4.8 Article

Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact lenses

期刊

BIOMATERIALS
卷 32, 期 24, 页码 5698-5705

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.04.044

关键词

Silicone hydrogel contact lenses; Biomimetic molecular imprinting; Drug-eluting contact lenses; Contact lens induced dry eye (CLIDE); Re-wetting/comfort agent; Extended wear contact lenses

资金

  1. CIBA Vision, Inc.

向作者/读者索取更多资源

Symptoms of contact lenses induced dry eye (CLIDE) are typically treated through application of macromolecular re-wetting agents via eye drops. Therapeutic soft contact lenses can be formulated to alleviate CLIDE symptoms by slowly releasing comfort agent from the lens. In this paper, we present an extended wear silicone hydrogel contact lens with extended, controllable release of 120 kDa hydroxypropyl methylcellulose (HPMC) using a molecular imprinting strategy. A commercial silicone hydrogel lens was tailored to release approximately 1000 mu g of HPMC over a period of up to 60 days in a constant manner at a rate of 16 mu g/day under physiological flowrates, releasing over the entire range of continuous wear. Release rates could be significantly varied by the imprinting effect and functional monomer to template ratio (M/T) with M/T values 0, 0.2, 2.8, 3.4 corresponding to HPMC release durations of 10, 13, 23, and 53 days, respectively. Lenses had high optical quality and adequate mechanical properties for contact lens use. This work highlights the potential of imprinting in the design and engineering of silicone hydrogel lenses to release macromolecules for the duration of wear, which may lead to decreased CLIDE symptoms and more comfortable contact lenses. (C) 2011 Elsevier Ltd. All rights reserved.

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