Article
Immunology
Chao Liang, Ying Bai, Rui Miao, Xuelian Yang, Yafeng Liu, Jiawei Zhou, Jianqiang Guo, Dong Hu, Jing Wu
Summary: This study explored potential mechanisms and therapeutic drugs for silicosis using bioinformatics, network pharmacology, and experimental validation. Celastrol was identified and verified as a novel and promising candidate drug for silicosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaohu Zeng, Xin Zhu, Qikang Tian, Xiaoke Tan, Ning Sun, Min Yan, Junwei Zhao, Xiangxiang Wu, Ruiqin Li, Zhenqiang Zhang, Huahui Zeng
Summary: In this study, a Cel-CSO conjugate was synthesized for the delivery of Celastrol. Cel-CSO exhibited good aqueous solubility and anti-tumor activity, with reduced cytotoxicity towards hepatic cells.
Article
Biochemistry & Molecular Biology
Max L. B. Gronloh, Janine J. G. Arts, Sebastian Palacios Martinez, Amerens A. van Der Veen, Lanette Kempers, Abraham C. van Steen, Joris J. T. H. Roelofs, Martijn A. Nolte, Joachim Goedhart, Jaap D. van Buul
Summary: Using a photoconvertible probe, researchers traced and identified the original endothelial transmigration hotspots, and found that these hotspots function to limit vascular leakage during transmigration events. The distribution of ICAM-1 determines the location of the transmigration hotspot.
Article
Medicine, General & Internal
Judith Heiss, Katja Grun, Laura Tempel, Mattia Matasci, Andrea Schrepper, Michael Schwarzer, Reinhard Bauer, Martin Forster, Alexander Berndt, Christian Jung, P. Christian Schulze, Dario Neri, Marcus Franz
Summary: This study compared two formats of immunocytokines and identified potential target cells of IL9. The results showed that targeted delivery of IL9 could have beneficial effects in a mouse model of pulmonary hypertension (PH). Furthermore, IL9 treatment increased the number of regulatory T cells (Tregs) and reduced lung tissue damage in PH mice.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
Ni Fan, Jia Zhao, Wei Zhao, Xiuying Zhang, Qingchun Song, Yanting Shen, Ho Cheung Shum, Yu Wang, Jianhui Rong
Summary: This study developed biodegradable albumin-based nanoparticles for delivering celastrol (CEL) to the liver to treat non-alcoholic fatty liver disease (NAFLD). The CEL-loaded nanoparticles showed improved hepatocyte uptake and hepatic deposition, and outperformed in reducing lipid deposition and improving liver function. CEL-Lac-BSA has the potential to be a clinical therapy for obesity and NAFLD.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Medicinal
Na Wang, Yifan Li, Fei He, Susu Liu, Yuan Liu, Jinting Peng, Jiahui Liu, Changyuan Yu, Shihui Wang
Summary: Cel-ZIF-8 provides a new assembly strategy for hydrophobic drugs, addressing the encapsulation issue of Cel in nano-delivery systems. This strategy significantly improves the assembly efficiency of Cel and allows for drug release in an acidic tumor microenvironment. Cel-ZIF-8 is easily taken up by cancer cells and exhibits a better therapeutic effect on tumor cells.
Article
Pharmacology & Pharmacy
Xuan Zhao, Chengyuan Huang, Meiling Su, Yu Ran, Ying Wang, Zongning Yin
Summary: The study demonstrated that CLT/BRNP exhibits significant anti-arthritic effects in the treatment of rheumatoid arthritis, and has lower toxic effects compared to free celastrol.
Article
Biochemistry & Molecular Biology
Sho Kohara, Kazushige Ogawa
Summary: Kupffer cells are maintained through self-renewal within liver sinusoidal endothelial cells (LSECs). In this study, liver macrophages (Mo) were propagated from mice using mixed culture with hepatic fibroblastic cells. The propagated liver Mo expressed specific transcription factors and exhibited similar gene expression and surface markers as primary LSECs, suggesting that their properties resemble those of Kupffer cells. Further investigation revealed the expression of certain Eph receptors and ephrin ligands, as well as integrin subunits and corresponding ligands, potentially contributing to the adhesion and residence of Kupffer cells within the liver sinusoid.
Article
Immunology
Mona Singh, Mony Thakur, Manish Mishra, Manisha Yadav, Rajkamal Vibhuti, Athira M. Menon, Girima Nagda, Ved Prakash Dwivedi, Tikam Chand Dakal, Vinod Yadav
Summary: ICAM-1 is a key inducible cell adhesion molecule involved in immune functions, with its expression regulated by various inflammatory mediators such as transcription factors and signaling pathways. Transcriptional regulation and epigenetic modifications play important roles in controlling ICAM-1 expression.
IMMUNOLOGY LETTERS
(2021)
Article
Multidisciplinary Sciences
Victor Pui-Yan Ma, Yuesong Hu, Anna Kellner, Joshua M. Brockman, Arventh Velusamy, Aaron T. Blanchard, Brian D. Evavold, Ronen Alon, Khalid Salaita
Summary: T cells defend against cancer and viral infections by binding to specific peptide antigens on target cells. It has been found that the forces transmitted through the LFA-1 /ICAM-1 complex can tune T cell signaling and enhance T cell activation and TCR discrimination.
Review
Cell Biology
Jing Yang, Qiu-yi Song, Shu-xuan Niu, Hui-jing Chen, Robert B. Petersen, Yu Zhang, Kun Huang
Summary: ANGPTLs, a family of secreted glycoproteins, play key roles in lipid metabolism and inflammation. Their potential roles and mechanisms in inflammatory diseases have attracted significant attention from researchers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medical Laboratory Technology
Varinder Singh, Rupinder Kaur, Pratima Kumari, Chirag Pasricha, Ravinder Singh
Summary: Leukocyte migration is vital for lymphocyte recirculation and immune response. ICAM-1 and VCAM-1 play a crucial role in leukocyte adherence to endothelial cells in various diseases. They contribute to inflammation, leukocyte migration, and have implications in multiple pathological states. Understanding their immunoregulatory role and pathophysiological effects helps in disease management.
CLINICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
John Aaron Howell, Nicholas Gaouette, Mariper Lopez, Stephen P. Burke, Eddie Perkins, Gene L. L. Bidwell III
Summary: In this study, a new protein inhibitor called SynB1-ELP-p50i, which inhibits the NF-κB inflammatory pathway, has been developed. It successfully reduces inflammation-induced tissue damage following ischemic stroke in rat models, leading to a decrease in infarct volume and an improvement in survival rate. These findings demonstrate the potential of ELP-delivered biologics as a therapy for ischemic stroke and other central nervous system disorders, and highlight the importance of targeting inflammation in stroke treatment.
Article
Biochemistry & Molecular Biology
John Aaron Howell, Nicholas Gaouette, Mariper Lopez, Stephen P. Burke, Eddie Perkins, Gene L. Bidwell
Summary: This study demonstrates the potential of SynB1-ELP-p50i as a therapeutic strategy for ischemic stroke, as it effectively reduces inflammatory cytokine production, decreases infarct volume, improves survival, and has no toxic effects. These findings highlight the importance of targeting inflammation in the treatment of ischemic stroke and other CNS disorders.
Review
Pharmacology & Pharmacy
Christopher D. Conrady, Steven Yeh
Summary: Uveitis is a group of inflammatory disorders of the eye that require medical and surgical management, with challenges in drug delivery due to absorption barriers. New drugs and drug delivery platforms are being developed to reduce intraocular inflammation and its complications.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.