Review
Polymer Science
Naiyu Cui, Chun-Yu Dai, Xuran Mao, Xun Lv, Yue Gu, Eui-Seok Lee, Heng-Bo Jiang, Yunhan Sun
Summary: Poloxamer, as a triblock copolymer with amphiphilicity and reversible thermal responsiveness, has wide application prospects in biomedicine. It plays a crucial role as injectable scaffolds in tissue engineering and 3D printing, creating an appropriate microenvironment for cell growth and vascular network formation.
Article
Biochemistry & Molecular Biology
Vadym Burchak, Fritz Koch, Leonard Siebler, Sonja Haase, Verena K. Horner, Xenia Kempter, G. Bjoern Stark, Ute Schepers, Alisa Grimm, Stefan Zimmermann, Peter Koltay, Sandra Strassburg, Gunter Finkenzeller, Filip Simunovic, Florian Lampert
Summary: This study evaluated the printability and biocompatibility of a semi-synthetic hydrogel system (GelNB/GelS) for bioprinting of adipose-tissue-derived mesenchymal stem cells (ASCs). The results showed that GelNB/GelS hydrogels supported ASCs viability, proliferation and differentiation. The mechanical properties of GelNB/GelS system influenced the differentiation fate of ASCs. The hydrogel system may have potential applications in in vivo tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Parisa Khayambashi, Janaki Iyer, Sangeeth Pillai, Akshaya Upadhyay, Yuli Zhang, Simon D. Tran
Summary: Tissue engineering has a long history in regenerative medicine, and methods such as cell-encapsulated hydrogels and exosomes can enhance the regenerative potential of various tissues, with hydrogels being the most user-friendly, economical, and accessible material for encapsulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Nobuhiro Okuno, Shuhei Otsuki, Jo Aoyama, Kosuke Nakagawa, Tomohiko Murakami, Kuniaki Ikeda, Yoshinobu Hirose, Hitoshi Wakama, Tomohiro Okayoshi, Yoshinori Okamoto, Yoshiaki, Masashi Neo
Summary: The study demonstrated that the peptide hydrogel scaffold KI24RGDS can promote repair and regeneration of meniscus in a rabbit model, showing significant healing effects. The hydrogel is highly biocompatible and biodegradable, mimicking the three-dimensional structure of the extracellular matrix and promoting cell adhesion and proliferation.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Carlo Diaferia, Elisabetta Rosa, Enrico Gallo, Giovanni Smaldone, Mariano Stornaiuolo, Giancarlo Morelli, Antonella Accardo
Summary: Peptide-based hydrogels, specifically the Fmoc derivatives of series K, are capable of self-assembly and gelation in aqueous solutions, with Fmoc-K3 hydrogel showing potential for tissue engineering applications by supporting cell adhesion, survival, and duplication. The gelification process is dependent on the balance of aggregation forces within the peptide sequences, such as van der Waals, hydrogen bonding, and pi-pi stacking.
Article
Polymer Science
Kamran Hidayat Ullah, Faisal Raza, Syed Mohsin Munawar, Muhammad Sohail, Hajra Zafar, Mazhar Iqbal Zafar, Tofeeq Ur-Rehman
Summary: The study successfully enhanced the gel strength and drug loading of P407 gel by modifying the formulation, utilizing thioglycolic acid as a nail penetration enhancer. The developed P407 gel demonstrated promising potential for transungual delivery of hydrophobic antifungal agents with sufficient gel strength and drug loading.
Article
Engineering, Biomedical
Isabel Mayoral, Elisa Bevilacqua, Gorka Gomez, Abdelkrim Hmadcha, Ignacio Gonzalez-Loscertales, Esther Reina, Julio Sotelo, Antonia Dominguez, Pedro Perez-Alcantara, Younes Smani, Patricia Gonzalez-Puertas, Ana Mendez, Sergio Uribe, Tarik Smani, Antonio Ordonez, Israel Valverde
Summary: In this study, a patient-specific patch was designed using a hybrid 3D printing technique and VSMC differentiation. Through computational modeling and experimental evaluation, the patch demonstrated favorable hemodynamic characteristics, mechanical properties, cell infiltration, viability, and functionality. This innovative 3D biotechnology holds great potential for applications in regenerative medicine and heart disease prevention.
MATERIALS TODAY BIO
(2022)
Review
Biotechnology & Applied Microbiology
Xin Yao, Yicun Hu, Maoqiang Lin, Kaichen Peng, Peng Wang, Yanbing Gao, Xidan Gao, Taowen Guo, Xiaobo Zhang, Haiyu Zhou
Summary: RADA16 is a peptide-based biomaterial that can quickly form a 3D structure with good biocompatibility and ease of modification, making it suitable for tissue engineering. However, its weak mechanical properties and poor hydrophilicity are limitations that can be overcome through modification.
Review
Polymer Science
Zheng Li, Muxin Yue, Yunsong Liu, Ping Zhang, Jia Qing, Hao Liu, Yongsheng Zhou
Summary: Organoids are novel in vitro cell culture models that recapitulate the characteristics of organs and have the ability for self-renewal and further differentiation. Hydrogel technology holds great potential for organoid culture.
Review
Polymer Science
Cosimo Ligorio, Judith A. Hoyland, Alberto Saiani
Summary: Low back pain caused by intervertebral disc degeneration is a major contributor to global disability. Current treatments are limited, and alternative strategies using soft biomaterials as injectable carriers for disc repair are being explored.
Article
Biochemistry & Molecular Biology
Aleksandra Serafin, Mario Culebras, Maurice N. Collins
Summary: Tissue engineering is proposed as a potential solution to organ shortages. Various hydrogel formulations have been studied, including organic and biocompatible materials that mimic the native tissue. However, comparing studies is difficult due to differences in material concentrations and preparation methods. The current study aims to investigate popular biomaterials and their behaviors for targeted tissue engineering strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Rongshuai Yang, Min Chen, Xuanxin Yang, Wenzhe Sun, Chao Lu, Qi Hui, Changcan Shi, Xiaokun Li, Xiaojie Wang
Summary: The study demonstrated that the use of PHA hydrogel loaded with KGF-2 effectively improved the morphology and inflammation of articular cartilage, reduced the loss of proteoglycan, and balanced collagen metabolism in rats with OA, showing promise as a therapeutic strategy.
MATERIALS & DESIGN
(2021)
Article
Nanoscience & Nanotechnology
Sevda Pouraghaei Sevari, Jin Koo Kim, Chider Chen, Amir Nasajpour, Cun-Yu Wang, Paul H. Krebsbach, Ali Khademhosseini, Sahar Ansari, Paul S. Weiss, Alireza Moshaverinia
Summary: The study developed an osteogenic niche composed of a commercially modified alginate hydrogel and whitlockite microparticles, showing a high effectiveness in promoting osteogenesis of human gingival mesenchymal stem cells. Results indicate that this osteogenic hydrogel can effectively direct bone repair and regeneration, demonstrating superior osteogenic effects compared to existing hydroxyapatite microparticles.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Jiyun Cheng, Zheng Chen, Can Liu, Mei Zhong, Shihuan Wang, Yongjian Sun, Huiquan Wen, Tao Shu
Summary: This study successfully utilized 3D gelatin methacrylate hydrogel as a delivery system for transplanted exosomes, enhancing neuronal differentiation and extension of neural stem cells, while promoting neurogenesis and attenuating glial scars in damaged lesions.
Article
Chemistry, Applied
Penghui Wang, Yajie Pu, Yanhan Ren, Rong Yang, Wenjie Zhang, Xiaoyan Tan, Wenliang Xue, Shuai Liu, Shuang Li, Bo Chi
Summary: This research introduces a novel hybrid hydrogel system based on sodium alginate and polyglutamic acid, with adjustable gelation time and mechanical strength, prolonged degradation time and reduced swelling rate, dynamic response characteristics, excellent self-healing and injectable ability. The system shows positive cytocompatibility and accelerated regulatory gene expression in cartilage tissue, indicating broad application prospects in future biomedical engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.