Article
Biotechnology & Applied Microbiology
Feng Wang, Shuguang Wang, Liping Nan, Jiawei Lu, Ziqi Zhu, Jintao Yang, Dong Zhang, Junjian Liu, Xiao Zhao, Desheng Wu
Summary: Wound injuries can lead to serious consequences, and the use of biomedical hydrogels as wound dressings has shown great potential in accelerating wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Engineering, Environmental
Lirong Wang, Mengyun Zhou, Tailin Xu, Xueji Zhang
Summary: The multifunctional hydrogel wound dressing promotes wound healing by providing antibacterial, hemostatic, and adhesive properties, while also enabling real-time monitoring of wound status. The personalized wound management model accurately analyzes and evaluates wound healing and infection status using the colorimetric signal of the hydrogel dressing, achieving high accuracy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Miaomiao Zhang, Shixin Xu, Chen Du, Ruoying Wang, Cuicui Han, Yongan Che, Wei Feng, Chengwei Wang, Shan Gao, Wen Zhao
Summary: In this study, a novel bilayer wound dressing made of poly(L-lactate-caprolactone) copolymer (PLCL) nanofibrous and keratin hydrogel loaded with fibroblast growth factor (FGF-2) was prepared using the low-pressure filtration-assisted method. The bilayer dressing was found to mimic the dermis and epidermis. It exhibited good porosity, maximum water absorption, and tight bond at the interface. In vitro and in vivo studies demonstrated the biocompatibility, biodegradability, and ability to promote skin healing of the bilayer dressing, making it a promising biomedical wound dressing for skin tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Mahla Lashkari, Mahya Rahmani, Yaser Yousefpoor, Meysam Ahmadi-Zeidabadi, Reza Faridi-Majidi, Zahra Ameri, Moein Salary, Shahrzad Azizi, Arman Shahabi, Amid Rahi, Mohamad Javad Mirzaei-Parsa
Summary: In this study, a bilayer scaffold composed of hydrogel and nanofibers was fabricated to improve the regeneration of injured skin. The results showed that re-epithelialization, angiogenesis, and collagen remodeling were enhanced in ADSCs-seeded bilayer scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Biochemistry & Molecular Biology
Mehdi Farokhi, Fatemeh Mottaghitalab, Mercedeh Babaluei, Yasamin Mojarab, Subhas C. Kundu
Summary: Skin injuries, especially chronic wounds, remain a significant healthcare problem. Recent developments in multifunctional wound dressings aim to improve wound repair.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Dongqing Wang, Heying Chen, Li Lei, Jun Chen, Jimin Gao, Jiahe Liu, Qianyin Li, Yajun Xie, Yi Hu, Yilu Ni
Summary: Effective skin wound healing involves anti-inflammation, fibrosis, matrix reconstruction, and angiogenesis. This study aimed to integrate macrophage-mediated anti-inflammation and fibroblast-assisted matrix reconstruction to enhance wound healing. The results showed that M2 macrophage cytomembranes promoted wound closure, and the addition of fibroblast membranes contributed to better matrix reconstruction and angiogenesis.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Polymer Science
Jie Liu, Wenqi Jiang, Qianyue Xu, Yongjie Zheng
Summary: Antibacterial hydrogel is widely used in biomedical, intelligent textiles, cosmetics, and other fields, especially in medical dressings. It has the characteristics of absorbing wound liquid, controlling drug release, and its preparation method is simple with easily accessible materials.
Article
Biochemistry & Molecular Biology
Mengmeng Xie, Yanbo Zeng, Hang Wu, Shige Wang, Jiulong Zhao
Summary: A multifunctional hydrogel has been developed that can rapidly stop bleeding and has antibacterial properties, promoting wound healing and repair. The hydrogel has good water retention capacity and mimics the three-dimensional structure of the natural extracellular matrix, making it promising for applications in hemostasis and wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Paper & Wood
Faheem Ahmad, Bushra Mushtaq, Faaz Ahmed Butt, Abher Rasheed, Sheraz Ahmad
Summary: A novel biodegradable composite of sodium alginate hydrogel with wool needle-punched nonwoven fabric was developed for wound dressing, showing increased wound exudate absorbing capacity, enhanced tensile strength, and improved moisture management properties. The unique combination provides a moist environment and promotes cell proliferation during the wound healing process.
Review
Polymer Science
Olga Luneva, Roman Olekhnovich, Mayya Uspenskaya
Summary: A wide range of skin diseases necessitates the search for alternative and effective treatment options, particularly for various types of wounds. This review examines the advantages and methods of bilayer dressings in wound treatment and skin tissue regeneration, focusing on hydrogel-based materials. The use of such materials can provide unique properties, such as antimicrobial, adhesion, and hemostasis capabilities, as well as drug delivery and self-healing abilities.
Article
Biochemistry & Molecular Biology
Ying Chen, Xiaokun Fan, Jiawei Lu, Xin Liu, Jin Chen, Yi Chen
Summary: This study presents the preparation of multifunctional chitosan/polydopamine/polyacrylamide hydrogels with superior tissue adhesion, self-healing, and antibacterial properties. The hydrogels show great potential in accelerating skin tissue regeneration and promoting wound healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Xia Qiu, Jiamin Zhang, Lilong Cao, Qin Jiao, Junhao Zhou, Lijun Yang, Hong Zhang, Yuping Wei
Summary: Dextran-based hydrogels with zwitterionic structures showed faster wound healing rates compared to natural dextran hydrogel and commercial dressings, attributed to their protein resistance and ability to scavenge free radicals. These hydrogels also demonstrated excellent cytocompatibility and antibacterial properties, along with self-healing capabilities for irregular wounds, providing a new pathway for multifunctional polysaccharide hydrogels in wound treatment and pain relief during dressing changes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Hira Mahmood, Muhammad Asif, Syed Haroon Khalid, Ikram Ullah Khan, Zunera Chauhdary, Fizza Abdul Razzaq, Sajid Asghar
Summary: In this study, a composite functional wound dressing based on kappa-carrageenan and tannic acid was prepared and co-encapsulated with simvastatin and Geranium oil. The prepared films had excellent mechanical strength, high swelling rate, and good water solubility. The dressing showed superior antioxidant, anti-inflammatory, and broader anti-bacterial activity. The CS/G/TA hydrogel film exhibited excellent wound healing effect through improved angiogenesis and down regulation in the expression of inflammatory markers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.