promoting angiogenesis, collagen secretion, and better host integration compared to other meshes containing only VEGF or TGF-β1.
Article
Peripheral Vascular Disease
Lukasz Znaniecki, Jakub Brzezinski, Joanna Halman, Piotr Marciniuk, Pawel Michalski, Jacek Wojciechowski
Summary: This study retrospectively analyzed the early and mid-term results of in-situ reconstruction of abdominal aortic infections using surgeon-constructed porcine pericardial tubes. The results showed high technical success rate, but relatively high mortality rate within 30 days and 1 year. Further observations and validations are needed.
Article
Engineering, Biomedical
Elena Filova, Marie Steinerova, Martina Travnickova, Jarmila Knitlova, Jana Musilkova, Adam Eckhardt, Daniel Hadraba, Roman Matejka, Simon Prazak, Jana Stepanovska, Johanka Kucerova, Tomas Riedel, Eduard Brynda, Alena Lodererova, Eva Honsova, Jan Pirk, Miroslav Konarik, Lucie Bacakova
Summary: The study demonstrated that modified decellularized porcine pericardium scaffolds, seeded with human adipose tissue-derived stem cells and facilitated with fibrin mesh, heparin, and VEGF, were able to be fully repopulated within days. The recellularization process by ASCs produced various extracellular matrix proteins in the scaffold. Additionally, thin layers of human umbilical endothelial cells formed rapidly on the scaffold surfaces pre-seeded with ASCs.
BIOMEDICAL MATERIALS
(2021)
Article
Urology & Nephrology
Kathy H. Huen, Amanda Macaraeg, Carol A. Davis-Dao, Sarah H. Williamson, Timothy C. Boswell, Kai-wen Chuang, Heidi A. Stephany, Elias J. Wehbi, Antoine E. Khoury
Summary: This study describes the initial experience of using Cytal as corporal graft in pediatric patients undergoing correction of ventral curvature. In the follow-up, all patients maintained straight erections, had no postoperative complications, and no reports of systemic adverse effects were found.
Article
Chemistry, Multidisciplinary
Xiangyi Yin, Yuanping Hao, Yun Lu, Dongjie Zhang, Yaodong Zhao, Li Mei, Kunyan Sui, Qihui Zhou, Jilin Hu
Summary: The study developed a novel bio-multifunctional hydrogel patch for accelerating full-thickness abdominal wall defect repair, showing excellent self-healing and mechanical properties, antibacterial ability, and promotion of cell proliferation.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Orthopedics
Robert A. Christian, Kathryne J. Stabile, Anil K. Gupta, Bruce D. Leckey, Diana M. Cardona, Robert J. Nowinski, James D. Kelly, Alison P. Toth
Summary: This study evaluated cellular changes in graft explants from patients treated with porcine dermal grafts for rotator cuff tears, showing evidence of progressive remodeling of the grafts with vessel infiltration and collagen reorganization. The study suggests that ECM grafts can serve as effective scaffolds for host cell infiltration, collagen reorganization, and vascularization.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Chengwu Zang, Hang Xian, Hang Zhang, Min Che, Yongxiang Chen, Fanliang Zhang, Rui Cong
Summary: This study investigates the clinical outcomes of a novel soft tissue repair patch in the treatment of full-thickness hand skin defects. The results show that the use of the patch achieves better cosmetic appearance compared to autologous skin graft.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, General & Internal
Joo Yeon Park, Jae Hee Chung
Summary: This is a case of giant omphalocele that was successfully repaired using surgical intervention. During the operation, there was dehiscence at the suture site, which was repaired using synthetic absorbable mesh. Using acellular porcine dermal matrix can be considered as a viable treatment option for repairing omphaloceles.
Article
Obstetrics & Gynecology
Zhi-yang Xu, Ling-xia Li, Xing-guo Wang, Meng-xin Wang, Gai-jing Cao, Bi-liang Chen, Shu-juan Liu
Summary: This study investigated the long-term outcomes for MRKH syndrome patients undergoing vaginoplasty using SIS grafts. The results showed that nearly half of the patients maintained good sexual function after the surgery. Both sexual function and psychological status improved as postoperative time increased. Additionally, reducing the diagnosis to surgery interval was associated with improved psychological function.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Materials Science, Biomaterials
Xiuli Sun, Yujie Qiao, Long Zhao, Zhen Shi, Xiaoyu Zhang, Rui Cao, Qingjun Zhou, Weiyun Shi
Summary: The study demonstrates that DPS can be used as an alternative material for emergency repair of corneal perforations and lamellar injuries with good therapeutic effects.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Shijie Qiu, Lijin Liang, Peng Zou, Qi Chen
Summary: The study developed a bi-layer composite scaffold using decellularized small intestine submucosa and polylactic-co-glycolic acid, with minimal residual DNA in the former and satisfactory mechanical properties in the scaffold. Cellular interactions within the scaffold showed desirable cell proliferation and phenotypic behaviors, laying a solid foundation for future in vivo studies and clinical applications.
REGENERATIVE BIOMATERIALS
(2021)
Article
Surgery
Laura Mazilescu, Catherine Parmentier, Sangeetha N. Kalimuthu, Sujani Ganesh, Masataka Kawamura, Toru Goto, Yuki Noguchi, Markus Selzner, Trevor W. Reichman
Summary: A novel NESPP technique was developed and tested, showing that it can keep pancreas metabolically active and improve the outcomes of transplantation by allowing for assessment and repair of the organ.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Otorhinolaryngology
Petra Membreno, Anas A. Eid, Christopher C. Vanison, M. Boyd Gillespie, John P. Gleysteen
Summary: The study evaluated the feasibility and outcomes of porcine submucosal allograft (Biodesign Sinonasal Repair Graft) in oral cavity and oropharynx reconstruction after ablative surgery, showing it to be a viable option for small and medium-sized defects in patients who are medically unfit or do not want to undergo free flap surgery.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.