Review
Chemistry, Multidisciplinary
Liviu Duta, Gabriela Dorcioman, Valentina Grumezescu
Summary: This review summarizes the results on the production of biphasic calcium phosphate (BCP) materials derived from fish wastes and discusses their potential applications in the biomedical field. Transforming waste into valuable products can have significant social, economic, and environmental benefits. The use of fish discards for BCP materials has shown promising results and is a safe, cheap, and simple procedure.
Review
Chemistry, Physical
Abhishek Indurkar, Rajan Choudhary, Kristaps Rubenis, Janis Locs
Summary: Calcium phosphate (CaP) biomaterials are widely used for bone defect reconstruction, but traditional sintering may lead to the formation of secondary phases and excessive grain growth. Therefore, researchers are exploring advanced sintering techniques to improve the densification of CaPs.
Article
Green & Sustainable Science & Technology
Szymon Skibinski, Joanna P. Czechowska, Maciej Guzik, Vladyslav Vivcharenko, Agata Przekora, Patryk Szymczak, Aneta Zima
Summary: Poly(3-hydroxybutyrate) (P(3HB)) and medium chain length PHA (mcl-PHA) blends were used as coatings on beta tricalcium phosphate (beta TCP) scaffolds, and their physicochemical properties were investigated. The blends showed high open porosity and improved compressive strength on the scaffolds. The wettability of the coatings could be tailored by modifying the composition of the blends. In vitro biocompatibility tests showed that all evaluated scaffolds were nontoxic, and the hydrophilicity of the surface positively influenced cell adhesion and proliferation.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Article
Biotechnology & Applied Microbiology
Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Mueller, Caitlyn J. Collins
Summary: This study highlights the importance of mechanical regulation for patients at risk of fracture and discusses the use of HR-pQCT and computed mechanical loads to investigate bone mechanoregulation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Daniel Maya-Anaya, Guillermo Urriolagoitia-Sosa, Beatriz Romero-Angeles, Miguel Martinez-Mondragon, Jesus Manuel German-Carcano, Martin Ivan Correa-Corona, Alfonso Trejo-Enriquez, Arturo Sanchez-Cervantes, Alejandro Urriolagoitia-Luna, Guillermo Manuel Urriolagoitia-Calderon
Summary: In this study, biomodels of the humerus, radius, and ulna were developed and used for numerical analysis. The mechanical properties of cortical and trabecular bone were taken into consideration, along with boundary conditions and external load. The results obtained provide information on stress and strain distribution, assisting in the diagnosis of structural problems and pain areas.
APPLIED SCIENCES-BASEL
(2023)
Article
Biophysics
Anna M. McDermott, Emily A. Eastburn, Daniel J. Kelly, Joel D. Boerckel
Summary: Mechanical stimulation plays a role in regulating chondrocyte maturation and homeostasis, with the duration of chondrogenic priming affecting the response of engineered cartilage tissue to dynamic compression. Early loading may preserve chondrocyte homeostasis, while delayed loading could support cartilage maturation.
JOURNAL OF BIOMECHANICS
(2021)
Article
Engineering, Biomedical
Priscila T. A. Toledo, Caroline Anselmi, Renan Dal-Fabbro, Abdel H. Mahmoud, Alexandra K. Abel, Matthew L. Becker, Alberto C. B. Delbem, Marco C. Bottino
Summary: The aim of this study was to create and evaluate biodegradable polymer-based nanofibers incorporating different concentrations of calcium trimetaphosphate (Ca-TMP) for periodontal tissue engineering. The fibers were fabricated using electrospinning technique and characterized using various techniques. The addition of Ca-TMP improved the degradation stability and dimensional stability of the fibers without compromising their mechanical properties. Although Ca-TMP extracts enhanced cell viability and alkaline phosphatase activity, there was no significant difference between the scaffold groups in terms of cell function.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Endocrinology & Metabolism
Matthias Walle, Danielle E. Whittier, Denis Schenk, Penny R. Atkins, Michael Blauth, Philippe Zysset, Kurt Lippuner, Ralph Mueller, Caitlyn J. Collins
Summary: This study developed bone mechanoregulation markers and their precision using participants from two cohorts. The results showed that bone formation occurred in high-strain regions and bone resorption occurred in low-strain regions for all participants, indicating a consistent response to mechanical stimuli. This work provides novel and robust bone mechanoregulation markers for designing future clinical studies.
Article
Mechanics
Robert M. Auenhammer, Lars P. Mikkelsen, Leif E. Asp, Brina J. Blinzler
Summary: This study presents a complete procedure for generating finite element models based on X-ray computer tomography data on the fiber bundle scale for non-crimp fabric reinforced composites. The method includes a fully automated segmentation process and an element-wise material orientation mapping of X-ray computer tomographic data. This methodology combines recent research progress and improvements in image analysis, providing a fast, accurate, and repeatable data transfer and analysis process with a high degree of automation.
COMPOSITE STRUCTURES
(2021)
Article
Engineering, Biomedical
Petr Marcian, Libor Borak, Tomas Zikmund, Ladislava Horackova, Jozef Kaiser, Marek Joukal, Jan Wolff
Summary: A patient-specific approach in computational simulations of biomechanical systems has gained popularity, but the quality of models created from imaging data may be compromised by low-resolution images. This study analyzed the effects of image resolution on modeling and mechanical strains in bone with implants, finding that low-resolution images can lead to biased results and incorrect mechanical strains.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Physical
Dmitriy Soloviev, Leonid Maslov, Mikhail Zhmaylo
Summary: The purpose of this study is to use the finite element method to analyze the strength and stability of a system consisting of the pelvis and a custom implant under functional loads. A technique for assessing elastic properties of bone tissue using computer tomography was considered, and finite element models of pelvic bones and a custom endoprosthesis were constructed based on initial geometric models. Calculations were performed for the stress-strain state of the biomechanical system during walking, as well as under maximum loads during stair ascent and descent. The analysis provided conclusions about the strength and stability of the studied device.
Review
Materials Science, Multidisciplinary
Mengyao Zhu, Yingzhi Gu, Ce Bian, Xianju Xie, Yuxing Bai, Ning Zhang
Summary: This article reviews the application of miRNAs in bone tissue engineering and their role in promoting osteoblast differentiation and gene expression. It also discusses the advantages of nonviral vectors in miRNA transfection and provides an overview of different types of nonviral miRNA-transfected biomaterials.
FRONTIERS IN MATERIALS
(2022)
Article
Mathematics
Inigo Calderon-Uriszar-Aldaca, Sergio Perez, Ravi Sinha, Maria Camara-Torres, Sara Villanueva, Carlos Mota, Alessandro Patelli, Amaia Matanza, Lorenzo Moroni, Alberto Sanchez
Summary: Finite element modeling was used to simulate AM scaffolds for bone tissue regeneration, with experimental validation using polymer and nano-filler composites. The simulations overestimated scaffold performance due to lack of printing accuracy, highlighting the importance of calibration for expected scenarios.
Article
Engineering, Biomedical
Jamie A. Cyr, Anke Husmann, Serena M. Best, Ruth E. Cameron
Summary: The study aims to demonstrate an innovative freeze-casting system for precise architectural control of collagen scaffolds and to develop a predictive simulation as a design tool. The embedded heat sources were used to manipulate the thermal environment and achieve complex lamellar orientations in the scaffolds. The finite element model accurately predicted the freezing process and lamellar orientation. This approach offers an exciting opportunity for tailored design of regenerative scaffolds.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Sandra Loerakker, Jay D. Humphrey
Summary: Advances in genomics, molecular and cellular mechanobiology, and immunobiology have led to the increasing importance of computational models in tissue and organ mechanobiology and mechanics, particularly in the field of regenerative medicine. This review focuses on the development and application of computational models in designing tissue engineered constructs, with examples from cardiovascular medicine, highlighting the current methods and ongoing needs.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Wenjian Yang, Damien Lacroix, Lay Poh Tan, Jinju Chen
Summary: Changes in the apparent moduli of cells are related to cell abnormalities and diseases. Indentation is a common method used to measure these moduli, but the protocol employed can affect the results. A finite element model of key intracellular components has been developed to study indentation protocol-dependent cell mechanics, which has shown that the moduli obtained with conical indenters decrease with increasing cone angle. The interplay between indenter geometry and intracellular components has also been investigated for understanding the structure-mechanics-function relationships of cells.
JOURNAL OF MATERIALS RESEARCH
(2021)
Article
Surgery
Peter Endre Eltes, Marton Bartos, Benjamin Hajnal, Agoston Jakab Pokorni, Laszlo Kiss, Damien Lacroix, Peter Pal Varga, Aron Lazary
Summary: A new method utilizing CT scan, 3D reconstruction, FEA analysis, CAD design, and 3D printing technology was proposed to assist surgeons in performing optimal surgical technique for revision surgery of non-union at the lumbosacral level, specifically addressing complications such as broken screws. Results showed that the modified bicortical convergent insertion technique is stiffer compared to monocortical divergent placement, indicating the potential for improved surgical outcomes.
FRONTIERS IN SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Martina Tortorici, Ansgar Petersen, Klara Ehrhart, Georg N. Duda, Sara Checa
Summary: Mechanical and biological factors are known to play key roles in osteochondral defect healing, but the underlying principles and how they can be applied in treatment strategies are still largely unknown. A computational approach was used to investigate the impact of scaffold mechanical and architectural properties on osteochondral defect healing, revealing that scaffold material elastic modulus and structural stability are crucial for supporting the repair process.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Pinaki Bhattacharya, Qiao Li, Damien Lacroix, Visakan Kadirkamanathan, Marco Viceconti
Summary: The study proposes a method to define scale based on measurement limitations and variations in time and space, and uses it to construct a multiscale modelling methodology. This methodology can be easily adapted to a wide range of engineering problems.
Article
Biotechnology & Applied Microbiology
Vincenzo Orassi, Georg N. Duda, Max Heiland, Heilwig Fischer, Carsten Rendenbach, Sara Checa
Summary: This study investigated the biomechanics of sheep mandibles as a preclinical model for testing mechanical strength of fixation devices and biomechanical environment induced on mandibular fractures. Results showed differences in mechanical environments and stress between human and sheep mandibles, suggesting careful consideration when using sheep mandibles for studying the effect of fixation devices on healing outcome.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Javier Gil, Clara Sandino, Miguel Cerrolaza, Roman Perez, Mariano Herrero-Climent, Blanca Rios-Carrasco, Jose Vicente Rios-Santos, Aritza Brizuela
Summary: The purpose of this study was to investigate the biomechanical response of dental implants in different positions and cortical bone thicknesses. Numerical simulations and in vivo experiments showed that implants placed 0.5 mm below the bone level with smaller thickness had the best performance in terms of osseointegration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Vincenzo Orassi, Heilwig Fischer, Georg N. Duda, Max Heiland, Sara Checa, Carsten Rendenbach
Summary: This study evaluated the biomechanical competence of magnesium alloy WE43 fixation devices for mandibular fracture healing. The results showed that magnesium alloy WE43 provided a suitable biomechanical environment for mandibular fracture healing in the early stages, with similar biomechanical performance to clinically used titanium devices and the added advantages of biodegradability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Peter Endre Eltes, Mate Turbucz, Jennifer Fayad, Ferenc Bereczki, Gyoergy Szoke, Tamas Terebessy, Damien Lacroix, Peter Pal Varga, Aron Lazary
Summary: 25 special forces members have completed a 3-month training course and successfully adapted to various environments. They will participate in local counter-terrorism operations and other special missions, and continue training.
FRONTIERS IN SURGERY
(2022)
Article
Engineering, Biomedical
Camille Perier-Metz, Amaia Cipitria, Dietmar W. Hutmacher, Georg N. Duda, Sara Checa
Summary: This article uses computer modeling to investigate the mechano-biological principles behind scaffold-guided bone regeneration and the impact of scaffold design on the regeneration process. The study identifies two key factors in scaffold-guided regeneration: the scaffold surface guiding cellular migration and tissue formation processes, and the stimulation of progenitor cell activity by the scaffold material composition. Additionally, a lower scaffold surface-area-to-volume ratio is found to be beneficial for bone regeneration, and a reduced scaffold Young's modulus also favors bone formation.
ACTA BIOMATERIALIA
(2022)
Review
Biochemical Research Methods
Patrina S. P. Poh, Thomas Lingner, Stefan Kalkhof, Sven Mardian, Jan Baumbach, Patrick Dondl, Georg N. Duda, Sara Checa
Summary: Additive manufacturing can produce personalized scaffolds for large volume defect tissue regeneration, but faces challenges due to the heterogeneous biological regeneration potential across individuals. By combining technologies such as in silico modeling, omics, bioinformatics, and information technology, personalized tissue regeneration strategies can be developed using additive manufacturing, which has great potential in advancing precision medicine.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Camille Perier-Metz, Laurent Corte, Rachele Allena, Sara Checa
Summary: A computer model based on mechanical strain accumulation was proposed to investigate the mechanobiological regulation of bone remodeling during the late phase of healing. The model successfully predicted the reopening of the bone marrow cavity and the resorption of the external callus. The results suggest that local strain accumulation can explain the fracture remodeling process and this mechanobiological response is conserved among different mammal species.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Martina Tortorici, Ansgar Petersen, Georg N. Duda, Sara Checa
Summary: This study analyzed the degradation-induced changes in material and architectural properties of a scaffold with strut-like architecture in treating osteochondral defects, finding that different degradation modalities significantly affected the repair outcome. Bulk degradation with autocatalysis led to mechanical failure of the scaffold, while scaffolds degrading by surface erosion and slow bulk degradation showed better repair outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biophysics
Tamer Abdalrahman, Sara Checa
Summary: This article reviews the use of computational models in angiogenesis, with a focus on the role of mechanical signals. The study found that a better understanding of the mechanobiology of angiogenesis requires the development of computer models that incorporate the interactions between multiple mechanical signals and their effect on cellular responses.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Jun Pan, Damien Lacroix, Yilu Zhou, Bin Wang
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Mahdi Jaber, Lorenz C. Hofbauer, Christine Hofbauer, Georg N. Duda, Sara Checa
Summary: Bone regeneration is impaired in type 2 diabetes mellitus (T2DM), with alterations in MSC proliferation, migration, and osteoblast differentiation playing a significant role. Mechanical changes have minimal impact on reduced bone regeneration in T2DM. These findings have clinical implications for the treatment of bone fractures in patients with T2DM.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.