Review
Biochemistry & Molecular Biology
Chun-Yan Kong, Zhen Guo, Peng Song, Xin Zhang, Yu-Pei Yuan, Teng Teng, Ling Yan, Qi-Zhu Tang
Summary: This review provides a comprehensive overview of the mechanisms underlying the oxidative stress and cell death pathways induced by doxorubicin, which are the major factors responsible for the acute cardiotoxicity. The authors aim to offer new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xianchou Xu, Qingbo Liu, Jiahao Li, Mengjie Xiao, Ting Gao, Xiaohui Zhang, Guangping Lu, Jie Wang, Yuanfang Guo, Peinan Wen, Junlian Gu
Summary: The study demonstrated that co-treatment with RES and FGF1 significantly inhibited DOX-induced hepatic inflammation and apoptosis, while also markedly suppressing DOX-induced hepatic oxidative stress via targeting the AMPK/NRF2 pathway. This combination may provide a new therapeutic strategy for limiting DOX-induced hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Guangping Lu, Qingbo Liu, Ting Gao, Jiahao Li, Jingjing Zhang, Ou Chen, Cong Cao, Min Mao, Mengjie Xiao, Xiaohui Zhang, Jie Wang, Yuanfang Guo, Yufeng Tang, Junlian Gu
Summary: This study aimed to explore the therapeutic potential and underlying mechanisms of the co-treatment of resveratrol (RES) and fibroblast growth factor 1 (FGF1) in a doxorubicin (DOX)-treated model. The results showed that RES could reduce the growth-promoting activity of FGF1 and exhibited a more powerful antioxidative capacity in a DOX-treated model, with cardioprotective action mediated through the SIRT1/NRF2 pathway.
Article
Medicine, Research & Experimental
Farshid Maleki, Mona Salimi, Reza Shirkoohi, Mohsen Rezaei
Summary: Transplantation of freshly isolated mitochondria into cardiomyocytes damaged by doxorubicin has been shown to significantly reduce the toxicity of doxorubicin on the heart and improve cell viability.
Article
Biochemistry & Molecular Biology
Jie A. Wang, Yufeng Tang, Jingjing Zhang, Jie B. Wang, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu
Summary: In this study, the researchers investigated the role of the interaction between SIRT1 and SESN2 in DOX-induced cardiomyopathy. They found that SIRT1 deficiency aggravated cardiac damage, while the activation of SIRT1 had protective effects. Further studies revealed that SIRT1 reduced oxidative damage and apoptosis by attenuating the interaction between SESN2 and MDM2, thereby protecting the heart from DOX-induced toxicity.
Article
Pharmacology & Pharmacy
Sara A. A. Al-Kenany, Nada N. N. Al-Shawi
Summary: This study found that cafestol can alleviate the cardiotoxic effects induced by doxorubicin through the activation of the Nrf2 pathway. Cafestol improved doxorubicin-induced cardiac injury, reduced levels of cardiac enzymes in the blood, increased antioxidant levels, suppressed inflammation, inhibited cardiac apoptosis, and regulated the expression of related genes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Menglong Wang, Jishou Zhang, Mengmeng Zhao, Jianfang Liu, Jing Ye, Yao Xu, Zhen Wang, Di Ye, Dan Li, Jun Wan
Summary: This study demonstrates that RvD1 attenuates Dox-induced cardiac injury through improving cardiac function, reducing apoptosis and oxidative stress, and inhibiting inflammation and endoplasmic reticulum stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xiaofen Li, Jiyi Liang, Anquan Qin, Tao Wang, Sili Liu, Wei Li, Chuqiao Yuan, Liping Qu, Wenjun Zou
Summary: This study investigated the potential protective effect of DXXK against chronic cardiotoxicity induced by DOX. The results showed that DXXK could alleviate DOX-induced cardiotoxicity and reduce oxidative stress and inflammation by regulating HIF-1 alpha and NF-Kappa B p65.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hamidreza Dorostkar, Bibi Fatemeh Haghiralsadat, Mahdie Hemati, Fatemeh Safari, Azam Hassanpour, Seyed Morteza Naghib, Mohammad Hossein Roozbahani, M. R. Mozafari, Ali Moradi
Summary: Liposomal doxorubicin with favorable characteristics was designed and synthesized, and its physicochemical properties were investigated. The co-administration of liposomal doxorubicin with free doxorubicin and quercetin showed promising results in reducing cardiac enzymes, oxidative stress, and apoptosis, as well as improving antioxidant capacity in heart tissue.
Article
Plant Sciences
Yanfen Cheng, Xiaoping Wu, Xin Nie, Yihan Wu, Chen Zhang, Simon Ming-Yuen Lee, Kongpeng Lv, George Pak-Heng Leung, Chaomei Fu, Jinming Zhang, Jingjing Li
Summary: Glycyrrhetinic acid (GA) protects against doxorubicin-induced cardiotoxicity by suppressing oxidative stress, mitochondrial dysfunction, and apoptosis via upregulating the Nrf2/HO-1 signaling pathway.
Article
Biochemistry & Molecular Biology
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali
Summary: The study showed that diosmin has a protective effect against doxorubicin-induced hepatotoxicity by restoring hepatic antioxidant factors, reducing inflammatory and apoptotic proteins and genes.
Article
Biochemistry & Molecular Biology
Michela Pecoraro, Stefania Marzocco, Raffaella Belvedere, Antonello Petrella, Silvia Franceschelli, Ada Popolo
Summary: This study aimed to evaluate the protective effects of Simvastatin on Doxorubicin-induced cardiotoxicity. The results showed that Simvastatin co-treatment significantly reduced oxidative stress, calcium homeostasis disturbance, and apoptosis. Furthermore, Simvastatin co-treatment also affected the expression and cellular localization of Connexin 43, which is involved in cardioprotection. Based on these findings, Simvastatin could be a promising adjuvant in Doxorubicin anticancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chontida Yarana, Panjaree Siwaponanan, Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Nanthip Prathumsap, Siriporn C. Chattipakorn, Nipon Chattipakorn, Kovit Pattanapanyasat
Summary: The study indicates that EVs released from DOXO-treated rats have protective effects on cardiomyocytes, reducing ROS production and cell death. However, they have detrimental effects on macrophages, leading to activation of immune responses and suppression. These results highlight the pleiotropic roles of EVs in DIC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuting Ji, Dekui Jin, Jingyi Qi, Xuan Wang, Chengying Zhang, Peng An, Yongting Luo, Junjie Luo
Summary: Fucoidan has potent protective effects against DOXO-induced cardiotoxicity by reducing oxidative stress and preventing mitochondrial function injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Farshid Maleki, Shahram Rabbani, Reza Shirkoohi, Mohsen Rezaei
Summary: Intravenous mitochondrial transplantation can reduce doxorubicin-induced cardiotoxicity by decreasing ROS production, lipid peroxidation, and inflammation, and increasing ATP and antioxidant enzymes levels, thereby reducing apoptosis and necrosis in heart tissue.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Mariana Seke, Milica Markelic, Arian Morina, Danica Jovic, Aleksandra Korac, Dragana Milicic, Aleksandar Djordjevic
Article
Pathology
Vesna Jacevic, Aleksandar Djordjevic, Branislava Srdjenovic, Vukosava Milic-Tores, Zoran Segrt, Viktorija Dragojevic-Simic, Kamil Kuca
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2017)
Article
Environmental Sciences
Aleksandar Djordjevic, Daniela Sojic Merkulov, Marina Lazarevic, Ivana Borisev, Igor Medic, Vladimir Pavlovic, Bojan Miljevic, Biljana Abramovic
Article
Pathology
Danijela Petrovic, Mariana Seke, Milica Labudovic Borovic, Danica Jovic, Ivana Borisev, Branislava Srdjenovic, Zlatko Rakocevic, Vladimir Pavlovic, Aleksandar Djordjevic
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2018)
Review
Nanoscience & Nanotechnology
Ivana Borisev, Jasminka Mrdanovic, Danijela Petrovic, Mariana Seke, Danica Jovic, Branislava Srdenovic, Natasa Latinovic, Aleksandar Djordjevic
Article
Chemistry, Physical
Marina Lazarevic, Daniela Sojic Merkulov, Vesna Despotovic, Aleksandar Djordjevic, Nina Fincur, Nemanja Banic, Biljana Abramovic
REACTION KINETICS MECHANISMS AND CATALYSIS
(2019)
Article
Chemistry, Multidisciplinary
Mariana Seke, Danijela Petrovic, Milica Labudovic Borovic, Ivana Borisev, Mirjana Novakovic, Zlatko Rakocevic, Aleksandar Djordjevic
JOURNAL OF NANOPARTICLE RESEARCH
(2019)
Article
Environmental Sciences
Danijela Kojic, Jelena Purac, Tatjana V. Celic, Danica Jovic, Elvira L. Vukasinovic, Ivan Pihler, Ivana Borisev, Aleksandar Djordjevic
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Multidisciplinary Sciences
Tihomir Kovac, Ivana Borisev, Marija Kovac, Ante Loncaric, Frane Cacic Kenjeric, Aleksandar Djordjevic, Ivica Strelec, Chibundu N. Ezekiel, Michael Sulyok, Rudolf Krska, Bojan Sarkanj
SCIENTIFIC REPORTS
(2020)
Article
Food Science & Technology
Tihomir Kovac, Bojan Sarkanj, Ivana Borisev, Aleksandar Djordjevic, Danica Jovic, Ante Loncaric, Jurislav Babic, Antun Jozinovic, Tamara Krska, Johann Gangl, Chibundu N. Ezekiel, Michael Sulyok, Rudolf Krska
Article
Energy & Fuels
Nemanja Banic, Jugoslav Krstic, Stevan Stojadinovic, Andela Brnovic, Aleksandar Djordjevic, Biljana Abramovic
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2020)
Review
Chemistry, Multidisciplinary
Danica Jovic, Vesna Jacevic, Kamil Kuca, Ivana Borisev, Jasminka Mrdjanovic, Danijela Petrovic, Mariana Seke, Aleksandar Djordjevic
Article
Chemistry, Multidisciplinary
Daniela Sojic Merkulov, Marina Lazarevic, Aleksandar Djordjevic, Mate Nafradi, Tunde Alapi, Predrag Putnik, Zlatko Rakocevic, Mirjana Novakovic, Bojan Miljevic, Szabolcs Bognar, Biljana Abramovic
Article
Medicine, General & Internal
Rade Injac
Summary: Men can improve their own spermatogenesis by changing their lifestyle, habits, reducing stress levels, engaging in sports activities, improving nutrition quality, and medication usage. Steroids are a key issue for young men during their reproductive phase. This report presents a case of a healthy and sporty man who experienced recovery in sperm count after using steroids.
CLINICAL CASE REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
V. V. Kojic, I Djan, V. V. Bogdanovic, I Borisev, A. N. Djordjevic, T. Ivkovic-Kapicl, D. S. Jakimov
INTERNATIONAL JOURNAL OF RADIATION RESEARCH
(2019)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
