Article
Cell Biology
Guo-Chen Zhu, Da-Jiang Xiao, Bi-Wen Zhu, Yan Xiao
Summary: Acellular nerve allografts achieved satisfactory results in bridging facial nerve defects, but limited allogeneic donors are available. This experiment constructed a monkey model of whole nerve defect and studied xenogeneic acellular nerve grafts. The results showed that xenogeneic acellular nerve grafts were safe and effective for repairing facial nerve defects, similar to autografts.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Elsa Gonzalez-Cubero, Maria Luisa Gonzalez-Fernandez, Maria Rodriguez-Diaz, Marta Palomo-Irigoyen, Ashwin Woodhoo, Vega Villar-Suarez
Summary: The study investigated the therapeutic benefits of adipose tissue derived-mesenchymal stem cells (ASCs) and ASC-conditioned medium (CM) in promoting myelination and axonal regeneration. Results showed that both ASCs and CM could potentially aid in nerve regeneration, especially in reversing the effects of TNF-induced nerve damage on myelination-related genes and proteins.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Shuangpeng Jiang, Guangzhao Tian, Zhen Yang, Xiang Gao, Fuxin Wang, Juntan Li, Zhuang Tian, Bo Huang, Fu Wei, Xinyu Sang, Liuqi Shao, Jian Zhou, Zhenyong Wang, Shuyun Liu, Xiang Sui, Quanyi Guo, Weimin Guo, Xu Li
Summary: This study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. The promoting effect may be related to the polarization of macrophages and inhibition of inflammatory response by hWJMSC-Exos. Additionally, hWJMSC-Exos contain miRNAs that can promote hyaline cartilage regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Medicine, General & Internal
Mehmet Burak Yalcin, Ejder Saylav Bora, Muemin Alper Erdogan, Adem Cakir, Oytun Erbas
Summary: This study investigated the role of syndecan-1 and heat shock protein 70 (HSP-70) in mediating the regenerative effects of adipose-derived mesenchymal stem cells (ADSCs) on peripheral nerves. The results showed that ADSCs could secrete syndecan-1 and HSP-70 in response to stress conditions, and ADSC treatment significantly improved functional recovery and nerve regeneration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Physical
Yan Li, Zhaoyang Chen, Junnian Zhou, Yanjun Guan, Jiahua Xing, Zehao Niu, Biao Zhang, Quan Zeng, Xuetao Pei, Yu Wang, Jiang Peng, Wenjing Xu, Wen Yue, Yan Han
Summary: An injectable decellularised matrix hydrogel (DAM-gel) was developed to simulate the stem cell microenvironment, promoting the repair of peripheral nerve defects with adipose-derived mesenchymal stem cells (ADSCs). The ADSC-loaded DAM-gel significantly improved Schwann cell proliferation, axonal regeneration, and neurological function recovery in a rat model. These findings suggest that DAM-gels have great potential for enhancing the repair capacity of ADSCs in peripheral nerve defects.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Cell & Tissue Engineering
Shune Xiao, Chunfang Xiao, Yong Miao, Jin Wang, Ruosi Chen, Zhexiang Fan, Zhiqi Hu
Summary: The study demonstrated that hAAM scaffolds incorporated with ADSC-Exos can promote diabetic skin wound healing by regulating inflammation, stimulating vascularization, and promoting the production of extracellular matrix.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Yoshiyuki Tago, Chiho Kobayashi, Mineko Ogura, Jutaro Wada, Sho Yamaguchi, Takashi Yamaguchi, Masahiro Hayashi, Tomoyuki Nakaishi, Hiroshi Kubo, Yasuyoshi Ueda
Summary: The study found that human amnion-derived mesenchymal stem cells (AMSC) exhibit significant immunosuppressive effects and can delay the progression of acute graft-versus-host disease (GVHD) mainly by preventing T cell activation and proliferation through the PD-1 pathway.
SCIENTIFIC REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Kaiyang Liu, Yunfan He, Feng Lu
Summary: This review discusses recent advancements in understanding the behavior of inflammatory cells during the regeneration of acellular adipose matrix (AAM). The findings will inform the development of AAM products with enhanced properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Kaiyang Liu, Yunfan He, Yao Yao, Yuchen Zhang, Zihan Cai, Jiangjiang Ru, Xiangdong Zhang, Xiaoxuan Jin, Mimi Xu, Yibao Li, Qizhuan Ma, Jianhua Gao, Feng Lu
Summary: The study demonstrates that the modified decellularization method with mPEG can preserve bioactive components in AAM and reduce immunogenicity after xenogeneic transplantation, promoting adipogenesis. This suggests that mPEG-modified AAM could be a promising biomaterial for xenogeneic adipose tissue engineering.
MATERIALS TODAY BIO
(2021)
Article
Engineering, Biomedical
Yanhua Lan, Huizhi Xie, Qianrui Jin, Xiaomin Zhao, Yang Shi, Yanyan Zhou, Zihe Hu, Yi Ye, Xiaoyuan Huang, Yingjia Sun, Zhuo Chen, Zhijian Xie
Summary: This study reveals that extracellular vesicles (EVs) derived from Nell1-modified bone marrow stem cells (BMSCs) have a stronger ability to promote BMSC osteogenesis due to the downregulation of miR-25-5p. Additionally, the 3D-Nell1/EV hydrogel system is shown to be beneficial for bone regeneration in vivo, possibly because of the slow and continuous release of EVs at a high concentration in the bone defect area.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Vlad Bloanca, Horia Haragus, Anca-Maria Campean, Andrei Cosma, Tiberiu Bratu, Zorin Crainiceanu
Summary: The study aimed to analyze the involvement of adipose-sourced mast cells in nerve repair. Results showed that mechanically processed adipose tissue augmented nerve repair does not seem to increase mast cell expression but may support angiogenesis in an experimental model.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Jun Ho Lee, Yu Jin Won, Hail Kim, Minji Choi, Esther Lee, Bumsik Ryoou, Seok-Geun Lee, Byong Seung Cho
Summary: Exosomes derived from adipose tissue-derived stem cells (ASCs) have shown beneficial effects on cell proliferation, migration, and gene expression related to wound healing. Combining these ASC-derived exosomes (ASC-EXOs) with hyaluronic acid (HA) can enhance wound closure rates, tissue regeneration, and collagen production in animal models. This suggests the potential for their use in clinical and regenerative aesthetic applications for skin repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shuwei Xiao, Pengchao Wang, Jian Zhao, Zhengyun Ling, Ziyan An, Zhouyang Fu, Weijun Fu, Jin Zhou, Xu Zhang
Summary: Bladder patches constructed with BAM and ASCs were incubated with omentum for bladder reconstruction, showing that the BAM-ASCs group could regenerate bladder wall structure better. ASCs could promote the regeneration of smooth muscle, neurons, and blood vessels, and restore physiological functions in the bladder.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tianhao Yu, Qiang Ao, Tianrang Ao, Muhammad Arslan Ahmad, Aijun Wang, Yingxi Xu, Zhongti Zhang, Qing Zhou
Summary: This study developed an optimized multichannel acellular nerve allograft (ANA) with improved ultrastructure and mechanical properties. The ANAs retained more extracellular matrix (ECM) components and bioactive molecules, which enhanced their regenerative capacity and biocompatibility. Both in vitro and in vivo results showed that the optimized ANAs had significant advantages in promoting nerve regeneration and functional recovery.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.