Article
Energy & Fuels
Roy A. Pillers, Theodore J. Heindel
Summary: This study utilized X-ray imaging to capture temporal images of hydrate formation in off-shore oil extraction, finding that formation trends correlated with temperature histories, but quantitative analysis remained challenging due to variations in X-ray intensity and temperature histories.
JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Qiaolin Wei, Jian He, Shuaifei Wang, Shiyuan Hua, Yuchen Qi, Fangyuan Li, Daishun Ling, Min Zhou
Summary: The study developed a Raman-tagged hollow gold nanoparticle with SERS property, which efficiently accumulated in the tumor site under low-dose X-ray pre-irradiation and showed highly effective antitumor effects in a breast cancer model. It integrated Raman/PA imaging and PTT functions into a single platform, with promising prospects for clinical applications in enhancing drug delivery and accumulation in tumor theranostics, especially in combination with low-dose X-ray irradiation as an adjuvant.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jin Wang, Qiao Yu, Xiang-Ling Li, Xue-Li Zhao, Hong-Yuan Chen, Jing-Juan Xu
Summary: Understanding the pH changes during endocytosis is crucial for biology and nanotherapeutic design. In this study, a plasmonic Au@PANI core-shell nanoprobe was developed with distinct scattering properties under different pH conditions. The scattering signal of the nanoprobe showed a positive linear correlation with the pH value in both PBS and nigericin-treated cells.
Article
Biochemistry & Molecular Biology
Henrik Kahl, Theresa Staufer, Christian Koernig, Oliver Schmutzler, Kai Rothkamm, Florian Gruener
Summary: Immunotherapy is a breakthrough in cancer treatment, but only a subgroup of patients respond to these novel drugs. X-ray fluorescence imaging (XFI) shows potential for tracking immune cells and monitoring immune response, although its detection threshold is influenced by tumor depth and surrounding tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Arthur Ungerer, Theresa Staufer, Oliver Schmutzler, Christian Koernig, Kai Rothkamm, Florian Gruener
Summary: The study demonstrates the potential application of X-ray fluorescence imaging for tracking genetically modified immune cells in cancer therapy, providing computer simulation results. Immune cells labeled with gold nanoparticles can be detected using their setup, showing feasibility for immune cell tracking in human-sized objects. The findings suggest that current technological developments form a good basis for high sensitivity X-ray fluorescence imaging.
Article
Computer Science, Information Systems
Sandun Jayarathna, Md Foiez Ahmed, Liam O'ryan, Hem Moktan, Yonggang Cui, Sang Hyun Cho
Summary: Pixelated semi-conductor detector HEXITEC was characterized for its performance in benchtop XFCT system, demonstrating the necessity for application-specific detector characterization and highlighting the characteristics of HEXITEC under different working conditions. The investigation also showed the potential of high energy resolution in parallel acquisition of XRF signals using HEXITEC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Maritina Rouchota, George Loudos, George C. Kagadis
Summary: A simulation platform has been developed to predict contrast induction and minimum detectable concentration of Gold Nanoparticles on X-ray systems, applicable to preclinical and clinical studies. This model could facilitate the deployment of GNPs in radiology imaging.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Physics, Multidisciplinary
Hans Rabus, Philine Hepperle, Christoph Schlueter, Andrei Hloskovsky, Woon Yong Baek
Summary: The electron emission spectra of gold nanoparticles (AuNPs) after photon interaction were measured to provide reference data for Monte Carlo radiation-transport simulations. The experiments were conducted using the HAXPES spectrometer at the PETRA III high-brilliance beamline P22 at DESY, Germany. The study focused on AuNPs samples with different diameters on carbon foils.
Article
Chemistry, Inorganic & Nuclear
R. Figueroa, F. Geser, J. Lopez-Correa, F. Malano, M. Valente
Summary: The traditional X-ray tube design has limitations in optimizing high incident fluence spatial concentration, while a novel X-ray tube design is capable of producing a convergent X-ray beam, improving overall performance and spatial resolution for applications like X-ray fluorescence imaging. This study suggests the feasibility of the proposed design for achieving high fluence concentration, particularly useful for applications such as tumor targeting by X-ray fluorescence imaging with high atomic number nanoparticle infusion.
APPLIED RADIATION AND ISOTOPES
(2021)
Article
Chemistry, Analytical
Yan Tan, Jianxing Zhou, Xiaotong Xing, Junren Wang, Jinkun Huang, Huiyu Liu, Jiajie Chen, Mingjie Dong, Qin Xiang, Haifeng Dong, Xueji Zhang
Summary: In this study, the controllable self-assembly of DNA-linked gold nanoparticles (AuNPs) for in vivo biomedical applications was achieved by using programmable DNA tetrahedral structures. Three different sizes of AuNPs (20nm, 10nm, and 5nm) were organized and positioned using this method. The density and arrangement of the satellite AuNPs around the core AuNPs were controlled by tuning the size and amount of DNA tetrahedron functionalized on the core AuNPs, resulting in strong electromagnetic field enhancement. With the conjugation of Raman molecules, strong surface-enhanced Raman scattering photoacoustic imaging signals were generated, allowing for the imaging of microRNA-21 and tumor tissues in vivo. This study provides an efficient strategy for building precision plasmonic superstructures in plasmonic-based bioanalysis and imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Brian S. Ferguson, Leslie E. Neidert, Matthew J. Rogatzki, Keith R. Lohse, L. Bruce Gladden, Heidi A. Kluess
Summary: The study found no significant difference in the release of ATP from RBCs of different densities under hypoxic and normoxic conditions, and the release of ATP was linearly correlated with the release of Hb.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Garrit Koller, Alexander P. Morrell, Rui Pedro Galao, Suzanne Pickering, Eithne MacMahon, Joanna Johnson, Konstantin Ignatyev, Stuart J. D. Neil, Sherif Elsharkawy, Roland Fleck, Pedro Miguel Pereira Machado, Owen Addison
Summary: The study reveals inadequacies in the direct-readout SARS-CoV-2 LFDs in discriminating a potentially infective viral concentration, potentially leading to high false-negative rates and increased risk of virus transmission. By utilizing X-ray fluorescence imaging and quantifying viral copy numbers, it was found that samples scored as negative could actually contain a significant amount of virus, highlighting the limitations of current LFD technology in detecting low viral concentrations.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Qian Yang, Jinhui Shang, Yancao Chen, Decui Tang, Yuzhi Ouyang, Bin Xiong, Xiaobing Zhang
Summary: Ligand-induced receptor clustering on cell membrane plays crucial roles in pattern recognition and transmembrane signaling. A data-mining-integrated plasmon coupling microscopy has been proposed recently to study the dynamic interactions between receptor clusters on cell surface, providing insights into the dynamic characteristics of receptor clustering.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tobias Lappan, Dominic Herting, Muhammad Ziauddin, Julian Stenzel, Natalia Shevchenko, Sven Eckert, Kerstin Eckert, Sascha Heitkam
Summary: In mineral processing, froth flotation is used to recover valuable mineral particles through overflowing froth. However, the velocity profile of the overflowing froth beneath its free surface cannot be observed optically. This study combines X-ray radiography and particle tracking velocimetry to measure local flow velocities within an optically opaque foam at a weir. Tracer particles were used to trace the flow in X-ray image sequences, and the velocity profile above the weir crest was determined.
APPLIED SCIENCES-BASEL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taeyun Kim, Woo Seung Lee, Miyeon Jeon, Hyejin Kim, Mingi Eom, Seongmoon Jung, Hyung-Jun Im, Sung-Joon Ye
Summary: A dual imaging modality of pinhole XRF and CT imaging system and L-shell XRF detection system were successfully developed. The developed systems are a promising modality for in vivo imaging and ex vivo quantification for preclinical studies using MNPs. In addition, we discussed further improvements for the routine preclinical applications of the systems.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
